Kunze-Szikszay, Nils

[["dc.bibliographiccitation.artnumber","122"],["dc.bibliographiccitation.journal","Scandinavian Journal of Trauma Resuscitation and Emergency Medicine"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Kunze-Szikszay, Nils"],["dc.contributor.author","Krack, Lennart A."],["dc.contributor.author","Wildenauer, Pauline"],["dc.contributor.author","Wand, Saskia"],["dc.contributor.author","Heyne, Tim"],["dc.contributor.author","Walliser, Karoline"],["dc.contributor.author","Spering, Christopher"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Roessler, Markus"],["dc.date.accessioned","2018-11-07T10:07:07Z"],["dc.date.available","2018-11-07T10:07:07Z"],["dc.date.issued","2016"],["dc.description.abstract","Background: Hyperfibrinolysis (HF) is a major contributor to coagulopathy and mortality in trauma patients. This study investigated (i) the rate of HF during the pre-hospital management of patients with multiple injuries and (ii) the effects of pre-hospital tranexamic acid (TxA) administration on the coagulation system. Methods: From 27 trauma patients with pre-hospital an estimated injury severity score (ISS) >= 16 points blood was obtained at the scene and on admission to the emergency department (ED). All patients received 1 g of TxA after the first blood sample was taken. Rotational thrombelastometry (ROTEM) was performed for both blood samples, and the results were compared. HF was defined as a maximum lysis (ML) >15 % in EXTEM. Results: The median (min-max) ISS was 17 points (4-50 points). Four patients (15 %) had HF diagnosed via ROTEM at the scene, and 2 patients (7.5 %) had HF diagnosed via ROTEM on admission to the ED. The median ML before TxA administration was 11 % (3-99 %) vs. 10 % after TxA administration (4-18 %; p > 0.05). TxA was administered 37 min (10-85 min) before ED arrival. The ROTEM results before and after TxA administration did not significantly differ. No adverse drug reactions were observed after TxA administration. Discussion: HF can be present in severely injured patients during pre-hospital care. Antifibrinolytic therapy administered at the scene is a significant time saver. Even in milder trauma fibrinogen can be decreased to critically low levels. Early administration of TxA cannot reverse or entirely stop this decrease. Conclusions: The pre-hospital use of TxA should be considered for severely injured patients to prevent the worsening of trauma-induced coagulopathy and unnecessarily high fibrinogen consumption."],["dc.identifier.doi","10.1186/s13049-016-0314-4"],["dc.identifier.isi","000384950400003"],["dc.identifier.pmid","27724970"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13894"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39223"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1757-7241"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","The pre-hospital administration of tranexamic acid to patients with multiple injuries and its effects on rotational thrombelastometry: a prospective observational study in pre-hospital emergency medicine"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","69"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Microbiology"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Kunze-Szikszay, Nils"],["dc.contributor.author","Euler, Maximilian"],["dc.contributor.author","Kuhns, Martin"],["dc.contributor.author","Thieß, Melanie"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Perl, Thorsten"],["dc.date.accessioned","2021-04-14T08:28:09Z"],["dc.date.accessioned","2022-08-18T12:35:52Z"],["dc.date.available","2021-04-14T08:28:09Z"],["dc.date.available","2022-08-18T12:35:52Z"],["dc.date.issued","2021-02-28"],["dc.date.updated","2022-07-29T12:07:23Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n Hospital-acquired pneumonia (HAP) is a common problem in intensive care medicine and the patient outcome depends on the fast beginning of adequate antibiotic therapy. Until today pathogen identification is performed using conventional microbiological methods with turnaround times of at least 24 h for the first results. It was the aim of this study to investigate the potential of headspace analyses detecting bacterial species-specific patterns of volatile organic compounds (VOCs) for the rapid differentiation of HAP-relevant bacteria.\r\n \r\n \r\n Methods\r\n Eleven HAP-relevant bacteria (Acinetobacter baumanii, Acinetobacter pittii, Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Klebsiella oxytoca, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Staphylococcus aureus, Serratia marcescens) were each grown for 6 hours in Lysogeny Broth and the headspace over the grown cultures was investigated using multi-capillary column-ion mobility spectrometry (MCC-IMS) to detect differences in the VOC composition between the bacteria in the panel. Peak areas with changing signal intensities were statistically analysed, including significance testing using one-way ANOVA or Kruskal-Wallis test (p < 0.05).\r\n \r\n \r\n Results\r\n 30 VOC signals (23 in the positive ion mode and 7 in the negative ion mode of the MCC-IMS) showed statistically significant differences in at least one of the investigated bacteria. The VOC patterns of the bacteria within the HAP panel differed substantially and allowed species differentiation.\r\n \r\n \r\n Conclusions\r\n MCC-IMS headspace analyses allow differentiation of bacteria within HAP-relevant panel after 6 h of incubation in a complex fluid growth medium. The method has the potential to be developed towards a feasible point-of-care diagnostic tool for pathogen differentiation on HAP."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.citation","BMC Microbiology. 2021 Feb 28;21(1):69"],["dc.identifier.doi","10.1186/s12866-021-02102-8"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17742"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82517"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112945"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","BioMed Central"],["dc.relation.eissn","1471-2180"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject","Pneumonia"],["dc.subject","Microbiological techniques"],["dc.subject","Volatile organic compound"],["dc.subject","Metabolite"],["dc.subject","Ion mobility spectrometry"],["dc.title","Headspace analyses using multi-capillary column-ion mobility spectrometry allow rapid pathogen differentiation in hospital-acquired pneumonia relevant bacteria"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","708"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Anaesthesia"],["dc.bibliographiccitation.lastpage","713"],["dc.bibliographiccitation.volume","74"],["dc.contributor.author","Perl, T."],["dc.contributor.author","Kunze‐Szikszay, N."],["dc.contributor.author","Bräuer, A."],["dc.contributor.author","Quintel, M."],["dc.contributor.author","Röhrig, A. L."],["dc.contributor.author","Kerpen, K."],["dc.contributor.author","Telgheder, U."],["dc.date.accessioned","2021-06-01T10:47:11Z"],["dc.date.available","2021-06-01T10:47:11Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1111/anae.14601"],["dc.identifier.eissn","1365-2044"],["dc.identifier.issn","0003-2409"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85512"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1365-2044"],["dc.relation.issn","0003-2409"],["dc.title","Aluminium release by coated and uncoated fluid‐warming devices"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","46"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Intensive Care Medicine Experimental"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Cambiaghi, Barbara"],["dc.contributor.author","Vasques, Francesco"],["dc.contributor.author","Mörer, Onnen"],["dc.contributor.author","Ritter, Christian"],["dc.contributor.author","Mauri, Tommaso"],["dc.contributor.author","Kunze-Szikszay, Nils"],["dc.contributor.author","Holke, Karin"],["dc.contributor.author","Collino, Francesca"],["dc.contributor.author","Maiolo, Giorgia"],["dc.contributor.author","Rapetti, Francesca"],["dc.contributor.author","Schulze-Kalthoff, Elias"],["dc.contributor.author","Tonetti, Tommaso"],["dc.contributor.author","Hahn, Günter"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Gattinoni, Luciano"],["dc.date.accessioned","2020-12-10T18:41:24Z"],["dc.date.available","2020-12-10T18:41:24Z"],["dc.date.issued","2017"],["dc.description.abstract","Abstract Background Severe hypoperfusion can cause lung damage. We studied the effects of regional perfusion block in normal lungs and in the lungs that had been conditioned by lavage with 500 ml saline and high V T (20 ml kg−1) ventilation. Methods Nineteen pigs (61.2 ± 2.5 kg) were randomized to five groups: controls (n = 3), the right lower lobe block alone (n = 3), lavage and high V T (n = 4), lung lavage, and high V T plus perfusion block of the right (n = 5) or left (n = 4) lower lobe. Gas exchange, respiratory mechanics, and hemodynamics were measured hourly. After an 8-h observation period, CT scans were obtained at 0 and 15 cmH2O airway pressure. Results Perfusion block did not damage healthy lungs. In conditioned lungs, the left perfusion block caused more edema in the contralateral lung (777 ± 62 g right lung vs 484 ± 204 g left; p < 0.05) than the right perfusion block did (581 ± 103 g right lung vs 484 ± 204 g left; p n.s.). The gas/tissue ratio, however, was similar (0.5 ± 0.3 and 0.8 ± 0.5; p n.s.). The lobes with perfusion block were not affected (gas/tissue ratio right 1.6 ± 0.9; left 1.7 ± 0.5, respectively). Pulmonary artery pressure, PaO2/FiO2, dead space, and lung mechanics were more markedly affected in animals with left perfusion block, while the gas/tissue ratios were similar in the non-occluded lobes. Conclusions The right and left perfusion blocks caused the same “intensity” of edema in conditioned lungs. The total amount of edema in the two lungs differed because of differences in lung size. If capillary permeability is altered, increased blood flow may induce or increase edema."],["dc.identifier.doi","10.1186/s40635-017-0161-2"],["dc.identifier.eissn","2197-425X"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15183"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77572"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","Springer"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Effects of regional perfusion block in healthy and injured lungs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","284"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Laboratory Animals"],["dc.bibliographiccitation.lastpage","291"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Reupke, Verena"],["dc.contributor.author","Walliser, Karoline"],["dc.contributor.author","Perl, Thorsten"],["dc.contributor.author","Kimmina, Sarah"],["dc.contributor.author","Schraepler, Anke"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Kunze-Szikszay, Nils"],["dc.date.accessioned","2018-11-07T10:23:32Z"],["dc.date.available","2018-11-07T10:23:32Z"],["dc.date.issued","2017"],["dc.description.abstract","The aim of this study was to evaluate a total intravenous anaesthesia (TIVA) protocol using propofol and sufentanil without neuromuscular blocking agents (NBAs) for a non-recovery lung pathology study in rabbits including 10 h of pressure-controlled ventilation. TIVA was started with 20 mg/kg/h propofol and 0.5 mg/kg/h sufentanil. The depth of anaesthesia was assessed by reflex testing and monitoring of spontaneous movements or respiratory efforts. Vital parameters were monitored to assess the effects of the TIVA protocol. The infusion rates were increased whenever reflex testing indicated inadequate depth of anaesthesia, and were reduced when vital parameters indicated unnecessarily deep levels. Median infusion rates of 35 mg/kg/h propofol and 2.0 mg/kg/h sufentanil were needed to ensure an adequate depth of anaesthesia. This protocol suppressed spontaneous movements, breathing and palpebral reflexes, but was unable to suppress corneal and pedal withdrawal reflexes. Since significant drops in arterial blood pressure (ABP) were observed and the animals were not exposed to painful procedures, positive corneal and pedal withdrawal reflexes were tolerated. In conclusion, propofol and sufentanil is a suitable combination for long-term anaesthesia in non-recovery lung pathology models in rabbits without painful procedures. ABP must be monitored carefully because of the circulatory side-effects, but it is an inappropriate surrogate marker for depth of anaesthesia. Due to the lack of neuromuscular blockade this TIVA protocol allows the adjustment of infusion rates based on reflex testing. The resulting decreased risk of unnoticed awareness is a decisive refinement in anaesthesia for similar studies including long-term mechanical ventilation in rabbits."],["dc.description.sponsorship","Faculty of Medicine of the University of Gottingen"],["dc.identifier.doi","10.1177/0023677216660337"],["dc.identifier.isi","000401251400005"],["dc.identifier.pmid","27413175"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42476"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Sage Publications Inc"],["dc.relation.issn","1758-1117"],["dc.relation.issn","0023-6772"],["dc.title","Total intravenous anaesthesia using propofol and sufentanil allows controlled long-term ventilation in rabbits without neuromuscular blocking agents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","163"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Anesthesiology"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Perl, Thorsten"],["dc.contributor.author","Kunze-Szikszay, N."],["dc.contributor.author","Bräuer, A."],["dc.contributor.author","Quintel, M."],["dc.contributor.author","Roy, T."],["dc.contributor.author","Kerpen, K."],["dc.contributor.author","Telgheder, U."],["dc.date.accessioned","2021-06-01T10:48:02Z"],["dc.date.accessioned","2022-08-16T12:37:25Z"],["dc.date.available","2021-06-01T10:48:02Z"],["dc.date.available","2022-08-16T12:37:25Z"],["dc.date.issued","2021-05-27"],["dc.date.updated","2022-07-29T12:00:16Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n Fluid warming, recommended for fluid rates of > 500 ml h-1, is an integral part of patient temperature management strategies. Fluid warming devices using an uncoated aluminium containing heating element have been reported to liberate aluminium resulting in critical aluminium concentrations in heated fluids. We investigated saline solution (0.9%), artificially spiked with organic acids to determine the influence of fluid composition on aluminium release using the uncoated enFlow® device. Additionally, the Level1® as a high volume fluid warming device and the ThermoSens® device were investigated with artificial spiked fluid at high risk for aluminum release and a clinically used crystalloid solution.\r\n \r\n \r\n Results\r\n Saline solution spiked with lactate more than acetate, especially at a non neutral pH, led to high aluminium release. Next to the enFlow® device, aluminium release was observed for the Level1® device, but not for the coated ThermoSens®-device.\r\n \r\n \r\n Conclusion\r\n Uncoated aluminium containing fluid warming devices lead to potentially toxic levels of aluminium in heated fluids, especially in fluids with non-neutral pH containing organic acids and their salts like balanced electrolyte solutions."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.citation","BMC Anesthesiology. 2021 May 27;21(1):163"],["dc.identifier.doi","10.1186/s12871-021-01378-7"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85808"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112736"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1471-2253"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.subject","Hypothermia"],["dc.subject","Prevention"],["dc.subject","Warming techniques"],["dc.subject","Fluid warming"],["dc.title","Aluminium release and fluid warming: provocational setting and devices at risk"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e234"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Critical Care Medicine"],["dc.bibliographiccitation.lastpage","e240"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Kunze-Szikszay, Nils"],["dc.contributor.author","Walliser, Karoline"],["dc.contributor.author","Luther, Jakob"],["dc.contributor.author","Cambiaghi, Barbara"],["dc.contributor.author","Reupke, Verena"],["dc.contributor.author","Dullin, Christian"],["dc.contributor.author","Vautz, Wolfgang"],["dc.contributor.author","Bremmer, Felix"],["dc.contributor.author","Telgheder, Ursula"],["dc.contributor.author","Zscheppank, Cornelia"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Perl, Thorsten"],["dc.date.accessioned","2020-12-10T18:19:50Z"],["dc.date.available","2020-12-10T18:19:50Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1097/CCM.0000000000003573"],["dc.identifier.issn","0090-3493"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75397"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Detecting Early Markers of Ventilator-Associated Pneumonia by Analysis of Exhaled Gas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]