Keric, Naureen

[["dc.bibliographiccitation.firstpage","S88"],["dc.bibliographiccitation.journal","Translational Stroke Research"],["dc.bibliographiccitation.lastpage","S93"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Keric, Naureen"],["dc.contributor.author","Maier, Gerrit Steffen"],["dc.contributor.author","Samadani, Uzma"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Heuer, J. F."],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2018-11-07T09:08:53Z"],["dc.date.available","2018-11-07T09:08:53Z"],["dc.date.issued","2012"],["dc.description.abstract","Hematoma puncture and subsequent clot lysis with recombinant tissue plasminogen activator (rtPA) emerged as an alternative therapy for spontaneous intracerebral hemorrhage (ICH) and is associated with delayed edema possibly counteracting the beneficial effects of hematoma volume reduction. We hypothesized that immediate reversal of rtPA activity after clot lysis and hematoma drainage diminishes edema formation. To test this hypothesis, we administered plasminogen activator inhibitor (PAI)-1 after rtPA lysis of experimentally induced ICH. A right frontal ICH was placed through a twist drill burr hole and autologous blood injection. Following creation of the frontal ICH, pigs received no further treatment (n=5), lysis with rtPA (n=7), or lysis with rtPA followed by administration of PAI-1 (n=6). Hematoma and edema volumes were assessed with magnetic resonance imaging on days 0, 4, and 10. The rtPA significantly reduced hematoma volume and contributed to edema on day 10 after experimentally induced ICH. Administration of PAI-1 attenuated the rtPA-induced edema volume on day 10, but the hematoma volume reduction was less pronounced. In conclusion, PAI-1 attenuated delayed cerebral edema after rtPA lysis of experimental ICH but also reduced the lytic activity of rtPA. The combination of rtPA clot lysis with PAI-1 might have the potential to further improve the effect of the lytic therapy of ICH, but additional studies to define the optimum time point for PAI-1 administration are required."],["dc.identifier.doi","10.1007/s12975-012-0188-3"],["dc.identifier.isi","000305436500011"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8890"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26132"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1868-4483"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Tissue Plasminogen Activator Induced Delayed Edema in Experimental Porcine Intracranial Hemorrhage: Reduction with Plasminogen Activator Inhibitor-1 Administration"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","533"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Acta Neurochirurgica"],["dc.bibliographiccitation.lastpage","539"],["dc.bibliographiccitation.volume","153"],["dc.contributor.author","Bock, Hans Christoph"],["dc.contributor.author","Cohnen, Joseph"],["dc.contributor.author","Keric, Naureen"],["dc.contributor.author","Kantelhardt, Sven Rainer"],["dc.contributor.author","Giese, Alf"],["dc.date.accessioned","2018-11-07T08:58:58Z"],["dc.date.available","2018-11-07T08:58:58Z"],["dc.date.issued","2011"],["dc.description.abstract","Implantation of 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) wafer for malignant glioma is not recommended in the case of surgical opening of the ventricular system during microsurgical tumor resection because the wafer material may dislocate from the resection cavity into the ventricular system and cause obstructive hydrocephalus. TachoSil is an adhesive collagen fleece used in different surgical disciplines that provides an air- and liquid-tight seal closing communications between the ventricular system and the resection cavity after tumor removal. Occlusion of ventricular defects with TachoSil after microsurgical glioma resection was performed in two patients with newly diagnosed and seven patients with recurrent malignant glioma prior to BCNU wafer implantation into the resection cavity. Early postoperative cranial computed tomography (CCT)/MRI and follow-up MRI at 3 months' intervals were performed with a median follow-up of 10.4 months. The collagen fleece was identified as a linear structure hypodense/hypointense to white matter on postoperative CT/MRI separating the resection cavity from the ventricular lumen in all cases. In no case did early CCT/MRI or follow-up MRI reveal wafer material within the ventricular system. In no case did signs of obstructive hydrocephalus occur. Sealing of the ventricular system using a fibrinogen-coated collagen fleece effectively separates the resection cavity from the ventricular system and allows implantation of BCNU wafers into the resection cavity. No morphological evidence for wafer material dislocation into the ventricular system or obstruction of CSF pathways was found in nine patients who received 41 follow-up MRI over 10.4 months of follow-up."],["dc.identifier.doi","10.1007/s00701-010-0923-z"],["dc.identifier.isi","000287497500012"],["dc.identifier.pmid","21210161"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6645"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23777"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.issn","0001-6268"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Occlusion of surgical opening of the ventricular system with fibrinogen-coated collagen fleece: a case collection study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]