Matthias, Christoph

[["dc.bibliographiccitation.firstpage","859"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK"],["dc.bibliographiccitation.lastpage","866"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Martin, Alexios"],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Kron, Martina"],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Steiner, Wolfgang"],["dc.date.accessioned","2018-11-07T09:39:38Z"],["dc.date.available","2018-11-07T09:39:38Z"],["dc.date.issued","2014"],["dc.description.abstract","BackgroundThe purpose of this study was to evaluate oncological and functional results of transoral laser microsurgery (TLM) in patients with T2 and T3 glottic laryngeal squamous cell carcinoma (SCC). MethodsA retrospective chart analysis was carried out. Cases were classified into categories pT2a, pT2b, and pT3. Treatment was exclusively TLMselective neck dissection and adjuvant (chemo)radiotherapy. ResultsThree hundred ninety-one patients were treated by TLM; 142 cases were category pT2a, 127 were pT2b, and 122 were pT3. Median follow-up was 71 months. Five-year overall, recurrence-free, and disease specific survival rates were 72.2%, 76.4%, and 93.2% for pT2a tumors, 64.9%, 57.3%, and 83.9% for pT2b tumors, and 58.6%, 57.8%, and 84.1% for pT3 tumors, respectively. Larynx preservation was achieved in 93% (pT2a) and 83% (pT2b and pT3). ConclusionResults are comparable to open partial or total laryngectomy and superior to primary (chemo)radiotherapy. TLM results in a lower morbidity and superior function compared to standard treatment. (c) 2013 Wiley Periodicals, Inc. Head Neck 36: 859-866, 2014"],["dc.identifier.doi","10.1002/hed.23389"],["dc.identifier.isi","000336493200019"],["dc.identifier.pmid","23720321"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33329"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1097-0347"],["dc.relation.issn","1043-3074"],["dc.title","Transoral laser microsurgery in treatment of pT2 and pT3 glottic laryngeal squamous cell carcinoma - results of 391 patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","531"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","The Laryngoscope"],["dc.bibliographiccitation.lastpage","537"],["dc.bibliographiccitation.volume","124"],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Koehler, Sabrina"],["dc.contributor.author","Meyer, Alexander C."],["dc.contributor.author","Blum, Jenny"],["dc.contributor.author","Strenzke, Nicola"],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Canis, Martin"],["dc.date.accessioned","2018-11-07T09:44:44Z"],["dc.date.available","2018-11-07T09:44:44Z"],["dc.date.issued","2014"],["dc.description.abstract","Objectives/HypothesisTo review the results of obliteration of a preexisting mastoid cavity with abdominal fat and Vibrant Soundbridge implantation in patients with mixed hearing loss (MHL) and to compare the data with results of Vibrant Soundbridge implantation in patients with MHL without mastoid cavity and with pure sensorineural hearing loss (SNHL). Study DesignRetrospective chart analysis of 10 patients (10 ears) with MHL and preexisting mastoid cavity, 18 patients (19 ears) with MHL alone and nine patients (10 ears) with SNHL treated in one tertiary referral center. MethodsVibrant Soundbridge implantation and obliteration in case a mastoid cavity existed previously. Pure tone audiometry (average air-bone gap, average functional gain), speech audiometry (Freiburg Monosyllabic Test) and complication rate were main outcome measures. ResultsPostoperative average air-bone gap was -15.121.2 dB in patients with MHL with mastoid cavity obliteration, -7.211.4 dB in patients with MHL without mastoid cavity, and -5.7 +/- 11.2 dB in patients with SNHL. Average functional gain was 40.0 +/- 23.5 dB, 39.7 +/- 12.1 dB, and 9.5 +/- 10.6 dB. Postoperative speech discrimination rate was 77.9 +/- 20.8%, 83.3 +/- 13.6%, and 83.6 +/- 6.3%. No severe intraoperative or postoperative complications were noted. ConclusionsMastoid cavity obliteration during Vibrant Soundbridge implantation in patients with MHL and preexisting mastoid cavity is a safe procedure. The audiometric results are satisfying and comparable to those of other patient groups implanted with the same device. Level of Evidence4. Laryngoscope, 124:531-537, 2014"],["dc.description.sponsorship","MED-EL, Innsbruck, Austria"],["dc.identifier.doi","10.1002/lary.24180"],["dc.identifier.isi","000329929900041"],["dc.identifier.pmid","23918587"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34461"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1531-4995"],["dc.relation.issn","0023-852X"],["dc.title","Mastoid Cavity Obliteration and Vibrant Soundbridge Implantation for Patients With Mixed Hearing Loss"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","246"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","American Journal of Otolaryngology"],["dc.bibliographiccitation.lastpage","250"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Weiss, Bernhard G."],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Canis, Martin"],["dc.date.accessioned","2018-11-07T09:43:07Z"],["dc.date.available","2018-11-07T09:43:07Z"],["dc.date.issued","2014"],["dc.description.abstract","After laryngectomy or lateral pharyngotomy for treatment of laryngeal or hypopharyngeal cancer the occurrence of a pharyngo-cutaneous fistula is a challenging complication. Especially after previous radiotherapy and expanded surgical resections of mucosa the management is demanding. Besides the prolonged hospital stay, increased treatment costs and reduced quality of life, a delayed adjuvant treatment follows the development of a fistula. Treatment strategies range from conservative procedures comprising parenteral nutrition, antibiotics and local wound care to primary surgical closure or reconstructive tissue transfer. We report three cases of using the fibrin/thrombin-coated collagen patch TachoSil (R) as a solitary or adjuvant strategy in surgical treatment. In one patient primary closure of the fistula was achieved by transoral application of the collagen patch. In the other cases a not tension free primary suture was strengthened by the adjuvant use of TachoSil (R). The healing process was rapid and straightforward in all patients. The use of TachoSil (R) may be indicated in between conservative treatment strategies and reconstructive surgery. After occurrence of a fistula the healing process is intended to be accelerated by primary closure with TachoSil (R) or by sealing of a primary suture. (C) 2014 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.amjoto.2013.11.005"],["dc.identifier.isi","000333541800031"],["dc.identifier.pmid","24315631"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34107"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","W B Saunders Co-elsevier Inc"],["dc.relation.issn","1532-818X"],["dc.relation.issn","0196-0709"],["dc.title","Coated collagen patches for closure of pharyngo-cutaneous fistulas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1589"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","European Archives of Oto-Rhino-Laryngology"],["dc.bibliographiccitation.lastpage","1598"],["dc.bibliographiccitation.volume","273"],["dc.contributor.author","Kuenzel, Julian"],["dc.contributor.author","Hainz, Michael"],["dc.contributor.author","Ziebart, Thomas"],["dc.contributor.author","Pitz, Susanne"],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Strieth, Sebastian"],["dc.contributor.author","Matthias, Christoph"],["dc.date.accessioned","2018-11-07T10:13:56Z"],["dc.date.available","2018-11-07T10:13:56Z"],["dc.date.issued","2016"],["dc.description.abstract","The objective of this study is to analyze the outcome of treatment for solitary fibrous tumors (SFTs) in the head and neck area. SFTs present as slow-growing masses, often with local compressive symptoms that are difficult to distinguish from other soft-tissue tumors. SFTs are commonly treated using local excision without adjuvant therapy. To date, only heterogeneous small series have been published, documenting the treatment results and outcome with these tumors. Retrospective study of patients with histopathologically confirmed SFT treated at two tertiary referral hospitals between 2004 and 2014. Eight men and four women with histologically confirmed SFT were identified in the records. Their age range was 37-82 years (mean 57.8 years). The mean follow-up period for eight patients was 6.75 years (range 1-24 years). Four patients were lost to follow-up. Sublocalizations were neck (n = 3), orbit (n = 2), paranasal sinus (n = 2), cheek (n = 2), hard palate (n = 1), parotid gland (n = 1), and tongue (n = 1). The first-line treatment for all of the tumors identified was surgical excision. In four cases, the surgical margins were narrow or unclear due to piecemeal resection in the paranasal sinus and orbit (n = 3) or a tumor location deep in the parapharyngeal space (n = 1). Recurrences developed in two of these cases (in the orbit and parapharyngeal space), and the other two patients were lost to follow-up. Radiotherapy and chemotherapy were not administered as first-line treatments. Overall, the local recurrence rate (n = 2/8) was 25 %. The disease-specific survival rate was 100 %. These results are consistent with the literature data and show that safe surgical excision, without opening of the tumor capsule, reduces the risk of local recurrence and leads to a favorable outcome. Tumors in the head and neck often represent a surgical challenge, and wide surgical margins are rarely possible due to the complex three-dimensional anatomic compartments in the region. Head and neck surgeons should therefore be aware that there is an increased risk of recurrence in these patients; tightly scheduled follow-up visits are mandatory for at least 10 years, if not longer. Radiotherapy only appears to be an option in patients with unresectable tumors or when wide surgical excision would cause severe functional morbidity."],["dc.identifier.doi","10.1007/s00405-015-3670-1"],["dc.identifier.isi","000375607700033"],["dc.identifier.pmid","26026772"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40523"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1434-4726"],["dc.relation.issn","0937-4477"],["dc.title","Head and neck solitary fibrous tumors: a rare and challenging entity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2719"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","European Archives of Oto-Rhino-Laryngology"],["dc.bibliographiccitation.lastpage","2727"],["dc.bibliographiccitation.volume","270"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Martin, Alexios"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Steiner, Wolfgang"],["dc.date.accessioned","2018-11-07T09:20:45Z"],["dc.date.available","2018-11-07T09:20:45Z"],["dc.date.issued","2013"],["dc.description.abstract","The main objective of this study is to assess the feasibility of transoral laser microsurgery (TLM) in the treatment of T4a laryngeal cancer and to report the oncological and functional outcomes. This is a retrospective case-series study, held in a single-institute, academic tertiary referral center. Seventy-nine patients with previously untreated T4a glottic (n = 31, 39 %) or supraglottic laryngeal carcinoma (n = 48, 61 %) were included in this study. Five patients (6 %) were treated exclusively by TLM, 16 (20 %) had TLM and unilateral neck dissection, 27 (35 %) had TLM and bilateral neck dissection. Adjuvant (chemo)radiotherapy was additionally administered in 26 (33 %) cases following TLM and neck dissection, and in 5 (6 %) cases after TLM without neck dissection. The main outcome measures included organ preservation, local control, functional outcome, overall, recurrence-free, and disease-specific survival. The median follow-up period was 49 months, 5 year organ preservation rate and local control rate were 80.0 and 67.2 %, 5 year overall, recurrence-free and disease-specific survival were 55.8, 61.9 and 71.8 %. The 5 year overall survival rates were 62.5 % in pN0 cases and 57.2 % in cases with pN-positive neck disease. With respect to survival, these results are comparable to total laryngectomy, while being superior to primary (chemo)radiotherapy. TLM results in a low morbidity, rapid recovery and good function and can be a valid option for organ preserving surgery of pT4a glottic and supraglottic cancer."],["dc.identifier.doi","10.1007/s00405-013-2382-7"],["dc.identifier.isi","000323739100020"],["dc.identifier.pmid","23408021"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10308"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28952"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0937-4477"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Organ preservation in T4a laryngeal cancer: is transoral laser microsurgery an option?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","889"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK"],["dc.bibliographiccitation.lastpage","895"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Martin, Alexios"],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Steiner, Wolfgang"],["dc.date.accessioned","2018-11-07T09:56:40Z"],["dc.date.available","2018-11-07T09:56:40Z"],["dc.date.issued","2015"],["dc.description.abstract","BackgroundVarious therapeutic options exist for treatment of T1a glottic squamous cell cancer (SCC). Radiotherapy (RT) has been favored over surgical excision. This has been challenged by transoral laser microsurgery (TLM) showing low morbidity and good functional results. MethodsA retrospective chart review was carried out. Patients with untreated T1a glottic SCC were included in the study. Endpoints were locoregional control, overall survival, disease-specific survival, and absolute rate of larynx preservation. ResultsFour hundred four patients were included in this study. Five-year Kaplan-Meier estimates were: local control 86.8%, overall survival 87.8%, disease-specific survival 98.0%, recurrence-free survival 76.1%, and larynx preservation 97.3%. The complication rate was 1%; the majority of patients had either normal or mildly dysphonic voices. ConclusionLow complication rates, excellent functional outcome, and high rates of organ preservation favor TLM. In agreement with the literature, TLM should be the treatment of choice for patients presenting with T1a glottic SCC. (c) 2014 Wiley Periodicals, Inc. Head Neck 37: 889-895, 2015"],["dc.identifier.doi","10.1002/hed.23688"],["dc.identifier.isi","000355012000021"],["dc.identifier.pmid","24623709"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37008"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1097-0347"],["dc.relation.issn","1043-3074"],["dc.title","Transoral laser microsurgery for T1a glottic cancer: Review of 404 cases"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1315"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","HISTOLOGY AND HISTOPATHOLOGY"],["dc.bibliographiccitation.lastpage","1324"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Stoeckelhuber, Mechthild"],["dc.contributor.author","Olzowy, Bernhard"],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Scherer, Elias Q."],["dc.contributor.author","Babaryka, Gregor"],["dc.contributor.author","Loeffelbein, Denys J."],["dc.contributor.author","Rohleder, Nils H."],["dc.contributor.author","Nieberler, Markus"],["dc.contributor.author","Kesting, Marco R."],["dc.date.accessioned","2018-11-07T09:34:31Z"],["dc.date.available","2018-11-07T09:34:31Z"],["dc.date.issued","2014"],["dc.description.abstract","Secretory cells in the seromucous glands of paranasal sinuses secrete antibacterial proteins for innate immune mucosal integrity. We studied the localization of antimicrobial and cytoskeletal components of the human seromucous glands and respiratory epithelium of the maxillary sinus and the ethmoidal cells by immunohistochemical methods. The presence of a variety of defense proteins such as lysozyme, lactoferrin, cathelicidin, and defensin-1, -2, -3 point to a crucial role in the immune defense for the respiratory tract. Cytoskeletal proteins such as actin, myosin 2, cytokeratin 7 and 19, alpha- and beta- tubulin, investigated for the first time in glands of paranasal sinuses, showed a stronger expression at the apical and lateral cell membrane. The localization of the cytoskeletal proteins might point to their participation in exocrine secretory processes and stabilizing effects."],["dc.identifier.isi","000343124300009"],["dc.identifier.pmid","24737387"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32187"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","F Hernandez"],["dc.relation.issn","1699-5848"],["dc.relation.issn","0213-3911"],["dc.title","Immunolocalization of antimicrobial and cytoskeletal components in the serous glands of human sinonasal mucosa"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","156"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK"],["dc.bibliographiccitation.lastpage","161"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Steiner, Wolfgang"],["dc.date.accessioned","2018-11-07T10:01:43Z"],["dc.date.available","2018-11-07T10:01:43Z"],["dc.date.issued","2015"],["dc.description.abstract","BackgroundThe purpose of this study was to evaluate oncologic outcomes of transoral laser microsurgery (TLM) in patients with cancer of the oropharyngeal and/or hypopharyngeal posterior wall. MethodsBetween August 1986 and December 2006, 25 patients (oropharyngeal n=12; hypopharyngeal n=13) were treated by primary CO2 laser microsurgery. Treatment was exclusively TLM with or without selective neck dissection in 12 cases (48%); TLM with adjuvant (chemo)radiotherapy was performed in 13 cases (52%). ResultsData were analyzed by using the Kaplan-Meier method. The median follow-up was 41.6 months. The 5-year overall, recurrence-free, and disease-specific survival rates for stages I/II were 36,5%, 60,0%, and 87,5% and for stages III/IVa 41,2%, 36,4%, and 56,3%, respectively. ConclusionWith respect to local control and survival, results are comparable to conventional surgery. (c) 2014 Wiley Periodicals, Inc. Head Neck37: 156-161, 2015"],["dc.identifier.doi","10.1002/hed.23571"],["dc.identifier.isi","000348548700007"],["dc.identifier.pmid","24519973"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38080"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1097-0347"],["dc.relation.issn","1043-3074"],["dc.title","Oncologic results of transoral laser microsurgery for squamous cell carcinoma of the posterior pharyngeal wall"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","810"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","International Journal of Audiology"],["dc.bibliographiccitation.lastpage","816"],["dc.bibliographiccitation.volume","53"],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Pelz, Sabrina"],["dc.contributor.author","Coors, Melanie"],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Canis, Martin"],["dc.date.accessioned","2018-11-07T09:33:14Z"],["dc.date.available","2018-11-07T09:33:14Z"],["dc.date.issued","2014"],["dc.description.abstract","Objective: Cochlear implantation trauma causes both macroscopic and inflammatory trauma. The aim of the present study was to evaluate the effectiveness of the TNF-alpha inhibitor etanercept applied after cochlear implantation trauma on the preservation of acoustic hearing. Design: Guinea pigs were randomly assigned to three groups receiving cochlear implantation trauma by cochleostomy. In one group, the site was sealed by bone cement with no further treatment. A second group was additionally implanted with an osmotic minipump delivering artificial perilymph into the scala tympani for seven days. In the third group, etanercept 1 mg/ml was added to artificial perilymph. Hearing was assessed by auditory brainstem responses at 2, 4, 6, and 8 kHz prior to and after surgery and on days 3, 5, 7, 14, 28. Study sample: Fifteen healthy guinea pigs. Results: The trauma led to threshold shifts from 50.3 dB +/- 16.3 dB to 68.0 dB +/- 19.3 dB. Hearing thresholds were significantly lower in etanercept-treated animals compared to controls on day 28 at 8 kHz and from day 3 onwards at 4 and 2 kHz (p < 0.01; two-way RM ANOVA / Bonferroni t-test). Conclusion: The application of etanercept led to preservation of acoustic hearing after cochlear implantation trauma."],["dc.identifier.doi","10.3109/14992027.2014.938369"],["dc.identifier.isi","000343928200004"],["dc.identifier.pmid","25311100"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31923"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Informa Healthcare"],["dc.relation.issn","1708-8186"],["dc.relation.issn","1499-2027"],["dc.title","Application of a TNF-alpha-inhibitor into the scala tympany after cochlear electrode insertion trauma in guinea pigs: Preliminary audiologic results"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1075"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","European Archives of Oto-Rhino-Laryngology"],["dc.bibliographiccitation.lastpage","1083"],["dc.bibliographiccitation.volume","270"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Christiansen, Hans"],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Steiner, Wolfgang"],["dc.date.accessioned","2018-11-07T09:27:42Z"],["dc.date.available","2018-11-07T09:27:42Z"],["dc.date.issued","2013"],["dc.description.abstract","The objective of the study was to determine the oncological and functional results in patients after excision of tongue base carcinoma by transoral laser microsurgery. A retrospective unicenter study performed between 1986 and 2007. 82 patients with previously untreated squamous cell carcinoma of the tongue base (T1-4, N0-2, M0) underwent transoral laser surgery with curative intent. Stage distribution was as follows: stage I, 1 case (1 %): stage II, 6 cases (7 %): stage III, 14 cases (17 %): stage IV 61 cases (75 %). Main outcome measures are local control rate, overall survival, recurrence-free survival, complications, and feeding tube dependence. The results were Kaplan-Meier 5-year local control rate for all patients was 84 %. T-stage-related local control rate after 5 years was 94 % for stage I-II, 78 % for stage III and 81 % for stage IV. 5-year overall survival and recurrence-free survival were 59 and 69 %, respectively. UICC stage-related overall survival and recurrence-free survival were 70 and 86 % for stage I-II, 44 and 54 % for stage III and 58 and 69 % for stage IV. Postoperative bleeding at the primary tumor site occurred in 9 patients (11 %). Gastrostomy tubes remained in place permanently in 5 patients (6 %). Primary transoral laser microsurgery of tongue base carcinoma offers convincing oncological and functional results comparable to other treatment modalities, e.g., radio(chemo)therapy but has lower rates of morbidity."],["dc.identifier.doi","10.1007/s00405-012-2097-1"],["dc.identifier.isi","000315443000039"],["dc.identifier.pmid","22763429"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30604"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0937-4477"],["dc.title","Oncologic and functional results after transoral laser microsurgery of tongue base carcinoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]