Mansouri, Ahmed

[["dc.bibliographiccitation.firstpage","3948"],["dc.bibliographiccitation.issue","24"],["dc.bibliographiccitation.journal","Cell Cycle"],["dc.bibliographiccitation.lastpage","3957"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Shamsi, Farnaz"],["dc.contributor.author","Parlato, Rosanna"],["dc.contributor.author","Collombat, Patrick"],["dc.contributor.author","Mansouri, Ahmed"],["dc.date.accessioned","2018-11-07T09:31:14Z"],["dc.date.available","2018-11-07T09:31:14Z"],["dc.date.issued","2014"],["dc.description.abstract","The putative induction of adult -cell regeneration represents a promising approach for the treatment of type 1 diabetes. Toward this ultimate goal, it is essential to develop an inducible model mimicking the long-lasting disease progression. In the current study, we have established a novel -cell ablation mouse model, in which the -cell mass progressively declines, as seen in type 1 diabetes. The model is based on the -cell specific genetic ablation of the transcription initiation factor 1A, TIF-IA, essential for RNA Polymerase I activity (TIF-IA(/)). Using this approach, we induced a slow apoptotic response that eventually leads to a protracted -cell death. In this model, we observed -cell regeneration that resulted in a complete recovery of the -cell mass and normoglycemia. In addition, we showed that adaptive proliferation of remaining -cells is the prominent mechanism acting to compensate for the massive -cell loss in young but also aged mice. Interestingly, at any age, we also detected -like cells expressing the glucagon hormone, suggesting a transition between - and -cell identities or vice versa. Taken together, the TIF-IA(/) mouse model can be used to investigate the potential therapeutic approaches for type 1 diabetes targeting -cell regeneration."],["dc.identifier.doi","10.4161/15384101.2014.952176"],["dc.identifier.isi","000348329600024"],["dc.identifier.pmid","25558832"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31496"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Landes Bioscience"],["dc.relation.issn","1551-4005"],["dc.relation.issn","1538-4101"],["dc.title","A genetic mouse model for progressive ablation and regeneration of insulin producing beta-cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Tissue Antigens"],["dc.bibliographiccitation.volume","84"],["dc.contributor.author","Monecke, Sebastian"],["dc.contributor.author","Hamann, Carina"],["dc.contributor.author","Elsner, Leslie"],["dc.contributor.author","Nolte, Jessica"],["dc.contributor.author","Engel, Wolfgang"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Guan, Kaomei"],["dc.contributor.author","Mansouri, Ahmed"],["dc.contributor.author","Dressel, Ralf"],["dc.date.accessioned","2018-11-07T09:38:32Z"],["dc.date.available","2018-11-07T09:38:32Z"],["dc.date.issued","2014"],["dc.format.extent","5"],["dc.identifier.isi","000337546000002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33083"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.eventlocation","Stockholm, SWEDEN"],["dc.relation.issn","1399-0039"],["dc.relation.issn","0001-2815"],["dc.title","PLURIPOTENT STEM CELLS VARYING IN A SINGLE MINOR HISTOCOMPATIBILITY ANTIGEN ELICIT CELLULAR AND HUMORAL IMMUNE RESPONSES THAT CAN MEDIATE GRAFT REJECTION"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","103787"],["dc.bibliographiccitation.journal","Ore Geology Reviews"],["dc.bibliographiccitation.volume","127"],["dc.contributor.author","Alibabaie, N."],["dc.contributor.author","Esmaeily, D."],["dc.contributor.author","Peters, S.T.M."],["dc.contributor.author","Horn, I."],["dc.contributor.author","Gerdes., A."],["dc.contributor.author","Nirooamand, S."],["dc.contributor.author","Jian, W."],["dc.contributor.author","Mansouri, T."],["dc.contributor.author","Tudeshki, H."],["dc.contributor.author","Lehmann, B."],["dc.date.accessioned","2021-04-14T08:28:41Z"],["dc.date.available","2021-04-14T08:28:41Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.oregeorev.2020.103787"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82683"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.issn","0169-1368"],["dc.title","Evolution of the Kiruna-type Gol-e-Gohar iron ore district, Sanandaj-Sirjan zone, Iran"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","86"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Developmental Cell"],["dc.bibliographiccitation.lastpage","100"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Al-Hasani, Keith"],["dc.contributor.author","Pfeifer, Anja"],["dc.contributor.author","Courtney, Monica"],["dc.contributor.author","Ben-Othman, Nouha"],["dc.contributor.author","Gjernes, Elisabet"],["dc.contributor.author","Vieira, Andhira"],["dc.contributor.author","Druelle, Noemie"],["dc.contributor.author","Avolio, Fabio"],["dc.contributor.author","Ravassard, Philippe"],["dc.contributor.author","Leuckx, Gunter"],["dc.contributor.author","Lacas-Gervais, Sandra"],["dc.contributor.author","Ambrosetti, Damien"],["dc.contributor.author","Benizri, Emmanuel"],["dc.contributor.author","Hecksher-Sorensen, Jacob"],["dc.contributor.author","Gounon, Pierre"],["dc.contributor.author","Ferrer, Jorge"],["dc.contributor.author","Gradwohl, Gerard"],["dc.contributor.author","Heimberg, Harry"],["dc.contributor.author","Mansouri, Ahmed"],["dc.contributor.author","Collombat, Patrick"],["dc.date.accessioned","2018-11-07T09:22:22Z"],["dc.date.available","2018-11-07T09:22:22Z"],["dc.date.issued","2013"],["dc.description.abstract","It was recently demonstrated that embryonic glucagon-producing cells in the pancreas can regenerate and convert into insulin-producing beta-like cells through the constitutive/ectopic expression of the Pax4 gene. However, whether alpha cells in adult mice display the same plasticity is unknown. Similarly, the mechanisms underlying such reprogramming remain unclear. We now demonstrate that the misexpression of Pax4 in glucagon(+) cells age-independently induces their conversion into beta-like cells and their glucagon shortage-mediated replacement, resulting in islet hypertrophy and in an unexpected islet neogenesis. Combining several lineage-tracing approaches, we show that, upon Pax4-mediated alpha-to-beta-like cell conversion, pancreatic duct-lining precursor cells are continuously mobilized, re-express the developmental gene Ngn3, and successively adopt a glucagon+ and a beta-like cell identity through a mechanism involving the reawakening of the epithelial-to-mesenchymal transition. Importantly, these processes can repeatedly regenerate the whole beta cell mass and thereby reverse several rounds of toxin-induced diabetes, providing perspectives to design therapeutic regenerative strategies."],["dc.identifier.doi","10.1016/j.devcel.2013.05.018"],["dc.identifier.isi","000322087400009"],["dc.identifier.pmid","23810513"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29326"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.relation.issn","1534-5807"],["dc.title","Adult Duct-Lining Cells Can Reprogram into beta-like Cells Able to Counter Repeated Cycles of Toxin-Induced Diabetes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","838"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Seminars in Cell and Developmental Biology"],["dc.bibliographiccitation.lastpage","844"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Collombat, Patrick"],["dc.contributor.author","Xu, X."],["dc.contributor.author","Heimberg, Harry"],["dc.contributor.author","Mansouri, Ahmed"],["dc.date.accessioned","2018-11-07T08:38:58Z"],["dc.date.available","2018-11-07T08:38:58Z"],["dc.date.issued","2010"],["dc.description.abstract","The pancreas is composed of two main compartments consisting of endocrine and exocrine tissues. The majority of the organ is exocrine and responsible for the synthesis of digestive enzymes and for their transport via an intricate ductal system into the duodenum. The endocrine tissue represents less than 2% of the organ and is organized into functional units called islets of Langerhans, comprising alpha-, beta-, delta-, epsilon- and PP-cells, producing the hormones glucagon, insulin, somatostatin, ghrelin and pancreatic polypeptide (PP), respectively. Insulin-producing beta- cells play a central role in the control of the glucose homeostasis. Accordingly, absolute or relative deficiency in beta-cells may ultimately lead to type 1 and/or type 2 diabetes, respectively. One major goal of diabetes research is therefore to understand the molecular mechanisms controlling the development of beta-cells during pancreas morphogenesis, but also those underlying the regeneration of adult injured pancreas, and assess their significance for future cell-based therapy. In this review, we will therefore present new insights into beta-cell development with focus on beta-cell regeneration. (C) 2010 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.semcdb.2010.07.007"],["dc.identifier.isi","000283598400010"],["dc.identifier.pmid","20688184"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18878"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Ltd- Elsevier Science Ltd"],["dc.relation.issn","1084-9521"],["dc.title","Pancreatic beta-cells: From generation to regeneration"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","396"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Stem Cells"],["dc.bibliographiccitation.lastpage","404"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Baier, Paul Christian"],["dc.contributor.author","Schindehutte, J."],["dc.contributor.author","Thinyane, K."],["dc.contributor.author","Flugge, G."],["dc.contributor.author","Fuchs, E."],["dc.contributor.author","Mansouri, Ahmed"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Gruss, P."],["dc.contributor.author","Trenkwalder, Claudia"],["dc.date.accessioned","2018-11-07T10:53:15Z"],["dc.date.available","2018-11-07T10:53:15Z"],["dc.date.issued","2004"],["dc.description.abstract","Objective. Transplantation of fetal mesencephalic cells into the striatum has been performed in about 350 patients with Parkinson's disease and has been intensively studied in rat models of Parkinson's disease. Limited access to this material has shifted the focus toward embryonic stem (ES) cells. The grafting of undifferentiated ES cells to 6-hydroxy-dopamine (6-OHDA)-lesioned rats leads to behavioral improvements but may induce teratoma-like structures. This risk might be avoided by using more differentiated ES cells. In this study, we aimed to investigate differentiated mouse ES cells regarding their in vivo development and fate after transplantation in the striatum in the 6-OHDA rat model and the behavioral changes induced after transplantation. Methods. Mouse ES cells were differentiated on PA6 feeder cells for 14 days before grafting. Twenty to twenty-five percent of the neurons obtained were positive for tyrosine-hydroxylase (TH). PKH26-labeled cells were transplanted in the striata of unilaterally 6-OHDA-lesioned rats. Results. Direct PKH26 fluorescence visualization and TH staining proved the existence of cell deposits in the striata of all grafted animals, indicating cell survival for at least 5 weeks posttransplantation. There was no evidence of tumor formation. Immunocytochemical staining showed glial immunoreactivity surrounding the grafted cell deposits, probably inhibiting axonal outgrowth into the surrounding host tissue. There was a significant reduction in amphetamine-induced rotational behavior seen in grafted animals, which was not observed in sham-operated animals. Conclusions. The findings of this study suggest that the amphetamine-induced rotational behavioral test without histological confirmation is not proof of morphological integration with axonal outgrowth within the first 4 weeks posttransplantation."],["dc.identifier.doi","10.1634/stemcells.22-3-396"],["dc.identifier.isi","000221869600019"],["dc.identifier.pmid","15153616"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49315"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1066-5099"],["dc.title","Behavioral changes in unilaterally 6-hydroxy-dopamine lesioned rats after transplantation of differentiated mouse embryonic stem cells without morphological integration"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","538"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","MHR Basic science of reproductive medicine"],["dc.bibliographiccitation.lastpage","549"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Jung, Laura"],["dc.contributor.author","Tropel, Philippe"],["dc.contributor.author","Moal, Yohann"],["dc.contributor.author","Teletin, Marius"],["dc.contributor.author","Jeandidier, Eric"],["dc.contributor.author","Gayon, Regis"],["dc.contributor.author","Himmelspach, Christian"],["dc.contributor.author","Bello, Fiona"],["dc.contributor.author","Andre, Cecile"],["dc.contributor.author","Tosch, Adeline"],["dc.contributor.author","Mansouri, Ahmed"],["dc.contributor.author","Bruant-Rodier, Catherine"],["dc.contributor.author","Bouille, Pascale"],["dc.contributor.author","Viville, Stephane"],["dc.date.accessioned","2018-11-07T09:39:45Z"],["dc.date.available","2018-11-07T09:39:45Z"],["dc.date.issued","2014"],["dc.description.abstract","The advent of human induced pluripotent stem cells (hiPSC) is revolutionizing many research fields including cell-replacement therapy, drug screening, physiopathology of specific diseases and more basic research such as embryonic development or diseases modeling. Despite the large number of reports on reprogramming methods, techniques in use remain globally inefficient. We present here a new optimized approach to improve this efficiency. After having tested different monocistronic vectors with poor results, we adopted a polycistronic cassette encoding Thomson's cocktail OCT4, NANOG, SOX2 and LIN28 (ONSL) separated by 2A peptides. This cassette was tested in various vector backbones, based on lentivirus or retrovirus under a LTR or EF1 alpha promoter. This allowed us to show that ONSL-carrier retrovectors reprogrammed adult fibroblast cells with a much higher efficiency (up to 0.6%) than any other tested. We then compared the reprogramming efficiencies of two different polycistronic genes, ONSL and OCT4, SOX2, KLF4 and cMYC (OSKM) placed in the same retrovector backbone. Interestingly, in this context ONSL gene reprograms more efficiently than OSKM but OSKM reprograms faster suggesting that the two cocktails may reprogram through distinct pathways. By equally mixing RV-LTR-ONSL and RV-LTR-OSKM, we indeed observed a remarkable synergy, yielding a reprogramming efficiency of > 2%. We present here a drastic improvement of the reprogramming efficiency, which opens doors to the development of automated and high throughput strategies of hiPSC production. Furthermore, non-integrative reprogramming protocols (i.e. mRNA) may take advantage of this synergy to boost their efficiency."],["dc.identifier.doi","10.1093/molehr/gau012"],["dc.identifier.isi","000336495100007"],["dc.identifier.pmid","24501429"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33356"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1460-2407"],["dc.relation.issn","1360-9947"],["dc.title","ONSL and OSKM cocktails act synergistically in reprogramming human somatic cells into induced pluripotent stem cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3450"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Cell Cycle"],["dc.bibliographiccitation.lastpage","3451"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Collombat, Patrick"],["dc.contributor.author","Mansouri, Ahmed"],["dc.date.accessioned","2018-11-07T11:22:28Z"],["dc.date.available","2018-11-07T11:22:28Z"],["dc.date.issued","2009"],["dc.description.sponsorship","NIDDK NIH HHS [U19 DK 072495-01]"],["dc.identifier.doi","10.4161/cc.8.21.9791"],["dc.identifier.isi","000272218600009"],["dc.identifier.pmid","19838059"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55998"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Landes Bioscience"],["dc.relation.issn","1538-4101"],["dc.title","Turning on the beta-cell identity in the pancreas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4299"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Journal of Cell Biology"],["dc.bibliographiccitation.lastpage","4311"],["dc.bibliographiccitation.volume","216"],["dc.contributor.author","Druelle, Noémie"],["dc.contributor.author","Vieira, Andhira"],["dc.contributor.author","Shabro, Aidin"],["dc.contributor.author","Courtney, Monica"],["dc.contributor.author","Mondin, Magali"],["dc.contributor.author","Rekima, Samah"],["dc.contributor.author","Napolitano, Tiziana"],["dc.contributor.author","Silvano, Serena"],["dc.contributor.author","Navarro-Sanz, Sergi"],["dc.contributor.author","Hadzic, Biljana"],["dc.contributor.author","Avolio, Fabio"],["dc.contributor.author","Rassoulzadegan, Minoo"],["dc.contributor.author","Schmid, Herbert A."],["dc.contributor.author","Mansouri, Ahmed"],["dc.contributor.author","Collombat, Patrick"],["dc.date.accessioned","2020-12-10T18:15:35Z"],["dc.date.available","2020-12-10T18:15:35Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1083/jcb.201704044"],["dc.identifier.eissn","1540-8140"],["dc.identifier.issn","0021-9525"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74895"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Ectopic expression of Pax4 in pancreatic δ cells results in β-like cell neogenesis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","IUBMB Life"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Mansouri, Ahmed"],["dc.contributor.author","Kuhlmann, Tanja"],["dc.contributor.author","Dressel, Ralf"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T08:32:13Z"],["dc.date.available","2018-11-07T08:32:13Z"],["dc.date.issued","2009"],["dc.format.extent","282"],["dc.identifier.isi","000264089500015"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17287"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","John Wiley & Sons Inc"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1521-6543"],["dc.title","EMBRYONIC STEM CELL-DERIVED DOPAMINERGIC NEURONS FOR THE THERAPY OF PARKINSON'S DISEASE"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]