Kusch, Harald

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[["dc.bibliographiccitation.firstpage","554"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Molecular Genetics and Genomics"],["dc.bibliographiccitation.lastpage","565"],["dc.bibliographiccitation.volume","271"],["dc.contributor.author","Schwanfelder, S"],["dc.contributor.author","Engelmann, Susanne"],["dc.contributor.author","Kusch, Harald"],["dc.contributor.author","Biswas, K"],["dc.contributor.author","Rogers, PD"],["dc.contributor.author","Morschhäuser, Joachim"],["dc.contributor.author","Hecker, Michael"],["dc.creator.author","Schwanfelder S"],["dc.creator.author","Hecker M"],["dc.creator.author","Engelmann S"],["dc.creator.author","Biswas K"],["dc.creator.author","Kusch H"],["dc.creator.author","Rogers PD"],["dc.creator.author","Morschhäuser J"],["dc.date.accessioned","2019-10-09T09:04:41Z"],["dc.date.available","2019-10-09T09:04:41Z"],["dc.date.issued","2004"],["dc.identifier.doi","10.1007/s00438-004-0984-x"],["dc.identifier.pmid","15114480"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62474"],["dc.language.iso","en"],["dc.title","A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","245"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Archives of Microbiology"],["dc.bibliographiccitation.lastpage","267"],["dc.bibliographiccitation.volume","197"],["dc.contributor.author","Neumann, Yvonne"],["dc.contributor.author","Ohlsen, Knut"],["dc.contributor.author","Donat, Stefanie"],["dc.contributor.author","Engelmann, Susanne"],["dc.contributor.author","Kusch, Harald"],["dc.contributor.author","Albrecht, Dirk"],["dc.contributor.author","Cartron, Michael"],["dc.contributor.author","Hurd, Alexander"],["dc.contributor.author","Foster, Simon J."],["dc.date.accessioned","2018-11-07T10:00:42Z"],["dc.date.available","2018-11-07T10:00:42Z"],["dc.date.issued","2015"],["dc.description.abstract","Staphylococcus aureus is a commensal of the human nose and skin. Human skin fatty acids, in particular cis-6-hexadecenoic acid (C-6-H), have high antistaphylococcal activity and can inhibit virulence determinant production. Here, we show that sub-MIC levels of C-6-H result in induction of increased resistance. The mechanism(s) of C-6-H activity was investigated by combined transcriptome and proteome analyses. Proteome analysis demonstrated a pleiotropic effect of C-6-H on virulence determinant production. In response to C-6-H, transcriptomics revealed altered expression of over 500 genes, involved in many aspects of virulence and cellular physiology. The expression of toxins (hla, hlb, hlgBC) was reduced, whereas that of host defence evasion components (cap, sspAB, katA) was increased. In particular, members of the SaeRS regulon had highly reduced expression, and the use of specific mutants revealed that the effect on toxin production is likely mediated via SaeRS."],["dc.description.sponsorship","European Union; MRC [78981]; DFG [TRR34]"],["dc.identifier.doi","10.1007/s00203-014-1048-1"],["dc.identifier.isi","000349391400011"],["dc.identifier.pmid","25325933"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11155"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37864"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-072X"],["dc.relation.issn","0302-8933"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","The effect of skin fatty acids on Staphylococcus aureus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.firstpage","133"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","International Journal of Medical Microbiology"],["dc.bibliographiccitation.lastpage","141"],["dc.bibliographiccitation.volume","304"],["dc.contributor.author","Kusch, Harald"],["dc.contributor.author","Engelmann, Susanne"],["dc.date.accessioned","2019-08-06T10:44:01Z"],["dc.date.available","2019-08-06T10:44:01Z"],["dc.date.issued","2014"],["dc.description.abstract","Secreted proteins constitute a reservoir of virulence factors. Here, an in silico analysis of the secretome of 15 S. aureus reference strains is presented revealing that about 30% of the encoded proteome of this bacterium could be secreted. In total 1354 proteins were predicted to be localized outside the cytoplasm representing the pan-secretome of S. aureus. 41% of these proteins have been identified to be expressed using different approaches. The function of at least 50% of the secreted proteins encoded by S. aureus is not yet clear and a possible role in virulence has to be elucidated."],["dc.identifier.doi","10.1016/j.ijmm.2013.11.005"],["dc.identifier.pmid","24424242"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62302"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1618-0607"],["dc.relation.issn","1438-4221"],["dc.title","Secrets of the secretome in Staphylococcus aureus"],["dc.type","journal_article"],["dc.type.internalPublication","no"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.firstpage","489"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","International Journal of Medical Microbiology"],["dc.bibliographiccitation.lastpage","508"],["dc.bibliographiccitation.volume","299"],["dc.contributor.author","Shevchuk, Olga"],["dc.contributor.author","Batzilla, Christoph"],["dc.contributor.author","Hägele, Sonja"],["dc.contributor.author","Kusch, Harald"],["dc.contributor.author","Engelmann, Susanne"],["dc.contributor.author","Hecker, Michael"],["dc.contributor.author","Haas, Albert"],["dc.contributor.author","Heuner, Klaus"],["dc.contributor.author","Glöckner, Gernot"],["dc.contributor.author","Steinert, Michael"],["dc.date.accessioned","2018-04-24T15:32:26Z"],["dc.date.available","2018-04-24T15:32:26Z"],["dc.date.issued","2009"],["dc.identifier.doi","10.1016/j.ijmm.2009.03.006"],["dc.identifier.pmid","19482547"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/13767"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.title","Proteomic analysis of Legionella-containing phagosomes isolated from Dictyostelium"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]