Keil, Maria

[["dc.bibliographiccitation.firstpage","57"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","66"],["dc.bibliographiccitation.volume","265"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Weber, Kristina"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Diekhof, Esther"],["dc.contributor.author","Keil, Maria"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2017-09-07T11:47:50Z"],["dc.date.available","2017-09-07T11:47:50Z"],["dc.date.issued","2014"],["dc.description.abstract","Depression is a debilitating psychiatric disorder characterized among other aspects by the inability to properly experience or respond to reward. However, it remains unclear whether patients with depression present impaired reward system due to abnormal modulatory mechanisms. We investigated the activation of the nucleus accumbens (NAcc), a crucial region involved in reward processing, with functional magnetic resonance imaging using the desire-reason-dilemma paradigm. This task allows tracking the activity of the NAcc during the acceptance or the rejection of previously conditioned reward stimuli. Patients were assigned into subgroups of lower (LA) or higher (HA) NAcc activation according to beta weights. LA patients presented significant hypoactivation in the ventral tegmental area in addition to bilateral ventral striatum, confirming impairments in the bottom-up input to the NAcc. Conversely, HA patients presented significant hyperactivation in prefrontal areas such as the rostral anterior cingulate cortex and the anterior ventral prefrontal cortex in addition to bilateral ventral striatum, suggesting disturbances in the top-down regulation of the NAcc. Demographic and clinical differences explaining the abnormal co-activations of midbrain and prefrontal regions were not identified. Therefore, we provide evidence for dysfunctional bottom-up processing in one potential neurobiological subtype of depression (LA) and dysfunctional top-down modulation in another subtype (HA). We suggest that the midbrain and prefrontal regions are more specific pathophysiological substrates for each depression subtype. Above all, our results encourage the segregation of patients by similar dysfunctional mechanisms of the dopaminergic system, which would finally contribute to disentangle more specific pathogeneses and guide the development of more personalized targets for future therapies."],["dc.identifier.doi","10.1007/s00406-014-0552-2"],["dc.identifier.gro","3150742"],["dc.identifier.pmid","25327829"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7532"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","0940-1334"],["dc.title","Dissociating pathomechanisms of depression with fMRI: bottom-up or top-down dysfunctions of the reward system"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","808"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Human Brain Mapping"],["dc.bibliographiccitation.lastpage","818"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Brodmann, Katja"],["dc.contributor.author","Keil, Maria"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2017-09-07T11:47:50Z"],["dc.date.available","2017-09-07T11:47:50Z"],["dc.date.issued","2015"],["dc.description.abstract","Misdiagnosing bipolar depression can lead to very deleterious consequences of mistreatment. Although depressive symptoms may be similarly expressed in unipolar and bipolar disorder, changes in specific brain networks could be very distinct, being therefore informative markers for the differential diagnosis. We aimed to characterize specific alterations in candidate large-scale networks (frontoparietal, cingulo-opercular, and default mode) in symptomatic unipolar and bipolar patients using resting state fMRI, a cognitively low demanding paradigm ideal to investigate patients.MethodsNetworks were selected after independent component analysis, compared across 40 patients acutely depressed (20 unipolar, 20 bipolar), and 20 controls well-matched for age, gender, and education levels, and alterations were correlated to clinical parameters.ResultsDespite comparable symptoms, patient groups were robustly differentiated by large-scale network alterations. Differences were driven in bipolar patients by increased functional connectivity in the frontoparietal network, a central executive and externally-oriented network. Conversely, unipolar patients presented increased functional connectivity in the default mode network, an introspective and self-referential network, as much as reduced connectivity of the cingulo-opercular network to default mode regions, a network involved in detecting the need to switch between internally and externally oriented demands. These findings were mostly unaffected by current medication, comorbidity, and structural changes. Moreover, network alterations in unipolar patients were significantly correlated to the number of depressive episodes. Conclusion: Unipolar and bipolar groups displaying similar symptomatology could be clearly distinguished by characteristic changes in large-scale networks, encouraging further investigation of network fingerprints for clinical use."],["dc.identifier.doi","10.1002/hbm.23070"],["dc.identifier.gro","3150744"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7534"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","1065-9471"],["dc.title","Differentiating unipolar and bipolar depression by alterations in large-scale brain networks"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2970"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Cerebral Cortex"],["dc.bibliographiccitation.lastpage","2981"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Wolf, Claudia"],["dc.contributor.author","Mohr, Holger"],["dc.contributor.author","Diekhof, Esther"],["dc.contributor.author","Vieker, Henning"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Krämer, Bernd"],["dc.contributor.author","Keil, Maria"],["dc.contributor.author","Binder, Elisabeth B."],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2017-09-07T11:47:50Z"],["dc.date.available","2017-09-07T11:47:50Z"],["dc.date.issued","2015"],["dc.description.abstract","Cyclic AMP response element-binding protein (CREB) contributes to adaptation of mesocorticolimbic networks by modulating activity-regulated transcription and plasticity in neurons. Activity or expression changes of CREB in the nucleus accumbens (NAc) and orbital frontal cortex (OFC) interact with behavioral changes during reward-motivated learning. However, these findings from animal models have not been evaluated in humans. We tested whether CREB1 genotypes affect reward-motivated decisions and related brain activation, using BOLD fMRI in 224 young and healthy participants. More specifically, participants needed to adapt their decision to either pursue or resist immediate rewards to optimize the reward outcome. We found significant CREB1 genotype effects on choices to pursue increases of the reward outcome and on BOLD signal in the NAc, OFC, insula cortex, cingulate gyrus, hippocampus, amygdala, and precuneus during these decisions in comparison with those decisions avoiding total reward loss. Our results suggest that CREB1 genotype effects in these regions could contribute to individual differences in reward- and associative memory-based decision-making."],["dc.identifier.doi","10.1093/cercor/bhv104"],["dc.identifier.gro","3150743"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7533"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","1047-3211"],["dc.title","CREB1Genotype Modulates Adaptive Reward-Based Decisions in Humans"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","172"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Creativity Research Journal"],["dc.bibliographiccitation.lastpage","178"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Goya-Maldonado, Roberto"],["dc.contributor.author","Keil, Maria"],["dc.contributor.author","Brodmann, Katja"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2019-11-18T13:04:52Z"],["dc.date.accessioned","2021-10-27T13:21:29Z"],["dc.date.available","2019-11-18T13:04:52Z"],["dc.date.available","2021-10-27T13:21:29Z"],["dc.date.issued","2018"],["dc.description.abstract","creativity, reward, artist, fMRI"],["dc.description.abstract","Humans possess an invaluable ability of self-expression that extends into visual, literary, musical and many other fields of creation. More than any other profession, artists are in close contact with this subdomain of creativity. Probably one of the most intriguing aspects of creativity is its negative correlation with the availability of monetary reward. With this study we aimed to investigate the reactivity of the dopaminergic reward system in artists and non-artist controls using the desire-reason-dilemma (DRD) paradigm, which allows separate evaluation of reactivity to the acceptance and rejection of rewards. Using fMRI, we measured blood-oxygen-level-dependent (BOLD) responses in key regions of the reward system, namely the ventral striatum (VS), the ventral tegmental area (VTA), and the anterior ventral prefrontal cortex (AVPFC). In contrast to controls, artists presented significantly weaker VS activation in reward acceptance. Additionally, they showed stronger suppression of the VS by the AVPFC in reward rejection. No other differences in demographic or behavioral data were evidenced. These results support the existence of characteristic neural traits in artists, who display reduced reactions to monetary reward acceptance and increased reactions to monetary reward rejection."],["dc.identifier.doi","10.1080/10400419.2018.1414994"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16683"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/92025"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.haserratum","/handle/2/74688"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Reactivity of the reward system in artists during acceptance and rejection of monetary rewards"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","submitted_version"],["dspace.entity.type","Publication"]]