Keric, Naureen

[["dc.bibliographiccitation.firstpage","317"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Neurosurgical Anesthesiology"],["dc.bibliographiccitation.lastpage","323"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Keric, Naureen"],["dc.contributor.author","Kantelhardt, Sven Rainer"],["dc.contributor.author","Neulen, Axel"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Henning, Antonia"],["dc.contributor.author","Vollmer, Fritz C."],["dc.contributor.author","Thiemann, Ingmar"],["dc.contributor.author","Giese, Alf"],["dc.date.accessioned","2018-11-07T09:22:51Z"],["dc.date.available","2018-11-07T09:22:51Z"],["dc.date.issued","2013"],["dc.description.abstract","Background: Although the skull limits applicability of sonography, bedside intracranial endosonography might be an alternative to computed tomography scans to detect adverse events in sedated patients. However, the usefulness of intracranial endosonography for potential clinical application has not been evaluated. The present study was designed to investigate the suitability of an image-guided intracranial endosonography (IGIE) catheter for intracranial ultrasound imaging in an ex vivo phantom model and in a large animal model.Materials and Methods: IGIE was evaluated in a cranial phantom and a porcine intracranial hemorrhage (ICH) model. Two anesthetized animals underwent an initial magnetic resonance imaging (MRI) scan, followed by placement of an endosonography catheter in the frontal lobe. After anatomic imaging, an experimental ICH was placed in the contralateral hemisphere. B-scan imaging, duplex, Doppler sonography, and a second MRI were performed. A standard image-guiding device tracked the ultrasound catheter.Results: Endosonography provided high-definition imaging of intracranial structures. Image guidance allowed direction of the catheter to and intuitive identification of anatomic structures. Doppler imaging allowed analysis of blood flow in intracranial vessels. Ultrasound imaging was used to monitor evolution of ICH and the resulting brain edema in real time. Coregistration of ultrasound and MRI images acquired after ICH placement demonstrated the high accuracy of the spatial resolution of IGIE (largest mismatch <5 mm).Conclusions: IGIE provides high-definition images of intracranial structures, Doppler analysis of blood flow, and real-time monitoring of intracranial structural lesions. We suggest that IGIE might prove a valuable tool for intracranial monitoring of sedated patients over extended time periods."],["dc.identifier.doi","10.1097/ANA.0b013e31828cb27e"],["dc.identifier.isi","000323217100015"],["dc.identifier.pmid","23552276"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29441"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0898-4921"],["dc.title","Image-guided Intracranial Endosonography"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","ons257"],["dc.bibliographiccitation.firstpage","257"],["dc.bibliographiccitation.journal","Neurosurgery"],["dc.bibliographiccitation.lastpage","265"],["dc.bibliographiccitation.volume","68"],["dc.contributor.author","Kantelhardt, Sven Rainer"],["dc.contributor.author","Greke, Christian"],["dc.contributor.author","Keric, Naureen"],["dc.contributor.author","Vollmer, Fritz C."],["dc.contributor.author","Thiemann, Ingmar"],["dc.contributor.author","Giese, Alf"],["dc.date.accessioned","2018-11-07T08:55:36Z"],["dc.date.available","2018-11-07T08:55:36Z"],["dc.date.issued","2011"],["dc.description.abstract","BACKGROUND: Transcranial Doppler (TCD) ultrasonography is an important tool for noninvasive detection and monitoring of vasospasm and other pathological conditions of the intracranial vessels. OBJECTIVE: To demonstrate that image-guided TCD allows rapid identification and blood-flow analysis of specific sections of the vascular anatomy and provides excellent orientation, also allowing diagnostic procedures on pathological vascular structures. METHODS: Three patients who underwent computed tomographic angiography scanning for reasons not related to this study were examined by neuronavigated image-guided TCD. The Doppler probe was fitted with reflective markers and tracked by a commercially available Kolibri image guidance system. RESULTS: Image-guided TCD allowed identification of all major intracranial vessels. Unilateral acquisition of reliable Doppler signals for the internal carotid artery, carotid T, middle cerebral artery, middle cerebral artery bifurcation, and anterior cerebral artery required 14 +/- 6 minutes. Preregistration of these targets and detection by neuronavigation alone shortened examination times significantly to 8 +/- 2 minutes. Registering the optimal examination trajectories on the neuronavigational device and applying navigational pilot software shortened times for repetitive examination further to 4 +/- 1 minutes and ensured that the examination was done at the exact same spot under the same angle as in previous examinations. CONCLUSION: Image guidance can be applied easily and efficiently to TCD. It provides anatomic orientation and may help to standardize investigation protocols, define pathological vascular territories for repeat investigations, and thus reduce inter-investigator variations. Image guidance may also extend the use of TCD to situations of a pathological or variant vascular anatomy."],["dc.identifier.doi","10.1227/NEU.0b013e31821553b2"],["dc.identifier.isi","000291219500004"],["dc.identifier.pmid","21389880"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22945"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1524-4040"],["dc.relation.issn","0148-396X"],["dc.title","Image Guidance for Transcranial Doppler Ultrasonography"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","533"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Acta Neurochirurgica"],["dc.bibliographiccitation.lastpage","539"],["dc.bibliographiccitation.volume","153"],["dc.contributor.author","Bock, Hans Christoph"],["dc.contributor.author","Cohnen, Joseph"],["dc.contributor.author","Keric, Naureen"],["dc.contributor.author","Kantelhardt, Sven Rainer"],["dc.contributor.author","Giese, Alf"],["dc.date.accessioned","2018-11-07T08:58:58Z"],["dc.date.available","2018-11-07T08:58:58Z"],["dc.date.issued","2011"],["dc.description.abstract","Implantation of 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) wafer for malignant glioma is not recommended in the case of surgical opening of the ventricular system during microsurgical tumor resection because the wafer material may dislocate from the resection cavity into the ventricular system and cause obstructive hydrocephalus. TachoSil is an adhesive collagen fleece used in different surgical disciplines that provides an air- and liquid-tight seal closing communications between the ventricular system and the resection cavity after tumor removal. Occlusion of ventricular defects with TachoSil after microsurgical glioma resection was performed in two patients with newly diagnosed and seven patients with recurrent malignant glioma prior to BCNU wafer implantation into the resection cavity. Early postoperative cranial computed tomography (CCT)/MRI and follow-up MRI at 3 months' intervals were performed with a median follow-up of 10.4 months. The collagen fleece was identified as a linear structure hypodense/hypointense to white matter on postoperative CT/MRI separating the resection cavity from the ventricular lumen in all cases. In no case did early CCT/MRI or follow-up MRI reveal wafer material within the ventricular system. In no case did signs of obstructive hydrocephalus occur. Sealing of the ventricular system using a fibrinogen-coated collagen fleece effectively separates the resection cavity from the ventricular system and allows implantation of BCNU wafers into the resection cavity. No morphological evidence for wafer material dislocation into the ventricular system or obstruction of CSF pathways was found in nine patients who received 41 follow-up MRI over 10.4 months of follow-up."],["dc.identifier.doi","10.1007/s00701-010-0923-z"],["dc.identifier.isi","000287497500012"],["dc.identifier.pmid","21210161"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6645"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23777"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.issn","0001-6268"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Occlusion of surgical opening of the ventricular system with fibrinogen-coated collagen fleece: a case collection study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]