Kusch, Harald

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[["dc.bibliographiccitation.firstpage","291"],["dc.bibliographiccitation.issue","3/4"],["dc.bibliographiccitation.journal","International Journal of Medical Microbiology"],["dc.bibliographiccitation.lastpage","318"],["dc.bibliographiccitation.volume","298"],["dc.contributor.author","Bode, Rüdiger"],["dc.contributor.author","Engelmann, Susanne"],["dc.contributor.author","Hecker, Michael"],["dc.contributor.author","Albrecht, Dirk"],["dc.contributor.author","Kusch, Harald"],["dc.contributor.author","Morschhäuser, Joachim"],["dc.creator.author","Hecker M"],["dc.creator.author","Bode R"],["dc.creator.author","Kusch H"],["dc.creator.author","Engelmann S"],["dc.creator.author","Albrecht D"],["dc.creator.author","Morschhäuser J"],["dc.date.accessioned","2019-10-09T09:38:18Z"],["dc.date.available","2019-10-09T09:38:18Z"],["dc.date.issued","2008"],["dc.identifier.doi","10.1016/j.ijmm.2007.03.020"],["dc.identifier.pmid","17588813"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62478"],["dc.language.iso","en"],["dc.title","A proteomic view of Candida albicans yeast cell metabolism in exponential and stationary growth phases"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.firstpage","245"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Archives of Microbiology"],["dc.bibliographiccitation.lastpage","267"],["dc.bibliographiccitation.volume","197"],["dc.contributor.author","Neumann, Yvonne"],["dc.contributor.author","Ohlsen, Knut"],["dc.contributor.author","Donat, Stefanie"],["dc.contributor.author","Engelmann, Susanne"],["dc.contributor.author","Kusch, Harald"],["dc.contributor.author","Albrecht, Dirk"],["dc.contributor.author","Cartron, Michael"],["dc.contributor.author","Hurd, Alexander"],["dc.contributor.author","Foster, Simon J."],["dc.date.accessioned","2018-11-07T10:00:42Z"],["dc.date.available","2018-11-07T10:00:42Z"],["dc.date.issued","2015"],["dc.description.abstract","Staphylococcus aureus is a commensal of the human nose and skin. Human skin fatty acids, in particular cis-6-hexadecenoic acid (C-6-H), have high antistaphylococcal activity and can inhibit virulence determinant production. Here, we show that sub-MIC levels of C-6-H result in induction of increased resistance. The mechanism(s) of C-6-H activity was investigated by combined transcriptome and proteome analyses. Proteome analysis demonstrated a pleiotropic effect of C-6-H on virulence determinant production. In response to C-6-H, transcriptomics revealed altered expression of over 500 genes, involved in many aspects of virulence and cellular physiology. The expression of toxins (hla, hlb, hlgBC) was reduced, whereas that of host defence evasion components (cap, sspAB, katA) was increased. In particular, members of the SaeRS regulon had highly reduced expression, and the use of specific mutants revealed that the effect on toxin production is likely mediated via SaeRS."],["dc.description.sponsorship","European Union; MRC [78981]; DFG [TRR34]"],["dc.identifier.doi","10.1007/s00203-014-1048-1"],["dc.identifier.isi","000349391400011"],["dc.identifier.pmid","25325933"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11155"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37864"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-072X"],["dc.relation.issn","0302-8933"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","The effect of skin fatty acids on Staphylococcus aureus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3914"],["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","Proteomics"],["dc.bibliographiccitation.lastpage","3927"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Kolata, Julia"],["dc.contributor.author","Bode, Lonneke G. M."],["dc.contributor.author","Holtfreter, Silva"],["dc.contributor.author","Steil, Leif"],["dc.contributor.author","Kusch, Harald"],["dc.contributor.author","Holtfreter, Birte"],["dc.contributor.author","Albrecht, Dirk"],["dc.contributor.author","Hecker, Michael"],["dc.contributor.author","Engelmann, Susanne"],["dc.contributor.author","van Belkum, Alex"],["dc.contributor.author","Volker, Uwe"],["dc.contributor.author","Bröker, Barbara M."],["dc.date.accessioned","2019-08-06T10:50:27Z"],["dc.date.available","2019-08-06T10:50:27Z"],["dc.date.issued","2011"],["dc.description.abstract","Staphylococcus aureus is both a prominent cause of nosocomial infections with significant morbidity and mortality and a commensal with nasal carriage in around 30% of the population. The rapid spread of multi-resistant strains necessitates novel therapeutic strategies, a challenging task because the species S. aureus and the host response against it are highly variable. In a prospective study among 2023 surgical and non-surgical patients, 12 patients developed S. aureus bacteremia. They were analysed in detail using a personalized approach. For each patient, the extracellular proteins of the infecting S. aureus strain were identified and the developing antibody response was assessed on 2-D immunoblots. S. aureus carriers showed clear evidence of strain-specific pre-immunization. In all immune-competent bacteremia patients, antibody binding increased strongly, in most cases already at diagnosis. In endogenous infections, the pattern of antibody binding was similar to the pre-infection pattern. In exogenous infections, in contrast, the pre-infection pattern was radically altered with the acquisition of new specificities. These were characteristic for individual patients. Nevertheless, a common signature of 11 conserved S. aureus proteins, recognized in at least half of the bacteremic patients, was identified. All patients mounted a dynamic antibody response to a subset of these proteins."],["dc.identifier.doi","10.1002/pmic.201000760"],["dc.identifier.pmid","21805632"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62303"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1615-9861"],["dc.relation.issn","1615-9853"],["dc.title","Distinctive patterns in the human antibody response to Staphylococcus aureus bacteremia in carriers and non-carriers"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","686"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Proteomics"],["dc.bibliographiccitation.lastpage","697"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Morschhäuser, Joachim"],["dc.contributor.author","Engelmann, Susanne"],["dc.contributor.author","Kusch, Harald"],["dc.contributor.author","Albrecht, Dirk"],["dc.contributor.author","Hecker, Michael"],["dc.creator.author","Hecker M"],["dc.creator.author","Engelmann S"],["dc.creator.author","Kusch H"],["dc.creator.author","Albrecht D"],["dc.creator.author","Morschhäuser J"],["dc.date.accessioned","2019-10-09T09:24:28Z"],["dc.date.available","2019-10-09T09:24:28Z"],["dc.date.issued","2007"],["dc.identifier.doi","10.1002/pmic.200600575"],["dc.identifier.pmid","17285563"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62475"],["dc.language.iso","en"],["dc.title","Proteomic analysis of the oxidative stress response in Candida albicans"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e70669"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","PloS one"],["dc.bibliographiccitation.lastpage","e70669"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Fuchs, Stephan"],["dc.contributor.author","Zühlke, Daniela"],["dc.contributor.author","Pané-Farré, Jan"],["dc.contributor.author","Kusch, Harald"],["dc.contributor.author","Wolf, Carmen"],["dc.contributor.author","Reiß, Swantje"],["dc.contributor.author","Binh, Le Thi Nguyen"],["dc.contributor.author","Albrecht, Dirk"],["dc.contributor.author","Riedel, Katharina"],["dc.contributor.author","Hecker, Michael"],["dc.contributor.author","Engelmann, Susanne"],["dc.date.accessioned","2019-07-09T11:40:11Z"],["dc.date.available","2019-07-09T11:40:11Z"],["dc.date.issued","2013"],["dc.description.abstract","Gel-based proteomics is a powerful approach to study the physiology of Staphylococcus aureus under various growth restricting conditions. We analyzed 679 protein spots from a reference 2-dimensional gel of cytosolic proteins of S. aureus COL by mass spectrometry resulting in 521 different proteins. 4,692 time dependent protein synthesis profiles were generated by exposing S. aureus to nine infection-related stress and starvation stimuli (H2O2, diamide, paraquat, NO, fermentation, nitrate respiration, heat shock, puromycin, mupirocin). These expression profiles are stored in an online resource called Aureolib (http://www.aureolib.de). Moreover, information on target genes of 75 regulators and regulatory elements were included in the database. Cross-comparisons of this extensive data collection of protein synthesis profiles using the tools implemented in Aureolib lead to the identification of stress and starvation specific marker proteins. Altogether, 226 protein synthesis profiles showed induction ratios of 2.5-fold or higher under at least one of the tested conditions with 157 protein synthesis profiles specifically induced in response to a single stimulus. The respective proteins might serve as marker proteins for the corresponding stimulus. By contrast, proteins whose synthesis was increased or repressed in response to more than four stimuli are rather exceptional. The only protein that was induced by six stimuli is the universal stress protein SACOL1759. Most strikingly, cluster analyses of synthesis profiles of proteins differentially synthesized under at least one condition revealed only in rare cases a grouping that correlated with known regulon structures. The most prominent examples are the GapR, Rex, and CtsR regulon. In contrast, protein synthesis profiles of proteins belonging to the CodY and σ(B) regulon are widely distributed. In summary, Aureolib is by far the most comprehensive protein expression database for S. aureus and provides an essential tool to decipher more complex adaptation processes in S. aureus during host pathogen interaction."],["dc.identifier.doi","10.1371/journal.pone.0070669"],["dc.identifier.fs","597423"],["dc.identifier.pmid","23967085"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10724"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58109"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1932-6203"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.mesh","Adaptation, Biological"],["dc.subject.mesh","Bacterial Proteins"],["dc.subject.mesh","Cluster Analysis"],["dc.subject.mesh","Computational Biology"],["dc.subject.mesh","Databases, Genetic"],["dc.subject.mesh","Gene Expression Regulation, Bacterial"],["dc.subject.mesh","Hydrogen Peroxide"],["dc.subject.mesh","Proteome"],["dc.subject.mesh","Proteomics"],["dc.subject.mesh","Signal Transduction"],["dc.subject.mesh","Staphylococcus aureus"],["dc.subject.mesh","Stress, Physiological"],["dc.subject.mesh","User-Computer Interface"],["dc.title","Aureolib - a proteome signature library: towards an understanding of staphylococcus aureus pathophysiology."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.firstpage","1967"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Proteomics"],["dc.bibliographiccitation.lastpage","1981"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Engelmann, Susanne"],["dc.contributor.author","Kempf, VA"],["dc.contributor.author","Albrecht, Dirk"],["dc.contributor.author","Kusch, Harald"],["dc.contributor.author","Eberhardt, C"],["dc.contributor.author","Hecker, Michael"],["dc.contributor.author","Autenrieth, IB"],["dc.creator.author","Hecker M"],["dc.creator.author","Engelmann S"],["dc.creator.author","Autenrieth IB"],["dc.creator.author","Albrecht D"],["dc.creator.author","Kempf VA"],["dc.creator.author","Kusch H"],["dc.creator.author","Eberhardt C"],["dc.date.accessioned","2019-10-09T09:44:11Z"],["dc.date.available","2019-10-09T09:44:11Z"],["dc.date.issued","2009"],["dc.identifier.doi","10.1002/pmic.200700670"],["dc.identifier.pmid","19333998"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62481"],["dc.language.iso","en"],["dc.title","Proteomic analysis of the bacterial pathogen Bartonella henselae and identification of immunogenic proteins for serodiagnosis"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]