Just, Hanjörg

[["dc.bibliographiccitation.firstpage","994"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Cardiovascular Research"],["dc.bibliographiccitation.lastpage","1002"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Holubarsch, Christian"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Just, Hanjörg"],["dc.contributor.author","Alpert, N. R."],["dc.date.accessioned","2017-09-07T11:51:25Z"],["dc.date.available","2017-09-07T11:51:25Z"],["dc.date.issued","1994"],["dc.description.abstract","Objective: The aim was to study the effect of three positive inotropic interventions on myocardial force development and heat production in guinea pig papillary muscles in order to investigate the energetic consequences. Methods: The positive inotropic agents used were epinine (beta adrenoceptor stimulation), E-1020 (phosphodiesterase inhibition), and ouabain (sodium-potassium ATPase inhibition). Heat measurements were accomplished using antimony-bismuth thermopiles and initial heat was separated into tension dependent and tension independent heat using the butanedione-monoxime (BDM) and the shortening methods. Results: Optimal concentrations of epinine, E-1020, and ouabain increased peak developed force from 20.0(SD 6.6) to 55.5(9.3) (n = 5; p < 0.01), from 20.9(9.1) to 27.2(7.2) (n = 6; p < 0.05), and from 23.4(9.2) to 44.9(18.0) mN.mm(-2) (n = 6; p < 0.01), respectively. Epinine and E-1020 decreased the tension-time integral per unit initial heat, ie, the economy of isometric contraction, from 5.5(1.4) to 3.6(0.5) (p < 0.01) and from 5.5(1.4) to 3.1(0.9) N.m.s.J(-1) (p < 0.01), respectively; no significant change was observed with ouabain [6.7(1.4) to 8.3(0.5) N.m.s.J(-1)]. The tension independent heat (calcium turnover) was measured in two different ways using BDM or shortening to abolish force production. It was increased significantly by epinine (by 141-243%), E-1020 (by 77-114%), and ouabain (by 23-38%). The first measurement in brackets is the BDM estimate, the second is the shortening estimate. From the tension-time integral and the tension dependent heat the crossbridge force-time integral was analysed: epinine and E-1020 decreased the crossbridge force-time integral from 0.46(0.16) to 0.31(0.06) pN.s (p < 0.01) and from 0.50(0.19) to 0.31(0.08) pN.s (p < 0.01), respectively, while ouabain left the force-time integral unchanged [0.59(0.27) to 0.63(0.20) pN.s]. Conclusions: (1) The inotropic effect of ouabain results from an increase in muscle activation with no change in crossbridge kinetics; (2) epinine and E-1020 increase the tension independent heat and decrease the crossbridge force-time integral, both effects reducing the overall economy; and (3) the shortening and BDM methods for measuring the tension independent heat give qualitatively similar but quantitatively different results."],["dc.identifier.doi","10.1093/cvr/28.7.994"],["dc.identifier.gro","3144727"],["dc.identifier.isi","A1994PA71400009"],["dc.identifier.pmid","7954612"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2383"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0008-6363"],["dc.title","POSITIVE INOTROPISM AND MYOCARDIAL ENERGETICS - INFLUENCE OF BETA-RECEPTOR AGONIST STIMULATION, PHOSPHODIESTERASE INHIBITION, AND OUABAIN"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","91"],["dc.bibliographiccitation.lastpage","102"],["dc.bibliographiccitation.volume","88"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Mulieri, L. A."],["dc.contributor.author","Holubarsch, Christian"],["dc.contributor.author","Blanchard, Etienne"],["dc.contributor.author","Just, Hanjörg"],["dc.contributor.author","Alpert, N. R."],["dc.date.accessioned","2017-09-07T11:51:33Z"],["dc.date.available","2017-09-07T11:51:33Z"],["dc.date.issued","1993"],["dc.description.abstract","Myocardial adaptation to stress and development includes reorganization of subcellular systems. Using a myothermal method, changes in the contractile protein system were investigated across species (rat, rabbit, human myocardium) and in consequence of hemodynamic (volume overload human, pressure overload rabbit myocardium) or hormonal stresses (hypothyroid rat, hyperthyroid rabbit myocardium). Mechanical and myothermal measurements were performed in isometrically contracting right or left ventricular muscle strips and the force-time integral of the individual crossbridge cycle was calculated from heat and force data. Within species, crossbridge force-time integral increased by 85% from control human to volume overload human myocardium. Crossbridge force-time integral increased by 100% from control to hypothyroid rat myocardium. In rabbit myocardium, crossbridge force-time integral increased by 164% in pressure overload and decreased by 47% in hyperthyroid compared to control myocardium. Across species, crossbridge force-time integral was smallest in control rat myocardium (0.16+/-0.01 pNs) and increased in the order: control rat < hyperthyroid rabbit < hypothyroid rat, control rabbit < control human < pressure overload rabbit < volume overload human myocardium (0.96+/-0.01 pNs). Within and across species, crossbridge force-time integral was positively correlated with time to peak tension (r=0.86; p<0.05) and negatively correlated with maximum rate of tension rise (r=-0.85; p<0.05) and maximum rate of tension fall (r=-0.78; p<0.05). Furthermore, there were significant correlations between crossbridge force-time integral and total activity related heat (r=-0.81; p<0.05) as well as total activity related heat per tension-time integral (r=-0.89; p<0.005). Thus, the close relationship between crossbridge force-time integral and myocardial function within and across species demonstrates that alterations of crossbridge force-time integral reflect an important mechanism of subcellular adaptation to stress from a mechanical point of view. Moreover, alterations of the crossbridge force-time integral have pronounced effects on energy consumption in the different types of myocardium."],["dc.identifier.gro","3144781"],["dc.identifier.isi","A1993MN67400011"],["dc.identifier.pmid","8147839"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2442"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.publisher.place","Berlin 33"],["dc.relation.eventlocation","KARL FRANZENS UNIV GRAZ, GRAZ, AUSTRIA"],["dc.relation.ispartof","Basic Research in Cardiology"],["dc.relation.issn","0300-8428"],["dc.title","MYOCARDIAL ADAPTATION TO STRESS FROM THE VIEWPOINT OF ADAPTATION AND DEVELOPMENT"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","251"],["dc.bibliographiccitation.journal","Basic Research in Cardiology"],["dc.bibliographiccitation.lastpage","259"],["dc.bibliographiccitation.volume","82"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Holubarsch, Christian"],["dc.contributor.author","Just, Hanjörg"],["dc.contributor.author","Blanchard, Etienne"],["dc.contributor.author","Mulieri, L. A."],["dc.contributor.author","Alpert, N. R."],["dc.date.accessioned","2017-09-07T11:52:03Z"],["dc.date.available","2017-09-07T11:52:03Z"],["dc.date.issued","1987"],["dc.identifier.gro","3144871"],["dc.identifier.isi","A1987J879100025"],["dc.identifier.pmid","3663019"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2542"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0300-8428"],["dc.title","ENERGETIC ASPECTS OF INOTROPIC INTERVENTIONS IN RAT MYOCARDIUM"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","81"],["dc.bibliographiccitation.journal","Basic Research in Cardiology"],["dc.bibliographiccitation.lastpage","92"],["dc.bibliographiccitation.volume","87"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Mulieri, L. A."],["dc.contributor.author","Holubarsch, Christian"],["dc.contributor.author","Pieske, Burkert"],["dc.contributor.author","Just, Hanjörg"],["dc.contributor.author","Alpert, N. R."],["dc.date.accessioned","2017-09-07T11:51:50Z"],["dc.date.available","2017-09-07T11:51:50Z"],["dc.date.issued","1992"],["dc.description.abstract","Using sensitive antimony-bismuth thermopiles, isometric force and heat output were measured in muscle strips from nonfailing human hearts and from failing dilated cardiomyopathic hearts at a stimulation rate of 60 beats per minute (37-degrees-C). This frequency was chosen because analysis of the force-frequency relation showed significant differences in isometric force between failing and nonfailing human myocardium at 60 beats per minute and at higher frequencies, whereas at lower rates of stimulation (30 beats per minute) force of contraction was similar in failing and nonfailing myocardium. The liberated initial heat was partitioned into its two components, tension-dependent heat and tension-independent heat from high-energy phosphate hydrolysis by contractile proteins and excitation-contraction coupling processes, respectively. Tension-dependent heat reflects the total number of cross-bridge interactions, and tension-independent heat is an index of the amount of calcium cycling during the contraction-relaxation cycle. In failing compared to nonfailing human myocardium, peak twitch tension, maximum rate of tension rise and maximum rate of tension fall were reduced significantly. Reduced mechanical performance was associated with reduced liberation of both tension-dependent and tension-independent heat in the failing heart. The reduction of tension-dependent heat by 61 % and of tension-independent heat by 69 % indicate considerable decreases in the number of crossbridge interactions activated and calcium ions cycled during the isometric twitch. In addition, the rate of calcium removal was reduced in the failing human heart as is indicated by a 71 % reduction in tension-independent heat rate. The efficiency of excitation-contraction coupling with respect to crossbridge activation was similar in failing and nonfailing myocardium. These data indicate that impaired myocardial performance in dilated cardiomyopathy may result from disturbed excitation-contraction coupling with reduced amount of calcium cycling and reduced rate of calcium removal."],["dc.identifier.gro","3144799"],["dc.identifier.isi","A1992KQ21200009"],["dc.identifier.pmid","1299212"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2463"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0300-8428"],["dc.title","ENERGETICS OF CALCIUM CYCLING IN NONFAILING AND FAILING HUMAN MYOCARDIUM"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","107"],["dc.bibliographiccitation.lastpage","116"],["dc.bibliographiccitation.volume","87"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Mulieri, L. A."],["dc.contributor.author","Leavitt, B. J."],["dc.contributor.author","Allen, P. D."],["dc.contributor.author","Holubarsch, Christian"],["dc.contributor.author","Just, Hanjörg"],["dc.contributor.author","Alpert, N. R."],["dc.date.accessioned","2017-09-07T11:51:50Z"],["dc.date.available","2017-09-07T11:51:50Z"],["dc.date.issued","1992"],["dc.description.abstract","Isometric heat and force measurements were used to relate mechanical performance to function of contractile proteins in muscle strips from failing and nonfailing human hearts (37-degrees-C, 60 beats per minute). Compared to control myocardium, crossbridge behavior was altered in myocardium from hearts with end-stage failing dilated and ischemic cardiomyopathy, resulting in increased crossbridge force-time integral by 33% and 36%, respectively. Peak isometric twitch tension was reduced significantly by 46% in muscle strips from hearts with dilated cardiomyopathy. In myocardium from hearts with ischemic cardiomyopathy peak isometric twitch tension was comparable to values from nonfailing hearts. including all three types of myocardium, there was a close correlation between the number of crossbridge interactions during the isometric twitch (tension-dependent heat) and peak twitch tension (r = 0.88; p < 0.001). Compared to control, in failing myocardium from dilated cardiomyopathic hearts, tension-independent heat (calcium cycling) was significantly reduced. This indicates that in dilated cardiomyopathy reduced peak twitch tension results from decreased calcium activation of contractile proteins with reduced number of crossbridge interactions during the isometric twitch. In ischemic cardiomyopathy mechanisms different from those observed in dilated cardiomyopathy seem to be involved in the development of heart failure."],["dc.identifier.gro","3144800"],["dc.identifier.isi","A1992JA17800010"],["dc.identifier.pmid","1497566"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2464"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.publisher.place","Berlin 33"],["dc.relation.eventlocation","GARGELLEN, AUSTRIA"],["dc.relation.ispartof","Basic Research in Cardiology"],["dc.relation.issn","0300-8428"],["dc.title","CONTRACTILE PROTEIN FUNCTION IN FAILING AND NONFAILING HUMAN MYOCARDIUM"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3155"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.lastpage","3160"],["dc.bibliographiccitation.volume","94"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Mulieri, L. A."],["dc.contributor.author","Allen, P. D."],["dc.contributor.author","Just, Hanjörg"],["dc.contributor.author","Alpert, N. R."],["dc.date.accessioned","2017-09-07T11:52:59Z"],["dc.date.available","2017-09-07T11:52:59Z"],["dc.date.issued","2012"],["dc.identifier.doi","10.1161/01.cir.94.12.3155"],["dc.identifier.gro","3144994"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2682"],["dc.notes.intern","Crossref Import"],["dc.notes.status","public"],["dc.publisher","Ovid Technologies (Wolters Kluwer Health)"],["dc.relation.issn","0009-7322"],["dc.title","Influence of Isoproterenol and Ouabain on Excitation-Contraction Coupling, Cross-Bridge Function, and Energetics in Failing Human Myocardium"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S13"],["dc.bibliographiccitation.journal","Journal of Cardiovascular Pharmacology"],["dc.bibliographiccitation.lastpage","S17"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Holubarsch, Christian"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Just, Hanjörg"],["dc.contributor.author","Blanchard, Etienne"],["dc.contributor.author","Mulieri, L. A."],["dc.contributor.author","Alpert, N. R."],["dc.date.accessioned","2017-09-07T11:51:59Z"],["dc.date.available","2017-09-07T11:51:59Z"],["dc.date.issued","1989"],["dc.identifier.gro","3144843"],["dc.identifier.isi","A1989AR93600004"],["dc.identifier.pmid","2478786"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2512"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: PHS HHS [28001-07]"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Lippincott-raven Publ"],["dc.relation.issn","0160-2446"],["dc.title","INFLUENCE OF THE POSITIVE INOTROPIC SUBSTANCE PIMOBENDAN (UD-CG 115 BS) ON CONTRACTILE ECONOMY OF GUINEA-PIG PAPILLARY-MUSCLES"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","95"],["dc.bibliographiccitation.journal","Basic Research in Cardiology"],["dc.bibliographiccitation.lastpage","102"],["dc.bibliographiccitation.volume","81"],["dc.contributor.author","Holubarsch, Christian"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Blanchard, Etienne"],["dc.contributor.author","Alpert, N. R."],["dc.contributor.author","Mulieri, L. A."],["dc.contributor.author","Just, Hanjörg"],["dc.date.accessioned","2017-09-07T11:52:02Z"],["dc.date.available","2017-09-07T11:52:02Z"],["dc.date.issued","1986"],["dc.identifier.gro","3144879"],["dc.identifier.isi","A1986E271600011"],["dc.identifier.pmid","3790048"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2551"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0300-8428"],["dc.title","MYOTHERMAL ECONOMY OF RAT MYOCARDIUM, CHRONIC ADAPTATION VERSUS ACUTE INOTROPISM"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","147"],["dc.bibliographiccitation.journal","Basic Research in Cardiology"],["dc.bibliographiccitation.lastpage","155"],["dc.bibliographiccitation.volume","84"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Holubarsch, Christian"],["dc.contributor.author","Blanchard, Etienne"],["dc.contributor.author","Mulieri, L. A."],["dc.contributor.author","Alpert, N. R."],["dc.contributor.author","Just, Hanjörg"],["dc.date.accessioned","2017-09-07T11:51:59Z"],["dc.date.available","2017-09-07T11:51:59Z"],["dc.date.issued","1989"],["dc.identifier.doi","10.1007/BF02650354"],["dc.identifier.gro","3144838"],["dc.identifier.isi","A1989CB18400015"],["dc.identifier.pmid","2818454"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2506"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: PHS HHS [28001-07]"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.relation.issn","0300-8428"],["dc.title","INFLUENCE OF ISOPROTERENOL ON MYOCARDIAL ENERGETICS - EXPERIMENTAL AND CLINICAL INVESTIGATIONS"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","33"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Cardioscience"],["dc.bibliographiccitation.lastpage","41"],["dc.bibliographiccitation.volume","1"],["dc.contributor.author","Holubarsch, Christian"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Just, Hanjörg"],["dc.contributor.author","Blanchard, Etienne"],["dc.contributor.author","Mulieri, L. A."],["dc.contributor.author","Alpert, N. R."],["dc.date.accessioned","2017-09-07T11:51:55Z"],["dc.date.available","2017-09-07T11:51:55Z"],["dc.date.issued","1990"],["dc.identifier.gro","3144824"],["dc.identifier.isi","A1990DL02000007"],["dc.identifier.pmid","2102794"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2491"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Canal Press"],["dc.relation.issn","1015-5007"],["dc.title","MODULATION OF MYOTHERMAL ECONOMY OF ISOMETRIC FORCE GENERATION BY POSITIVE INOTROPIC INTERVENTIONS IN THE GUINEA-PIG MYOCARDIUM"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]