Tsikolia, Nikoloz

[["dc.bibliographiccitation.artnumber","e0275164"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","PLOS ONE"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Petri, Natalia"],["dc.contributor.author","Nordbrink, Rhea"],["dc.contributor.author","Tsikolia, Nikoloz"],["dc.contributor.author","Kremnyov, Stanislav"],["dc.contributor.editor","Brand, Thomas"],["dc.date.accessioned","2022-12-01T08:31:27Z"],["dc.date.available","2022-12-01T08:31:27Z"],["dc.date.issued","2022"],["dc.description.abstract","Left-right symmetry breaking in most studied vertebrates makes use of so-called leftward flow, a mechanism which was studied in detail especially in mouse and\r\n Xenopus laevis\r\n embryos and is based on rotation of monocilia on specialized epithelial surface designated as left-right organizer or laterality coordinator. However, it has been argued that prior to emergence of leftward flow an additional mechanism operates during early cleavage stages in\r\n Xenopus\r\n embryo which is based on cytoskeletal processes. Evidence in favour of this early mechanism was supported by left-right abnormalities after chemical inhibition of cytoskeletal protein formin. Here we analyzed temporal dimension of this effect in detail and found that reported abnormalities arise only after treatment at gastrula-neurula stages, i.e. just prior to and during the operation of left-right organizer. Moreover, molecular and morphological analysis of the left-right organizer reveals its abnormal development. Our results strongly indicate that left-right abnormalities reported after formin inhibition cannot serve as support of models based on early symmetry breaking event in\r\n Xenopus\r\n embryo."],["dc.description.sponsorship"," Lomonosov Moscow State University http://dx.doi.org/10.13039/501100016971"],["dc.description.sponsorship"," Koltzov Institute of Developmental Biology, Russian Academy of Sciences http://dx.doi.org/10.13039/501100014785"],["dc.description.sponsorship","Göttingen University"],["dc.identifier.doi","10.1371/journal.pone.0275164"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/118169"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.eissn","1932-6203"],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Abnormal left-right organizer and laterality defects in Xenopus embryos after formin inhibitor SMIFH2 treatment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","4"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","EvoDevo"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Kremnyov, Stanislav"],["dc.contributor.author","Viebahn, Christoph"],["dc.contributor.author","Tsikolia, Nikoloz"],["dc.contributor.author","Henningfeld, Kristine A."],["dc.date.accessioned","2018-04-18T14:43:20Z"],["dc.date.accessioned","2021-10-27T13:21:04Z"],["dc.date.available","2018-04-18T14:43:20Z"],["dc.date.available","2021-10-27T13:21:04Z"],["dc.date.issued","2018-01-31"],["dc.date.updated","2018-04-18T14:43:20Z"],["dc.description.abstract","Abstract Background The notochord has organizer properties and is required for floor plate induction and dorsoventral patterning of the neural tube. This activity has been attributed to sonic hedgehog (shh) signaling, which originates in the notochord, forms a gradient, and autoinduces shh expression in the floor plate. However, reported data are inconsistent and the spatiotemporal development of the relevant shh expression domains has not been studied in detail. We therefore studied the expression dynamics of shh in rabbit, chicken and Xenopus laevis embryos (as well as indian hedgehog and desert hedgehog as possible alternative functional candidates in the chicken). Results Our analysis reveals a markedly divergent pattern within these vertebrates: whereas in the rabbit shh is first expressed in the notochord and its floor plate domain is then induced during subsequent somitogenesis stages, in the chick embryo shh is expressed in the prospective neuroectoderm prior to the notochord formation and, interestingly, prior to mesoderm immigration. Neither indian hedgehog nor desert hedgehog are expressed in these midline structures although mRNA of both genes was detected in other structures of the early chick embryo. In X. laevis, shh is expressed at the beginning of gastrulation in a distinct area dorsal to the dorsal blastopore lip and adjacent to the prospective neuroectoderm, whereas the floor plate expresses shh at the end of gastrulation. Conclusions While shh expression patterns in rabbit and X. laevis embryos are roughly compatible with the classical view of “ventral to dorsal induction” of the floor plate, the early shh expression in the chick floor plate challenges this model. Intriguingly, this alternative sequence of domain induction is related to the asymmetrical morphogenesis of the primitive node and other axial organs in the chick. Our results indicate that the floor plate in X. laevis and chick embryos may be initially induced by planar interaction within the ectoderm or epiblast. Furthermore, we propose that the mode of the floor plate induction adapts to the variant topography of interacting tissues during gastrulation and notochord formation and thereby reveals evolutionary plasticity of early embryonic induction."],["dc.identifier.doi","10.1186/s13227-017-0090-x"],["dc.identifier.pmid","29423139"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15170"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91992"],["dc.language.iso","en"],["dc.language.rfc3066","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","2041-9139"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Divergent axial morphogenesis and early shh expression in vertebrate prospective floor plate"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","92"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Development (Cambridge)"],["dc.bibliographiccitation.lastpage","98"],["dc.bibliographiccitation.volume","142"],["dc.contributor.author","Stankova, Viktoria"],["dc.contributor.author","Tsikolia, Nikoloz"],["dc.contributor.author","Viebahn, Christoph"],["dc.date.accessioned","2021-06-01T10:48:14Z"],["dc.date.available","2021-06-01T10:48:14Z"],["dc.date.issued","2015"],["dc.description.abstract","During animal gastrulation, the specification of the embryonic axes is accompanied by epithelio-mesenchymal transition (EMT), the first major change in cell shape after fertilization. EMT takes place in disparate topographical arrangements, such as the circular blastopore of amphibians, the straight primitive streak of birds and mammals or in intermediate gastrulation forms of other amniotes such as reptiles. Planar cell movements are prime candidates to arrange specific modes of gastrulation but there is no consensus view on their role in different vertebrate classes. Here, we test the impact of interfering with Rho kinase-mediated cell movements on gastrulation topography in blastocysts of the rabbit, which has a flat embryonic disc typical for most mammals. Time-lapse video microscopy, electron microscopy, gene expression and morphometric analyses of the effect of inhibiting ROCK activity showed – besides normal specification of the organizer region – a dose-dependent disruption of primitive streak formation; this disruption resulted in circular, arc-shaped or intermediate forms, reminiscent of those found in amphibians, fishes and reptiles. Our results reveal a crucial role of ROCK-controlled directional cell movements during rabbit primitive streak formation and highlight the possibility that temporal and spatial modulation of cell movements were instrumental for the evolution of gastrulation forms."],["dc.identifier.doi","10.1242/dev.111583"],["dc.identifier.isi","000348240500014"],["dc.identifier.pmid","25516971"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85863"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.eissn","1477-9129"],["dc.relation.issn","0950-1991"],["dc.title","Rho kinase activity controls directional cell movements during primitive streak formation in the rabbit embryo"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","614"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Genesis"],["dc.bibliographiccitation.lastpage","625"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Otto, Annalena"],["dc.contributor.author","Pieper, Tobias"],["dc.contributor.author","Viebahn, Christoph"],["dc.contributor.author","Tsikolia, Nikoloz"],["dc.date.accessioned","2018-11-07T09:39:17Z"],["dc.date.available","2018-11-07T09:39:17Z"],["dc.date.issued","2014"],["dc.description.abstract","The primitive node is the \"hub\" of early left-right patterning in the chick embryo: (1) it undergoes asymmetrical morphogenesis immediately after its appearance at Stage 4; (2) it is closely linked to the emerging asymmetrical expression of nodal and shh at Stage 5; and (3) its asymmetry is spatiotemporally related to the emerging notochord, the midline barrier maintaining molecular left-right patterning from Stage 6 onward. Here, we study the correlation of node asymmetry to notochord marker expression using high-resolution histology, and we test pharmacological inhibition of shh signaling using cyclopamine at Stages 4 and 5. Just as noggin expression mirrors an intriguing structural continuity between the right node shoulder and the notochord, shh expression in the left node shoulder confirms a similar continuity with the future floor plate. Shh inhibition at Stage 4 or 5 suppressed nodal in both its paraxial or lateral plate mesoderm domains, respectively, and resulted in randomized heart looping. Thus, the \"primordial\" paraxial nodal asymmetry at Stage 4/5 (1) appears to be dependent on, but not instructed by, shh signaling and (2) may be fixed by asymmetrical roots of the notochord and the floor plate, thereby adding further twists to the node's pivotal role during left-right patterning. (C) 2014 Wiley Periodicals, Inc."],["dc.identifier.doi","10.1002/dvg.22773"],["dc.identifier.isi","000338011500016"],["dc.identifier.pmid","24648137"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33245"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1526-968X"],["dc.relation.issn","1526-954X"],["dc.title","Early Left-Right Asymmetries During Axial Morphogenesis in the Chick Embryo"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","957211"],["dc.bibliographiccitation.journal","Frontiers in Cell and Developmental Biology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.affiliation","Negretti, Maria Isabella; \r\n1\r\nAnatomy and Embryology, University Medical Center Göttingen, Göttingen, Germany"],["dc.contributor.affiliation","Böse, Nina; \r\n1\r\nAnatomy and Embryology, University Medical Center Göttingen, Göttingen, Germany"],["dc.contributor.affiliation","Petri, Natalia; \r\n2\r\nDepartment of Embryology, Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia"],["dc.contributor.affiliation","Kremnyov, Stanislav; \r\n2\r\nDepartment of Embryology, Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia"],["dc.contributor.affiliation","Tsikolia, Nikoloz; \r\n1\r\nAnatomy and Embryology, University Medical Center Göttingen, Göttingen, Germany"],["dc.contributor.author","Negretti, Maria Isabella"],["dc.contributor.author","Böse, Nina"],["dc.contributor.author","Petri, Natalia"],["dc.contributor.author","Kremnyov, Stanislav"],["dc.contributor.author","Tsikolia, Nikoloz"],["dc.date.accessioned","2022-10-04T10:21:48Z"],["dc.date.available","2022-10-04T10:21:48Z"],["dc.date.issued","2022"],["dc.date.updated","2022-11-11T13:13:24Z"],["dc.description.abstract","Development of visceral left–right asymmetry in bilateria is based on initial symmetry breaking followed by subsequent asymmetric molecular patterning. An important step is the left-sided expression of transcription factor\r\n pitx2\r\n which is mediated by asymmetric expression of the\r\n nodal\r\n morphogen in the left lateral plate mesoderm of vertebrates. Processes leading to emergence of the asymmetric\r\n nodal\r\n domain differ depending on the mode of symmetry breaking. In\r\n Xenopus laevis\r\n and mouse embryos, the leftward fluid flow on the ventral surface of the left–right organizer leads through intermediate steps to enhanced activity of the nodal protein on the left side of the organizer and subsequent asymmetric\r\n nodal\r\n induction in the lateral plate mesoderm. In the chick embryo, asymmetric morphogenesis of axial organs leads to paraxial\r\n nodal\r\n asymmetry during the late gastrulation stage. Although it was shown that hedgehog signaling is required for initiation of the\r\n nodal\r\n expression, the mechanism of its asymmetry remains to be clarified. In this study, we established the activation of hedgehog signaling in early chick embryos to further study its role in the initiation of asymmetric\r\n nodal\r\n expression. Our data reveal that hedgehog signaling is sufficient to induce the\r\n nodal\r\n expression in competent domains of the chick embryo, while treatment of\r\n Xenopus\r\n embryos led to moderate\r\n nodal\r\n inhibition. We discuss the role of symmetry breaking and competence in the initiation of asymmetric gene expression."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.3389/fcell.2022.957211"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114505"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-600"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","2296-634X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Nodal asymmetry and hedgehog signaling during vertebrate left–right symmetry breaking"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","309"],["dc.bibliographiccitation.lastpage","317"],["dc.bibliographiccitation.seriesnr","1650"],["dc.contributor.author","Sydow, Hans-Georg"],["dc.contributor.author","Pieper, Tobias Karl"],["dc.contributor.author","Viebahn, Christoph"],["dc.contributor.author","Tsikolia, Nikoloz"],["dc.contributor.editor","Sheng, G."],["dc.date.accessioned","2019-11-11T12:47:47Z"],["dc.date.available","2019-11-11T12:47:47Z"],["dc.date.issued","2017"],["dc.description.abstract","Appropriate mechanical tension of the vitelline membrane as the culture substrate for the early chick embryo is frequently reported to be required for successful in vitro development. Here we describe a modified device, made of anodized aluminum, for in vitro culture which we used for studies of left-right symmetry breaking with emphasis on morphology and gene expression as readouts. The technique allows for easy, high-throughput tissue handling and provides a suitable tension in a stable and easily reproducible manner proven to be suitable for correct molecular left-right patterning and heart looping after long-term culture."],["dc.identifier.doi","10.1007/978-1-4939-7216-6_21"],["dc.identifier.pmid","28809031"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62594"],["dc.language.iso","en"],["dc.relation.crisseries","Methods in Molecular Biology"],["dc.relation.doi","10.1007/978-1-4939-7216-6"],["dc.relation.eissn","1940-6029"],["dc.relation.isbn","978-1-4939-7215-9"],["dc.relation.isbn","978-1-4939-7216-6"],["dc.relation.ispartof","Avian and Reptilian Developmental Biology"],["dc.relation.ispartofseries","Methods in molecular biology;1650"],["dc.relation.issn","1064-3745"],["dc.relation.issn","1940-6029"],["dc.title","An Early Chick Embryo Culture Device for Extended Continuous Observation"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","131"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Progress in Histochemistry and Cytochemistry"],["dc.bibliographiccitation.lastpage","184"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Merkwitz, Claudia"],["dc.contributor.author","Lochhead, Paul"],["dc.contributor.author","Tsikolia, Nika"],["dc.contributor.author","Koch, Daniela"],["dc.contributor.author","Sygnecka, Katja"],["dc.contributor.author","Sakurai, Michiharu"],["dc.contributor.author","Spanel-Borowski, Katharina"],["dc.contributor.author","Ricken, Albert M."],["dc.date.accessioned","2018-11-07T09:01:59Z"],["dc.date.available","2018-11-07T09:01:59Z"],["dc.date.issued","2011"],["dc.description.abstract","KIT is a type III receptor protein tyrosine kinase, and KITL its cognate ligand. KIT can mediate its effects via several intracellular signalling pathways, or by formation of a cell-cell anchor with its ligand. Through these mechanisms, KIT controls fundamental cellular processes, including migration, proliferation, differentiation and survival. These cellular processes are modulated by soluble KIT, a cleavage product of KIT, generated at the cell membrane. A cell-retained KIT cleavage fragment also arises from this cleavage event. This cleavage fragment must be distinguished from truncated KIT (trKIT), which originates through cryptic promoter usage. The expression of trKIT is highly restricted to postmeiotic germ cells in the testis. In contrast, KIT, together with its cleavage products, is present in somatic cells and germ cells in the gonads of both sexes. A functional KITL/KIT system is mandatory for normal population of the gonads by germ cells. Signalling via the KITL/KIT system promotes the growth. maturation, and survival of germ cells within the gonads, and prevents meiotic entry and progression. In addition to its importance in germ cell biology, the KITL/KIT system is crucial for gonadal stromal differentiation. During foetal life, KIT is expressed by testicular stromal precursor cells, which develop into Leydig cells. In the ovary. stromal cell KIT expression accompanies theca layer development around advanced follicles. After ovulation, KIT-immunopositive cells translocate from the theca layer to the luteal ganulosa where they contribute to a delicate cellular network that extends between the fully luteinised large luteal cells. In the outer regions of the developing corpus luteum, a highly conspicuous subpopulation of KIT/CD14-double-immunopositive cells can be observed. KIT/CD14-double-immunopositive cells are also seen in the haematopoietic-like colonies of long-term granulosa cultures established from late antral follicles. These cultures demonstrate expression of pluripotency marker genes such as octamer binding transcription factor-3/4 and sex determining region Y-box 2. The KIT/CD14-double-immunopositive cells can be purified and enriched by KIT-immunopositive magnetic cell sorting. Subsequent exposure of the KIT-expressing cells to the hanging drop culture method, combined with haematopoietic differentiation medium, provides the signals necessary for their differentiation into endothelial and steroidogenic cells. This suggests that monocyte-derived multipotent cells are involved in ovarian tissue remodelling. In summary, multicelluar KITL/KIT signalling organizes the stroma in the ovary and testis; nnonocyte-derived multipotent cells may be involved. (C) 2011 Elsevier GmbH. All rights reserved."],["dc.identifier.doi","10.1016/j.proghi.2011.09.001"],["dc.identifier.isi","000297563200001"],["dc.identifier.pmid","21962837"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24566"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.relation.issn","0079-6336"],["dc.title","Expression of KIT in the ovary, and the role of somatic precursor cells"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1010"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Anatomy"],["dc.bibliographiccitation.lastpage","1022"],["dc.bibliographiccitation.volume","238"],["dc.contributor.author","Schäfer, Tobias"],["dc.contributor.author","Stankova, Viktoria"],["dc.contributor.author","Viebahn, Christoph"],["dc.contributor.author","Bakker, Bernadette"],["dc.contributor.author","Tsikolia, Nikoloz"],["dc.date.accessioned","2021-04-14T08:31:28Z"],["dc.date.available","2021-04-14T08:31:28Z"],["dc.date.issued","2020"],["dc.description.abstract","Abstract Bilaterally symmetrical primordia of visceral organs undergo asymmetrical morphogenesis leading to typical arrangement of visceral organs in the adult. Asymmetrical morphogenesis within the upper abdomen leads, among others, to the formation of the omental bursa dorsally to the rotated stomach. A widespread view of this process assumes kinking of thin mesenteries as a main mechanism. This view is based on a theory proposed already by Johannes Müller in 1830 and was repeatedly criticized, but some of the most plausible alternative views (initially proposed by Swaen in 1897 and Broman in 1904) still remain to be proven. Here, we analyzed serial histological sections of human embryos between stages 12 and 15 at high light microscopical resolution to reveal the succession of events giving rise to the development of the omental bursa and its relation to the emerging stomach asymmetry. Our analysis indicates that morphological symmetry breaking in the upper abdomen occurs within a wide mesenchymal plate called here mesenteric septum and is based on differential behavior of the coelomic epithelium which causes asymmetric paragastric recess formation and, importantly, precedes initial rotation of stomach. Our results thus provide the first histological evidence of breaking the symmetry of the early foregut anlage in the human embryo and pave the way for experimental studies of left‐right symmetry breaking in the upper abdomen in experimental model organisms."],["dc.description.sponsorship","De Snoo – van ’t Hoogerhuijs Foundation"],["dc.identifier.doi","10.1111/joa.13344"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83606"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1469-7580"],["dc.relation.issn","0021-8782"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made."],["dc.title","Initial morphological symmetry breaking in the foregut and development of the omental bursa in human embryos"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Mechanisms of Development"],["dc.bibliographiccitation.volume","145"],["dc.contributor.author","Pieper, Tobias Karl"],["dc.contributor.author","Carpaij, Meriam"],["dc.contributor.author","Sang, Helen"],["dc.contributor.author","Viebahn, Christoph"],["dc.contributor.author","Tsikolia, Nikoloz"],["dc.date.accessioned","2018-11-07T10:22:23Z"],["dc.date.available","2018-11-07T10:22:23Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.mod.2017.04.190"],["dc.identifier.isi","000402994800264"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42262"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Elsevier Science Bv"],["dc.publisher.place","Amsterdam"],["dc.relation.conference","18th International Congress of Developmental Biology"],["dc.relation.eventlocation","Natil Univ Singapore, Singapore, SINGAPORE"],["dc.title","Asymmetrical morphogenesis and microcavities in the axial mesoderm of the chick"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Mechanisms of Development"],["dc.bibliographiccitation.volume","145"],["dc.contributor.author","Tsikolia, Nikoloz"],["dc.contributor.author","Rulle, Alexander"],["dc.contributor.author","Behr, Rüdiger"],["dc.contributor.author","Viebahn, Christoph"],["dc.date.accessioned","2018-11-07T10:22:24Z"],["dc.date.available","2018-11-07T10:22:24Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.mod.2017.04.297"],["dc.identifier.isi","000402994800370"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42263"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Elsevier Science Bv"],["dc.publisher.place","Amsterdam"],["dc.relation.conference","18th International Congress of Developmental Biology"],["dc.relation.eventlocation","Natil Univ Singapore, Singapore, SINGAPORE"],["dc.title","Early left-sided nodal expression near the neurenteric canal of Callithrix jacchus supports flow-independent symmetry breaking in amniotes"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]