Becker, Tamara

[["dc.bibliographiccitation.firstpage","95"],["dc.bibliographiccitation.journal","Virus Research"],["dc.bibliographiccitation.lastpage","102"],["dc.bibliographiccitation.volume","204"],["dc.contributor.author","Plotzki, Elena"],["dc.contributor.author","Buerck, Lelia Wolf-van"],["dc.contributor.author","Knauf, Yvonne"],["dc.contributor.author","Becker, Tamara"],["dc.contributor.author","Maetz-Rensing, Kerstin"],["dc.contributor.author","Schuster, Marion"],["dc.contributor.author","Baehr, Andrea"],["dc.contributor.author","Klymiuk, Nikolai"],["dc.contributor.author","Wolf, Eckhard"],["dc.contributor.author","Seissler, Jochen"],["dc.contributor.author","Denner, Joachim"],["dc.date.accessioned","2022-10-06T13:33:28Z"],["dc.date.available","2022-10-06T13:33:28Z"],["dc.date.issued","2015"],["dc.description.sponsorship"," https://doi.org/10.13039/100007798 German Research Foundation"],["dc.identifier.doi","10.1016/j.virusres.2015.04.016"],["dc.identifier.pii","S0168170215001677"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115639"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0168-1702"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","Virus safety of islet cell transplantation from transgenic pigs to marmosets"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","093056"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","New Journal of Physics"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Maniraj, M."],["dc.contributor.author","Lyu, L."],["dc.contributor.author","Mousavion, S."],["dc.contributor.author","Becker, S."],["dc.contributor.author","Emmerich, S."],["dc.contributor.author","Jungkenn, D."],["dc.contributor.author","Schlagel, D. L."],["dc.contributor.author","Lograsso, T. A."],["dc.contributor.author","Barman, S. R."],["dc.contributor.author","Mathias, Stefan"],["dc.contributor.author","Stadtmüller, B."],["dc.contributor.author","Aeschlimann, M."],["dc.date.accessioned","2021-03-05T08:58:51Z"],["dc.date.available","2021-03-05T08:58:51Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1088/1367-2630/abb342"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/80274"],["dc.notes.intern","DOI Import GROB-393"],["dc.relation.eissn","1367-2630"],["dc.title","Aperiodically ordered nano-graphene on the quasicrystalline substrate"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","7151"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","The Journal of Immunology"],["dc.bibliographiccitation.lastpage","7161"],["dc.bibliographiccitation.volume","178"],["dc.contributor.author","Averdam, Anne"],["dc.contributor.author","Kuhl, Heiner"],["dc.contributor.author","Sontag, Mario"],["dc.contributor.author","Becker, Tamara"],["dc.contributor.author","Hughes, Austin L."],["dc.contributor.author","Reinhardt, Richard"],["dc.contributor.author","Walter, Lutz"],["dc.date.accessioned","2022-10-06T13:26:53Z"],["dc.date.available","2022-10-06T13:26:53Z"],["dc.date.issued","2007"],["dc.identifier.doi","10.4049/jimmunol.178.11.7151"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115192"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1550-6606"],["dc.relation.issn","0022-1767"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Genomics and Diversity of the Common Marmoset Monkey NK Complex"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","159"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Maturitas"],["dc.bibliographiccitation.lastpage","170"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Wuttke, Wolfgang"],["dc.contributor.author","Jarry, Hubertus"],["dc.contributor.author","Becker, Tamara"],["dc.contributor.author","Schultens, Alexander"],["dc.contributor.author","Christoffel, Volker"],["dc.contributor.author","Gorkow, Christoph"],["dc.contributor.author","Seidlová-Wuttke, Dana"],["dc.date.accessioned","2021-06-01T10:49:46Z"],["dc.date.available","2021-06-01T10:49:46Z"],["dc.date.issued","2008"],["dc.identifier.doi","10.1016/j.maturitas.2008.11.012"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86406"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0378-5122"],["dc.title","Reprint of Phytoestrogens: endocrine disrupters or replacement for hormone replacement therapy?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","155"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Clinical Science"],["dc.bibliographiccitation.lastpage","162"],["dc.bibliographiccitation.volume","126"],["dc.contributor.author","Curths, Christoph"],["dc.contributor.author","Wichmann, Judy"],["dc.contributor.author","Dunker, Sarah"],["dc.contributor.author","Windt, Horst"],["dc.contributor.author","Hoymann, Heinz-Gerd"],["dc.contributor.author","Lauenstein, Hans D."],["dc.contributor.author","Hohlfeld, Jens"],["dc.contributor.author","Becker, Tamara"],["dc.contributor.author","Kaup, Franz-Josef"],["dc.contributor.author","Braun, Armin"],["dc.contributor.author","Knauf, Sascha"],["dc.date.accessioned","2022-10-06T13:34:22Z"],["dc.date.available","2022-10-06T13:34:22Z"],["dc.date.issued","2013"],["dc.description.abstract","Animal models with a high predictive value for human trials are needed to develop novel human-specific therapeutics for respiratory diseases. The aim of the present study was to examine lung-function parameters in marmoset monkeys (Callithrix jacchus) that can be used to detect pharmacologically or provocation-induced AHR (airway hyper-responsiveness). Therefore a custom-made lung-function device that allows application of defined aerosol doses during measurement was developed. It was hypothesized that LPS (lipopolysaccharide)-challenged marmosets show AHR compared with non-challenged healthy subjects. Invasive plethysmography was performed in 12 anaesthetized orotracheally intubated and spontaneously breathing marmosets. Pulmonary data of RL (lung resistance), Cdyn (dynamic compliance), EF50 (mid-expiratory flow), Poes (oesophageal pressure), MV (minute volume), respiratory frequency (f) and VT (tidal volume) were collected. Measurements were conducted under baseline conditions and under MCh (methacholine)-induced bronchoconstriction. The measurement was repeated with the same group of animals after induction of an acute lung inflammation by intratracheal application of LPS. PDs (provocative doses) of MCh to achieve a certain increase in RL were significantly lower after LPS administration. AHR was demonstrated in the LPS treated compared with the naïve animals. The recorded lung-function data provide ground for pre-clinical efficacy and safety testing of anti-inflammatory substances in the common marmoset, a new translational NHP (non-human primate) model for LPS-induced lung inflammation."],["dc.identifier.doi","10.1042/CS20130101"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115892"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1470-8736"],["dc.relation.issn","0143-5221"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","http://creativecommons.org/licenses/by/3.0/"],["dc.title","Airway hyper-responsiveness in lipopolysaccharide-challenged common marmosets ( Callithrix jacchus )"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","505"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Cells"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Drummer, Charis"],["dc.contributor.author","Vogt, Edgar-John"],["dc.contributor.author","Heistermann, Michael"],["dc.contributor.author","Roshani, Berit"],["dc.contributor.author","Becker, Tamara"],["dc.contributor.author","Mätz-Rensing, Kerstin"],["dc.contributor.author","Kues, Wilfried A."],["dc.contributor.author","Kügler, Sebastian"],["dc.contributor.author","Behr, Rüdiger"],["dc.date.accessioned","2021-06-01T09:42:32Z"],["dc.date.available","2021-06-01T09:42:32Z"],["dc.date.issued","2021"],["dc.description.abstract","Genetic modification of non-human primates (NHP) paves the way for realistic disease models. The common marmoset is a NHP species increasingly used in biomedical research. Despite the invention of RNA-guided nucleases, one strategy for protein overexpression in NHP is still lentiviral transduction. We generated three male and one female enhanced green fluorescent protein (EGFP)-transgenic founder marmosets via lentiviral transduction of natural preimplantation embryos. All founders accomplished germline transmission of the transgene by natural mating, yielding 20 transgenic offspring together (in total, 45 pups; 44% transgenic). This demonstrates that the transgenic gametes are capable of natural fertilization even when in competition with wildtype gametes. Importantly, 90% of the transgenic offspring showed transgene silencing, which is in sharp contrast to rodents, where the identical transgene facilitated robust EGFP expression. Furthermore, we consistently discovered somatic, but so far, no germ cell chimerism in mixed wildtype/transgenic litters. Somatic cell chimerism resulted in false-positive genotyping of the respective wildtype littermates. For the discrimination of transgenic from transgene-chimeric animals by polymerase chain reaction on skin samples, a chimeric cell depletion protocol was established. In summary, it is possible to establish a cohort of genetically modified marmosets by natural mating, but specific requirements including careful promoter selection are essential."],["dc.identifier.doi","10.3390/cells10030505"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85277"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","2073-4409"],["dc.title","Generation and Breeding of EGFP-Transgenic Marmoset Monkeys: Cell Chimerism and Implications for Disease Modeling"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2414"],["dc.bibliographiccitation.issue","18"],["dc.bibliographiccitation.journal","Animals"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Drummer, Charis"],["dc.contributor.author","Münzker, Julia"],["dc.contributor.author","Heistermann, Michael"],["dc.contributor.author","Becker, Tamara"],["dc.contributor.author","Mißbach, Sophie"],["dc.contributor.author","Behr, Rüdiger"],["dc.date.accessioned","2022-10-04T10:21:49Z"],["dc.date.available","2022-10-04T10:21:49Z"],["dc.date.issued","2022"],["dc.description.abstract","Non-human primates (NHPs) serve as embryo donors for embryo collection in order to mimic genetic diseases in humans by genetic modification. Reproductive health of the embryo donors is crucial, and chronic distress needs to be avoided. Embryo retrieval rates (ERR), anti-Müllerian hormone (AMH) concentrations, cortisol levels, and body weight fluctuations were assessed as markers for fertility and distress. With regard to successful embryo retrievals (total n = 667), the animals were either used for extended periods (long-term group; LTG) or only for short periods (short-term group; STG). Retrospective evaluation expectedly showed that animals in the LTG had a higher ERR than animals in the STG (p < 0.0001). Importantly, ERR in the LTG remained stable throughout the experimental period, and high embryo rates were already encountered during the first year of experimental use (p = 0.0002). High ERR were associated with high AMH and low cortisol levels, and minimal body weight fluctuations following anesthesia, indicating a superior ability of the LTG animals to handle distress. We conclude that the long-term experimental use of marmosets does not impair their fertility or health status per se, supporting the view that animal reuse can be in accordance with the 3R-principle, implying reduction, replacement, and refinement in animal experimentation."],["dc.identifier.doi","10.3390/ani12182414"],["dc.identifier.pii","ani12182414"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114507"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-600"],["dc.relation.eissn","2076-2615"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Performance of Marmoset Monkeys as Embryo Donors Is Reflected by Different Stress-Related Parameters"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Immunology"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Weil, Sandra"],["dc.contributor.author","Memmer, Stefanie"],["dc.contributor.author","Lechner, Axel"],["dc.contributor.author","Huppert, Volker"],["dc.contributor.author","Giannattasio, Ariane"],["dc.contributor.author","Becker, Tamara"],["dc.contributor.author","Müller-Runte, Andreas"],["dc.contributor.author","Lampe, Karen"],["dc.contributor.author","Beutner, Dirk"],["dc.contributor.author","Quaas, Alexander"],["dc.contributor.author","Koch, Joachim"],["dc.date.accessioned","2022-10-06T13:26:43Z"],["dc.date.available","2022-10-06T13:26:43Z"],["dc.date.issued","2017"],["dc.description.sponsorship"," Hessisches Ministerium für Wissenschaft und Kunst http://dx.doi.org/10.13039/501100003495"],["dc.description.sponsorship"," Wilhelm Sander-Stiftung http://dx.doi.org/10.13039/100008672"],["dc.description.sponsorship"," Alfons und Gertrud Kassel-Stiftung http://dx.doi.org/10.13039/501100005110"],["dc.identifier.doi","10.3389/fimmu.2017.00387"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115148"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1664-3224"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Natural Killer Group 2D Ligand Depletion Reconstitutes Natural Killer Cell Immunosurveillance of Head and Neck Squamous Cell Carcinoma"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","159"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Maturitas"],["dc.bibliographiccitation.lastpage","170"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Wuttke, Wolfgang"],["dc.contributor.author","Jarry, Hubertus"],["dc.contributor.author","Becker, Tamara"],["dc.contributor.author","Schultens, Alexander"],["dc.contributor.author","Christoffel, Volker"],["dc.contributor.author","Gorkow, Christoph"],["dc.contributor.author","Seidlova-Wuttke, Dana"],["dc.date.accessioned","2018-11-07T11:11:42Z"],["dc.date.available","2018-11-07T11:11:42Z"],["dc.date.issued","2008"],["dc.description.abstract","Objectives: This review presents findings with clear statements from the literature as well as own results of effects of soy, red clover and their isoflavones as well as of the Cimicifuga racemosa extract BNO 1055. Experimental and clinical effects on climacteric complaints, osteoprotective effects, activity in the urogenital tract, and risks concerning cardiovascular diseases and mammary and endometrial tissue will be compared, also in comparison to classical hormone preparations. The question whether soy and red clover products and/or Cimicifuga racemosa (CR) preparations are endocrine disrupters or may fulfill the criteria of the so-called phyto-SERNIs will be discussed. Methods: Review of selected publications since 1980 and summary of unpublished own results of the authors. Results: Experimental and clinical evidences suggest that soy/red clover and their isoflavones do not fulfill the criteria of an ideal SERM. They appear to have mild osteoprotective effects but do not improve climacteric complaints. Furthermore, they seem to stimulate uterine growth and mammary epithelial proliferation. In ovariectomized rats, the CR extract BNO 1055 showed many of the beneficial effects of 17 beta-estradiol, including effects in the brain/hypothalamus to reduce serum LH levels, effects in the bone to prevent osteoporosis and estrogenic effects in the urinary bladder. The CR extract BNO 1055 had no uterotrophic effect. Conclusion: If clinical studies confirm these results, the Cimicifuga racemosa preparation BNO 1055 would appear as an ideal SERM and may therefore be an alternative to hormone replacement therapy. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved."],["dc.identifier.doi","10.1016/S0378-5122(02)00344-4"],["dc.identifier.isi","000261850400016"],["dc.identifier.pmid","12609555"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53492"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.relation.issn","0378-5122"],["dc.title","Phytoestrogens: endocrine disrupters or replacement for hormone replacement therapy? (Reprinted from Maturitas, vol 44, pg S9-S20, 2003)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]