Matthias, Christoph

[["dc.bibliographiccitation.firstpage","662"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Annals of Otology Rhinology & Laryngology"],["dc.bibliographiccitation.lastpage","669"],["dc.bibliographiccitation.volume","118"],["dc.contributor.author","Roedel, Ralf M. W."],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Blomeyer, Barbara D."],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Christiansen, Hans"],["dc.date.accessioned","2018-11-07T11:24:31Z"],["dc.date.available","2018-11-07T11:24:31Z"],["dc.date.issued","2009"],["dc.description.abstract","Objectives: Treatment methods for patients with cervical cancer of an unknown primary site (CUP) are still under discussion. The purpose of this retrospective study was to analyze the oncological follow-up of 58 patients treated for cervical CUP. Methods: From 1986 to 2006, 58 patients with cervical CUP were treated at the authors' institution. Treatment consisted of neck dissection alone in 8, irradiation or chemoradiation in 5, combined surgery and radiotherapy in 28, and surgery and radiochemotherapy in 17. Results: The 3-year and 5-year overall survival rates for all patients were 52.9% and 40.9%, respectively. The 3-year and 5-year disease-specific Survival rates were 50.9% and 39.7%, respectively. The 3-year and 5-year neck control rates were 73.7% and 67.3%, respectively. Neck dissection followed by radiochemotherapy was associated with the best 3-year and 5-year locoregional control rates. Extracapsular extension was a predictor of survival, but not of neck control. Distant metastases developed in about one third of all patients and were the most frequent cause of tumor-related death in cases of advanced neck disease. Conclusions: Despite the fact that regional control can be achieved in many cases, survival rates may be limited by distant metastasis, especially in patients with advanced neck disease."],["dc.identifier.isi","000270190000010"],["dc.identifier.pmid","19810608"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56424"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Annals Publ Co"],["dc.relation.issn","0003-4894"],["dc.title","Impact of Distant Metastasis in Patients With Cervical Lymph Node Metastases From Cancer of an Unknown Primary Site"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","864"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Radiology"],["dc.bibliographiccitation.lastpage","871"],["dc.bibliographiccitation.volume","258"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Daldrup, Benjamin"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Overbeck, Tobias R."],["dc.contributor.author","Hennies, Steffen"],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.contributor.author","Roedel, Ralf M. W."],["dc.contributor.author","Christiansen, Hans"],["dc.date.accessioned","2018-11-07T08:58:48Z"],["dc.date.available","2018-11-07T08:58:48Z"],["dc.date.issued","2011"],["dc.description.abstract","Purpose: To test for an association between high-grade acute organ toxicity during adjuvant radiation and chemotherapy and treatment outcome in patients with locally advanced head and neck squamous cell carcinoma (HNSCC). Materials and Methods: Institutional review board approval was obtained for this retrospective study. From September 1994 to October 2008, 294 HNSCC patients were treated with adjuvant radiation and chemotherapy at the authors' department. They received normofractionated (2 Gy per fraction) irradiation to include associated nodal drainage sites, for a cumulative dose of 60-64 Gy. From January 2002 to December 2009, 91 patients received additional concomitant cisplatin-based chemotherapy. Toxicity during treatment was monitored weekly according to the common toxicity criteria (CTC); any CTC toxicity grade 3 or higher, including mucositis, dysphagia, or skin reaction, was considered high-grade acute organ toxicity. The influence of possible prognostic factors on overall survival and locoregional control was studied by means of uni- and multivariate Cox regression. Results: A statistically significant association was found between high-grade acute organ toxicity and both overall survival and locoregional control. Patients with CTC grade 3 or greater acute organ toxicity had a 5-year overall survival and locoregional control rate of 90% and 97%, respectively, as compared with 24% and 74%, respectively, in patients without such toxicity (P < .01). Multivariate analyses revealed that this association was independent from other factors that may influence treatment toxicity, especially concomitant chemotherapy and/or radiation therapy. Conclusion: The data suggest that normal tissue and tumor tissue may behave similarly with respect to treatment response, as high-grade acute organ toxicity during radiation and chemotherapy was associated with better outcomes in the patient population; therefore, the hypothesis should be further analyzed on the biomolecular and clinical level and with other tumor entities in prospective clinical trials. (C)RSNA, 2011"],["dc.identifier.doi","10.1148/radiol.10100705"],["dc.identifier.isi","000287573100023"],["dc.identifier.pmid","21339350"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23729"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Radiological Soc North America"],["dc.relation.issn","0033-8419"],["dc.title","High-Grade Acute Organ Toxicity as Positive Prognostic Factor in Adjuvant Radiation and Chemotherapy for Locally Advanced Head and Neck Cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","International Journal of Radiation Oncology*Biology*Physics"],["dc.bibliographiccitation.volume","75"],["dc.contributor.author","Christiansen, Hans"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.contributor.author","Roedel, Ralf M. W."],["dc.contributor.author","Steiner, Wolfgang"],["dc.contributor.author","Matthias, Christoph"],["dc.date.accessioned","2018-11-07T11:23:46Z"],["dc.date.available","2018-11-07T11:23:46Z"],["dc.date.issued","2009"],["dc.format.extent","633"],["dc.identifier.doi","10.1016/j.ijrobp.2009.05.062"],["dc.identifier.isi","000269941600047"],["dc.identifier.pmid","19735892"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56260"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","0360-3016"],["dc.title","LARYNX PRESERVATION CLINICAL TRIAL DESIGN: KEY ISSUES AND RECOMMENDATIONS-A CONSENSUS PANEL SUMMARY: IN REGARD TO LEFEBVRE ET AL., FOR THE LARYNX PRESERVATION CONSENSUS PANEL (INT J RADIAT ONCOL BIOL PHYS 2009;73:1293-1303)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","45"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES"],["dc.bibliographiccitation.lastpage","49"],["dc.bibliographiccitation.volume","71"],["dc.contributor.author","Roedel, Ralf M. W."],["dc.contributor.author","Christiansen, Hans"],["dc.contributor.author","Mueller, Roland M."],["dc.contributor.author","Matthias, Christoph"],["dc.date.accessioned","2018-11-07T08:35:18Z"],["dc.date.available","2018-11-07T08:35:18Z"],["dc.date.issued","2009"],["dc.description.abstract","Background: To investigate long-term results of transoral CO 2 laser microresection (TLM) in glottic carcinoma in situ (CIS). Methods: A retrospective study of 34 patients with glottic CIS treated initially with TLM between 1986 and 2004. Median post-operative follow-up time was 62 months. Results: Three- and 5-year local control rates were 97 and 93%, respectively. Four patients developed local recurrence (rTis, rTis, rT1, rT4) that could be salvaged by repeated TLM in all cases. Neither adjuvant radiotherapy nor open partial or total laryngectomy was performed. There was no tumour-related death in this series. Conclusion: TLM can be considered as an effective method in the treatment of glottic CIS not only for the primary therapy, but also in cases of local recurrence. Copyright (c) 2008 S. Karger AG, Basel"],["dc.identifier.doi","10.1159/000176191"],["dc.identifier.isi","000261521900009"],["dc.identifier.pmid","19033717"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9330"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18030"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","0301-1569"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Transoral Laser Microsurgery for Carcinoma in situ of the Glottic Larynx"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.volume","184"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Overbeck, Tobias R."],["dc.contributor.author","Roedel, Ralf M. W."],["dc.contributor.author","Hermann, Robert Michael"],["dc.contributor.author","Herrmann, M."],["dc.contributor.author","Kertesz, Tereza"],["dc.contributor.author","Vorwerk, Hilke"],["dc.contributor.author","Hille, Andrea"],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Hess, C. F."],["dc.contributor.author","Christiansen, H."],["dc.date.accessioned","2018-11-07T11:15:52Z"],["dc.date.available","2018-11-07T11:15:52Z"],["dc.date.issued","2008"],["dc.format.extent","134"],["dc.identifier.isi","000255034700367"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54464"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.conference","14th Annual Congress of the Deutschen-Gesellschaft-fur-Radioonkologie/25th Annual Conference of the Osterreichischen-Gesellschaft-fur-Radioonkologie-Radiobiologie-und-Mediz inische-Radiophysik"],["dc.relation.eventlocation","Vienna, AUSTRIA"],["dc.relation.issn","0179-7158"],["dc.title","Effectiveness and toxicity of low dose, daily cisplatine-application (6 mg/m2 body surface) for the combined radiochemotherapy of local advanced head-throat-tumor"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","145"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Radiation and Environmental Biophysics"],["dc.bibliographiccitation.lastpage","154"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Rolke, David"],["dc.contributor.author","Rave-Fraenk, Margret"],["dc.contributor.author","Schirmer, Markus"],["dc.contributor.author","Eicheler, Wolfgang"],["dc.contributor.author","Doerfler, Annegret"],["dc.contributor.author","Hille, Andrea"],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Roedel, Ralf M. W."],["dc.contributor.author","Christiansen, Hans"],["dc.date.accessioned","2018-11-07T08:58:47Z"],["dc.date.available","2018-11-07T08:58:47Z"],["dc.date.issued","2011"],["dc.description.abstract","The purpose of this work was to analyze chemokine and chemokine receptor expression in untreated and in irradiated squamous cell carcinoma of the head and neck (SCCHN) tumor cell lines, aiming at the establishment of assays to test for the relevance of chemokine and chemokine receptor expression in the response of SCCHN to radiotherapy and radiochemotherapy. Five low passage and 10 established SCCHN lines, as well as two normal cell lines, were irradiated at 2 Gy or sham-irradiated, and harvested between 1 and 48 h after treatment. For chemokines with CC and CXC structural motifs and their receptors, transcript levels of target and reference genes were quantified relatively by real-time PCR. In addition, CXCL1 and CXCL12 protein expression was analyzed by ELISA. A substantial variation in chemokine and chemokine receptor expression between SCCHN was detected. Practically, all cell lines expressed CCL5 and CCL20, while CCL2 was expressed in normal cells and in some of the tumor cell lines. CXCL1, CXCL2, CXCL3, CXCL10, and CXCL11 were expressed in the vast majority of the cell lines, while the expression of CXCL9 and CXCL12 was restricted to fibroblasts and few tumor cell lines. None of the analyzed cell lines expressed the chemokines CCL3, CCL4, or CCL19. Of the receptors, transcript expression of CCR1, CCR2, CCR3, CCR5, CCR7, CCXR2, and CCXR3 was not detected, and CCR6, CXCR1, and CXCR4 expression was restricted to few tumor cells. Radiation caused up- and down-regulation with respect to chemokine expressions, while for chemokine receptor expressions down-regulations were prevailing. CXCL1 and CXCL12 protein expression corresponded well with the mRNA expression. We conclude that the substantial variation in chemokine and chemokine receptor expression between SCCHN offer opportunities for the establishment of assays to test for the relevance of chemokine and chemokine receptor expression in the response of SCCHN to radiotherapy and radiochemotherapy."],["dc.identifier.doi","10.1007/s00411-010-0341-x"],["dc.identifier.isi","000287512400013"],["dc.identifier.pmid","21085979"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6619"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23728"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0301-634X"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Analysis of chemokine and chemokine receptor expression in squamous cell carcinoma of the head and neck (SCCHN) cell lines"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.volume","186"],["dc.contributor.author","Christiansen, H."],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Bosch, Jan"],["dc.contributor.author","Jung, K."],["dc.contributor.author","Overbeck, Tobias R."],["dc.contributor.author","Herrmann, M. K. A."],["dc.contributor.author","Hennies, Steffen"],["dc.contributor.author","Vorwerk, Hilke"],["dc.contributor.author","Hille, Andrea"],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Roedel, Ralf M. W."],["dc.date.accessioned","2018-11-07T08:43:05Z"],["dc.date.available","2018-11-07T08:43:05Z"],["dc.date.issued","2010"],["dc.format.extent","127"],["dc.identifier.isi","000278071200346"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19871"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.conference","16th Annual Meeting of the German-Society-of-Radio-Oncology"],["dc.relation.eventlocation","Magdeburg, GERMANY"],["dc.relation.issn","0179-7158"],["dc.title","Higher grade acute organ toxicity (fflCTC grade 3) during preoperative radio (chemo) therapy as a prognostic factor in patients with local advanced, inoperable squamous cell carcinoma of the head and neck area (oral cavity, oropharynx, larynx, hypopharynx)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Strahlentherapie und Onkologie"],["dc.bibliographiccitation.volume","187"],["dc.contributor.author","Rolke, D."],["dc.contributor.author","Rave-Fraenk, Margret"],["dc.contributor.author","Schirmer, Markus Anton"],["dc.contributor.author","Eichler, W."],["dc.contributor.author","Hille, Andrea"],["dc.contributor.author","Hess, C. F."],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Roedel, Ralf M. W."],["dc.contributor.author","Christiansen, H."],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.date.accessioned","2018-11-07T08:55:27Z"],["dc.date.available","2018-11-07T08:55:27Z"],["dc.date.issued","2011"],["dc.format.extent","24"],["dc.identifier.isi","000291236200060"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22908"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.conference","17th Annual Meeting of the German-Society-for-Radiation-Oncology"],["dc.relation.eventlocation","Wiesbaden, GERMANY"],["dc.relation.issn","0179-7158"],["dc.title","Analysis of the Expression of Chemokines and Chemokine receptors in Head and Neck Tumor cells (SCCHN)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1600"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","International Journal of Radiation Oncology*Biology*Physics"],["dc.bibliographiccitation.lastpage","1601"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Christiansen, Hans"],["dc.contributor.author","Wolfe, Hendrik A."],["dc.contributor.author","Roedel, Ralf M. W."],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.date.accessioned","2018-11-07T08:44:33Z"],["dc.date.available","2018-11-07T08:44:33Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1016/j.ijrobp.2009.12.014"],["dc.identifier.isi","000276675300050"],["dc.identifier.pmid","20338485"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20225"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","0360-3016"],["dc.title","HYPERBARIC OXYGEN THERAPY FOR LATE RADIATION-ASSOCIATED TISSUE NECROSES: IS IT SAFE IN PATIENTS WITH LOCOREGIONALLY RECURRENT AND THEN SUCCESSFULLY SALVAGED HEAD-AND-NECK CANCERS? (INT J RADIAT ONCOL BIOL PHYS 2009;74:1077-1082)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","340"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Auris Nasus Larynx"],["dc.bibliographiccitation.lastpage","346"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Roedel, Ralf M. W."],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Christiansen, Hans"],["dc.date.accessioned","2018-11-07T08:42:27Z"],["dc.date.available","2018-11-07T08:42:27Z"],["dc.date.issued","2010"],["dc.description.abstract","Objectives: To analyze the oncological results of repeated transoral laser microresection (TLM) in case of failure after primary laser resection of early glottic cancer (pTis-pT2). Methods: Fifty-six patients with local or loco-regional recurrence of early glottic cancer were treated between 1988 and 2005 by repeated TLM followed, if necessary, by neck dissection and/or adjuvant radio- or radiochemotherapy. Data on overall survival, disease-specific survival, and loco-regional control rates were analyzed retrospectively and calculated by the Kaplan-Meier method. Results: Forty-four patients (78.6%) presented with early local recurrence (rTis-rT2N0; Stage I/II) and 12 patients (21.4%) had advanced local or loco-regional recurrence (pT3 and pT4N0/N+; Stage III/IV). Three- and five-year overall survival rates for patients with early and advanced recurrence were 75.1% vs. 51.6% and 61.6% vs. 25.8%, respectively. The corresponding three- and five-year disease-specific survival rates were 87.2% vs. 85.7% and 81.0% vs. 85.7%, respectively. Three- and five-year loco-regional control was significantly higher for patients treated for early recurrence (67.6% vs. 27.5% and 63.6% vs. 27.5%, respectively; p = 0.02). Salvage laryngectomy rates for patients with early and advanced recurrence were 9.1 and 25.0%, respectively. In patients with early local recurrence, anterior commissure involvement (n = 11) did not affect the oncological results. Conclusions: In case of early local recurrence after primary TLM of early glottic cancer, further TLM seems to be justified as an organ-preserving treatment option. In contrast, salvage laryngectomy should be considered early for patients with advanced local or loco-regional recurrence. (C) 2009 Elsevier Ireland Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.anl.2009.07.004"],["dc.identifier.isi","000276542900013"],["dc.identifier.pmid","19700251"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19704"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","0385-8146"],["dc.title","Repeated transoral laser microsurgery for early and advanced recurrence of early glottic cancer after primary laser resection"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]