Mani, Nivedita

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Biological psychiatry"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Loth, Eva"],["dc.contributor.author","Poline, Jean Baptiste"],["dc.contributor.author","Thyreau, Benjamin"],["dc.contributor.author","Jia, Tianye"],["dc.contributor.author","Tao, Chenyang"],["dc.contributor.author","Lourdusamy, Anbarasu"],["dc.contributor.author","Stacey, David"],["dc.contributor.author","Cattrell, Anna"],["dc.contributor.author","Desrivieres, Sylvane"],["dc.contributor.author","Ruggeri, Barbara"],["dc.contributor.author","Fritsch, Virgile"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Barker, Gareth J."],["dc.contributor.author","Bokde, Arun L. W."],["dc.contributor.author","Buchel, Christian"],["dc.contributor.author","Carvalho, Fabiana M."],["dc.contributor.author","Conrod, Patricia J."],["dc.contributor.author","Fauth-Buehler, Mira"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Gallinat, Jürgen"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Bruehl, Ruediger"],["dc.contributor.author","Lawrence, Claire"],["dc.contributor.author","Mani, Nivedita"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Paus, Tomas"],["dc.contributor.author","Pausova, Zdenka"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Struve, Maren"],["dc.contributor.author","Feng, Jianfeng"],["dc.contributor.author","Schumann, Gunter"],["dc.date.accessioned","2017-09-07T11:52:43Z"],["dc.date.available","2017-09-07T11:52:43Z"],["dc.date.issued","2014"],["dc.description.abstract","BACKGROUND: Common variants in the oxytocin receptor gene (OXTR) have been shown to influence social and affective behavior and to moderate the effect of adverse experiences on risk for social-affective problems. However, the intermediate neurobiological mechanisms are not fully understood. Although human functional neuroimaging studies have reported that oxytocin effects on social behavior and emotional states are mediated by amygdala function, animal models indicate that oxytocin receptors in the ventral striatum (VS) modulate sensitivity to social reinforcers. This study aimed to comprehensively investigate OXTR-dependent brain mechanisms associated with social-affective problems.; METHODS: In a sample of 1445 adolescents we tested the effect of 23-tagging single nucleotide polymorphisms across the OXTR region and stressful life events (SLEs) on functional magnetic resonance imaging blood oxygen level-dependent activity in the VS and amygdala to animated angry faces. Single nucleotide polymorphisms for which gene-wide significant effects on brain function were found were then carried forward to examine associations with social-affective problems.; RESULTS: A gene-wide significant effect of rs237915 showed that adolescents with minor CC-genotype had significantly lower VS activity than CT/TT-carriers. Significant or nominally significant gene environment effects on emotional problems (in girls) and peer problems (in boys) revealed a strong increase in clinical symptoms as a function of SLEs in CT/TT-carriers but not CC-homozygotes. However, in low-SLE environments, CC-homozygotes had more emotional problems (girls) and peer problems (boys). Moreover, among CC-homozygotes, reduced VS activity was related to more peer problems.; CONCLUSIONS: These findings suggest that a common OXTR-variant affects brain responsiveness to negative social cues and that in \"risk-carriers\" reduced sensitivity is simultaneously associated with more social-affective problems in \"favorable environments\" and greater resilience against stressful experiences. 2013 Society of Biological Psychiatry Published by Society of Biological Psychiatry All rights reserved."],["dc.identifier.doi","10.1016/j.biopsych.2013.07.043"],["dc.identifier.gro","3151229"],["dc.identifier.pmid","24120094"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8011"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-07-25"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1873-2402"],["dc.title","Oxytocin receptor genotype modulates ventral striatal activity to social cues and response to stressful life events"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.volume","56"],["dc.contributor.author","Schneider, S."],["dc.contributor.author","Peters, Jan"],["dc.contributor.author","Bromberg, Uli"],["dc.contributor.author","Brassen, S."],["dc.contributor.author","Menz, M. M."],["dc.contributor.author","Miedl, S. F."],["dc.contributor.author","Loth, Eva"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Barbot, A."],["dc.contributor.author","Barker, Gareth J."],["dc.contributor.author","Conrod, Patricia J."],["dc.contributor.author","Dalley, J. W."],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Gallinat, Jürgen"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Mallik, C."],["dc.contributor.author","Mani, Nivedita"],["dc.contributor.author","Artiges, Eric"],["dc.contributor.author","Paus, Tomas"],["dc.contributor.author","Poline, Jean Baptiste"],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Reed, L."],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Spanagel, Rainer"],["dc.contributor.author","Speiser, C."],["dc.contributor.author","Strohle, Andreas"],["dc.contributor.author","Struve, Maren"],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Buchel, Christian"],["dc.date.accessioned","2017-09-07T11:52:45Z"],["dc.date.available","2017-09-07T11:52:45Z"],["dc.date.issued","2011"],["dc.description.abstract","Previous studies have observed a sex-dependent lateralization of amygdala activation related to emotional memory. Specifically, it was shown that the activity of the right amygdala correlates significantly stronger with memory for images judged as arousing in men than in women, and that there is a significantly stronger relationship in women than in men between activity of the left amygdala and memory for arousing images. Using a large sample of 235 male adolescents and 235 females matched for age and handedness, we investigated the sex-specific lateralization of amygdala activation during an emotional face perception fMRI task. Performing a formal sex by hemisphere analysis, we observed in males a significantly stronger right amygdala activation as compared to females. Our results indicate that adolescents display a sex-dependent lateralization of amygdala activation that is also present in basic processes of emotional perception. This finding suggests a sex-dependent development of human emotion processing and may further implicate possible etiological pathways for mental disorders most frequent in adolescent males (i.e., conduct disorder). Copyright 2011 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.neuroimage.2011.02.019"],["dc.identifier.gro","3151258"],["dc.identifier.pmid","21316467"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8043"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-07-25"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1095-9572"],["dc.title","Boys do it the right way: sex-dependent amygdala lateralization during face processing in adolescents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2285"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Psychological medicine"],["dc.bibliographiccitation.lastpage","2294"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Galinowski, A."],["dc.contributor.author","Miranda, R."],["dc.contributor.author","Lemaitre, Herve"],["dc.contributor.author","Paillère Martinot, Marie-Laure"],["dc.contributor.author","Artiges, Eric"],["dc.contributor.author","Vulser, Helene"],["dc.contributor.author","Goodman, Robert"],["dc.contributor.author","Penttila, Jani"],["dc.contributor.author","Struve, Maren"],["dc.contributor.author","Barbot, A."],["dc.contributor.author","Fadai, Tahmine"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Conrod, Patricia J."],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Barker, Gareth J."],["dc.contributor.author","Bokde, Arun L. W."],["dc.contributor.author","Bromberg, Uli"],["dc.contributor.author","Buchel, Christian"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Gallinat, Jürgen"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Kappel, Viola"],["dc.contributor.author","Lawrence, Claire"],["dc.contributor.author","Loth, Eva"],["dc.contributor.author","Mani, Nivedita"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Paus, Tomas"],["dc.contributor.author","Pausova, Zdenka"],["dc.contributor.author","Poline, Jean Baptiste"],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Robbins, Trevor W."],["dc.contributor.author","Smolka, M."],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.date.accessioned","2017-09-07T11:52:09Z"],["dc.date.available","2017-09-07T11:52:09Z"],["dc.date.issued","2015"],["dc.description.abstract","BACKGROUND: Resilience is the capacity of individuals to resist mental disorders despite exposure to stress. Little is known about its neural underpinnings. The putative variation of white-matter microstructure with resilience in adolescence, a critical period for brain maturation and onset of high-prevalence mental disorders, has not been assessed by diffusion tensor imaging (DTI). Lower fractional anisotropy (FA) though, has been reported in the corpus callosum (CC), the brain's largest white-matter structure, in psychiatric and stress-related conditions. We hypothesized that higher FA in the CC would characterize stress-resilient adolescents.; METHOD: Three groups of adolescents recruited from the community were compared: resilient with low risk of mental disorder despite high exposure to lifetime stress (n = 55), at-risk of mental disorder exposed to the same level of stress (n = 68), and controls (n = 123). Personality was assessed by the NEO-Five Factor Inventory (NEO-FFI). Voxelwise statistics of DTI values in CC were obtained using tract-based spatial statistics. Regional projections were identified by probabilistic tractography.; RESULTS: Higher FA values were detected in the anterior CC of resilient compared to both non-resilient and control adolescents. FA values varied according to resilience capacity. Seed regional changes in anterior CC projected onto anterior cingulate and frontal cortex. Neuroticism and three other NEO-FFI factor scores differentiated non-resilient participants from the other two groups.; CONCLUSION: High FA was detected in resilient adolescents in an anterior CC region projecting to frontal areas subserving cognitive resources. Psychiatric risk was associated with personality characteristics. Resilience in adolescence may be related to white-matter microstructure."],["dc.identifier.doi","10.1017/S0033291715000239"],["dc.identifier.gro","3151216"],["dc.identifier.pmid","25817177"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7995"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-07-25"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1469-8978"],["dc.title","Resilience and corpus callosum microstructure in adolescence"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Witt, Stephanie H."],["dc.contributor.author","Lourdusamy, Anbarasu"],["dc.contributor.author","Vollstadt-Klein, Sabine"],["dc.contributor.author","Steiner, Sabina"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Barker, Gareth J."],["dc.contributor.author","Buchel, Christian"],["dc.contributor.author","Conrod, Patricia J."],["dc.contributor.author","Frank, J."],["dc.contributor.author","Gallinat, Jürgen"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Loth, Eva"],["dc.contributor.author","Mani, Nivedita"],["dc.contributor.author","Artiges, Eric"],["dc.contributor.author","Paus, Tomas"],["dc.contributor.author","Pausova, Zdenka"],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Struve, Maren"],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Flor, Herta"],["dc.date.accessioned","2017-09-07T11:46:56Z"],["dc.date.available","2017-09-07T11:46:56Z"],["dc.date.issued","2013"],["dc.description.abstract","Genetic variation in a genomic region on chromosome 15q25.1, which encodes the alpha5, alpha3, and beta4 subunits of the cholinergic nicotinic receptor genes, confers risk to smoking and nicotine dependence (ND). Neural reward-related responses have previously been identified as important factors in the development of drug dependence involving ND. Applying an imaging genetics approach in two cohorts (N=487; N=478) of healthy non-smoking adolescents, we aimed to elucidate the impact of genome-wide significant smoking-associated variants in the CHRNA5-CHRNA3-CHRNB4 gene cluster on reward-related neural responses in central regions such as the striatum, orbitofrontal and anterior cingulate cortex (ACC), and personality traits related to addiction. In both samples, carriers of the rs578776 GG compared with AG/AA genotype showed a significantly lower neural response to reward outcomes in the right ventral and dorsal ACC but not the striatum or the orbitofrontal cortex. Rs578776 was unrelated to neural reward anticipation or reward magnitude. Significantly higher scores of anxiety sensitivity in GG compared with AG/AA carriers were found only in sample 1. Associations with other personality traits were not observed. Our findings suggest that the rs578776 risk variant influences susceptibility to ND by dampening the response of the ACC to reward feedback, without recruiting the striatum or orbitofrontal cortex during feedback or anticipation. Thus, it seems to have a major role in the processing of and behavioral adaptation to changing reward outcomes."],["dc.identifier.doi","10.1038/npp.2013.131"],["dc.identifier.gro","3151964"],["dc.identifier.pmid","23689675"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8804"],["dc.notes.intern","WoS Import 2017-07-25"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1740-634X"],["dc.title","Genetic risk for nicotine dependence in the cholinergic system and activation of the brain reward system in healthy adolescents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Alcohol (Fayetteville, N.Y.)"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Nees, Frauke"],["dc.contributor.author","Witt, Stephanie H."],["dc.contributor.author","Dinu-Biringer, R"],["dc.contributor.author","Lourdusamy, Anbarasu"],["dc.contributor.author","Tzschoppe, Jelka"],["dc.contributor.author","Vollstadt-Klein, Sabine"],["dc.contributor.author","Millenet, Sabina"],["dc.contributor.author","Bach, Christiane"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Barker, Gareth J."],["dc.contributor.author","Bokde, Arun L. W."],["dc.contributor.author","Bromberg, Uli"],["dc.contributor.author","Buchel, Christian"],["dc.contributor.author","Conrod, Patricia J."],["dc.contributor.author","Frank, J"],["dc.contributor.author","Frouin, Vincent"],["dc.contributor.author","Gallinat, Jürgen"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Gowland, Penny"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Mani, Nivedita"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Paus, Tomas"],["dc.contributor.author","Pausova, Zdenka"],["dc.contributor.author","Robbins, Trevor W."],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Flor, Herta"],["dc.date.accessioned","2017-09-07T11:46:32Z"],["dc.date.available","2017-09-07T11:46:32Z"],["dc.date.issued","2015"],["dc.description.abstract","Changes in reward processing have been identified as one important pathogenetic mechanism in alcohol addiction. The nonsynonymous single nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene (rs6265/Val66Met) modulates the central nervous system activity of neurotransmitters involved in reward processing such as serotonin, dopamine, and glutamate. It was identified as crucial for alcohol consumption in healthy adults and, in rats, specifically related to the function in the striatum, a region that is commonly involved in reward processing. However, studies in humans on the association of BDNF Val66Met and reward-related brain functions and its role for alcohol consumption, a significant predictor of later alcohol addiction, are missing. Based on an intermediate phenotype approach, we assessed the early orientation toward alcohol and alcohol consumption in 530 healthy adolescents that underwent a monetary incentive delay task during functional magnetic resonance imaging. We found a significantly lower response in the putamen to reward anticipation in adolescent Met carriers with high versus low levels of alcohol consumption. During reward feedback, Met carriers with low putamen reactivity were significantly more likely to orient toward alcohol and to drink alcohol 2 years later. This study indicates a possible effect of BDNF Val66Met on alcohol addiction-related phenotypes in adolescence. Copyright 2015 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.alcohol.2014.12.004"],["dc.identifier.gro","3151943"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8780"],["dc.notes.intern","WoS Import 2017-07-25"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1873-6823"],["dc.title","BDNF Val66Met and reward-related brain function in adolescents: role for early alcohol consumption"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Molecular psychiatry"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Paillère Martinot, Marie-Laure"],["dc.contributor.author","Lemaitre, Herve"],["dc.contributor.author","Artiges, Eric"],["dc.contributor.author","Miranda, R."],["dc.contributor.author","Goodman, Robert"],["dc.contributor.author","Penttila, Jani"],["dc.contributor.author","Struve, Maren"],["dc.contributor.author","Fadai, Tahmine"],["dc.contributor.author","Kappel, Viola"],["dc.contributor.author","Poustka, Luise"],["dc.contributor.author","Conrod, Patricia J."],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Barbot, A."],["dc.contributor.author","Barker, Gareth J."],["dc.contributor.author","Buchel, Christian"],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Gallinat, Jürgen"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Lawrence, Claire"],["dc.contributor.author","Loth, Eva"],["dc.contributor.author","Mani, Nivedita"],["dc.contributor.author","Paus, Tomas"],["dc.contributor.author","Pausova, Zdenka"],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Robbins, Trevor W."],["dc.contributor.author","Smolka, Michael N."],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.date.accessioned","2017-09-07T11:52:44Z"],["dc.date.available","2017-09-07T11:52:44Z"],["dc.date.issued","2014"],["dc.description.abstract","Abnormalities in white-matter (WM) microstructure, as lower fractional anisotropy (FA), have been reported in adolescent-onset bipolar disorder and in youth at familial risk for bipolarity. We sought to determine whether healthy adolescents with subthreshold bipolar symptoms (SBP) would have early WM microstructural alterations and whether those alterations would be associated with differences in gray-matter (GM) volumes. Forty-two adolescents with three core manic symptoms and no psychiatric diagnosis, and 126 adolescents matched by age and sex, with no psychiatric diagnosis or symptoms, were identified after screening the IMAGEN database of 2223 young adolescents recruited from the general population. After image quality control, voxel-wise statistics were performed on the diffusion parameters using tract-based spatial statistics in 25 SBP adolescents and 77 controls, and on GM and WM images using voxel-based morphometry in 30 SBP adolescents and 106 controls. As compared with healthy controls, adolescents with SBP displayed lower FA values in a number of WM tracts, particularly in the corpus callosum, cingulum, bilateral superior and inferior longitudinal fasciculi, uncinate fasciculi and corticospinal tracts. Radial diffusivity was mainly higher in posterior parts of bilateral superior and inferior longitudinal fasciculi, inferior fronto-occipital fasciculi and right cingulum. As compared with controls, SBP adolescents had lower GM volume in the left anterior cingulate region. This is the first study to investigate WM microstructure and GM morphometric variations in adolescents with SBP. The widespread FA alterations in association and projection tracts, associated with GM changes in regions involved in mood disorders, suggest altered structural connectivity in those adolescents."],["dc.identifier.doi","10.1038/mp.2013.44"],["dc.identifier.gro","3151235"],["dc.identifier.pmid","23628983"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8017"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-07-25"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1476-5578"],["dc.title","White-matter microstructure and gray-matter volumes in adolescents with subthreshold bipolar symptoms"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Molecular psychiatry"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Schumann, Gunter"],["dc.contributor.author","Loth, Eva"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Barbot, A."],["dc.contributor.author","Barker, Gareth J."],["dc.contributor.author","Buchel, Christian"],["dc.contributor.author","Conrod, Patricia J."],["dc.contributor.author","Dalley, J. W."],["dc.contributor.author","Flor, Herta"],["dc.contributor.author","Gallinat, Jürgen"],["dc.contributor.author","Garavan, Hugh"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Ittermann, Bernd"],["dc.contributor.author","Lathrop, Mark"],["dc.contributor.author","Mallik, C."],["dc.contributor.author","Mani, Nivedita"],["dc.contributor.author","Martinot, Jean-Luc"],["dc.contributor.author","Paus, Tomas"],["dc.contributor.author","Poline, Jean Baptiste"],["dc.contributor.author","Robbins, Trevor W."],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Reed, L."],["dc.contributor.author","Smolka, M."],["dc.contributor.author","Spanagel, Rainer"],["dc.contributor.author","Speiser, C"],["dc.contributor.author","Stephens, D N"],["dc.contributor.author","Strohle, Andreas"],["dc.contributor.author","Struve, Maren"],["dc.date.accessioned","2017-09-07T11:47:01Z"],["dc.date.available","2017-09-07T11:47:01Z"],["dc.date.issued","2010"],["dc.description.abstract","A fundamental function of the brain is to evaluate the emotional and motivational significance of stimuli and to adapt behaviour accordingly. The IMAGEN study is the first multicentre genetic-neuroimaging study aimed at identifying the genetic and neurobiological basis of individual variability in impulsivity, reinforcer sensitivity and emotional reactivity, and determining their predictive value for the development of frequent psychiatric disorders. Comprehensive behavioural and neuropsychological characterization, functional and structural neuroimaging and genome-wide association analyses of 2000 14-year-old adolescents are combined with functional genetics in animal and human models. Results will be validated in 1000 adolescents from the Canadian Saguenay Youth Study. The sample will be followed up longitudinally at the age of 16 years to investigate the predictive value of genetics and intermediate phenotypes for the development of frequent psychiatric disorders. This review describes the strategies the IMAGEN consortium used to meet the challenges posed by large-scale multicentre imaging-genomics investigations. We provide detailed methods and Standard Operating Procedures that we hope will be helpful for the design of future studies. These include standardization of the clinical, psychometric and neuroimaging-acquisition protocols, development of a central database for efficient analyses of large multimodal data sets and new analytic approaches to large-scale genetic neuroimaging analyses."],["dc.identifier.doi","10.1038/mp.2010.4"],["dc.identifier.gro","3151986"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8828"],["dc.notes.intern","WoS Import 2017-07-25"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1476-5578"],["dc.title","The IMAGEN study: reinforcement-related behaviour in normal brain function and psychopathology"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]