Hülsmann, Swen

[["dc.bibliographiccitation.firstpage","193"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Brain Structure and Function"],["dc.bibliographiccitation.lastpage","203"],["dc.bibliographiccitation.volume","220"],["dc.contributor.author","Schnell, Christian"],["dc.contributor.author","Shahmoradi, Ali"],["dc.contributor.author","Wichert, Sven P."],["dc.contributor.author","Mayerl, Steffen"],["dc.contributor.author","Hagos, Yohannes"],["dc.contributor.author","Heuer, Heike"],["dc.contributor.author","Rossner, Moritz J."],["dc.contributor.author","Huelsmann, Swen"],["dc.date.accessioned","2018-11-07T10:03:38Z"],["dc.date.available","2018-11-07T10:03:38Z"],["dc.date.issued","2015"],["dc.description.abstract","Sulforhodamine 101 (SR101) is widely used for astrocyte identification, though the labeling mechanism remains unknown and the efficacy of labeling in different brain regions is heterogeneous. By combining region-specific isolation of astrocytes followed by transcriptome analysis, two-photon excitation microscopy, and mouse genetics, we identified the thyroid hormone transporter OATP1C1 as the SR101-uptake transporter in hippocampus and cortex."],["dc.identifier.doi","10.1007/s00429-013-0645-0"],["dc.identifier.isi","000348980800014"],["dc.identifier.pmid","24129767"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38516"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1863-2661"],["dc.relation.issn","1863-2653"],["dc.title","The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific sulforhodamine 101-labeling of hippocampal astrocytes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","18"],["dc.bibliographiccitation.journal","Respiratory Physiology & Neurobiology"],["dc.bibliographiccitation.lastpage","23"],["dc.bibliographiccitation.volume","226"],["dc.contributor.author","Schnell, Christian"],["dc.contributor.author","Negm, Mahmoud"],["dc.contributor.author","Driehaus, Johannes"],["dc.contributor.author","Scheller, Anja"],["dc.contributor.author","Huelsmann, Swen"],["dc.date.accessioned","2018-11-07T10:13:58Z"],["dc.date.available","2018-11-07T10:13:58Z"],["dc.date.issued","2016"],["dc.description.abstract","The neuronal activity in the respiratory network of the ventrolateral medulla strongly depends on a variety of different neuromodulators. Since the respiratory activity generated by neurons in the pre-Botzinger complex (preBotC) is stabilized by astrocytes, we investigated potential effects of the neuromodulator norepinephrine (NE) on the astrocytic calcium signaling in the ventral respiratory group. In acutely isolated brainstem slices from wild type mice (postnatal day 1-10) we performed calcium imaging experiments using Oregon Green 488 BAPTA-1 AM as a calcium indicator dye. Astrocytes in the preBotC, which were identified by their unique intracellular calcium rise after the reduction of the extracellular K+ concentration, showed calcium rises in response to norepinephrine. These calcium signals persisted after blockade of neuronal activity by tetrodotoxin (TTX) indicating that they were independent of neuronal activity. Furthermore, application of the endoplasmic reticulum calcium pump blocker cyclopiazonic acid (CPA) diminished norepinephrine-induced calcium signals. This results could be confirmed using trans genic mice with astrocyte specific expression of GCaMP3. Thus, norepinephrine might, apart from acting directly on neurons, influence and modulate respiratory network activity via the modulation of astroglial calcium signaling. (C) 2015 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.resp.2015.10.008"],["dc.identifier.isi","000375515800004"],["dc.identifier.pmid","26514085"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40532"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1878-1519"],["dc.relation.issn","1569-9048"],["dc.title","Norepinephrine-induced calcium signaling in astrocytes in the respiratory network of the ventrolateral medulla"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","815"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Glia"],["dc.bibliographiccitation.lastpage","827"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Haertel, Kai"],["dc.contributor.author","Schnell, Christian"],["dc.contributor.author","Huelsmann, Swen"],["dc.date.accessioned","2018-11-07T08:29:17Z"],["dc.date.available","2018-11-07T08:29:17Z"],["dc.date.issued","2009"],["dc.description.abstract","A controlled, periodic exchange of air between lungs and atmosphere requires a neuronal rhythm generated by a network of neurons in the ventral respiratory group (VRG) of the brainstem. Glial cells, e.g. astrocytes, have been shown to be supportive in stabilizing this neuronal activity in the central nervous system during development. In addition, a variety of neuromodulators including serotonin (5-HT), Substance P (SP), and thyrotropin-releasing hormone (TRH) stimulate respiratory neurons directly. If astrocytes in the VRG, like their neuronal neighbors, are also directly stimulated by neuromodulators, they might indirectly affect the respiratory neurons and consequently the respiratory rhythm. In the present study, we provide support for this concept by demonstrating expression of NK1-R, TRH-R, and 5-HT(2)-R in astrocytes of the VRG with immunohistochemistry. Additionally, we showed that the external application of the neuromodulators 5-HT, SP, and TRH activate calcium transients in VRG astrocytes. Consequently, we postulate that in the VRG of the neonatal mouse, neuromodulation by SP, TRH, and serotonin also involves astrocytic calcium signaling. (C) 2008 Wiley-Liss, Inc."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft (DFG)"],["dc.identifier.doi","10.1002/glia.20808"],["dc.identifier.isi","000265572300002"],["dc.identifier.pmid","19031447"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16613"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","0894-1491"],["dc.title","Astrocytic Calcium Signals Induced by Neuromodulators via Functional Metabotropic Receptors in the Ventral Respiratory Group of Neonatal Mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","97"],["dc.bibliographiccitation.lastpage","100"],["dc.bibliographiccitation.seriesnr","669"],["dc.contributor.author","Winter, Stefan M."],["dc.contributor.author","Fresemann, Jens"],["dc.contributor.author","Schnell, Christian"],["dc.contributor.author","Oku, Yoshitaka"],["dc.contributor.author","Hirrlinger, Johannes"],["dc.contributor.author","Huelsmann, Swen"],["dc.date.accessioned","2018-11-07T08:48:16Z"],["dc.date.available","2018-11-07T08:48:16Z"],["dc.date.issued","2010"],["dc.description.abstract","The neuronal network in the pre-Botzinger Complex is the key element of respiratory rhythm generation. Isolated in a slice preparation, the pre-Botzinger Complex network is still able to generate its inspiratory activity. Although the mechanism of rhythm generation in principle relies on glutamatergic neurons, interestingly we found that glycinergic neurons represent a major portion of all inspiratory neurons in the slice preparation."],["dc.identifier.doi","10.1007/978-1-4419-5692-7_20"],["dc.identifier.isi","000277995200020"],["dc.identifier.pmid","20217329"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21163"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Berlin"],["dc.relation.conference","11th Oxford Conference on Modeling and Control of Breathing"],["dc.relation.crisseries","Advances in Experimental Medicine and Biology"],["dc.relation.eventend","2009-07-26"],["dc.relation.eventlocation","Nara, Japan"],["dc.relation.eventstart","2009-07-23"],["dc.relation.isbn","978-1-4419-5691-0"],["dc.relation.ispartof","New frontiers in respiratory control"],["dc.relation.ispartofseries","Advances in Experimental Medicine and Biology; 669"],["dc.title","Glycinergic Interneurons in the Respiratory Network of the Rhythmic Slice Preparation"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Glia"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Schnell, Christian"],["dc.contributor.author","Hagos, Yohannes"],["dc.contributor.author","Huelsmann, Swen"],["dc.date.accessioned","2018-11-07T09:23:24Z"],["dc.date.available","2018-11-07T09:23:24Z"],["dc.date.issued","2013"],["dc.format.extent","S120"],["dc.identifier.isi","000320408400380"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29568"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","11th European Meeting on Glial Cell Function in Health and Disease"],["dc.relation.eventlocation","Berlin, GERMANY"],["dc.relation.issn","0894-1491"],["dc.title","DEHYDROEPIANDROSTERONE SULFATE AND SULFORHODAMINE 101 COMPETE FOR ACTIVE UPTAKE BY AN ORGANIC ANION TRANSPORTING POLYPEPTIDE IN HIPPOCAMPAL ASTROCYTES"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]