Tsikolia, Nikoloz

[["dc.bibliographiccitation.artnumber","957211"],["dc.bibliographiccitation.journal","Frontiers in Cell and Developmental Biology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.affiliation","Negretti, Maria Isabella; \r\n1\r\nAnatomy and Embryology, University Medical Center Göttingen, Göttingen, Germany"],["dc.contributor.affiliation","Böse, Nina; \r\n1\r\nAnatomy and Embryology, University Medical Center Göttingen, Göttingen, Germany"],["dc.contributor.affiliation","Petri, Natalia; \r\n2\r\nDepartment of Embryology, Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia"],["dc.contributor.affiliation","Kremnyov, Stanislav; \r\n2\r\nDepartment of Embryology, Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia"],["dc.contributor.affiliation","Tsikolia, Nikoloz; \r\n1\r\nAnatomy and Embryology, University Medical Center Göttingen, Göttingen, Germany"],["dc.contributor.author","Negretti, Maria Isabella"],["dc.contributor.author","Böse, Nina"],["dc.contributor.author","Petri, Natalia"],["dc.contributor.author","Kremnyov, Stanislav"],["dc.contributor.author","Tsikolia, Nikoloz"],["dc.date.accessioned","2022-10-04T10:21:48Z"],["dc.date.available","2022-10-04T10:21:48Z"],["dc.date.issued","2022"],["dc.date.updated","2022-11-11T13:13:24Z"],["dc.description.abstract","Development of visceral left–right asymmetry in bilateria is based on initial symmetry breaking followed by subsequent asymmetric molecular patterning. An important step is the left-sided expression of transcription factor\r\n pitx2\r\n which is mediated by asymmetric expression of the\r\n nodal\r\n morphogen in the left lateral plate mesoderm of vertebrates. Processes leading to emergence of the asymmetric\r\n nodal\r\n domain differ depending on the mode of symmetry breaking. In\r\n Xenopus laevis\r\n and mouse embryos, the leftward fluid flow on the ventral surface of the left–right organizer leads through intermediate steps to enhanced activity of the nodal protein on the left side of the organizer and subsequent asymmetric\r\n nodal\r\n induction in the lateral plate mesoderm. In the chick embryo, asymmetric morphogenesis of axial organs leads to paraxial\r\n nodal\r\n asymmetry during the late gastrulation stage. Although it was shown that hedgehog signaling is required for initiation of the\r\n nodal\r\n expression, the mechanism of its asymmetry remains to be clarified. In this study, we established the activation of hedgehog signaling in early chick embryos to further study its role in the initiation of asymmetric\r\n nodal\r\n expression. Our data reveal that hedgehog signaling is sufficient to induce the\r\n nodal\r\n expression in competent domains of the chick embryo, while treatment of\r\n Xenopus\r\n embryos led to moderate\r\n nodal\r\n inhibition. We discuss the role of symmetry breaking and competence in the initiation of asymmetric gene expression."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.3389/fcell.2022.957211"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114505"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-600"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","2296-634X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Nodal asymmetry and hedgehog signaling during vertebrate left–right symmetry breaking"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]