Hülsmann, Swen

[["dc.bibliographiccitation.firstpage","111"],["dc.bibliographiccitation.journal","Neuroscience"],["dc.bibliographiccitation.lastpage","122"],["dc.bibliographiccitation.volume","347"],["dc.contributor.author","Oku, Yoshitaka"],["dc.contributor.author","Huelsmann, Swen"],["dc.date.accessioned","2018-11-07T10:25:04Z"],["dc.date.available","2018-11-07T10:25:04Z"],["dc.date.issued","2017"],["dc.description.abstract","The topology of the respiratory network in the brainstem has been addressed using different computational models, which help to understand the functional properties of the system. We tested a neural mass model by comparing the result of activation and inhibition of inhibitory neurons in silico with recently published results of optogenetic manipulation of glycinergic neurons [Sherman, et al. (2015) Nat Neurosci 18:408]. The comparison revealed that a five-cell type model consisting of three classes of inhibitory neurons [I-DEC, E-AUG, E-DEC (PI)] and two excitatory populations (pre-I/1) and (I-AUG) neurons can be applied to explain experimental observations made by stimulating or inhibiting inhibitory neurons by light sensitive ion channels. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.neuroscience.2017.01.041"],["dc.identifier.isi","000398010100011"],["dc.identifier.pmid","28215988"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42776"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","1873-7544"],["dc.relation.issn","0306-4522"],["dc.title","A COMPUTATIONAL MODEL OF THE RESPIRATORY NETWORK CHALLENGED AND OPTIMIZED BY DATA FROM OPTOGENETIC MANIPULATION OF GLYCINERGIC NEURONS"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","The Journal of Physiological Sciences"],["dc.bibliographiccitation.volume","59"],["dc.contributor.author","Lal, Amit"],["dc.contributor.author","Oku, Yoshitaka"],["dc.contributor.author","Hulsmann, Swen"],["dc.contributor.author","Okada, Yasumasa"],["dc.contributor.author","Miwakeichi, Fumikazu"],["dc.contributor.author","Kawai, Shigeharu"],["dc.contributor.author","Tamura, Yoshiyasu"],["dc.contributor.author","Ishiguro, Makio"],["dc.date.accessioned","2018-11-07T08:34:57Z"],["dc.date.available","2018-11-07T08:34:57Z"],["dc.date.issued","2009"],["dc.format.extent","260"],["dc.identifier.isi","000271023101634"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17944"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Tokyo"],["dc.relation.issn","1880-6546"],["dc.title","NON-DETERMINISTIC BREAKDOWN OF THE PREBOTZINGER COMPLEX NEURONAL SYNCHRONICITY MAY LEAD TO QUANTAL SLOWING OF RESPIRATORY RHYTHM"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Physiology"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Oke, Yoshihiko"],["dc.contributor.author","Miwakeichi, Fumikazu"],["dc.contributor.author","Oku, Yoshitaka"],["dc.contributor.author","Hirrlinger, Johannes"],["dc.contributor.author","Hülsmann, Swen"],["dc.date.accessioned","2020-12-10T18:44:37Z"],["dc.date.available","2020-12-10T18:44:37Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.3389/fphys.2018.01586"],["dc.identifier.eissn","1664-042X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78533"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.iserratumof","/handle/2/78530"],["dc.title","Corrigendum: Cell Type-Dependent Activation Sequence During Rhythmic Bursting in the PreBötzinger Complex in Respiratory Rhythmic Slices From Mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","erratum_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","97"],["dc.bibliographiccitation.lastpage","100"],["dc.bibliographiccitation.seriesnr","669"],["dc.contributor.author","Winter, Stefan M."],["dc.contributor.author","Fresemann, Jens"],["dc.contributor.author","Schnell, Christian"],["dc.contributor.author","Oku, Yoshitaka"],["dc.contributor.author","Hirrlinger, Johannes"],["dc.contributor.author","Huelsmann, Swen"],["dc.date.accessioned","2018-11-07T08:48:16Z"],["dc.date.available","2018-11-07T08:48:16Z"],["dc.date.issued","2010"],["dc.description.abstract","The neuronal network in the pre-Botzinger Complex is the key element of respiratory rhythm generation. Isolated in a slice preparation, the pre-Botzinger Complex network is still able to generate its inspiratory activity. Although the mechanism of rhythm generation in principle relies on glutamatergic neurons, interestingly we found that glycinergic neurons represent a major portion of all inspiratory neurons in the slice preparation."],["dc.identifier.doi","10.1007/978-1-4419-5692-7_20"],["dc.identifier.isi","000277995200020"],["dc.identifier.pmid","20217329"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21163"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Berlin"],["dc.relation.conference","11th Oxford Conference on Modeling and Control of Breathing"],["dc.relation.crisseries","Advances in Experimental Medicine and Biology"],["dc.relation.eventend","2009-07-26"],["dc.relation.eventlocation","Nara, Japan"],["dc.relation.eventstart","2009-07-23"],["dc.relation.isbn","978-1-4419-5691-0"],["dc.relation.ispartof","New frontiers in respiratory control"],["dc.relation.ispartofseries","Advances in Experimental Medicine and Biology; 669"],["dc.title","Glycinergic Interneurons in the Respiratory Network of the Rhythmic Slice Preparation"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Acta Physiologica"],["dc.bibliographiccitation.volume","213"],["dc.contributor.author","Huelsmann, Swen"],["dc.contributor.author","Fresemann, Jens"],["dc.contributor.author","Miwakeichi, Fumikazu"],["dc.contributor.author","Oku, Yoshitaka"],["dc.date.accessioned","2018-11-07T09:59:52Z"],["dc.date.available","2018-11-07T09:59:52Z"],["dc.date.issued","2015"],["dc.format.extent","171"],["dc.identifier.isi","000362554200384"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37689"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1748-1716"],["dc.relation.issn","1748-1708"],["dc.title","Astrocyte calcium signaling in the Pre-Botzinger Complex"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Physiology"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Oke, Yoshihiko"],["dc.contributor.author","Miwakeichi, Fumikazu"],["dc.contributor.author","Oku, Yoshitaka"],["dc.contributor.author","Hirrlinger, Johannes"],["dc.contributor.author","Hülsmann, Swen"],["dc.date.accessioned","2020-12-10T18:44:37Z"],["dc.date.available","2020-12-10T18:44:37Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.3389/fphys.2018.01219"],["dc.identifier.eissn","1664-042X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78530"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.haserratum","/handle/2/78533"],["dc.title","Cell Type-Dependent Activation Sequence During Rhythmic Bursting in the PreBötzinger Complex in Respiratory Rhythmic Slices From Mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","11"],["dc.bibliographiccitation.journal","Respiratory Physiology & Neurobiology"],["dc.bibliographiccitation.lastpage","17"],["dc.bibliographiccitation.volume","226"],["dc.contributor.author","Oku, Yoshitaka"],["dc.contributor.author","Fresemann, Jens"],["dc.contributor.author","Miwakeichi, Fumikazu"],["dc.contributor.author","Huelsmann, Swen"],["dc.date.accessioned","2018-11-07T10:13:58Z"],["dc.date.available","2018-11-07T10:13:58Z"],["dc.date.issued","2016"],["dc.description.abstract","Astrocytes have been found to modulate neuronal activity through calcium-dependent signaling in various brain regions. However, whether astrocytes of the pre-Botzinger complex (preBotC) exhibit respiratory rhythmic fluctuations is still controversial. Here we evaluated calcium-imaging experiments within preBotC in rhythmically active medullary slices from TgN(hGFAP-EGFP) mice using advanced analyses. 13.8% of EGFP-negative cells, putative neurons, showed rhythmic fluorescent changes that were highly correlated to the respiratory rhythmic fluctuation (cross-correlation coefficient > 0.5 and dF/F > 0.2%). In contrast, a considerable number of astrocyte somata exhibited synchronized low frequency (<0.03 Hz) calcium oscillations. After band-pass filtering, signals that irregularly preceded the calcium signal of EGFP-negative cells were observed in 10.2% of astrocytes, indicating a functional coupling between astrocytes and neurons in preBotC. A model simulation confirmed that such preinspiratory astrocytic signals can arise from coupled neuronal and astrocytic oscillators, supporting a concept that slow oscillatory changes of astrocytic functions modulate neighboring neuronal activity to add variability in respiratory rhythm. (C) 2015 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.resp.2015.02.002"],["dc.identifier.isi","000375515800003"],["dc.identifier.pmid","25747384"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40531"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1878-1519"],["dc.relation.issn","1569-9048"],["dc.title","Respiratory calcium fluctuations in low-frequency oscillating astrocytes in the pre-Botzinger complex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]