Stradomska, Alicja M.

[["dc.bibliographiccitation.firstpage","7875"],["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","Proceedings of the National Academy of Sciences"],["dc.bibliographiccitation.lastpage","7880"],["dc.bibliographiccitation.volume","105"],["dc.contributor.author","Xue, Mingshan"],["dc.contributor.author","Stradomska, Alicja"],["dc.contributor.author","Chen, Hongmei"],["dc.contributor.author","Brose, Nils"],["dc.contributor.author","Zhang, Weiqi"],["dc.contributor.author","Rosenmund, Christian"],["dc.contributor.author","Reim, Kerstin"],["dc.date.accessioned","2017-09-07T11:48:17Z"],["dc.date.available","2017-09-07T11:48:17Z"],["dc.date.issued","2008"],["dc.description.abstract","Complexins (Cplxs) are key regulators of synaptic exocytosis, but whether they act as facilitators or inhibitors is currently being disputed controversially. We show that genetic deletion of all Cplxs expressed in the mouse brain causes a reduction in Ca2+-triggered and spontaneous neurotransmitter release at both excitatory and inhibitory synapses. Our results demonstrate that at mammalian central nervous system synapses, Cplxs facilitate neurotransmitter release and do not simply act as inhibitory clamps of the synaptic vesicle fusion machinery."],["dc.identifier.doi","10.1073/pnas.0803012105"],["dc.identifier.gro","3143281"],["dc.identifier.isi","000256648600045"],["dc.identifier.pmid","18505837"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/777"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: NINDS NIH HHS [NS50655, R01 NS050655, R01 NS050655-05]"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0027-8424"],["dc.title","Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]