Riemensperger, Thomas Dieter

[["dc.bibliographiccitation.journal","eLife"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Lavista-Llanos, Sofía"],["dc.contributor.author","Svatoš, Aleš"],["dc.contributor.author","Kai, Marco"],["dc.contributor.author","Riemensperger, Thomas"],["dc.contributor.author","Birman, Serge"],["dc.contributor.author","Stensmyr, Marcus C"],["dc.contributor.author","Hansson, Bill S"],["dc.date.accessioned","2017-05-05T06:44:08Z"],["dc.date.accessioned","2021-10-27T13:11:24Z"],["dc.date.available","2017-05-05T06:44:08Z"],["dc.date.available","2021-10-27T13:11:24Z"],["dc.date.issued","2014"],["dc.description.abstract","Many insect species are host-obligate specialists. The evolutionary mechanism driving the adaptation of a species to a toxic host is, however, intriguing. We analyzed the tight association of Drosophila sechellia to its sole host, the fruit of Morinda citrifolia, which is toxic to other members of the melanogaster species group. Molecular polymorphisms in the dopamine regulatory protein Catsup cause infertility in D. sechellia due to maternal arrest of oogenesis. In its natural host, the fruit compensates for the impaired maternal dopamine metabolism with the precursor l-DOPA, resuming oogenesis and stimulating egg production. l-DOPA present in morinda additionally increases the size of D. sechellia eggs, what in turn enhances early fitness. We argue that the need of l-DOPA for successful reproduction has driven D. sechellia to become an M. citrifolia obligate specialist. This study illustrates how an insect's dopaminergic system can sustain ecological adaptations by modulating ontogenesis and development."],["dc.identifier.doi","10.7554/eLife.03785"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14444"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91593"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","2050-084X"],["dc.relation.orgunit","Fakultät für Biologie und Psychologie"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","570"],["dc.title","Dopamine drives Drosophila sechellia adaptation to its toxic host"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","76"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Frontiers in Systems Neuroscience"],["dc.bibliographiccitation.lastpage","13"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Niens, Janna"],["dc.contributor.author","Reh, Fabienne"],["dc.contributor.author","Çoban, Büşra"],["dc.contributor.author","Cichewicz, Karol"],["dc.contributor.author","Eckardt, Julia"],["dc.contributor.author","Liu, Yi-Ting"],["dc.contributor.author","Hirsh, Jay"],["dc.contributor.author","Riemensperger, Thomas D."],["dc.date.accessioned","2019-07-09T11:44:30Z"],["dc.date.available","2019-07-09T11:44:30Z"],["dc.date.issued","2017"],["dc.description.abstract","Parkinson’s disease (PD) results from a progressive degeneration of the dopaminergic nigrostriatal system leading to a decline in movement control, with resting tremor, rigidity and postural instability. Several aspects of PD can be modeled in the fruit fly, Drosophila melanogaster, including a-synuclein-induced degeneration of dopaminergic neurons, or dopamine (DA) loss by genetic elimination of neural DA synthesis. Defective behaviors in this latter model can be ameliorated by feeding the DA precursor L-DOPA, analogous to the treatment paradigm for PD. Secondary complication from L-DOPA treatment in PD patients are associated with ectopic synthesis of DA in serotonin (5-HT)-releasing neurons, leading to DA/5-HT imbalance. Here we examined the neuroanatomical adaptations resulting from imbalanced DA/5-HT signaling in Drosophila mutants lacking neural DA. We find that, similar to rodent models of PD, lack of DA leads to increased 5-HT levels and arborizations in specific brain regions. Conversely, increased DA levels by L-DOPA feeding leads to reduced connectivity of 5-HT neurons to their target neurons in the mushroom body (MB). The observed alterations of 5-HT neuron plasticity indicate that loss of DA signaling is not solely responsible for the behavioral disorders observed in Drosophila models of PD, but rather a combination of the latter with alterations of 5-HT circuitry."],["dc.identifier.doi","10.3389/fnsys.2017.00076"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14799"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59024"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1662-5137"],["dc.relation.issn","1663-4365"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","570"],["dc.title","Dopamine Modulates Serotonin Innervation in the Drosophila Brain"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]