Schminke, Boris

[["dc.bibliographiccitation.firstpage","216"],["dc.bibliographiccitation.journal","Archives of Oral Biology"],["dc.bibliographiccitation.lastpage","222"],["dc.bibliographiccitation.volume","82"],["dc.contributor.author","Schubert, Andrea"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Miosge, Nicolai"],["dc.date.accessioned","2018-08-20T09:31:36Z"],["dc.date.available","2018-08-20T09:31:36Z"],["dc.date.issued","2017"],["dc.description.abstract","Periodontitis refers to inflammatory disease of the periodontal structures (the gingiva, dental cementum, periodontal ligament (PDL) and alveolar bone) that ultimately leads to their destruction. Whereas collagens are well-examined main components of the periodontium, little is known about the other structural proteins that make up this tissue. The aim of this study was to identify new extracellular matrix (ECM) components, including fibulins and matrilins, in the periodontium of mice. After sacrificing 14 mice (Sv/129 strain), jaws were prepared. Each tissue sample contained a molar and its surrounding alveolar bone. Immunohistochemistry was carried out on paraffin-embedded sections. Our results show that mice exhibit fibulin-3, -4 and -5 and matrilin-1, -2, -3 and -4 in PDL and in blood vessels of alveolar bone and PDL as well as in the pericellular matrix of osteocytes and cementocytes. In dental cementum, only fibulin-4 is expressed. For the first time, we show that fibulin-3, -4 and -5 and matrilin-1, -2, -3 and -4 are essential components of the periodontal tissues. Our findings indicate an association of these proteins with collagens and oxytalan fibers that might be of future interest in regenerative periodontitis therapy."],["dc.identifier.doi","10.1016/j.archoralbio.2017.06.008"],["dc.identifier.pmid","28654783"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16485"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15410"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","1879-1506"],["dc.relation.eissn","0003-9969"],["dc.rights","CC BY-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nd/4.0"],["dc.title","Fibulins and matrilins are novel structural components of the periodontium in the mouse"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","18"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Maxillofacial Plastic and Reconstructive Surgery"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Cordesmeyer, Robert"],["dc.contributor.author","Fouellefack, Giséle Awondzeko"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Wiese, Karl-Günther"],["dc.date.accessioned","2019-07-09T11:45:43Z"],["dc.date.available","2019-07-09T11:45:43Z"],["dc.date.issued","2018"],["dc.description.abstract","Background: Clefts in newborns are associated with severe morphological and functional impairment. Especially the lip is of importance as if the treatment result is unsatisfactory, it can lead to psychological changes in the patient. Different operative procedures have been developed over the last decades. The aim of the presented study was the comparison of the surgical techniques according to Millard and Pfeifer regarding the temporal development of the postoperative symmetry of the lip height and mouth width. Methods: Digitized photographs of patients from the department of oral and maxillofacial surgery at the University of Göttingen were evaluated from 1979 to 1996. With a video analysis program, the lip height and mouth width were analyzed regarding the symmetry. We demonstrated the symmetry values over a period of 8 years in order to show the influence of growth on postoperative results. Results: The development of the vertical symmetry of the Philtrum and the lip vermillion on the cleft side in comparison to the healthy side behaves differently depending on Pfeifer and Millard. The lip height of the cleft lip was shorter in both techniques than on the healthy side, but Pfeifer's difference was significantly more pronounced. The lip vermillion height on the cleft side was slightly shorter in the Millard group and markedly larger in the Pfeifer group. Both techniques can achieve good symmetry results for the vertical dimension of the lip. According to Pfeifer, the development of the horizontal dimension on the cleft side is bigger within the first 4 years than on the healthy side; according to the Millard technique, the horizontal development is smaller. These differences are greater within the first 6 years and approach between the 6th and 8th year. Conclusions: The Millard technique demonstrates better results concerning the philtrum and vermillion symmetry during growth within the first 6 years. Over the whole study period, growth corrects the philtrum and vermillion symmetry within the Pfeifer group."],["dc.identifier.doi","10.1186/s40902-018-0157-1"],["dc.identifier.pmid","30105221"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15255"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59294"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","In goescholar not merged with http://resolver.sub.uni-goettingen.de/purl?gs-1/15294 but duplicate"],["dc.relation.issn","2288-8101"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)."],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Postoperative long-term results for the comparison of the symmetry of the upper lip during lip closure according to Millard and Pfeifer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","440"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Journal of Immunology"],["dc.bibliographiccitation.lastpage","445"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Trautmann, Sandra"],["dc.contributor.author","Mai, Burkhard"],["dc.contributor.author","Miosge, Nicolai"],["dc.contributor.author","Blaschke, Sabine"],["dc.date.accessioned","2018-08-20T12:24:05Z"],["dc.date.available","2018-08-20T12:24:05Z"],["dc.date.issued","2016"],["dc.description.abstract","Mesenchymal stem cells are known to exert immunomodulatory effects in inflammatory diseases. Immuneregulatory cells lead to progressive joint destruction in rheumatoid arthritis (RA). Proinflammatory cytokines, such as tumour necrosis factor α (TNF-α) and interleukins (ILs) are the main players. Here, we studied progenitor cells from RA cartilage (RA-CPCs) that are positive for IL-17 receptors to determinate the effects of inflammation on their chondrogenic potenial. IL-17A/F reduced the chondrogenic potential of these cells via the upregulation of RUNX2 protein and enhanced IL-6 protein and MMP3 mRNA levels. Blocking antibodies against IL-17 positively influenced their repair potential. Furthermore, treating the RA-CPCs with the anti-human IL-17 antibody secukinumab or the anti-TNF-α antibody adalimumab reduced the proinflammatory IL-6 protein level and positively influenced the secretion of anti-inflammatory IL-10 protein. Additionally, adalimumab and secukinumab in particular reduced RUNX2 protein to promote chondrogenesis. The amelioration of inflammation, particularly via IL-17 antagonism, might be a new therapeutic approach for enhancing intrinsic cartilage repair mechanisms in RA patients."],["dc.identifier.doi","10.1002/eji.201545910"],["dc.identifier.pmid","26558442"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14042"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15432"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","1521-4141"],["dc.relation.eissn","0014-2980"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Interleukin 17 inhibits progenitor cells in rheumatoid arthritis cartilage"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","789"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Stem Cell Reports"],["dc.bibliographiccitation.lastpage","803"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Muhammad, Hayat"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Bode, Christa"],["dc.contributor.author","Roth, Moritz"],["dc.contributor.author","Albert, Julius"],["dc.contributor.author","von der Heyde, Silvia"],["dc.contributor.author","Rosen, Vicki"],["dc.contributor.author","Miosge, Nicolai"],["dc.date.accessioned","2018-08-20T12:45:38Z"],["dc.date.available","2018-08-20T12:45:38Z"],["dc.date.issued","2014"],["dc.description.abstract","Degeneration of the knee joint during osteoarthritis often begins with meniscal lesions. Meniscectomy, previously performed extensively after meniscal injury, is now obsolete because of the inevitable osteoarthritis that occurs following this procedure. Clinically, meniscus self-renewal is well documented as long as the outer, vascularized meniscal ring remains intact. In contrast, regeneration of the inner, avascular meniscus does not occur. Here, we show that cartilage tissue harvested from the avascular inner human meniscus during the late stages of osteoarthritis harbors a unique progenitor cell population. These meniscus progenitor cells (MPCs) are clonogenic and multipotent and exhibit migratory activity. We also determined that MPCs are likely to be controlled by canonical transforming growth factor β (TGF-β) signaling that leads to an increase in SOX9 and a decrease in RUNX2, thereby enhancing the chondrogenic potential of MPC. Therefore, our work is relevant for the development of novel cell biological, regenerative therapies for meniscus repair."],["dc.identifier.doi","10.1016/j.stemcr.2014.08.010"],["dc.identifier.pmid","25418724"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11350"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15440"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","2213-6711"],["dc.rights","CC BY-NC-ND 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/3.0"],["dc.title","Human Migratory Meniscus Progenitor Cells Are Controlled via the TGF-β Pathway"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","100300"],["dc.bibliographiccitation.journal","Bone Reports"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Rau, Anna"],["dc.contributor.author","Seidlová-Wuttke, Dana"],["dc.contributor.author","Jarry, Hubertus"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Matthes, Swantje"],["dc.contributor.author","Wiese, Karl Günter"],["dc.date.accessioned","2021-06-01T10:49:27Z"],["dc.date.available","2021-06-01T10:49:27Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.bonr.2020.100300"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17500"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86297"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2352-1872"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Effect of dihydrotestosterone, 17-β-estrogen, genistein and equol on remodeling and morphology of bone in osteoporotic male rats during bone healing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]