Kästner, Anne

[["dc.bibliographiccitation.firstpage","41"],["dc.bibliographiccitation.journal","Behavioural Brain Research"],["dc.bibliographiccitation.lastpage","49"],["dc.bibliographiccitation.volume","251"],["dc.contributor.author","El-Kordi, Ahmed"],["dc.contributor.author","Winkler, Daniela"],["dc.contributor.author","Hammerschmidt, Kurt"],["dc.contributor.author","Kästner, Anne"],["dc.contributor.author","Krueger, Dilja"],["dc.contributor.author","Ronnenberg, Anja"],["dc.contributor.author","Ritter, Caroline"],["dc.contributor.author","Jatho, Jasmin"],["dc.contributor.author","Radyushkin, Konstantin"],["dc.contributor.author","Bourgeron, Thomas"],["dc.contributor.author","Fischer, Julia"],["dc.contributor.author","Brose, Nils"],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.date.accessioned","2017-09-07T11:47:38Z"],["dc.date.available","2017-09-07T11:47:38Z"],["dc.date.issued","2013"],["dc.description.abstract","Autism is the short name of a complex and heterogeneous group of disorders (autism spectrum disorders, ASD) with several lead symptoms required for classification, including compromised social interaction, reduced verbal communication and stereotyped repetitive behaviors/restricted interests. The etiology of ASD is still unknown in most cases but monogenic heritable forms exist that have provided insights into ASD pathogenesis and have led to the notion of autism as a 'synapse disorder'. Among the most frequent monogenic causes of autism are loss-of-function mutations of the NLGN4X gene which encodes the synaptic cell adhesion protein neuroligin-4X (NLGN4X). We previously described autism-like behaviors in male Nlgn4 null mutant mice, including reduced social interaction and ultrasonic communication. Here, we extend the phenotypical characterization of Nlgn4 null mutant mice to both genders and add a series of additional autism-relevant behavioral readouts. We now report similar social interaction and ultrasonic communication deficits in females as in males. Furthermore, aggression, nest-building parameters, as well as self-grooming and circling as indicators of repetitive behaviors/stereotypies were explored in both genders. The construction of a gender-specific autism severity composite score for Nlgn4 mutant mice markedly diminishes population/sample heterogeneity typically obtained for single tests, resulting in p values of <0.00001 and a genotype predictability of 100% for male and of >83% for female mice. Taken together, these data underscore the similarity of phenotypical consequences of Nlgn4/NLGN4X loss-of-function in mouse and man, and emphasize the high relevance of Nlgn4 null mutant mice as an ASD model with both construct and face validity."],["dc.identifier.doi","10.1016/j.bbr.2012.11.016"],["dc.identifier.gro","3142307"],["dc.identifier.isi","000322927700006"],["dc.identifier.pmid","23183221"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/6831"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0166-4328"],["dc.subject","Social interaction; Nest building; Grooming; Repetitive behaviors; Stereotypies; Ultra-sound vocalization; Gender differences; ASD"],["dc.title","Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","95"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Der Anaesthesist"],["dc.bibliographiccitation.lastpage","107"],["dc.bibliographiccitation.volume","69"],["dc.contributor.author","Erlenwein, J."],["dc.contributor.author","Pfingsten, M."],["dc.contributor.author","Hüppe, M."],["dc.contributor.author","Seeger, D."],["dc.contributor.author","Kästner, A."],["dc.contributor.author","Graner, R."],["dc.contributor.author","Petzke, F."],["dc.date.accessioned","2020-12-10T14:08:07Z"],["dc.date.available","2020-12-10T14:08:07Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00101-019-00708-2"],["dc.identifier.eissn","1432-055X"],["dc.identifier.issn","0003-2417"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70378"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.haserratum","/handle/2/70384"],["dc.title","Management von Patienten mit chronischen Schmerzen in der Akut- und perioperativen Medizin"],["dc.title.alternative","Management of patients with chronic pain in acute and perioperative medicine. An interdisciplinary challenge"],["dc.title.subtitle","Eine interdisziplinäre Herausforderung"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","144"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Annals of Neurology"],["dc.bibliographiccitation.lastpage","151"],["dc.bibliographiccitation.volume","79"],["dc.contributor.author","Castillo-Gomez, Esther"],["dc.contributor.author","Kästner, Anne"],["dc.contributor.author","Steiner, Johann"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Hettling, Bilke"],["dc.contributor.author","Poggi, Giulia"],["dc.contributor.author","Ostehr, Kristin"],["dc.contributor.author","Uhr, Manfred"],["dc.contributor.author","Asif, Abdul R."],["dc.contributor.author","Matzke, Mike"],["dc.contributor.author","Schmidt, Ulrike"],["dc.contributor.author","Pfander, Viktoria"],["dc.contributor.author","Hammer, Christian"],["dc.contributor.author","Schulz, Thomas F."],["dc.contributor.author","Binder, Lutz"],["dc.contributor.author","Stöcker, Winfried"],["dc.contributor.author","Weber, Frank"],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.date.accessioned","2017-09-07T11:46:35Z"],["dc.date.available","2017-09-07T11:46:35Z"],["dc.date.issued","2016"],["dc.description.abstract","Autoantibodies (AB) against N-methyl-D-aspartate receptor subunit NR1 (NMDAR1) are highly seroprevalent in health and disease. Symptomatic relevance may arise upon compromised blood–brain barrier (BBB). However, it remained unknown whether circulating NMDAR1 AB appear in the cerebrospinal fluid (CSF). Of n = 271 subjects with CSF–serum pairs, 26 were NMDAR1 AB seropositive, but only 1 was CSF positive. Contrariwise, tetanus AB (non–brain-binding) were present in serum and CSF of all subjects, with CSF levels higher upon BBB dysfunction. Translational mouse experiments proved the hypothesis that the brain acts as an ‘immunoprecipitator’; simultaneous injection of NMDAR1 AB and the non–brain-binding green fluorescent protein AB resulted in high detectability of the former in brain and the latter in CSF."],["dc.identifier.doi","10.1002/ana.24545"],["dc.identifier.gro","3150536"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7309"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","chake"],["dc.relation.issn","0364-5134"],["dc.title","The brain as immunoprecipitator of serum autoantibodies against N-Methyl-D-aspartate receptor subunit NR1"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","330"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Der Anaesthesist"],["dc.bibliographiccitation.lastpage","330"],["dc.bibliographiccitation.volume","69"],["dc.contributor.author","Erlenwein, J."],["dc.contributor.author","Pfingsten, M."],["dc.contributor.author","Hüppe, M."],["dc.contributor.author","Seeger, D."],["dc.contributor.author","Kästner, A."],["dc.contributor.author","Graner, R."],["dc.contributor.author","Petzke, F."],["dc.date.accessioned","2020-12-10T14:08:08Z"],["dc.date.available","2020-12-10T14:08:08Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00101-020-00759-w"],["dc.identifier.eissn","1432-055X"],["dc.identifier.issn","0003-2417"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70384"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.iserratumof","/handle/2/70378"],["dc.title","Erratum zu: Management von Patienten mit chronischen Schmerzen in der Akut- und perioperativen Medizin"],["dc.title.alternative","Erratum to: Management of patients with chronic pain in acute and perioperativemedicine. An interdisciplinary challenge"],["dc.title.subtitle","Eine interdisziplinäre Herausforderung"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","erratum_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Minerva Anestesiologica"],["dc.bibliographiccitation.volume","86"],["dc.contributor.author","Ng Kuet Leong, Virginie S."],["dc.contributor.author","Kästner, Anne"],["dc.contributor.author","Petzke, Frank"],["dc.contributor.author","Przemeck, Michael"],["dc.contributor.author","Erlenwein, Joachim"],["dc.date.accessioned","2021-04-14T08:32:41Z"],["dc.date.available","2021-04-14T08:32:41Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.23736/S0375-9393.20.14084-7"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83983"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1827-1596"],["dc.relation.issn","0375-9393"],["dc.title","The influence of pain expectation on pain experience after orthopedic surgery: an observational cohort study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1306"],["dc.bibliographiccitation.issue","11-12"],["dc.bibliographiccitation.journal","Molecular Medicine"],["dc.bibliographiccitation.lastpage","1310"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.contributor.author","Kästner, Anne"],["dc.contributor.author","Weißenborn, Karin"],["dc.contributor.author","Streeter, Jackson"],["dc.contributor.author","Sperling, Swetlana"],["dc.contributor.author","Wang, Kevin K."],["dc.contributor.author","Worthmann, Hans"],["dc.contributor.author","Hayes, Ronald L."],["dc.contributor.author","Ahsen, Nico von"],["dc.contributor.author","Kastrup, Andreas"],["dc.contributor.author","Jeromin, Andreas"],["dc.contributor.author","Herrmann, Manfred"],["dc.date.accessioned","2017-09-07T11:46:19Z"],["dc.date.available","2017-09-07T11:46:19Z"],["dc.date.issued","2011"],["dc.description.abstract","The German Multicenter EPO Stroke Trial, which investigated safety and efficacy of erythropoietin (EPO) treatment in ischemic stroke, was formally declared a negative study. Exploratory subgroup analysis, however, revealed that patients not receiving thrombolysis most likely benefited from EPO during clinical recovery, a result demonstrated in the findings of the Göttingen EPO Stroke Study. The present work investigated whether the positive signal on clinical outcome in this patient subgroup was mirrored by respective poststroke biomarker profiles. All patients of the German Multicenter EPO Stroke Trial nonqualifying for thrombolysis were included if they (a) were treated per protocol and (b) had at least two of the five follow-up blood samples for circulating damage markers drawn (n = 163). The glial markers S100B and glial fibrillary acid protein (GFAP) and the neuronal marker ubiquitin C-terminal hydrolase (UCH-L1) were measured by enzyme-linked immunosorbent assay in serum on d 1, 2, 3, 4 and 7 poststroke. All biomarkers increased poststroke. Overall, EPO-treated patients had significantly lower concentrations (area under the curve) over 7 d of observation, as reflected by the composite score of all three markers (Cronbach α = 0.811) and by UCH-L1. S100B and GFAP showed a similar tendency. To conclude, serum biomarker profiles, as an outcome measure of brain damage, corroborate an advantageous effect of EPO in ischemic stroke. In particular, reduction in the neuronal damage marker UCH-L1 may reflect neuroprotection by EPO."],["dc.identifier.doi","10.2119/molmed.2011.00259"],["dc.identifier.gro","3150486"],["dc.identifier.pmid","21912808"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7256"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.title","Circulating damage marker profiles support a neuroprotective effect of erythropoietin in ischemic stroke patients"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1029"],["dc.bibliographiccitation.journal","Molecular Medicine"],["dc.bibliographiccitation.lastpage","1040"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Kästner, Anne"],["dc.contributor.author","Grube, Sabrina"],["dc.contributor.author","El-Kordi, Ahmed"],["dc.contributor.author","Stepniak, Beata"],["dc.contributor.author","Friedrichs, Heidi"],["dc.contributor.author","Sargin, Derya"],["dc.contributor.author","Schwitulla, Judith"],["dc.contributor.author","Begemann, Martin"],["dc.contributor.author","Giegling, Ina"],["dc.contributor.author","Miskowiak, Kamilla W."],["dc.contributor.author","Sperling, Swetlana"],["dc.contributor.author","Hannke, Kathrin"],["dc.contributor.author","Ramin, Anna"],["dc.contributor.author","Heinrich, Ralf"],["dc.contributor.author","Gefeller, Olaf"],["dc.contributor.author","Nave, Klaus-Armin"],["dc.contributor.author","Rujescu, Dan"],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.date.accessioned","2017-09-07T11:46:36Z"],["dc.date.available","2017-09-07T11:46:36Z"],["dc.date.issued","2012"],["dc.description.abstract","Erythropoietin (EPO) improves cognitive performance in clinical studies and rodent experiments. We hypothesized that an intrinsicrole of EPO for cognition exists, with particular relevance in situations of cognitive decline, which is reflected by associations ofEPO and EPO receptor (EPOR) genotypes with cognitive functions. To prove this hypothesis, schizophrenic patients (N > 1000) weregenotyped for 5′ upstream–located gene variants, EPO SNP rs1617640 (T/G) and EPOR STR(GA)n. Associations of these variants wereobtained for cognitive processing speed, fine motor skills and short-term memory readouts, with one particular combination ofgenotypes superior to all others (p < 0.0001). In an independent healthy control sample (N > 800), these associations were confirmed.A matching preclinical study with mice demonstrated cognitive processing speed and memory enhanced upon transgenicexpression of constitutively active EPOR in pyramidal neurons of cortex and hippocampus. We thus predicted that thehuman genotypes associated with better cognition would reflect gain-of-function effects. Indeed, reporter gene assays and quantitativetranscriptional analysis of peripheral blood mononuclear cells showed genotype-dependent EPO/EPOR expression differences.Together, these findings reveal a role of endogenous EPO/EPOR for cognition, at least in schizophrenic patients."],["dc.identifier.doi","10.2119/molmed.2012.00190"],["dc.identifier.gro","3150561"],["dc.identifier.pmid","22669473"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7335"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.title","Common variants of the genes encoding erythropoietin and its receptor modulate cognitive performance in schizophrenia"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","265"],["dc.bibliographiccitation.issue","S3"],["dc.bibliographiccitation.journal","Der Anaesthesist"],["dc.bibliographiccitation.lastpage","268"],["dc.bibliographiccitation.volume","68"],["dc.contributor.author","Erlenwein, J."],["dc.contributor.author","Kästner, A."],["dc.contributor.author","Petzke, F."],["dc.date.accessioned","2020-12-10T14:08:07Z"],["dc.date.available","2020-12-10T14:08:07Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00101-019-00681-w"],["dc.identifier.eissn","1432-055X"],["dc.identifier.issn","0003-2417"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70377"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","53/w zur elektiven Spondylodese bei chronischem Rückenschmerz"],["dc.title.alternative","53-years-old female for elective spondylodesis for chronic back pain. Preparation for the medical specialist examination: part 40"],["dc.title.subtitle","Vorbereitung auf die Facharztprüfung: Fall 40"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","450"],["dc.bibliographiccitation.journal","Behavioural Brain Research"],["dc.bibliographiccitation.lastpage","457"],["dc.bibliographiccitation.volume","252"],["dc.contributor.author","Hahn, Nina"],["dc.contributor.author","Geurten, Bart"],["dc.contributor.author","Gurvich, Artem"],["dc.contributor.author","Piepenbrock, David"],["dc.contributor.author","Kästner, Anne"],["dc.contributor.author","Zanini, Damiano"],["dc.contributor.author","Xing, Guanglin"],["dc.contributor.author","Xie, Wei"],["dc.contributor.author","Göpfert, Martin C."],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.contributor.author","Heinrich, Ralf"],["dc.date.accessioned","2017-09-07T11:46:23Z"],["dc.date.available","2017-09-07T11:46:23Z"],["dc.date.issued","2013"],["dc.description.abstract","Autism spectrum disorders (ASDs) are characterized by deficits in social interactions, language development and repetitive behaviours. Multiple genes involved in the formation, specification and maintenance of synapses have been identified as risk factors for ASDs development. Among these are the neuroligin genes which code for postsynaptic cell adhesion molecules that induce the formation of presynapses, promote their maturation and modulate synaptic functions in both vertebrates and invertebrates. Neuroligin-deficient mice display abnormal social and vocal behaviours that resemble ASDs symptoms.Here we show for the fly Drosophila melanogaster that deletion of the dnl2 gene, coding for one of four Neuroligin isoforms, impairs social interactions, alters acoustic communication signals, and affects the transition between different behaviours. dnl2-Deficient flies maintain larger distances to conspecifics and males perform less female-directed courtship and male-directed aggressive behaviours while the patterns of these behaviours and general locomotor activity were not different from wild type controls. Since tests for olfactory, visual and auditory perception revealed no sensory impairments of dnl2-deficient mutants, reduced social interactions seem to result from altered excitability in central nervous neuropils that initiate social behaviours. Our results demonstrate that Neuroligins are phylogenetically conserved not only regarding their structure and direct function at the synapse but also concerning a shared implication in the regulation of social behaviours that dates back to common ancestors of humans and flies. In addition to previously described mouse models, Drosophila can thus be used to study the contribution of Neuroligins to synaptic function, social interactions and their implication in ASDs."],["dc.identifier.doi","10.1016/j.bbr.2013.06.020"],["dc.identifier.gro","3150491"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7261"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","chake"],["dc.subject","Drosophila melanogaster; Neuroligin; Social behaviour; Acoustic communication; Behavioural transition; Autism"],["dc.title","Monogenic heritable autism gene neuroligin impacts Drosophila social behaviour"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]