Schmelting, Barthel

[["dc.bibliographiccitation.firstpage","369"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","MULTIPLE SCLEROSIS"],["dc.bibliographiccitation.lastpage","374"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Merkler, Doron"],["dc.contributor.author","Schmelting, Barthel"],["dc.contributor.author","Czeh, Boldizsar"],["dc.contributor.author","Fuchs, E."],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Brueck, Wolfgang"],["dc.date.accessioned","2018-11-07T09:30:14Z"],["dc.date.available","2018-11-07T09:30:14Z"],["dc.date.issued","2006"],["dc.description.abstract","Pathomorphological studies described pathological heterogeneity in patients with multiple sclerosis (MS). Different effector mechanisms might therefore be responsible for lesion formation in MS. The present report shows that myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) in common marmoset monkeys reflects one specific lesional subtype of MS, namely MS pattern 11 lesions with antibody/complement-mediated damage. MOG-induced EAE in marmoset monkeys will, therefore, provide an ideal model for therapeutic approaches directed against B-cell/antibody/complement in MS."],["dc.identifier.doi","10.1191/1352458506ms1290oa"],["dc.identifier.isi","000239431200002"],["dc.identifier.pmid","16900750"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31257"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Sage Publications Ltd"],["dc.relation.issn","1352-4585"],["dc.title","Myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in the common marmoset reflects the immunopathology of pattern II multiple sclerosis lesions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","MULTIPLE SCLEROSIS"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Merkler, Doron"],["dc.contributor.author","Schmelting, Barthel"],["dc.contributor.author","Czeh, Boldizsar"],["dc.contributor.author","Fuchs, E."],["dc.contributor.author","Bruck, Wolfgang W."],["dc.contributor.author","Stadelmann, Christine"],["dc.date.accessioned","2018-11-07T10:56:29Z"],["dc.date.available","2018-11-07T10:56:29Z"],["dc.date.issued","2005"],["dc.format.extent","S44"],["dc.identifier.isi","000232249900160"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50021"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Hodder Arnold, Hodder Headline Plc"],["dc.publisher.place","London"],["dc.relation.conference","21st Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis/10th Annual Meeting of Rehabilitation in MS"],["dc.relation.eventlocation","Thessaloniki, GREECE"],["dc.relation.issn","1352-4585"],["dc.title","MOG-induced EAE in the common marmoset shows extensive cortical demyelination"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3707"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Investigative Opthalmology & Visual Science"],["dc.bibliographiccitation.lastpage","3714"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Diem, Ricarda"],["dc.contributor.author","Demmer, Iris"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Merkler, Doron"],["dc.contributor.author","Schmelting, Barthel"],["dc.contributor.author","Williams, Sarah K."],["dc.contributor.author","Sättler, Muriel B."],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Michaelis, Thomas"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Brück, Wolfgang"],["dc.contributor.author","Fuchs, Eberhard"],["dc.date.accessioned","2017-09-07T11:45:29Z"],["dc.date.available","2017-09-07T11:45:29Z"],["dc.date.issued","2008"],["dc.description.abstract","purpose. To assess the use of visual evoked potentials (VEPs) for the in vivo detection of impaired visual function in a marmoset model of multiple sclerosis. The sensitivity of the VEP recordings was determined by comparison with magnetic resonance imaging (MRI) and histopathology.methods. Baseline VEPs were recorded in six healthy marmoset monkeys in response to light-flash stimulation. Experimental autoimmune encephalomyelitis (EAE) was induced in four of the six monkeys. Clinical scores were assessed daily, and VEPs were recorded every second week. In vivo MRI and subsequent histopathology of the brains and optic nerves were performed at the end of the study.results. After induction of EAE, all four marmosets exhibited clinical signs between day 26 and 38 after immunization. VEPs were normal during the induction phase of the disease, but deteriorated in amplitude with the occurrence of clinical symptoms in all animals. MRI revealed bilateral optic neuritis and signal alterations in the optic tracts and occipital subcortical white matter in two of the animals. In the remaining two animals, MRI detected signal alterations in the occipital subcortical white matter. Histopathologic results were concordant with the MRI findings.conclusions. VEPs are an easily accessible noninvasive tool for measuring visual function and diagnosing impairment of the visual pathway in a marmoset EAE model."],["dc.identifier.doi","10.1167/iovs.08-1896"],["dc.identifier.gro","3150371"],["dc.identifier.pmid","18450589"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7128"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","1552-5783"],["dc.title","Autoimmune Optic Neuritis in the Common Marmoset Monkey: Comparison of Visual Evoked Potentials with MRI and Histopathology"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Acta Neuropathologica"],["dc.bibliographiccitation.volume","110"],["dc.contributor.author","Merkler, Doron"],["dc.contributor.author","Schmelting, Barthel"],["dc.contributor.author","Czeh, Boldizsar"],["dc.contributor.author","Fuchs, E."],["dc.contributor.author","Bruck, Wolfgang W."],["dc.contributor.author","Stadelmann, Christine"],["dc.date.accessioned","2018-11-07T10:55:50Z"],["dc.date.available","2018-11-07T10:55:50Z"],["dc.date.issued","2005"],["dc.format.extent","333"],["dc.identifier.isi","000232160500064"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49876"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.conference","50th Annual Meeting of the German-Society-of-Neuropathology-and-Neuroanatomy"],["dc.relation.eventlocation","Graz, AUSTRIA"],["dc.relation.issn","0001-6322"],["dc.title","Extensive cortical demyelination in MOG-induced EAE in the common marmoset"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","41"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","NMR in Biomedicine"],["dc.bibliographiccitation.lastpage","49"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Schmelting, Barthel"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Merkler, Doron"],["dc.contributor.author","Tammer, Roland"],["dc.contributor.author","Czéh, Boldizsár"],["dc.contributor.author","Michaelis, Thomas"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Fuchs, Eberhard"],["dc.date.accessioned","2017-09-07T11:45:33Z"],["dc.date.available","2017-09-07T11:45:33Z"],["dc.date.issued","2006-02"],["dc.description.abstract","Experimental autoimmune encephalomyelitis (EAE) induced by myelin–oligodendrocyte glycoprotein (MOG) in common marmosets (Callithrix jacchus) is a model for multiple sclerosis. Here, EAE was induced in four common marmosets by 250–300 µg recombinant rat MOG. In addition to a detailed disability scoring, T2- and T1-weighted high-resolution 3D MRI was performed to assess the onset and development of cerebral lesions. The findings were confirmed by histopathology in all animals. Although the animals exhibited a large heterogeneity with regard to onset and localization of lesions and also to disease duration and severity of disability signs, none of the animals revealed any evidence of recovery. A specification of the disability scoring system to account for different aspects of the disease led to a good concurrence of the first MRI-detectable lesion and the onset of central nervous system (CNS) symptoms. The results suggest that MRI monitoring of white matter lesions in conjunction with disability scores that focus on CNS symptoms may be a suitable method to evaluate novel therapeutic interventions even in the presence of pronounced interindividual heterogeneity."],["dc.identifier.doi","10.1002/nbm.999"],["dc.identifier.gro","3150390"],["dc.identifier.pmid","16408325"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7149"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","0952-3480"],["dc.subject","magnetic resonance imaging; experimental autoimmune encephalitis; common marmoset; Callithrix jacchus"],["dc.title","Monitoring of EAE onset and progression in the common marmoset monkey by sequential high-resolution 3D MRI"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","117"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Brain Pathology"],["dc.bibliographiccitation.lastpage","123"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Merkler, Doron"],["dc.contributor.author","Boscke, R."],["dc.contributor.author","Schmelting, Barthel"],["dc.contributor.author","Czeh, Boldizsar"],["dc.contributor.author","Fuchs, E."],["dc.contributor.author","Bruck, Wolfgang W."],["dc.contributor.author","Stadelmann, Christine"],["dc.date.accessioned","2018-11-07T10:00:40Z"],["dc.date.available","2018-11-07T10:00:40Z"],["dc.date.issued","2006"],["dc.description.abstract","Recent studies revealed an important involvement of the cerebral cortex in multiple sclerosis (MS) patients. Cortical lesions in MS were reported to be less inflammatory and to show less structural damage than white matter lesions. Animal models reflecting the histopathological hallmarks of cortical demyelinated lesions in MS are sparse. Induction of experimental autoimmune encephalomyelitis (EAE) in the common marmoset has turned out to be an attractive non-human-primate model for MS. In the present study we investigated the presence and detailed cellular composition of cortical inflammatory demyelinating pathology in the common marmoset upon immunization with myelin oligodendrocyte glycoprotein (MOG). Extensive cortical demyelination reflecting the topographically distinct cortical lesion types in MS patients was revealed by immunohistochemistry for myelin basic protein (MBP). We explored the density of T- and B-lymphocytes, MHC-II expressing macrophages/microglia cells and early activated macrophages (MRP14) at perivascular and parenchymal lesions sites in neocortex and subcortical white matter. Despite a similar density of perivascular inflammatory infiltrates in the demyelinated neocortex, a considerable lower fraction of macrophages was found to express MRP14 in the neocortex indicating a different activation pattern in cortical compared with white matter lesions. Furthermore, cortical EAE lesions in marmoset monkeys revealed immunoglobulin leakage and complement component C9 deposition in intracortical but not subpial demyelination. Our findings indicate that the inflammatory response, especially macrophage and microglia activation, may be regulated differently in gray matter areas in primate brain."],["dc.identifier.doi","10.1111/j.1750-3639.2006.00004.x"],["dc.identifier.isi","000238144600003"],["dc.identifier.pmid","16768751"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37857"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","1015-6305"],["dc.title","Differential macrophage/microglia activation in neocortical EAE lesions in the marmoset monkey"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]