Otto, Markus

[["dc.bibliographiccitation.artnumber","alz.12790"],["dc.bibliographiccitation.journal","Alzheimer's & Dementia"],["dc.contributor.author","Oeckl, Patrick"],["dc.contributor.author","Anderl‐Straub, Sarah"],["dc.contributor.author","Danek, Adrian"],["dc.contributor.author","Diehl‐Schmid, Janine"],["dc.contributor.author","Fassbender, Klaus"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Halbgebauer, Steffen"],["dc.contributor.author","Huppertz, Hans‐Jürgen"],["dc.contributor.author","Jahn, Holger"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Otto, Markus"],["dc.contributor.authorgroup","for the FTLD Consortium"],["dc.date.accessioned","2022-10-04T10:21:38Z"],["dc.date.available","2022-10-04T10:21:38Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1002/alz.12790"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114461"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-600"],["dc.relation.eissn","1552-5279"],["dc.relation.issn","1552-5260"],["dc.title","Relationship of serum beta‐synuclein with blood biomarkers and brain atrophy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Neurochemistry"],["dc.bibliographiccitation.volume","138"],["dc.contributor.author","Straub, S."],["dc.contributor.author","Schroeter, M. L."],["dc.contributor.author","Diehl-Schmid, Janine"],["dc.contributor.author","Danek, A."],["dc.contributor.author","von Arnim, Christine A. F."],["dc.contributor.author","Bertram, L."],["dc.contributor.author","Einsiedler, B."],["dc.contributor.author","Fassbender, Klaus"],["dc.contributor.author","Feneberg, Emily"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Foerstl, Hans"],["dc.contributor.author","Huppertz, H-J"],["dc.contributor.author","Jahn, Holger"],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Kasper, E."],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Kestler, Hans A."],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Kubisch, C."],["dc.contributor.author","Landwehrmeyer, Bernhard"],["dc.contributor.author","Lauer, Martin"],["dc.contributor.author","Lausser, L."],["dc.contributor.author","Lill, C. M."],["dc.contributor.author","Ludolph, A."],["dc.contributor.author","Maler, M."],["dc.contributor.author","Muche, Rainer"],["dc.contributor.author","Pinkhardt, Elmar H."],["dc.contributor.author","Prudlo, Johannes"],["dc.contributor.author","Riedl, Lina"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Schomburg, R."],["dc.contributor.author","Teipel, Stefan J."],["dc.contributor.author","Uttner, Ingo"],["dc.contributor.author","Volk, Alexander E."],["dc.contributor.author","Otto, Markus"],["dc.date.accessioned","2018-11-07T10:10:49Z"],["dc.date.available","2018-11-07T10:10:49Z"],["dc.date.issued","2016"],["dc.format.extent","407"],["dc.identifier.isi","000382568400474"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39933"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","10th International Conference on Frontotemporal Dementias"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","1471-4159"],["dc.relation.issn","0022-3042"],["dc.title","Multivariate diagnostic approaches in Frontotemporal lobar degeneration Data from the german FTLDc"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Neurochemistry"],["dc.bibliographiccitation.volume","138"],["dc.contributor.author","Bisenius, Sandrine"],["dc.contributor.author","Mueller, K."],["dc.contributor.author","Diehl-Schmid, Janine"],["dc.contributor.author","Fassbender, Klaus"],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Stuke, K."],["dc.contributor.author","Danek, A."],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Schroeter, M. L."],["dc.date.accessioned","2018-11-07T10:10:48Z"],["dc.date.available","2018-11-07T10:10:48Z"],["dc.date.issued","2016"],["dc.format.extent","350"],["dc.identifier.isi","000382568400332"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39930"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","10th International Conference on Frontotemporal Dementias"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","1471-4159"],["dc.relation.issn","0022-3042"],["dc.title","Classifying primary progressive aphasias individually with support vector machine approaches in MRI data"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e1390"],["dc.bibliographiccitation.issue","15"],["dc.bibliographiccitation.journal","Neurology"],["dc.bibliographiccitation.lastpage","e1401"],["dc.bibliographiccitation.volume","91"],["dc.contributor.author","Steinacker, Petra"],["dc.contributor.author","Anderl-Straub, Sarah"],["dc.contributor.author","Diehl-Schmid, Janine"],["dc.contributor.author","Semler, Elisa"],["dc.contributor.author","Uttner, Ingo"],["dc.contributor.author","von Arnim, Christine A.F."],["dc.contributor.author","Barthel, Henryk"],["dc.contributor.author","Danek, Adrian"],["dc.contributor.author","Fassbender, Klaus"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Foerstl, Hans"],["dc.contributor.author","Grimmer, Timo"],["dc.contributor.author","Huppertz, Hans-Jürgen"],["dc.contributor.author","Jahn, Holger"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Landwehrmeyer, Bernhard"],["dc.contributor.author","Lauer, Martin"],["dc.contributor.author","Maler, Juan Manuel"],["dc.contributor.author","Mayer, Benjamin"],["dc.contributor.author","Oeckl, Patrick"],["dc.contributor.author","Prudlo, Johannes"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Volk, Alexander E."],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Schroeter, Matthias L."],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Otto, Markus"],["dc.date.accessioned","2020-12-10T18:41:45Z"],["dc.date.available","2020-12-10T18:41:45Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1212/WNL.0000000000006318"],["dc.identifier.eissn","1526-632X"],["dc.identifier.issn","0028-3878"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77663"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Serum neurofilament light chain in behavioral variant frontotemporal dementia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Alzheimer's & Dementia"],["dc.contributor.author","Lombardi, Jolina"],["dc.contributor.author","Mayer, Benjamin"],["dc.contributor.author","Semler, Elisa"],["dc.contributor.author","Anderl‐Straub, Sarah"],["dc.contributor.author","Uttner, Ingo"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Diehl‐Schmid, Janine"],["dc.contributor.author","Danek, Adrian"],["dc.contributor.author","Levin, Johannes"],["dc.contributor.author","Otto, Markus"],["dc.contributor.authorgroup","the FTLD consortium"],["dc.date.accessioned","2021-06-01T09:42:52Z"],["dc.date.available","2021-06-01T09:42:52Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1002/alz.12323"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85376"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1552-5279"],["dc.relation.issn","1552-5260"],["dc.title","Quantifying progression in primary progressive aphasia with structural neuroimaging"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","961"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Neurology"],["dc.bibliographiccitation.lastpage","969"],["dc.bibliographiccitation.volume","88"],["dc.contributor.author","Steinacker, Petra"],["dc.contributor.author","Semler, Elisa"],["dc.contributor.author","Anderl-Straub, Sarah"],["dc.contributor.author","Diehl-Schmid, Janine"],["dc.contributor.author","Schroeter, Matthias L."],["dc.contributor.author","Uttner, Ingo"],["dc.contributor.author","Foerstl, Hans"],["dc.contributor.author","Landwehrmeyer, Bernhard"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Oeckl, Patrick"],["dc.contributor.author","Huppertz, Hans-Jürgen"],["dc.contributor.author","Fassbender, Klaus"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Prudlo, Johannes"],["dc.contributor.author","Roßmeier, Carola"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Volk, Alexander E."],["dc.contributor.author","Lauer, Martin"],["dc.contributor.author","Danek, Adrian"],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","von Arnim, Christine A. F."],["dc.date.accessioned","2020-12-10T18:41:44Z"],["dc.date.available","2020-12-10T18:41:44Z"],["dc.date.issued","2017"],["dc.description.abstract","Objective: To assess the utility of serum neurofilament for diagnosis and monitoring of primary progressive aphasia (PPA) variants. Methods: We investigated neurofilament light chain (NF-L) levels in blood of 99 patients with PPA (40 with nonfluent variant PPA [nfvPPA], 38 with semantic variant PPA [svPPA], 21 with logopenic variant PPA [lvPPA]) and compared diagnostic performance with that reached by CSF NF-L, phosphorylated neurofilament heavy chain (pNF-H), b-amyloid (Ab(1)-42), tau, and phosphorylated tau. The longitudinal change of blood NF-L levels was measured and analyzed for correlation with functional decline and brain atrophy. Results: Serum NF-L is increased in PPA compared to controls and discriminates between nfvPPA/svPPA and lvPPA with 81% sensitivity and 67% specificity (cutoff 31 pg/mL). CSF NF-L, pNF-H, tau, phosphorylated tau, and Ab1-42 achieved similar performance, and pNF-H was the only marker for discrimination of nfvPPA from svPPA/lvPPA. In most patients with nfvPPA and svPPA, but not lvPPA, serum NF-L increased within follow-up. The increase correlated with functional decline and progression of atrophy of the left frontal lobe of all patients with PPAs and the right middle frontal gyrus of patients with nfvPPA and svPPA. Conclusions: Blood level of NF-L can aid the differential diagnosis of PPA variants, especially in combination with CSF pNF-H. Because serum NF-L correlates with functional decline and atrophy in the disease course, it qualifies as an objective disease status marker. Extended follow-up studies with cases of known neuropathology are imperative."],["dc.identifier.doi","10.1212/WNL.0000000000003688"],["dc.identifier.eissn","1526-632X"],["dc.identifier.isi","000397343300012"],["dc.identifier.issn","0028-3878"],["dc.identifier.pmid","28179468"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77660"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1526-632X"],["dc.relation.issn","0028-3878"],["dc.title","Neurofilament as a blood marker for diagnosis and monitoring of primary progressive aphasias"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","102112"],["dc.bibliographiccitation.journal","NeuroImage: Clinical"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Ballarini, Tommaso"],["dc.contributor.author","Albrecht, Franziska"],["dc.contributor.author","Mueller, Karsten"],["dc.contributor.author","Jech, Robert"],["dc.contributor.author","Diehl-Schmid, Janine"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Lauer, Martin"],["dc.contributor.author","Fassbender, Klaus"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Synofzik, Matthis"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Schroeter, Matthias L"],["dc.date.accessioned","2020-12-10T15:20:31Z"],["dc.date.available","2020-12-10T15:20:31Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.nicl.2019.102112"],["dc.identifier.issn","2213-1582"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72697"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Disentangling brain functional network remodeling in corticobasal syndrome – A multimodal MRI study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1284"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Movement Disorders"],["dc.bibliographiccitation.lastpage","1288"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Suessmuth, Sigurd D."],["dc.contributor.author","Uttner, Ingo"],["dc.contributor.author","Landwehrmeyer, Bernhard"],["dc.contributor.author","Pinkhardt, Elmar H."],["dc.contributor.author","Brettschneider, Johannes"],["dc.contributor.author","Petzold, Axel"],["dc.contributor.author","Kramer, Bernd"],["dc.contributor.author","Schulz, Joerg B."],["dc.contributor.author","Palm, Christian"],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Tumani, Hayrettin"],["dc.date.accessioned","2018-11-07T08:41:22Z"],["dc.date.available","2018-11-07T08:41:22Z"],["dc.date.issued","2010"],["dc.description.abstract","To evaluate cerebrospinal fluid (CSF) proteins reflecting processes of neurodegeneration and glial activation in progressive supranuclear palsy (PSP; Richardson's syndrome, n = 20; PSP-Parkinsonism, n = 7) and multiple system atrophy (MSA, n = 25), we analyzed tau, phosphorylated tau, amyloid-beta(1-42) (A beta 1-42), A beta 1-40, glial fibrillary acidic protein (GFAP), and CSF routine variables. Individuals with PSP-Parkinsonism and MSA had elevated tau levels when compared with Richardson's syndrome, Parkinson's disease (PD), and age-matched controls (P <= 0.001). Ratios of P-tau/T-tau were significantly different in Parkinsonian syndromes. CSF A beta 1-42 was decreased only in patients with Richardson's syndrome. In a subset of Parkinsonian syndromes, we found elevated GFAP concentrations and increased CSF/serum albumin ratios. There were no correlations between biomarker concentrations and clinical scores in any of the diseases. In conclusion, this preliminary data show that changes in CSF tau and A beta 1-42 may indicate different protein processing in PSP patients and might, therefore, be relevant in the differentiation of PSP subtypes. (C) 2010 Movement Disorder Society"],["dc.identifier.doi","10.1002/mds.22895"],["dc.identifier.isi","000280781500026"],["dc.identifier.pmid","20589870"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19453"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","0885-3185"],["dc.title","Differential Pattern of Brain-Specific CSF Proteins Tau and Amyloid-Beta in Parkinsonian Syndromes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]