Riemensperger, Thomas Dieter

[["dc.bibliographiccitation.journal","eLife"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Lavista-Llanos, Sofía"],["dc.contributor.author","Svatoš, Aleš"],["dc.contributor.author","Kai, Marco"],["dc.contributor.author","Riemensperger, Thomas"],["dc.contributor.author","Birman, Serge"],["dc.contributor.author","Stensmyr, Marcus C"],["dc.contributor.author","Hansson, Bill S"],["dc.date.accessioned","2017-05-05T06:44:08Z"],["dc.date.accessioned","2021-10-27T13:11:24Z"],["dc.date.available","2017-05-05T06:44:08Z"],["dc.date.available","2021-10-27T13:11:24Z"],["dc.date.issued","2014"],["dc.description.abstract","Many insect species are host-obligate specialists. The evolutionary mechanism driving the adaptation of a species to a toxic host is, however, intriguing. We analyzed the tight association of Drosophila sechellia to its sole host, the fruit of Morinda citrifolia, which is toxic to other members of the melanogaster species group. Molecular polymorphisms in the dopamine regulatory protein Catsup cause infertility in D. sechellia due to maternal arrest of oogenesis. In its natural host, the fruit compensates for the impaired maternal dopamine metabolism with the precursor l-DOPA, resuming oogenesis and stimulating egg production. l-DOPA present in morinda additionally increases the size of D. sechellia eggs, what in turn enhances early fitness. We argue that the need of l-DOPA for successful reproduction has driven D. sechellia to become an M. citrifolia obligate specialist. This study illustrates how an insect's dopaminergic system can sustain ecological adaptations by modulating ontogenesis and development."],["dc.identifier.doi","10.7554/eLife.03785"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14444"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91593"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","2050-084X"],["dc.relation.orgunit","Fakultät für Biologie und Psychologie"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","570"],["dc.title","Dopamine drives Drosophila sechellia adaptation to its toxic host"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e47518"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Huser, Annina"],["dc.contributor.author","Rohwedder, Astrid"],["dc.contributor.author","Apostolopoulou, Anthi A."],["dc.contributor.author","Widmann, Annekathrin"],["dc.contributor.author","Pfitzenmaier, Johanna E."],["dc.contributor.author","Maiolo, Elena M."],["dc.contributor.author","Selcho, Mareike"],["dc.contributor.author","Pauls, Dennis"],["dc.contributor.author","von Essen, Alina"],["dc.contributor.author","Gupta, Tripti"],["dc.contributor.author","Sprecher, Simon G."],["dc.contributor.author","Birman, Serge"],["dc.contributor.author","Riemensperger, Thomas"],["dc.contributor.author","Stocker, Reinhard F."],["dc.contributor.author","Thum, Andreas S."],["dc.date.accessioned","2018-11-07T09:04:33Z"],["dc.date.available","2018-11-07T09:04:33Z"],["dc.date.issued","2012"],["dc.description.abstract","The Drosophila larva has turned into a particularly simple model system for studying the neuronal basis of innate behaviors and higher brain functions. Neuronal networks involved in olfaction, gustation, vision and learning and memory have been described during the last decade, often up to the single-cell level. Thus, most of these sensory networks are substantially defined, from the sensory level up to third-order neurons. This is especially true for the olfactory system of the larva. Given the wealth of genetic tools in Drosophila it is now possible to address the question how modulatory systems interfere with sensory systems and affect learning and memory. Here we focus on the serotonergic system that was shown to be involved in mammalian and insect sensory perception as well as learning and memory. Larval studies suggested that the serotonergic system is involved in the modulation of olfaction, feeding, vision and heart rate regulation. In a dual anatomical and behavioral approach we describe the basic anatomy of the larval serotonergic system, down to the single-cell level. In parallel, by expressing apoptosis-inducing genes during embryonic and larval development, we ablate most of the serotonergic neurons within the larval central nervous system. When testing these animals for naive odor, sugar, salt and light perception, no profound phenotype was detectable; even appetitive and aversive learning was normal. Our results provide the first comprehensive description of the neuronal network of the larval serotonergic system. Moreover, they suggest that serotonin per se is not necessary for any of the behaviors tested. However, our data do not exclude that this system may modulate or fine-tune a wide set of behaviors, similar to its reported function in other insect species or in mammals. Based on our observations and the availability of a wide variety of genetic tools, this issue can now be addressed."],["dc.identifier.doi","10.1371/journal.pone.0047518"],["dc.identifier.isi","000311146900071"],["dc.identifier.pmid","23082175"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8324"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25130"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","The Serotonergic Central Nervous System of the Drosophila Larva: Anatomy and Behavioral Function"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Neurogenetics"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Gaffuri, A. L."],["dc.contributor.author","Riemensperger, Thomas"],["dc.contributor.author","Roland, A."],["dc.contributor.author","Gervasi, N."],["dc.contributor.author","Li, L."],["dc.contributor.author","Ladarre, D."],["dc.contributor.author","Placais, P. Y."],["dc.contributor.author","Willaime, H."],["dc.contributor.author","Tabeling, P."],["dc.contributor.author","Tchenio, P."],["dc.contributor.author","Birman, Serge"],["dc.contributor.author","Preat, T."],["dc.contributor.author","Lenkei, Z."],["dc.date.accessioned","2018-11-07T09:02:26Z"],["dc.date.available","2018-11-07T09:02:26Z"],["dc.date.issued","2012"],["dc.format.extent","7"],["dc.identifier.isi","000314975100015"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24682"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Informa Healthcare"],["dc.publisher.place","London"],["dc.relation.issn","0167-7063"],["dc.title","Subcellular dynamics of CAMP/PKA signaling in single Drosophila mushroom body neurons matured in low-density cultures"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","952"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Cell Reports"],["dc.bibliographiccitation.lastpage","960"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Riemensperger, Thomas"],["dc.contributor.author","Issa, Abdul-Raouf"],["dc.contributor.author","Pech, Ulrike"],["dc.contributor.author","Coulom, Helene"],["dc.contributor.author","My-Van Nguyen, My-Van Nguyen"],["dc.contributor.author","Cassar, Marlene"],["dc.contributor.author","Jacquet, Melanie"],["dc.contributor.author","Fiala, Andre"],["dc.contributor.author","Birman, Serge"],["dc.date.accessioned","2018-11-07T09:17:49Z"],["dc.date.available","2018-11-07T09:17:49Z"],["dc.date.issued","2013"],["dc.description.abstract","Expression of the human Parkinson-disease-associated protein alpha-synuclein in all Drosophila neurons induces progressive locomotor deficits. Here, we identify a group of 15 dopaminergic neurons per hemisphere in the anterior medial region of the brain whose disruption correlates with climbing impairments in this model. These neurons selectively innervate the horizontal beta and beta' lobes of the mushroom bodies, and their connections to the Kenyon cells are markedly reduced when they express alpha-synuclein. Using selective mushroom body drivers, we show that blocking or overstimulating neuronal activity in the beta' lobe, but not the beta or gamma lobes, significantly inhibits negative geotaxis behavior. This suggests that modulation of the mushroom body beta' lobes by this dopaminergic pathway is specifically required for an efficient control of startle-induced locomotion in flies."],["dc.identifier.doi","10.1016/j.celrep.2013.10.032"],["dc.identifier.isi","000328266000011"],["dc.identifier.pmid","24239353"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10671"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28258"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.relation.issn","2211-1247"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","A Single Dopamine Pathway Underlies Progressive Locomotor Deficits in a Drosophila Model of Parkinson Disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Systems Neuroscience"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Sun, Jun"],["dc.contributor.author","Xu, An Qi"],["dc.contributor.author","Giraud, Julia"],["dc.contributor.author","Poppinga, Haiko"],["dc.contributor.author","Riemensperger, Thomas"],["dc.contributor.author","Fiala, André"],["dc.contributor.author","Birman, Serge"],["dc.date.accessioned","2020-12-10T18:44:35Z"],["dc.date.available","2020-12-10T18:44:35Z"],["dc.date.issued","2018"],["dc.description.abstract","Startle-induced locomotion is commonly used in Drosophila research to monitor locomotor reactivity and its progressive decline with age or under various neuropathological conditions. A widely used paradigm is startle-induced negative geotaxis (SING), in which flies entrapped in a narrow column react to a gentle mechanical shock by climbing rapidly upwards. Here we combined in vivo manipulation of neuronal activity and splitGFP reconstitution across cells to search for brain neurons and putative circuits that regulate this behavior. We show that the activity of specific clusters of dopaminergic neurons (DANs) afferent to the mushroom bodies (MBs) modulates SING, and that DAN-mediated SING regulation requires expression of the DA receptor Dop1R1/Dumb, but not Dop1R2/Damb, in intrinsic MB Kenyon cells (KCs). We confirmed our previous observation that activating the MB α'β', but not αβ, KCs decreased the SING response, and we identified further MB neurons implicated in SING control, including KCs of the γ lobe and two subtypes of MB output neurons (MBONs). We also observed that co-activating the αβ KCs antagonizes α'β' and γ KC-mediated SING modulation, suggesting the existence of subtle regulation mechanisms between the different MB lobes in locomotion control. Overall, this study contributes to an emerging picture of the brain circuits modulating locomotor reactivity in Drosophila that appear both to overlap and differ from those underlying associative learning and memory, sleep/wake state and stress-induced hyperactivity."],["dc.identifier.doi","10.3389/fnsys.2018.00006"],["dc.identifier.eissn","1662-5137"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78518"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1662-5137"],["dc.rights","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Neural Control of Startle-Induced Locomotion by the Mushroom Bodies and Associated Neurons in Drosophila"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]