Reinert, Marie-Christine

[["dc.bibliographiccitation.firstpage","930"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Muscle & Nerve"],["dc.bibliographiccitation.lastpage","936"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Kutschenko, Anna"],["dc.contributor.author","Reinert, Marie-Christine"],["dc.contributor.author","Klinker, Florian"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Hesse, Stefan"],["dc.contributor.author","Liebetanz, David"],["dc.date.accessioned","2018-11-07T08:49:18Z"],["dc.date.available","2018-11-07T08:49:18Z"],["dc.date.issued","2011"],["dc.description.abstract","Introduction: To test the hypothesis that the efficacy of botulinum toxin depends on the activity of the neuromuscular junction, we developed an in vivo paradigm to determine the degree and duration of low-dose botulinum toxin-induced focal paresis in mice. Methods: We combined an automated wheel-running paradigm with low-dose botulinum toxin injections into the calf muscles of wild-type mice. Half of the mice were injected either before the nightly running or before the daily resting period. Results: After botulinum toxin injections, running distance and maximum velocity decreased dose-dependently. The degree and duration of decrease between the respective groups with regard to the time-points of injection were identical. Conclusions: This in vivo paradigm quantifies the degree of otherwise clinically inapparent botulinum toxin-induced focal calf muscle paresis. Increased muscle activity after low-dose injections does not influence the efficacy of botulinum toxin in normal muscles. Muscle Nerve 44: 930-936, 2011"],["dc.identifier.doi","10.1002/mus.22210"],["dc.identifier.isi","000297938800015"],["dc.identifier.pmid","22102464"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21429"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0148-639X"],["dc.title","BOTULINUM TOXIN-INDUCED FOCAL PARESIS IN MICE IS UNAFFECTED BY MUSCLE ACTIVITY"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","89"],["dc.bibliographiccitation.journal","Toxicon"],["dc.bibliographiccitation.lastpage","90"],["dc.bibliographiccitation.volume","68"],["dc.contributor.author","Kutschenko, Anna"],["dc.contributor.author","Reinert, M. C."],["dc.contributor.author","Klinker, Florian"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Hesse, Stefan"],["dc.contributor.author","Liebetanz, David"],["dc.date.accessioned","2018-11-07T09:23:39Z"],["dc.date.available","2018-11-07T09:23:39Z"],["dc.date.issued","2013"],["dc.identifier.doi","10.1016/j.toxicon.2012.07.089"],["dc.identifier.isi","000320075500077"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29632"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.publisher.place","Oxford"],["dc.relation.eventlocation","Santa Fe, NM"],["dc.relation.issn","0041-0101"],["dc.title","Novel in vivo test shows low-dosage botulinum toxin-induced focal calf muscle paresis is independent of increased muscle activity in wild-type mice"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","374"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Experimental Neurology"],["dc.bibliographiccitation.lastpage","379"],["dc.bibliographiccitation.volume","235"],["dc.contributor.author","Schmitz, Thomas"],["dc.contributor.author","Endesfelder, Stefanie"],["dc.contributor.author","Reinert, Marie-Christine"],["dc.contributor.author","Klinker, Florian"],["dc.contributor.author","Müller, Susann"],["dc.contributor.author","Bührer, Christoph"],["dc.contributor.author","Liebetanz, David"],["dc.date.accessioned","2018-11-07T09:10:49Z"],["dc.date.available","2018-11-07T09:10:49Z"],["dc.date.issued","2012"],["dc.description.abstract","In preterm infants, the risk to develop attention-deficit/hyperactivity disorder is 3 to 4-fold higher than in term infants. Moreover, preterm infants exhibit deficits in motor coordination and balance. Based on clinical data, higher oxygen levels in preterm infants lead to worse neurological outcome, and experimental hyperoxia causes wide-ranging cerebral changes in neonatal rodents. We hypothesize that hyperoxia in the immature brain may affect motor activity in preterm infants. We subjected newborn mice from P6 to P8 to 48 h of hyperoxia (80% O-2) and tested motor activity in running wheels starting at adolescent age P30. Subsequently, from P44 to P53, regular wheels were replaced by complex wheels with variable crossbar positions to assess motor coordination deficits. MRI with diffusion tensor imaging was performed in the corpus callosum to determine white matter diffusivity in mice after hyperoxia at ages P30 and P53 in comparison to control animals. Adolescent mice after neonatal hyperoxia revealed significantly higher values for maximum velocity and mean velocity in regular wheels than controls (P<0.05). In the complex running wheels, however, maximum velocity was decreased in animals after hyperoxia, as compared to controls (P<0.05). Decreased fractional anisotropy and increased radial diffusion coefficient were observed in the corpus callosum of P30 and P53 mice after neonatal hyperoxia compared to control mice. Hyperoxia in the immature brain causes hyperactivity, motor coordination deficits, and impaired white matter diffusivity in adolescent and young adult mice. (C) 2012 Elsevier Inc. All rights reserved."],["dc.description.sponsorship","Medical Faculty, University of Gottingen"],["dc.identifier.doi","10.1016/j.expneurol.2012.03.002"],["dc.identifier.isi","000303430400039"],["dc.identifier.pmid","22449476"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26581"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.relation.issn","0014-4886"],["dc.title","Adolescent hyperactivity and impaired coordination after neonatal hyperoxia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","45"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Neuroscience Methods"],["dc.bibliographiccitation.lastpage","48"],["dc.bibliographiccitation.volume","205"],["dc.contributor.author","Kutschenko, Anna"],["dc.contributor.author","Reinert, Marie-Christine"],["dc.contributor.author","Klinker, Florian"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Hesse, Stefan"],["dc.contributor.author","Liebetanz, David"],["dc.date.accessioned","2018-11-07T09:12:06Z"],["dc.date.available","2018-11-07T09:12:06Z"],["dc.date.issued","2012"],["dc.description.abstract","Tetanus neurotoxin (TeNT) enhances activity of motoneurons by blocking spinal inhibitory interneurons. Based on this pathomechanism, we propose that low-dosage intramuscular injections of TeNT could serve as a specific treatment for central paretic muscles. However in vivo TeNT research is restricted because of the fear of triggering widespread muscle spasms. In addition, no reliable test to measure the in vivo toxicity of low-dosage TeNT is available. We introduce a novel wheel running-based paradigm with mice to quantify functional effects and thus the toxicity of low-dosage TeNT in vivo. We accustomed three groups of wildtype mice (n=14) to using a complex running wheel with irregularly spaced crossbars. Each group received an injection with a different low-dosage of TeNT (0.15 ng, 0.1 ng or 0.05 ng TeNT) into both tibialis anterior muscles. The maximum running velocity and accumulative running time of the groups were recorded during the following weeks. Three days after TeNT injections, the mice exhibited an increase in muscle tone of the injected tibialis anterior muscles but no generalized symptoms. However, we found that normal running in the complex wheel set-up was disturbed such that the maximum running velocity and running time of the mice decreased with the size of the dose. This effect peaked on the fifth and sixth nights after injection and returned to baseline level again within the next two weeks. With this novel in vivo automated paradigm we can accurately and objectively quantify the duration and degree of TeNT-induced focal increase in muscle tone. (C) 2012 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.jneumeth.2011.12.019"],["dc.identifier.isi","000301688600006"],["dc.identifier.pmid","22227534"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26874"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0165-0270"],["dc.title","Accurate quantification of tetanus neurotoxin-induced focal spasticity in mice using complex running wheels"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Toxicon"],["dc.bibliographiccitation.volume","68"],["dc.contributor.author","Kutschenko, Anna"],["dc.contributor.author","Reinert, M. C."],["dc.contributor.author","Klinker, Florian"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Hesse, Stefan"],["dc.contributor.author","Liebetanz, David"],["dc.date.accessioned","2018-11-07T09:23:40Z"],["dc.date.available","2018-11-07T09:23:40Z"],["dc.date.issued","2013"],["dc.format.extent","90"],["dc.identifier.doi","10.1016/j.toxicon.2012.07.090"],["dc.identifier.isi","000320075500078"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29633"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.publisher.place","Oxford"],["dc.relation.conference","7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins (TOXINS)"],["dc.relation.eventlocation","Santa Fe, NM"],["dc.relation.issn","0041-0101"],["dc.title","Low-dosage tetanus neurotoxin induces focal, temporarily increased muscle tone in wild-type mice"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]