Now showing 1 - 8 of 8
  • 2015Journal Article
    [["dc.bibliographiccitation.firstpage","E3131"],["dc.bibliographiccitation.issue","24"],["dc.bibliographiccitation.journal","Proceedings of the National Academy of Sciences of the United States of America"],["dc.bibliographiccitation.lastpage","E3140"],["dc.bibliographiccitation.volume","112"],["dc.contributor.author","Huang, Xiaojie"],["dc.contributor.author","Stodieck, Sophia Katharina"],["dc.contributor.author","Goetze, Bianka"],["dc.contributor.author","Cui, Lei"],["dc.contributor.author","Wong, Man Ho"],["dc.contributor.author","Wenzel, Colin"],["dc.contributor.author","Hosang, Leon"],["dc.contributor.author","Dong, Yan"],["dc.contributor.author","Loewel, Siegrid"],["dc.contributor.author","Schlueter, Oliver M."],["dc.date.accessioned","2018-11-07T09:55:51Z"],["dc.date.available","2018-11-07T09:55:51Z"],["dc.date.issued","2015"],["dc.description.abstract","During critical periods, all cortical neural circuits are refined to optimize their functional properties. The prevailing notion is that the balance between excitation and inhibition determines the onset and closure of critical periods. In contrast, we show that maturation of silent glutamatergic synapses onto principal neurons was sufficient to govern the duration of the critical period for ocular dominance plasticity in the visual cortex of mice. Specifically, postsynaptic density protein-95 (PSD-95) was absolutely required for experience-dependent maturation of silent synapses, and its absence before the onset of critical periods resulted in lifelong juvenile ocular dominance plasticity. Loss of PSD-95 in the visual cortex after the closure of the critical period reinstated silent synapses, resulting in reopening of juvenile-like ocular dominance plasticity. Additionally, silent synapse-based ocular dominance plasticity was largely independent of the inhibitory tone, whose developmental maturation was independent of PSD-95. Moreover, glutamatergic synaptic transmission onto parvalbumin-positive interneurons was unaltered in PSD-95 KO mice. These findings reveal not only that PSD-95-dependent silent synapse maturation in visual cortical principal neurons terminates the critical period for ocular dominance plasticity but also indicate that, in general, once silent synapses are consolidated in any neural circuit, initial experience-dependent functional optimization and critical periods end."],["dc.identifier.doi","10.1073/pnas.1506488112"],["dc.identifier.isi","000356251800009"],["dc.identifier.pmid","26015564"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36839"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Natl Acad Sciences"],["dc.relation.issn","0027-8424"],["dc.title","Progressive maturation of silent synapses governs the duration of a critical period"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2010Journal Article
    [["dc.bibliographiccitation.firstpage","555"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Der Anaesthesist"],["dc.bibliographiccitation.lastpage","563"],["dc.bibliographiccitation.volume","59"],["dc.contributor.author","Russo, Sebastian Giuseppe"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Nickel, E. A."],["dc.contributor.author","Goetze, B."],["dc.contributor.author","Timmermann, Arnd"],["dc.contributor.author","Quintel, M."],["dc.date.accessioned","2018-11-07T08:42:23Z"],["dc.date.available","2018-11-07T08:42:23Z"],["dc.date.issued","2010"],["dc.description.abstract","Extraglottic airway devices (EGA) are not only used in routine anaesthesia practice, they also have a distinct value for in-hospital and out-of-hospital difficult airway management. In the environment of the intensive care unit (ICU) EGA are not used on a regular basis. However, expertise and knowledge regarding EGA coming from the operating theatre or the out-of-hospital setting may also be of value for the ICU setting. This review presents the potential indications for EGA on the ICU for the management of difficult airway situations as well as during percutaneous tracheotomy. Furthermore, the possible advantages of EGA during postoperative recovery from anaesthesia as well as termination of controlled ventilation for intensive care patients are discussed."],["dc.identifier.doi","10.1007/s00101-010-1728-4"],["dc.identifier.isi","000279027500009"],["dc.identifier.pmid","20502847"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19684"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-055X"],["dc.relation.issn","0003-2417"],["dc.title","Extraglottic airway devices in the intensive care unit"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2016Journal Article Research Paper
    [["dc.bibliographiccitation.firstpage","119"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Neuron"],["dc.bibliographiccitation.lastpage","132"],["dc.bibliographiccitation.volume","91"],["dc.contributor.author","Saab, Aiman S."],["dc.contributor.author","Tzvetavona, Iva D."],["dc.contributor.author","Trevisiol, Andrea"],["dc.contributor.author","Baltan, Selva"],["dc.contributor.author","Dibaj, Payam"],["dc.contributor.author","Kusch, Kathrin"],["dc.contributor.author","Möbius, Wiebke"],["dc.contributor.author","Goetze, Bianka"],["dc.contributor.author","Jahn, Hannah M."],["dc.contributor.author","Huang, Wenhui"],["dc.contributor.author","Steffens, Heinz"],["dc.contributor.author","Schomburg, Eike D."],["dc.contributor.author","Pérez-Samartín, Alberto"],["dc.contributor.author","Pérez-Cerdá, Fernando"],["dc.contributor.author","Bakhtiari, Davood"],["dc.contributor.author","Matute, Carlos"],["dc.contributor.author","Löwel, Siegrid"],["dc.contributor.author","Griesinger, Christian"],["dc.contributor.author","Hirrlinger, Johannes"],["dc.contributor.author","Kirchhoff, Frank"],["dc.contributor.author","Nave, Klaus-Armin"],["dc.date.accessioned","2017-09-07T11:44:48Z"],["dc.date.available","2017-09-07T11:44:48Z"],["dc.date.issued","2016"],["dc.description.abstract","Oligodendrocytes make myelin and support axons metabolically with lactate. However, it is unknown how glucose utilization and glycolysis are adapted to the different axonal energy demands. Spiking axons release glutamate and oligodendrocytes express NMDA receptors of unknown function. Here we show that the stimulation of oligodendroglial NMDA receptors mobilizes glucose transporter GLUT1, leading to its incorporation into the myelin compartment in vivo. When myelinated optic nerves from conditional NMDA receptor mutants are challenged with transient oxygen-glucose deprivation, they show a reduced functional recovery when returned to oxygen-glucose but are indistinguishable from wild-type when provided with oxygen-lactate. Moreover, the functional integrity of isolated optic nerves, which are electrically silent, is extended by preincubation with NMDA, mimicking axonal activity, and shortened by NMDA receptor blockers. This reveals a novel aspect of neuronal energy metabolismin which activity-dependent glutamate release enhances oligodendroglial glucose uptake and glycolytic support of fast spiking axons."],["dc.identifier.doi","10.1016/j.neuron.2016.05.016"],["dc.identifier.gro","3141651"],["dc.identifier.isi","000382394300016"],["dc.identifier.pmid","27292539"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/5454"],["dc.language.iso","en"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1097-4199"],["dc.relation.issn","0896-6273"],["dc.title","Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]
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  • 2007Conference Abstract
    [["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Clinical Chemistry"],["dc.bibliographiccitation.volume","53"],["dc.contributor.author","Binder, L."],["dc.contributor.author","Streit, Frank"],["dc.contributor.author","Engelmayer, J."],["dc.contributor.author","Goetze, S."],["dc.contributor.author","Luthe, Hilmar"],["dc.contributor.author","Budde, K."],["dc.contributor.author","Beckebaum, S."],["dc.contributor.author","Doll, S."],["dc.contributor.author","Oellerich, M."],["dc.date.accessioned","2018-11-07T11:01:40Z"],["dc.date.available","2018-11-07T11:01:40Z"],["dc.date.issued","2007"],["dc.format.extent","A88"],["dc.identifier.isi","000246843000278"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51200"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Clinical Chemistry"],["dc.publisher.place","Washington"],["dc.relation.conference","59th Annual Meeting of the American-Association-for-Clinical-Chemistry"],["dc.relation.eventlocation","San Diego, CA"],["dc.relation.issn","0009-9147"],["dc.title","Comparison of the ADVIA centaur (R) cyclosporine assay with tandem mass spectrometry (LC-MS/MS)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2014Journal Article
    [["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Experimental Gerontology"],["dc.bibliographiccitation.lastpage","11"],["dc.bibliographiccitation.volume","60"],["dc.contributor.author","Stodieck, Sophia Katharina"],["dc.contributor.author","Greifzu, Franziska"],["dc.contributor.author","Goetze, Bianka"],["dc.contributor.author","Schmidt, Karl-Friedrich"],["dc.contributor.author","Loewel, Siegrid"],["dc.date.accessioned","2018-11-07T09:32:06Z"],["dc.date.available","2018-11-07T09:32:06Z"],["dc.date.issued","2014"],["dc.description.abstract","In the primary visual cortex (V1), monocular deprivation (MD) induces a shift in the ocular dominance (OD) of binocular neurons towards the open eye (Wiesel and Hubel, 1963; Gordon and Stryker, 1996). In V1 of C57Bl/6J mice, this OD-plasticity is maximal in juveniles, declines in adults and is absent beyond postnatal day (PD) 110 (Lehmann and Lowel, 2008) if mice are raised in standard cages. Since it was recently shown that brief dark exposure (DE) restored OD-plasticity in young adult rats (PD70-100) (He et al., 2006), we wondered whether DE would restore OD-plasticity also in adult and old mice and after a cortical stroke. To this end, we raised mice in standard cages until adulthood and transferred them to a dark room for 10-14 days. Using intrinsic signal optical imaging we demonstrate that short-term DE can restore OD-plasticity after MD in both adult (PD138) and old mice (PD535), and that OD-shifts were mediated by an increase of open eye responses in V1. Interestingly, restored OD-plasticity after DE was accompanied by a reduction of both parvalbumin expressing cells and perineuronal nets and was prevented by increasing intracortical inhibition with diazepam. DE also maintained OD-plasticity in adult mice (PD150) after a stroke in the primary somatosensory cortex. In contrast, short-term DE did not affect basic visual parameters as measured by optomotry. In conclusion, short-termDEwas able to restore OD-plasticity in both adult and aging mice and even preserved plasticity after a cortical stroke, most likely mediated by reducing intracortical inhibition. (C) 2014 The Authors. Published by Elsevier Inc."],["dc.identifier.doi","10.1016/j.exger.2014.09.007"],["dc.identifier.isi","000346068300001"],["dc.identifier.pmid","25220148"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31673"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","1873-6815"],["dc.relation.issn","0531-5565"],["dc.title","Brief dark exposure restored ocular dominance plasticity in aging mice and after a cortical stroke"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2007Conference Abstract
    [["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Clinical Chemistry"],["dc.bibliographiccitation.volume","53"],["dc.contributor.author","Brandhorst, Gunnar"],["dc.contributor.author","Streit, Frank"],["dc.contributor.author","Goetze, S."],["dc.contributor.author","Rhode, K."],["dc.contributor.author","Engelmayer, J."],["dc.contributor.author","Luthe, Hilmar"],["dc.contributor.author","Oellerich, M."],["dc.date.accessioned","2018-11-07T11:01:41Z"],["dc.date.available","2018-11-07T11:01:41Z"],["dc.date.issued","2007"],["dc.format.extent","A96"],["dc.identifier.isi","000246843000303"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51201"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Clinical Chemistry"],["dc.publisher.place","Washington"],["dc.relation.conference","59th Annual Meeting of the American-Association-for-Clinical-Chemistry"],["dc.relation.eventlocation","San Diego, CA"],["dc.relation.issn","0009-9147"],["dc.title","Quantification of mycophenolic acid by an optimized LC-MS/MS method compared to a new IMPDH inhibition assay on the cobas C 501 analyzer"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2011Conference Abstract
    [["dc.bibliographiccitation.journal","Clinical Chemistry and Laboratory Medicine (CCLM)"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Brandhorst, Gunnar"],["dc.contributor.author","Engelmayer, J."],["dc.contributor.author","Goetze, S."],["dc.contributor.author","Oellerich, M."],["dc.contributor.author","von Ahsen, Nicolas"],["dc.date.accessioned","2018-11-07T08:56:24Z"],["dc.date.available","2018-11-07T08:56:24Z"],["dc.date.issued","2011"],["dc.format.extent","S715"],["dc.identifier.isi","000289974201425"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23142"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Walter De Gruyter & Co"],["dc.publisher.place","Berlin"],["dc.relation.issn","1434-6621"],["dc.title","PRE-ANALYTICAL EFFECTS OF PLASMA SEPARATION TUBES IN THE ROUTINE CLINICAL CHEMISTRY LABORATORY"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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  • 2017Conference Abstract
    [["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The Journal of Heart and Lung Transplantation"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Bellon, H."],["dc.contributor.author","Vandermeulen, E."],["dc.contributor.author","Verleden, S. E."],["dc.contributor.author","Heigl, T."],["dc.contributor.author","Vriens, H."],["dc.contributor.author","Lammertyn, E."],["dc.contributor.author","Verlinden, L."],["dc.contributor.author","Goetze, S."],["dc.contributor.author","Verstuyf, M."],["dc.contributor.author","Hoet, P. M."],["dc.contributor.author","Vos, R."],["dc.contributor.author","Verleden, G. M."],["dc.contributor.author","Vanaudenaerde, B. M."],["dc.date.accessioned","2018-11-07T10:25:25Z"],["dc.date.available","2018-11-07T10:25:25Z"],["dc.date.issued","2017"],["dc.format.extent","S409"],["dc.identifier.isi","000398839801369"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42857"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Elsevier Science Inc"],["dc.publisher.place","New york"],["dc.relation.conference","37th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation (ISHLT)"],["dc.relation.eventlocation","San Diego, CA"],["dc.relation.issn","1557-3117"],["dc.relation.issn","1053-2498"],["dc.title","The Effect of Immunosuppression on Airway Integrity"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]
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