Now showing 1 - 9 of 9
  • 2014Journal Article
    [["dc.bibliographiccitation.firstpage","493"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Der Schmerz"],["dc.bibliographiccitation.lastpage","503"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Erlenwein, Joachim"],["dc.contributor.author","Emons, Miriam I."],["dc.contributor.author","Hecke, A."],["dc.contributor.author","Nestler, N."],["dc.contributor.author","Przemeck, Michael"],["dc.contributor.author","Bauer, M."],["dc.contributor.author","Meissner, W."],["dc.contributor.author","Petzke, Frank"],["dc.date.accessioned","2018-11-07T09:34:49Z"],["dc.date.available","2018-11-07T09:34:49Z"],["dc.date.issued","2014"],["dc.description.abstract","The aim of this study was to analyze the degree of organization of different standard protocols for acute pain management, as well as the derivation and definition of typical but structurally different models. A total of 85 hospitals provided their written standardized protocols for analysis. Protocols for defined target processes from 76 hospitals and another protocol used by more than one hospital were included into the analysis. The suggested courses of action were theoretically simulated to identify and characterize process types in a multistage evaluation process. The analysis included 148 standards. Four differentiated process types were defined (\"standardized order\", \"analgesic ladder\", \"algorithm\", \"therapy path\"), each with an increasing level of organization. These four types had the following distribution: 27 % (n = 40) \"standardized order\", 47 % (n = 70) \"analgesic ladder\", 22 % (n = 33) \"algorithm\", 4 % (n = 5) \"therapy path\". Models with a higher degree of organization included more control elements, such as action and intervention triggers or safety and supervisory elements, and were also associated with a formally better access to medication. For models with a lower degree of organization, immediate courses of action were more dependent on individual decisions. Although not quantifiable, this was particularly evident when simulating downstream courses of action. Interfaces between areas of hospital activity and a cross-departmental-boundary validity were only considered in a fraction of the protocols. Concepts from clinics with a certificate in (acute) pain management were more strongly process-oriented. For children, there were proportionately more simple concepts with a lower degree of organization and less controlling elements. This is the first analysis of a large sample of standardized protocols for acute pain management focusing on the degree of organization and the possible influence on courses of action. The analysis shows how different the structures and presumably the practical objectives of the various concepts are. The analyzed protocols with a lower degree of organization can manage only the assignment of a particular medication to the corresponding patient group, with a presumably high requirement for considerable implicit knowledge of the responsible employees. Accordingly, a requirement for such protocols should be that they not only describe the preferred standard therapy, but also define the interactions between the staff members involved. It remains questionable whether a protocol with a low level of organization and a comparably high requirement for implicit knowledge and individual action-also from nonmedical personnel-is able to ensure efficient pain therapy, particularly in view changing staff and dynamic responses to changing pain situations."],["dc.identifier.doi","10.1007/s00482-014-1479-2"],["dc.identifier.isi","000342428400005"],["dc.identifier.pmid","25179416"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32259"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-2129"],["dc.relation.issn","0932-433X"],["dc.title","Process control in acute pain management. An analysis of the degree of organization of applied standard protocols"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2020Journal Article
    [["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Minerva Anestesiologica"],["dc.bibliographiccitation.volume","86"],["dc.contributor.author","Ng Kuet Leong, Virginie S."],["dc.contributor.author","Kästner, Anne"],["dc.contributor.author","Petzke, Frank"],["dc.contributor.author","Przemeck, Michael"],["dc.contributor.author","Erlenwein, Joachim"],["dc.date.accessioned","2021-04-14T08:32:41Z"],["dc.date.available","2021-04-14T08:32:41Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.23736/S0375-9393.20.14084-7"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83983"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1827-1596"],["dc.relation.issn","0375-9393"],["dc.title","The influence of pain expectation on pain experience after orthopedic surgery: an observational cohort study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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  • 2017Journal Article
    [["dc.bibliographiccitation.firstpage","587"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Pain Practice"],["dc.bibliographiccitation.lastpage","596"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Olesen, Anne E."],["dc.contributor.author","Nielsen, Lecia M."],["dc.contributor.author","Feddersen, Søren"],["dc.contributor.author","Erlenwein, Joachim"],["dc.contributor.author","Petzke, Frank"],["dc.contributor.author","Przemeck, Michael"],["dc.contributor.author","Christrup, Lona L."],["dc.contributor.author","Drewes, Asbjørn M."],["dc.date.accessioned","2020-12-10T18:36:21Z"],["dc.date.available","2020-12-10T18:36:21Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1111/papr.12648"],["dc.identifier.issn","1530-7085"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76598"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Association Between Genetic Polymorphisms and Pain Sensitivity in Patients with Hip Osteoarthritis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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  • 2017Journal Article
    [["dc.bibliographiccitation.firstpage","2183"],["dc.bibliographiccitation.journal","Journal of Pain Research"],["dc.bibliographiccitation.lastpage","2193"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Erlenwein, Joachim"],["dc.contributor.author","Müller, Martin"],["dc.contributor.author","Falla, Deborah"],["dc.contributor.author","Przemeck, Michael"],["dc.contributor.author","Pfingsten, Michael"],["dc.contributor.author","Budde, Stefan"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Petzke, Frank"],["dc.date.accessioned","2020-12-10T18:43:01Z"],["dc.date.available","2020-12-10T18:43:01Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.2147/JPR.S137892"],["dc.identifier.eissn","1178-7090"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14703"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78161"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-NC 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/3.0"],["dc.title","Clinical relevance of persistent postoperative pain after total hip replacement – a prospective observational cohort study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]
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  • 2017Journal Article
    [["dc.bibliographiccitation.artnumber","e0186400"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PloS one"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Gram, Mikkel"],["dc.contributor.author","Erlenwein, Joachim"],["dc.contributor.author","Petzke, Frank"],["dc.contributor.author","Falla, Deborah"],["dc.contributor.author","Przemeck, Michael"],["dc.contributor.author","Emons, Miriam I."],["dc.contributor.author","Reuster, Michael"],["dc.contributor.author","Olesen, Søren S."],["dc.contributor.author","Drewes, Asbjørn M."],["dc.date.accessioned","2019-07-09T11:44:41Z"],["dc.date.available","2019-07-09T11:44:41Z"],["dc.date.issued","2017"],["dc.description.abstract","BACKGROUND: Experimental models have been used extensively to evaluate pain using e.g., visual analogue scales or electroencephalography (EEG). Stimulation using tonic pain has been shown to better mimic the unpleasantness of chronic pain, but has mainly been evoked by non-clinical stimuli. This study aims to, evaluate the EEG during clinical pain in patients scheduled for total hip replacement with control and resting conditions. METHODS: The hip scheduled for replacement was moved by the examiner to evoke pain for 30 seconds while recording EEG. The control condition entailed movement of the opposite hip in a similar fashion and holding it for 30 seconds. In addition, EEG was recorded during the resting condition with open eyes. The relative spectral content was calculated from the EEG as well as functional connectivity using phase-lag index for frequency bands delta (1-4Hz), theta (4-8Hz), alpha (8-12Hz) and beta (12-32Hz). A mixed model was used for statistical comparison between the three recording conditions. RESULTS: Spectral content differed between conditions in all bands. Functional connectivity differed in delta and theta frequency bands. Post-hoc analysis revealed differences between the painful and control condition in delta, theta and beta for spectral content. Pain during the hip rotation was correlated to the theta (r = -0.24 P = 0.03) and beta (r = 0.25 P = 0.02) content in the EEG. CONCLUSION: EEG differences during hip movements in the affected and unaffected hip appeared in the spectral beta and theta content. This was correlated to the reported pain perceived, pointing towards pain specific brain activity related to clinical pain."],["dc.identifier.doi","10.1371/journal.pone.0186400"],["dc.identifier.pmid","29084278"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14866"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59066"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Cats"],["dc.subject.mesh","Cerebral Cortex"],["dc.subject.mesh","Electroencephalography"],["dc.subject.mesh","Female"],["dc.subject.mesh","Guinea Pigs"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Male"],["dc.subject.mesh","Osteoarthritis, Hip"],["dc.subject.mesh","Pain"],["dc.title","The cortical responses to evoked clinical pain in patients with hip osteoarthritis."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]
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  • 2017Journal Article
    [["dc.bibliographiccitation.firstpage","264"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Journal of Pain"],["dc.bibliographiccitation.lastpage","277"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Gram, Mikkel"],["dc.contributor.author","Erlenwein, Joachim"],["dc.contributor.author","Petzke, Frank"],["dc.contributor.author","Falla, Deborah"],["dc.contributor.author","Przemeck, Michael"],["dc.contributor.author","Emons, Miriam I."],["dc.contributor.author","Reuster, M."],["dc.contributor.author","Olesen, S. S."],["dc.contributor.author","Drewes, Asbjorn Mohr"],["dc.date.accessioned","2018-11-07T10:28:05Z"],["dc.date.available","2018-11-07T10:28:05Z"],["dc.date.issued","2017"],["dc.description.abstract","BackgroundOpioids are often used for pain treatment, but the response is often insufficient and dependent on e.g. the pain condition, genetic factors and drug class. Thus, there is an urgent need to identify biomarkers to enable selection of the appropriate drug for the individual patient, a concept known as personalized medicine. Quantitative sensory testing (QST) and clinical parameters can provide some guidance for response, but better and more objective biomarkers are urgently warranted. Electroencephalography (EEG) may be suitable since it assesses the central nervous system where opioids mediate their effects. MethodsClinical parameters, QST and EEG (during rest and tonic pain) was recorded from patients the day prior to total hip replacement surgery. Postoperative pain treatment was performed using oxycodone and piritramide as patient-controlled analgesia. Patients were stratified into responders and non-responders based on pain ratings 24h post-surgery. Parameters were analysed using conventional group-wise statistical methods. Furthermore, EEG was analysed by machine learning to predict individual response. ResultsEighty-one patients were included, of which 51 responded to postoperative opioid treatment (30 non-responders). Conventional statistics showed that more severe pre-existing chronic pain was prevalent among non-responders to opioid treatment (p=0.04). Preoperative EEG analysis was able to predict responders with an accuracy of 65% (p=0.009), but only during tonic pain. ConclusionsChronic pain grade before surgery is associated with the outcome of postoperative pain treatment. Furthermore, EEG shows potential as an objective biomarker and might be used to predict postoperative opioid analgesia. SignificanceThe current clinical study demonstrates the viability of EEG as a biomarker and with results consistent with previous experimental results. The combined method of machine learning and electroencephalography offers promising results for future developments of personalized pain treatment."],["dc.description.sponsorship","Innovation Fund Denmark - Individuals, Disease and Society [10-092786]"],["dc.identifier.doi","10.1002/ejp.921"],["dc.identifier.isi","000393771700006"],["dc.identifier.pmid","27470494"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43345"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1532-2149"],["dc.relation.issn","1090-3801"],["dc.title","Prediction of postoperative opioid analgesia using clinical-experimental parameters and electroencephalography"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2016Journal Article
    [["dc.bibliographiccitation.firstpage","236"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Pain"],["dc.bibliographiccitation.lastpage","247"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Erlenwein, Joachim"],["dc.contributor.author","Przemeck, Michael"],["dc.contributor.author","Degenhart, Astrid"],["dc.contributor.author","Budde, Stefan"],["dc.contributor.author","Falla, Deborah"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Pfingsten, Michael"],["dc.contributor.author","Petzke, Frank"],["dc.date.accessioned","2018-11-07T10:18:44Z"],["dc.date.available","2018-11-07T10:18:44Z"],["dc.date.issued","2016"],["dc.description.abstract","Pre-existing or chronic pain is an established risk factor for severe postoperative pain. In this prospective observational cohort study, we investigated whether a history of chronic pain, beyond the presence of hip-related pain, affected other postoperative factors including early mobilization, function, and psychological distress after hip surgery. Patients who underwent total hip replacement surgery were observed from the preoperative day until the seventh postoperative day. Before surgery, they were characterized by their pain history, pain intensity, function, and psychological characteristics. Postoperatively, pain intensity was evaluated on day 1, 3, 5, and 7 and the analgesic consumption was recorded for each of these days. Measures of function (functional questionnaire, ability to mobilize and to climb stairs, and range of hip motion) and psychological distress were re-evaluated on day 7. A history of chronic pain was associated with slower postoperative mobilization, poorer physical function, and greater psychological distress in addition to increased postoperative pain intensity. The comorbidity of a chronic pain disorder resulted in greater pain intensity after surgery, and also impeded postoperative rehabilitation. Identification of patients with a chronic pain disorder is necessary preoperatively so that appropriate pain management and rehabilitation can be planned to facilitate recovery. (C) 2016 by the American Pain Society"],["dc.identifier.doi","10.1016/j.jpain.2015.10.013"],["dc.identifier.isi","000370111600009"],["dc.identifier.pmid","26548971"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41511"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Churchill Livingstone"],["dc.relation.issn","1526-5900"],["dc.title","The Influence of Chronic Pain on Postoperative Pain and Function After Hip Surgery: A Prospective Observational Cohort Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2012Journal Article
    [["dc.bibliographiccitation.firstpage","971"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Der Anaesthesist"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Erlenwein, Joachim"],["dc.contributor.author","Stueder, D."],["dc.contributor.author","Lange, J.-P."],["dc.contributor.author","Bauer, M."],["dc.contributor.author","Petzke, Frank"],["dc.contributor.author","Przemeck, Michael"],["dc.date.accessioned","2018-11-07T09:03:51Z"],["dc.date.available","2018-11-07T09:03:51Z"],["dc.date.issued","2012"],["dc.description.abstract","Background. The aim of this investigation was to describe the effects of standardization and central control of the processes involved in postoperative pain management from patient and employee perspectives. Materials and methods. Patients (n = 282/307) and respective hospital staff (n = 149/119) evaluated the processes, the quality of postoperative pain management and result parameters 3 months before and 12 months after the introduction of standardization of the postoperative pain therapy process using a set of standardized questionnaires. Results. Pain level and the waiting period for an analgesic partially decreased and a higher subjective effectiveness of medication was achieved in patients after the standardization. Patients felt that the pain was taken more seriously and contacted the staff for additional medication more frequently. From an employee viewpoint the quality of care and individual competence and ability to treat pain increased after the introduction of standardization. Pain assessment was improved and employees rated their knowledge and education level as higher than before the intervention. Patients with pre-existing chronic pain and patients with special regional therapy benefited only partially after the introduction and an increase in pain intensity was even observed. Conclusions. The quality of care was improved by standardization of the postoperative pain management. The legal and practical ability of the nursing stuff to administer pain medication within well-defined margins reduced the dependence on the ward doctor and at the same time patient pain levels. Patients received analgesics more quickly and experienced increased effectiveness. These results should be an incentive to reconsider the importance of the organization of postoperative pain management, because the quality of care with all potential medical and economic advantages, can be easily optimized by such simple mechanisms. They also show that the quality assessment of acute pain and the selection of appropriate indicators need further development."],["dc.identifier.doi","10.1007/s00101-012-2095-0"],["dc.identifier.isi","000311510900008"],["dc.identifier.pmid","23135771"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24983"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0003-2417"],["dc.title","Process optimization by central control of acute pain therapy. Implementation of standardized treatment concepts and central pain management in hospitals"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2021Journal Article Research Paper
    [["dc.bibliographiccitation.artnumber","180"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Musculoskeletal Disorders"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Kästner, Anne"],["dc.contributor.author","Ng Kuet Leong, Virginie S. C."],["dc.contributor.author","Petzke, Frank"],["dc.contributor.author","Budde, Stefan"],["dc.contributor.author","Przemeck, Michael"],["dc.contributor.author","Müller, Martin"],["dc.contributor.author","Erlenwein, Joachim"],["dc.date.accessioned","2021-04-14T08:28:08Z"],["dc.date.available","2021-04-14T08:28:08Z"],["dc.date.issued","2021"],["dc.date.updated","2022-07-29T12:17:20Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n Emerging evidence highlights the importance of preoperative expectations in predicting patient-reported outcomes of orthopedic surgeries. To date, it is still a matter of controversy whether patient satisfaction can be maximized by promoting either optimistic or realistic outcome expectations before surgery. Adjusting overly optimistic outcome expectancies in favor of a more realistic outlook on the limitations of total hip arthroplasty could reduce the risk of disappointment and lead to greater satisfaction with surgery outcomes. Our prospective cohort study was aimed at comparing the relative predictive influence of baseline expectations, expectation fulfillment and symptomatic improvement on the global effectiveness of total hip arthroplasty.\r\n \r\n \r\n Methods\r\n Ninety patients (49 female, 41 male; mean age: 63 ± 12.87 years) fulfilled inclusion criteria and completed a comprehensive preoperative assessment comprising sociodemographic, clinical, functional and psychological phenotypes. Moreover, the strengths of preoperative expectations for improvements in eight pain-related and functional domains were recorded on a 5-point Likert-scale. At 12 months after surgery, patients were asked to rate perceived improvements in each of these domains as well as the global effectiveness of the total hip replacement on a 5-point Likert-scale. To evaluate the relative impact of preoperative expectations, symptom improvement and the fulfillment of expectations on the global effectiveness of surgery, a sequential multiple regression analysis was performed.\r\n \r\n \r\n Results\r\n Compared with the actual improvement at 12-months follow-up, prior expectations had been overly optimistic in about 28% of patients for hip pain, in about 45% for walking ability and around 60% for back pain, independence in everyday life, physical exercise, general function social interactions and mental well-being. An optimistic hip pain expectation, walking ability at baseline and the fulfillment of expectations for walking ability, general function and independence in everyday life were found to independently predict global effectiveness ratings.\r\n \r\n \r\n Conclusions\r\n Positive expectation about pain and the fulfillment of expectations concerning functional domains predicted higher global effectiveness ratings. In line with many authors investigating the relationship between the fulfillment of expectations and satisfaction with medical interventions, we suggest that professionals should explicitly address their patients’ expectations during the preoperative education and consultation."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.citation","BMC Musculoskeletal Disorders. 2021 Feb 13;22(1):180"],["dc.identifier.doi","10.1186/s12891-021-04040-y"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17730"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82512"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","BioMed Central"],["dc.relation.eissn","1471-2474"],["dc.relation.orgunit","Klinik für Anästhesiologie"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject","Expectations"],["dc.subject","Hip replacement"],["dc.subject","Postoperative pain"],["dc.subject","Predictors of postoperative outcomes"],["dc.subject","Observational cohort study"],["dc.subject","Patient-reported outcomes"],["dc.title","The virtue of optimistic realism - expectation fulfillment predicts patient-rated global effectiveness of total hip arthroplasty"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]
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