Dango, Sebastian

[["dc.bibliographiccitation.firstpage","227"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Minimally Invasive Therapy & Allied Technologies"],["dc.bibliographiccitation.lastpage","231"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Dango, Sebastian"],["dc.contributor.author","Antonakis, Fillimon"],["dc.contributor.author","Schrader, Dirk"],["dc.contributor.author","Radzikhovskiy, Arkadiy"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Hesterberg, Rudolf"],["dc.date.accessioned","2018-11-07T10:28:31Z"],["dc.date.available","2018-11-07T10:28:31Z"],["dc.date.issued","2017"],["dc.description.abstract","Introduction: Treatment failure of anal fistula results in high re-occurrence rate. Material and methods: Efficacy and safety of a nitinol closure clip system (bear-claw clip) were evaluated for anal fistulae treatment in a 36-month long-term follow-up study. Results: Twenty-two patients were included. No patient had been treated with a bear-claw clip system before. All patients were fully continent before treatment. Follow-up time was 36 months (range 19-48 months). We observed a re-occurrence rate of 41% (nine patients) with presence of an active fistula. Time to recurrence was on average 6.9 months (range 3-11 months). Thirteen patients (59%) showed a complete healing of the fistula. Placed clip was removed in all patients on average after almost 5.8 months (3-12 months), in three cases the clip was left in situ. We did not observe any incontinence; one patient reported recurrent burning after defecation once the clip system was removed. Discussions: Clip placement is a minimally invasive sphincter-preserving procedure with minimal complications and with an acceptable recurrence rate in the long term. However, bear-claw clip placement should probably be offered patients as a treatment option before more invasive procedures with higher perioperative morbidity are taken into consideration."],["dc.identifier.doi","10.1080/13645706.2017.1282521"],["dc.identifier.isi","000404934300006"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43438"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Taylor & Francis Ltd"],["dc.relation.issn","1365-2931"],["dc.relation.issn","1364-5706"],["dc.title","Long-term efficacy and safety of a nitinol closure clip system for anal fistula treatment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","36"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Clinical Pathology"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Lokka, Suvi"],["dc.contributor.author","Scheel, Andreas H."],["dc.contributor.author","Dango, Sebastian"],["dc.contributor.author","Schmitz, Katja"],["dc.contributor.author","Hesterberg, Rudolf"],["dc.contributor.author","Rüschoff, Josef"],["dc.contributor.author","Schildhaus, Hans-Ulrich"],["dc.date.accessioned","2019-07-09T11:40:00Z"],["dc.date.available","2019-07-09T11:40:00Z"],["dc.date.issued","2014"],["dc.description.abstract","Background Liposarcoma is the most frequent soft tissue sarcoma. Well differentiated liposarcoma may progress into dedifferentiated liposarcoma with pleomorphic histology. A minority additionally features myogenic, osteo- or chondrosarcomatous heterologous differentiation. Genomic amplification of the Mouse double minute 2 homolog (MDM2) locus is characteristic for well differentiated and dedifferentiated liposarcomas. Detection of MDM2 amplification may supplement histopathology and aid to distinguish liposarcoma from other soft tissue neoplasia. Case presentation Here we present two cases of dedifferentiated liposarcoma with challenging presentation. Case 1 features a myogenic component. As the tumour infiltrated the abdominal muscles and showed immunohistochemical expression of myogenic proteins, rhabdomyosarcoma had to be ruled out. Case 2 has an osteosarcomatous component resembling extraosseous osteosarcoma. The MDM2 status was determined in both cases and helped making the correct diagnosis. Overexpression of MDM2 and co-overexpression of Cyclin-dependent kinase 4 is demonstrated by immunohistochemistry. The underlying MDM2 amplification is shown by fluorescence in situ hybridisation. Since low grade osteosarcoma may also harbour MDM2 amplification it is emphasised that the amplification has to be present in the lipomatous parts of the tumour to distinguish liposarcoma from extraosseous osteosarcoma. Conclusions The two cases exemplify challenges in the diagnoses of dedifferentiated liposarcoma. Liposarcoma often has pleomorphic histology and additionally may feature heterologous components that mimic other soft tissue neoplasms. Amplification of MDM2 is characteristic for well differentiated and dedifferentiated liposarcomas. Determination of the MDM2 status by in situ hybridisation may assist histopathology and help to rule out differential diagnoses."],["dc.identifier.doi","10.1186/1472-6890-14-36"],["dc.identifier.fs","611818"],["dc.identifier.pmid","25126005"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10586"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58073"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Challenging dedifferentiated liposarcoma identified by MDM2-amplification, a report of two cases"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]