Dango, Sebastian

[["dc.bibliographiccitation.firstpage","509"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Langenbeck s Archives of Surgery"],["dc.bibliographiccitation.lastpage","519"],["dc.bibliographiccitation.volume","402"],["dc.contributor.author","Dango, Sebastian"],["dc.contributor.author","Beißbarth, Tim"],["dc.contributor.author","Weiss, Elisabeth"],["dc.contributor.author","Hosseini, Ali Seif Amir"],["dc.contributor.author","Raddatz, Dirk"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Beham, Alexander Wilhelm"],["dc.date.accessioned","2018-11-07T10:24:29Z"],["dc.date.available","2018-11-07T10:24:29Z"],["dc.date.issued","2017"],["dc.description.abstract","Upper GI bleeding remains one of the most common emergencies with a substantial overall mortality rate of up to 30%. In severe ill patients, death does not occur due to failure of hemostasis, either medical or surgical, but mainly from comorbidities, treatment complications, and decreased tolerated blood loss. Management strategies have changed dramatically over the last two decades and include primarily endoscopic intervention in combination with acid-suppressive therapy and decrease in surgical intervention. Herein, we present one of the largest patient-based analysis assessing clinical parameters and outcome in patients undergoing endoscopy with an upper GI bleeding. Data were further analyzed to identify potential new risk factors and to investigate the role of surgery. In this retrospective study, we aimed to analyze outcome of patients with an UGIB and data were analyzed to identify potential new risk factors and the role of surgery. Data collection included demographic data, laboratory results, endoscopy reports, and details of management including blood administration, and surgery was carried out. Patient events were grouped and defined as \"overall\" events and \"operated,\" \"non-operated,\" and \"operated and death\" as well as \"non-operated and death\" where appropriate. Blatchford, clinical as well as complete Rockall-score analysis, risk stratification, and disease-related mortality rate were calculated for each group for comparison. Overall, 253 patients were eligible for analysis: endoscopy was carried out in 96% of all patients, 17% needed surgical intervention after endoscopic failure of bleeding control due to persistent bleeding, and the remaining 4% of patients were subjected directly to surgery. The median length of stay to discharge was 26 days. Overall mortality was 22%; out of them, almost 5% were operated and died. Anticoagulation was associated with a high in-hospital mortality risk (23%) and was increased once patients were taken to surgery (43%). Patients taking steroids presented with a risk of death of 26%, once taken to surgery the risk increased to 80%. Patients with liver cirrhosis had a risk of death of 42%; we observed a better outcome for these patients once taken to theater. Clinically, once scored with Blatchford score, statistical correlation was found for initial need for blood transfusion and surgical intervention. Clinical as well as complete Rockall score revealed a correlation between need for blood transfusion as well as surgical intervention in addition with a decreased outcome with increasing Rockall scores. Risk factor analysis including comorbidity, drug administration, and anticoagulation therapy introduced the combination of tumor and non-steroidal antirheumatic medication as independent risk factors for increased disease-related mortality. UGIB remains challenging and endoscopy is the first choice of intervention. Care must be taken once a patient is taking antirheumatic non-steroidal pain medication and suffers from cancer. In patients with presence of liver cirrhosis, an earlier surgical intervention may be considered, in particular for patients with recurrent bleeding. Embolization is not widely available and carries the risk of necrosis of the affected organ and should be restricted to a subgroup of patients not primarily eligible for surgery once endoscopy has failed. Taken together, an interdisciplinary approach including gastroenterologists as well as surgeons should be used once the patient is admitted to the hospital to define the best treatment option."],["dc.identifier.doi","10.1007/s00423-017-1552-2"],["dc.identifier.isi","000400365500012"],["dc.identifier.pmid","28091770"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42673"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.relation.issn","1435-2451"],["dc.relation.issn","1435-2443"],["dc.title","Relevance of surgery in patients with non-variceal upper gastrointestinal bleeding"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","227"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Minimally Invasive Therapy & Allied Technologies"],["dc.bibliographiccitation.lastpage","231"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Dango, Sebastian"],["dc.contributor.author","Antonakis, Fillimon"],["dc.contributor.author","Schrader, Dirk"],["dc.contributor.author","Radzikhovskiy, Arkadiy"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Hesterberg, Rudolf"],["dc.date.accessioned","2018-11-07T10:28:31Z"],["dc.date.available","2018-11-07T10:28:31Z"],["dc.date.issued","2017"],["dc.description.abstract","Introduction: Treatment failure of anal fistula results in high re-occurrence rate. Material and methods: Efficacy and safety of a nitinol closure clip system (bear-claw clip) were evaluated for anal fistulae treatment in a 36-month long-term follow-up study. Results: Twenty-two patients were included. No patient had been treated with a bear-claw clip system before. All patients were fully continent before treatment. Follow-up time was 36 months (range 19-48 months). We observed a re-occurrence rate of 41% (nine patients) with presence of an active fistula. Time to recurrence was on average 6.9 months (range 3-11 months). Thirteen patients (59%) showed a complete healing of the fistula. Placed clip was removed in all patients on average after almost 5.8 months (3-12 months), in three cases the clip was left in situ. We did not observe any incontinence; one patient reported recurrent burning after defecation once the clip system was removed. Discussions: Clip placement is a minimally invasive sphincter-preserving procedure with minimal complications and with an acceptable recurrence rate in the long term. However, bear-claw clip placement should probably be offered patients as a treatment option before more invasive procedures with higher perioperative morbidity are taken into consideration."],["dc.identifier.doi","10.1080/13645706.2017.1282521"],["dc.identifier.isi","000404934300006"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43438"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Taylor & Francis Ltd"],["dc.relation.issn","1365-2931"],["dc.relation.issn","1364-5706"],["dc.title","Long-term efficacy and safety of a nitinol closure clip system for anal fistula treatment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","66"],["dc.bibliographiccitation.journal","Genome Medicine"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Liefke, Robert"],["dc.contributor.author","Windhof-Jaidhauser, Indra M."],["dc.contributor.author","Gaedcke, Jochen"],["dc.contributor.author","Salinas-Riester, Gabriela"],["dc.contributor.author","Wu, Feizhen"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Dango, Sebastian"],["dc.date.accessioned","2018-11-07T09:55:38Z"],["dc.date.available","2018-11-07T09:55:38Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: The oxidative DNA demethylase ALKBH3 targets single-stranded DNA (ssDNA) in order to perform DNA alkylation damage repair. ALKBH3 becomes upregulated during tumorigenesis and is necessary for proliferation. However, the underlying molecular mechanism remains to be understood. Methods: To further elucidate the function of ALKBH3 in cancer, we performed ChIP-seq to investigate the genomic binding pattern of endogenous ALKBH3 in PC3 prostate cancer cells coupled with microarray experiments to examine the expression effects of ALKBH3 depletion. Results: We demonstrate that ALKBH3 binds to transcription associated locations, such as places of promoter-proximal paused RNA polymerase II and enhancers. Strikingly, ALKBH3 strongly binds to the transcription initiation sites of a small number of highly active gene promoters. These promoters are characterized by high levels of transcriptional regulators, including transcription factors, the Mediator complex, cohesin, histone modifiers, and active histone marks. Gene expression analysis showed that ALKBH3 does not directly influence the transcription of its target genes, but its depletion induces an upregulation of ALKBH3 non-bound inflammatory genes. Conclusions: The genomic binding pattern of ALKBH3 revealed a putative novel hyperactive promoter type. Further, we propose that ALKBH3 is an intrinsic DNA repair protein that suppresses transcription associated DNA damage at highly expressed genes and thereby plays a role to maintain genomic integrity in ALKBH3-overexpressing cancer cells. These results raise the possibility that ALKBH3 may be a potential target for inhibiting cancer progression."],["dc.identifier.doi","10.1186/s13073-015-0180-0"],["dc.identifier.isi","000358641600001"],["dc.identifier.pmid","26221185"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12502"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36798"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1756-994X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1009"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Zeitschrift für Gastroenterologie"],["dc.bibliographiccitation.lastpage","1013"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Neesse, Albrecht"],["dc.contributor.author","Grade, Marian"],["dc.contributor.author","Dango, Sebastian"],["dc.contributor.author","Ghadimi, Michael"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Kunsch, Steffen"],["dc.contributor.author","Amanzada, Ahmad"],["dc.date.accessioned","2020-12-10T18:12:24Z"],["dc.date.available","2020-12-10T18:12:24Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1055/s-0043-108125"],["dc.identifier.eissn","1439-7803"],["dc.identifier.issn","0044-2771"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74358"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","A case report of delayed intra-abdominal and intra-luminal haemorrhage after polypectomy"],["dc.title.alternative","Rare complication after colonoscopy and polypectomy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1029"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Der Chirurg"],["dc.bibliographiccitation.lastpage","1033"],["dc.bibliographiccitation.volume","86"],["dc.contributor.author","Beham, Alexander W."],["dc.contributor.author","Dango, Sebastian"],["dc.contributor.author","Ghadimi, B. Michael"],["dc.date.accessioned","2018-11-07T09:49:26Z"],["dc.date.available","2018-11-07T09:49:26Z"],["dc.date.issued","2015"],["dc.description.abstract","Esophagectomy and subsequent reconstruction represent major physiological insults to the upper gastrointestinal (GI) tract, which as a consequence can lead to malnutrition, dysphagia and reflux. From a technical perspective, operative reconstruction involving gastric pull-up with a 2-3 cm wide tube and an anastomosis cranial to the azygos vein may minimize the symptoms. Overall, the problems tend to improve approximately 6 months after the operation. Newly occurring delayed physical functional impairments with previously known underlying malignant disease may be indicative of cancer relapse. Interventional techniques, such as stent placement or brachytherapy may be better suited for treatment of recurrent disease."],["dc.identifier.doi","10.1007/s00104-015-0086-9"],["dc.identifier.isi","000365221000005"],["dc.identifier.pmid","26400723"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35508"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1433-0385"],["dc.relation.issn","0009-4722"],["dc.title","Management of delayed complications after esophagectomy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]