Schmelting, Barthel

[["dc.bibliographiccitation.firstpage","S348"],["dc.bibliographiccitation.journal","European Neuropsychopharmacology"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Fuchs, E."],["dc.contributor.author","Corbach-Söhle, S."],["dc.contributor.author","Schmelting, B."],["dc.contributor.author","Mocaer, E."],["dc.contributor.author","Millan, M.J."],["dc.contributor.author","Gabriel-Gracia, C."],["dc.date.accessioned","2022-10-06T13:33:57Z"],["dc.date.available","2022-10-06T13:33:57Z"],["dc.date.issued","2008"],["dc.identifier.doi","10.1016/S0924-977X(08)70488-7"],["dc.identifier.pii","S0924977X08704887"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115783"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0924-977X"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","P.2.d.006 Effects of agomelatine and S32006, a selective 5-HT2C receptor antagonist, in chronically-stressed tree shrews"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","369"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","MULTIPLE SCLEROSIS"],["dc.bibliographiccitation.lastpage","374"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Merkler, Doron"],["dc.contributor.author","Schmelting, Barthel"],["dc.contributor.author","Czeh, Boldizsar"],["dc.contributor.author","Fuchs, E."],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Brueck, Wolfgang"],["dc.date.accessioned","2018-11-07T09:30:14Z"],["dc.date.available","2018-11-07T09:30:14Z"],["dc.date.issued","2006"],["dc.description.abstract","Pathomorphological studies described pathological heterogeneity in patients with multiple sclerosis (MS). Different effector mechanisms might therefore be responsible for lesion formation in MS. The present report shows that myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) in common marmoset monkeys reflects one specific lesional subtype of MS, namely MS pattern 11 lesions with antibody/complement-mediated damage. MOG-induced EAE in marmoset monkeys will, therefore, provide an ideal model for therapeutic approaches directed against B-cell/antibody/complement in MS."],["dc.identifier.doi","10.1191/1352458506ms1290oa"],["dc.identifier.isi","000239431200002"],["dc.identifier.pmid","16900750"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31257"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Sage Publications Ltd"],["dc.relation.issn","1352-4585"],["dc.title","Myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in the common marmoset reflects the immunopathology of pattern II multiple sclerosis lesions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","67"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","79"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Czeh, Boldizsár"],["dc.contributor.author","Simon, Mária"],["dc.contributor.author","van der Hart, Marieke GC"],["dc.contributor.author","Schmelting, Barthel"],["dc.contributor.author","Hesselink, Mayke B"],["dc.contributor.author","Fuchs, Eberhard"],["dc.date.accessioned","2022-10-06T13:34:21Z"],["dc.date.available","2022-10-06T13:34:21Z"],["dc.date.issued","2004"],["dc.identifier.doi","10.1038/sj.npp.1300581"],["dc.identifier.pii","BF1300581"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115888"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1740-634X"],["dc.relation.issn","0893-133X"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Chronic Stress Decreases the Number of Parvalbumin-Immunoreactive Interneurons in the Hippocampus: Prevention by Treatment with a Substance P Receptor (NK1) Antagonist"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S17"],["dc.bibliographiccitation.journal","International Clinical Psychopharmacology"],["dc.bibliographiccitation.lastpage","S20"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Fuchs, E."],["dc.contributor.author","Simon, Maria"],["dc.contributor.author","Schmelting, Barthel"],["dc.date.accessioned","2018-11-07T10:22:38Z"],["dc.date.available","2018-11-07T10:22:38Z"],["dc.date.issued","2006"],["dc.description.abstract","The limitations of current antidepressant medications merit the exploration of alternative agents with novel antidepressant mechanisms of action. The established clinical finding that desynchronization of internal rhythms plays an important role in the pathophysiology of depressive disorders has stimulated the idea that resetting normal circadian rhythms may have antidepressant potential. Recent experiments using the novel melatonin receptor agonist and serotonin 2 (5-HT2c) receptor antagonist agomelatine (S20098; N[2-(7-methoxy-1-naphthyl)ethyl]acetamide) revealed a notable chronobiotic activity and clear antidepressant-like effects in a variety of preclinical models. Binding studies performed in vitro proved that agomelatine is a high-affinity agonist at both the melatonin MT1 and MT2 receptor types. In addition, these studies revealed that agomelatine, in contrast to melatonin, blocks 5-HT2c receptors with significant affinity. Antagonism of 5-HT2c receptors is reported for various established antidepressant compounds. The antidepressant properties of agomelatine are thus based on its melatonergic actions and 5-HT2c receptor antagonism."],["dc.identifier.doi","10.1097/01.yic.0000199456.39552.c7"],["dc.identifier.isi","000235686900003"],["dc.identifier.pmid","16436935"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42313"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","Satellite Symposium on Acting on Melatonergic Receptors held at the 18th ECNP Congress"],["dc.relation.eventlocation","Amsterdam, NETHERLANDS"],["dc.relation.issn","0268-1315"],["dc.title","Pharmacology of a new antidepressant: benefit of the implication of the melatonergic system"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","MULTIPLE SCLEROSIS"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Merkler, Doron"],["dc.contributor.author","Schmelting, Barthel"],["dc.contributor.author","Czeh, Boldizsar"],["dc.contributor.author","Fuchs, E."],["dc.contributor.author","Bruck, Wolfgang W."],["dc.contributor.author","Stadelmann, Christine"],["dc.date.accessioned","2018-11-07T10:56:29Z"],["dc.date.available","2018-11-07T10:56:29Z"],["dc.date.issued","2005"],["dc.format.extent","S44"],["dc.identifier.isi","000232249900160"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50021"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Hodder Arnold, Hodder Headline Plc"],["dc.publisher.place","London"],["dc.relation.conference","21st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis/10th Annual Meeting of Rehabilitation in MS"],["dc.relation.eventlocation","Thessaloniki, GREECE"],["dc.relation.issn","1352-4585"],["dc.title","MOG-induced EAE in the common marmoset shows extensive cortical demyelination"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S364"],["dc.bibliographiccitation.journal","European Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","S365"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Corbach, S."],["dc.contributor.author","Schmelting, B."],["dc.contributor.author","Fuchs, E."],["dc.contributor.author","Mocaer, E."],["dc.date.accessioned","2022-10-06T13:33:56Z"],["dc.date.available","2022-10-06T13:33:56Z"],["dc.date.issued","2007"],["dc.identifier.doi","10.1016/S0924-977X(07)70534-5"],["dc.identifier.pii","S0924977X07705345"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115780"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0924-977X"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","P.2.d.005 Comparison of agomelatine and melatonin for effects in chronically stressed tree shrews, an animal model of depression"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3707"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Investigative Opthalmology & Visual Science"],["dc.bibliographiccitation.lastpage","3714"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Diem, Ricarda"],["dc.contributor.author","Demmer, Iris"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Merkler, Doron"],["dc.contributor.author","Schmelting, Barthel"],["dc.contributor.author","Williams, Sarah K."],["dc.contributor.author","Sättler, Muriel B."],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Michaelis, Thomas"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Brück, Wolfgang"],["dc.contributor.author","Fuchs, Eberhard"],["dc.date.accessioned","2017-09-07T11:45:29Z"],["dc.date.available","2017-09-07T11:45:29Z"],["dc.date.issued","2008"],["dc.description.abstract","purpose. To assess the use of visual evoked potentials (VEPs) for the in vivo detection of impaired visual function in a marmoset model of multiple sclerosis. The sensitivity of the VEP recordings was determined by comparison with magnetic resonance imaging (MRI) and histopathology.methods. Baseline VEPs were recorded in six healthy marmoset monkeys in response to light-flash stimulation. Experimental autoimmune encephalomyelitis (EAE) was induced in four of the six monkeys. Clinical scores were assessed daily, and VEPs were recorded every second week. In vivo MRI and subsequent histopathology of the brains and optic nerves were performed at the end of the study.results. After induction of EAE, all four marmosets exhibited clinical signs between day 26 and 38 after immunization. VEPs were normal during the induction phase of the disease, but deteriorated in amplitude with the occurrence of clinical symptoms in all animals. MRI revealed bilateral optic neuritis and signal alterations in the optic tracts and occipital subcortical white matter in two of the animals. In the remaining two animals, MRI detected signal alterations in the occipital subcortical white matter. Histopathologic results were concordant with the MRI findings.conclusions. VEPs are an easily accessible noninvasive tool for measuring visual function and diagnosing impairment of the visual pathway in a marmoset EAE model."],["dc.identifier.doi","10.1167/iovs.08-1896"],["dc.identifier.gro","3150371"],["dc.identifier.pmid","18450589"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7128"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","1552-5783"],["dc.title","Autoimmune Optic Neuritis in the Common Marmoset Monkey: Comparison of Visual Evoked Potentials with MRI and Histopathology"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Acta Neuropathologica"],["dc.bibliographiccitation.volume","110"],["dc.contributor.author","Merkler, Doron"],["dc.contributor.author","Schmelting, Barthel"],["dc.contributor.author","Czeh, Boldizsar"],["dc.contributor.author","Fuchs, E."],["dc.contributor.author","Bruck, Wolfgang W."],["dc.contributor.author","Stadelmann, Christine"],["dc.date.accessioned","2018-11-07T10:55:50Z"],["dc.date.available","2018-11-07T10:55:50Z"],["dc.date.issued","2005"],["dc.format.extent","333"],["dc.identifier.isi","000232160500064"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49876"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.conference","50th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy"],["dc.relation.eventlocation","Graz, AUSTRIA"],["dc.relation.issn","0001-6322"],["dc.title","Extensive cortical demyelination in MOG-induced EAE in the common marmoset"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","95"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Mammalian Biology"],["dc.bibliographiccitation.lastpage","105"],["dc.bibliographiccitation.volume","75"],["dc.contributor.author","Ferner, Kirsten"],["dc.contributor.author","Zeller, Ulrich"],["dc.contributor.author","Schmelting, Barthel"],["dc.contributor.author","Fuchs, Eberhard"],["dc.date.accessioned","2022-10-06T13:33:14Z"],["dc.date.available","2022-10-06T13:33:14Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1016/j.mambio.2009.03.004"],["dc.identifier.pii","S1616504709000366"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115581"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","1616-5047"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Ontogenetic and lung development in Tupaia belangeri during the early postnatal period"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","41"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","NMR in Biomedicine"],["dc.bibliographiccitation.lastpage","49"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Schmelting, Barthel"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Merkler, Doron"],["dc.contributor.author","Tammer, Roland"],["dc.contributor.author","Czéh, Boldizsár"],["dc.contributor.author","Michaelis, Thomas"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Fuchs, Eberhard"],["dc.date.accessioned","2017-09-07T11:45:33Z"],["dc.date.available","2017-09-07T11:45:33Z"],["dc.date.issued","2006-02"],["dc.description.abstract","Experimental autoimmune encephalomyelitis (EAE) induced by myelin–oligodendrocyte glycoprotein (MOG) in common marmosets (Callithrix jacchus) is a model for multiple sclerosis. Here, EAE was induced in four common marmosets by 250–300 µg recombinant rat MOG. In addition to a detailed disability scoring, T2- and T1-weighted high-resolution 3D MRI was performed to assess the onset and development of cerebral lesions. The findings were confirmed by histopathology in all animals. Although the animals exhibited a large heterogeneity with regard to onset and localization of lesions and also to disease duration and severity of disability signs, none of the animals revealed any evidence of recovery. A specification of the disability scoring system to account for different aspects of the disease led to a good concurrence of the first MRI-detectable lesion and the onset of central nervous system (CNS) symptoms. The results suggest that MRI monitoring of white matter lesions in conjunction with disability scores that focus on CNS symptoms may be a suitable method to evaluate novel therapeutic interventions even in the presence of pronounced interindividual heterogeneity."],["dc.identifier.doi","10.1002/nbm.999"],["dc.identifier.gro","3150390"],["dc.identifier.pmid","16408325"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7149"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","0952-3480"],["dc.subject","magnetic resonance imaging; experimental autoimmune encephalitis; common marmoset; Callithrix jacchus"],["dc.title","Monitoring of EAE onset and progression in the common marmoset monkey by sequential high-resolution 3D MRI"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]