Otto, Markus

[["dc.bibliographiccitation.artnumber","alz.12790"],["dc.bibliographiccitation.journal","Alzheimer's & Dementia"],["dc.contributor.author","Oeckl, Patrick"],["dc.contributor.author","Anderl‐Straub, Sarah"],["dc.contributor.author","Danek, Adrian"],["dc.contributor.author","Diehl‐Schmid, Janine"],["dc.contributor.author","Fassbender, Klaus"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Halbgebauer, Steffen"],["dc.contributor.author","Huppertz, Hans‐Jürgen"],["dc.contributor.author","Jahn, Holger"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Otto, Markus"],["dc.contributor.authorgroup","for the FTLD Consortium"],["dc.date.accessioned","2022-10-04T10:21:38Z"],["dc.date.available","2022-10-04T10:21:38Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1002/alz.12790"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114461"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-600"],["dc.relation.eissn","1552-5279"],["dc.relation.issn","1552-5260"],["dc.title","Relationship of serum beta‐synuclein with blood biomarkers and brain atrophy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","124"],["dc.bibliographiccitation.journal","Cortex"],["dc.bibliographiccitation.lastpage","135"],["dc.bibliographiccitation.volume","83"],["dc.contributor.author","Teipel, Stefan J."],["dc.contributor.author","Raiser, Theresa"],["dc.contributor.author","Riedl, Lina"],["dc.contributor.author","Riederer, Isabelle"],["dc.contributor.author","Schroeter, Matthias L."],["dc.contributor.author","Bisenius, Sandrine"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Grothe, Michel J."],["dc.contributor.author","Prudlo, Johannes"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Landwehrmeyer, Bernhard G."],["dc.contributor.author","Anderl-Straub, Sarah"],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Danek, Adrian"],["dc.date.accessioned","2018-11-07T10:07:28Z"],["dc.date.available","2018-11-07T10:07:28Z"],["dc.date.issued","2016"],["dc.description.abstract","Primary progressive aphasia (PPA) is characterized by profound destruction of cortical language areas. Anatomical studies suggest an involvement of cholinergic basal forebrain (BF) in PPA syndromes, particularly in the area of the nucleus subputaminalis (NSP). Here we aimed to determine the pattern of atrophy and structural covariance as a proxy of structural connectivity of BF nuclei in PPA variants. We studied 62 prospectively recruited cases with the clinical diagnosis of PPA and 31 healthy older control participants from the cohort study of the German consortium for frontotemporal lobar. degeneration (FTLD). We determined cortical and BF atrophy based on high-resolution magnetic resonance imaging (MRI) scans. Patterns of structural covariance of BF with cortical regions were determined using voxel-based partial least square analysis. We found significant atrophy of total BF and BF subregions in PPA patients compared with controls [F(1, 82) = 20.2, p < .001]. Atrophy was most pronounced in the NSP and the posterior BF, and most severe in the semantic variant and the nonfluent variant of PPA. Structural covariance analysis in healthy controls revealed associations of the BF nuclei, particularly the NSP, with left hemispheric predominant prefrontal, lateral temporal, and parietal cortical areas, including Broca's speech area (p < .001, permutation test). In contrast, the PPA patients showed preserved structural covariance of the BF nuclei mostly with right but not with left hemispheric cortical areas (p < .001, permutation test). Our findings agree with the neuroanatomically proposed involvement of the cholinergic BF, particularly the NSP, in PPA syndromes. We found a shift from a structural covariance of the BF with left hemispheric cortical areas in healthy aging towards right hemispheric cortical areas in PPA, possibly reflecting a consequence of the profound and early destruction of cortical language areas in PPA. (C) 2016 The Author(s). Published by Elsevier Ltd."],["dc.identifier.doi","10.1016/j.cortex.2016.07.004"],["dc.identifier.isi","000385599300011"],["dc.identifier.pmid","27509365"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14211"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39287"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.eissn","0010-9452"],["dc.relation.issn","1973-8102"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Atrophy and structural covariance of the cholinergic basal forebrain in primary progressive aphasia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Neurochemistry"],["dc.bibliographiccitation.volume","138"],["dc.contributor.author","Straub, S."],["dc.contributor.author","Schroeter, M. L."],["dc.contributor.author","Diehl-Schmid, Janine"],["dc.contributor.author","Danek, A."],["dc.contributor.author","von Arnim, Christine A. F."],["dc.contributor.author","Bertram, L."],["dc.contributor.author","Einsiedler, B."],["dc.contributor.author","Fassbender, Klaus"],["dc.contributor.author","Feneberg, Emily"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Foerstl, Hans"],["dc.contributor.author","Huppertz, H-J"],["dc.contributor.author","Jahn, Holger"],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Kasper, E."],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Kestler, Hans A."],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Kubisch, C."],["dc.contributor.author","Landwehrmeyer, Bernhard"],["dc.contributor.author","Lauer, Martin"],["dc.contributor.author","Lausser, L."],["dc.contributor.author","Lill, C. M."],["dc.contributor.author","Ludolph, A."],["dc.contributor.author","Maler, M."],["dc.contributor.author","Muche, Rainer"],["dc.contributor.author","Pinkhardt, Elmar H."],["dc.contributor.author","Prudlo, Johannes"],["dc.contributor.author","Riedl, Lina"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Schomburg, R."],["dc.contributor.author","Teipel, Stefan J."],["dc.contributor.author","Uttner, Ingo"],["dc.contributor.author","Volk, Alexander E."],["dc.contributor.author","Otto, Markus"],["dc.date.accessioned","2018-11-07T10:10:49Z"],["dc.date.available","2018-11-07T10:10:49Z"],["dc.date.issued","2016"],["dc.format.extent","407"],["dc.identifier.isi","000382568400474"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39933"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","10th International Conference on Frontotemporal Dementias"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","1471-4159"],["dc.relation.issn","0022-3042"],["dc.title","Multivariate diagnostic approaches in Frontotemporal lobar degeneration Data from the german FTLDc"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Neurochemistry"],["dc.bibliographiccitation.volume","138"],["dc.contributor.author","Bisenius, Sandrine"],["dc.contributor.author","Mueller, K."],["dc.contributor.author","Diehl-Schmid, Janine"],["dc.contributor.author","Fassbender, Klaus"],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Stuke, K."],["dc.contributor.author","Danek, A."],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Schroeter, M. L."],["dc.date.accessioned","2018-11-07T10:10:48Z"],["dc.date.available","2018-11-07T10:10:48Z"],["dc.date.issued","2016"],["dc.format.extent","350"],["dc.identifier.isi","000382568400332"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39930"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","10th International Conference on Frontotemporal Dementias"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","1471-4159"],["dc.relation.issn","0022-3042"],["dc.title","Classifying primary progressive aphasias individually with support vector machine approaches in MRI data"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e1390"],["dc.bibliographiccitation.issue","15"],["dc.bibliographiccitation.journal","Neurology"],["dc.bibliographiccitation.lastpage","e1401"],["dc.bibliographiccitation.volume","91"],["dc.contributor.author","Steinacker, Petra"],["dc.contributor.author","Anderl-Straub, Sarah"],["dc.contributor.author","Diehl-Schmid, Janine"],["dc.contributor.author","Semler, Elisa"],["dc.contributor.author","Uttner, Ingo"],["dc.contributor.author","von Arnim, Christine A.F."],["dc.contributor.author","Barthel, Henryk"],["dc.contributor.author","Danek, Adrian"],["dc.contributor.author","Fassbender, Klaus"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Foerstl, Hans"],["dc.contributor.author","Grimmer, Timo"],["dc.contributor.author","Huppertz, Hans-Jürgen"],["dc.contributor.author","Jahn, Holger"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Landwehrmeyer, Bernhard"],["dc.contributor.author","Lauer, Martin"],["dc.contributor.author","Maler, Juan Manuel"],["dc.contributor.author","Mayer, Benjamin"],["dc.contributor.author","Oeckl, Patrick"],["dc.contributor.author","Prudlo, Johannes"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Volk, Alexander E."],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Schroeter, Matthias L."],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Otto, Markus"],["dc.date.accessioned","2020-12-10T18:41:45Z"],["dc.date.available","2020-12-10T18:41:45Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1212/WNL.0000000000006318"],["dc.identifier.eissn","1526-632X"],["dc.identifier.issn","0028-3878"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77663"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Serum neurofilament light chain in behavioral variant frontotemporal dementia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","33"],["dc.bibliographiccitation.journal","Cortex"],["dc.bibliographiccitation.lastpage","40"],["dc.bibliographiccitation.volume","117"],["dc.contributor.author","Albrecht, Franziska"],["dc.contributor.author","Mueller, Karsten"],["dc.contributor.author","Ballarini, Tommaso"],["dc.contributor.author","Lampe, Leonie"],["dc.contributor.author","Diehl-Schmid, Janine"],["dc.contributor.author","Fassbender, Klaus"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Jahn, Holger"],["dc.contributor.author","Jech, Robert"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Landwehrmeyer, Bernhard"],["dc.contributor.author","Lauer, Martin"],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Lyros, Epameinondas"],["dc.contributor.author","Prudlo, Johannes"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Synofzik, Matthis"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Danek, Adrian"],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Schroeter, Matthias L."],["dc.contributor.author","Anderl-Straub, Sarah"],["dc.contributor.author","Brüggen, Katharina"],["dc.contributor.author","Fischer, Marie"],["dc.contributor.author","Förstl, Hans"],["dc.contributor.author","Hammer, Anke"],["dc.contributor.author","Homola, György"],["dc.contributor.author","Just, Walter"],["dc.contributor.author","Levin, Johannes"],["dc.contributor.author","Marroquin, Nicolai"],["dc.contributor.author","Marschhauser, Anke"],["dc.contributor.author","Nagl, Magdalena"],["dc.contributor.author","Oberstein, Timo"],["dc.contributor.author","Polyakova, Maryna"],["dc.contributor.author","Pellkofer, Hannah"],["dc.contributor.author","Richter-Schmidinger, Tanja"],["dc.contributor.author","Rossmeier, Carola"],["dc.contributor.author","Schuemberg, Katharina"],["dc.contributor.author","Semler, Elisa"],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Steinacker, Petra"],["dc.contributor.author","Thöne-Otto, Angelika"],["dc.contributor.author","Uttner, Ingo"],["dc.contributor.author","Zech, Heike"],["dc.date.accessioned","2020-12-10T14:23:17Z"],["dc.date.available","2020-12-10T14:23:17Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.cortex.2019.02.015"],["dc.identifier.issn","0010-9452"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16567"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71890"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Unraveling corticobasal syndrome and alien limb syndrome with structural brain imaging"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Alzheimer's & Dementia"],["dc.contributor.author","Lombardi, Jolina"],["dc.contributor.author","Mayer, Benjamin"],["dc.contributor.author","Semler, Elisa"],["dc.contributor.author","Anderl‐Straub, Sarah"],["dc.contributor.author","Uttner, Ingo"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Diehl‐Schmid, Janine"],["dc.contributor.author","Danek, Adrian"],["dc.contributor.author","Levin, Johannes"],["dc.contributor.author","Otto, Markus"],["dc.contributor.authorgroup","the FTLD consortium"],["dc.date.accessioned","2021-06-01T09:42:52Z"],["dc.date.available","2021-06-01T09:42:52Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1002/alz.12323"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85376"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1552-5279"],["dc.relation.issn","1552-5260"],["dc.title","Quantifying progression in primary progressive aphasia with structural neuroimaging"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","656"],["dc.bibliographiccitation.journal","NeuroImage. Clinical"],["dc.bibliographiccitation.lastpage","662"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Meyer, Sebastian"],["dc.contributor.author","Mueller, Karsten"],["dc.contributor.author","Stuke, Katharina"],["dc.contributor.author","Bisenius, Sandrine"],["dc.contributor.author","Diehl-Schmid, Janine"],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Prudlo, Johannes"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Schuemberg, Katharina"],["dc.contributor.author","Yakushev, Igor"],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Schroeter, Matthias L."],["dc.date.accessioned","2019-07-09T11:44:53Z"],["dc.date.available","2019-07-09T11:44:53Z"],["dc.date.issued","2017"],["dc.description.abstract","PURPOSE: Frontotemporal lobar degeneration (FTLD) is a common cause of early onset dementia. Behavioral variant frontotemporal dementia (bvFTD), its most common subtype, is characterized by deep alterations in behavior and personality. In 2011, new diagnostic criteria were suggested that incorporate imaging criteria into diagnostic algorithms. The study aimed at validating the potential of imaging criteria to individually predict diagnosis with machine learning algorithms. MATERIALS & METHODS: Brain atrophy was measured with structural magnetic resonance imaging (MRI) at 3 Tesla in a multi-centric cohort of 52 bvFTD patients and 52 healthy control subjects from the German FTLD Consortium's Study. Beside group comparisons, diagnosis bvFTD vs. controls was individually predicted in each subject with support vector machine classification in MRI data across the whole brain or in frontotemporal, insular regions, and basal ganglia known to be mainly affected based on recent meta-analyses. Multi-center effects were controlled for with a new method, \"leave one center out\" conjunction analyses, i.e. repeatedly excluding subjects from each center from the analysis. RESULTS: Group comparisons revealed atrophy in, most consistently, the frontal lobe in bvFTD beside alterations in the insula, basal ganglia and temporal lobe. Most remarkably, support vector machine classification enabled predicting diagnosis in single patients with a high accuracy of up to 84.6%, where accuracy was highest in a region-of-interest approach focusing on frontotemporal, insular regions, and basal ganglia in comparison with the whole brain approach. CONCLUSION: Our study demonstrates that MRI, a widespread imaging technology, can individually identify bvFTD with high accuracy in multi-center imaging data, paving the road to personalized diagnostic approaches in the future."],["dc.identifier.doi","10.1016/j.nicl.2017.02.001"],["dc.identifier.pmid","28348957"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14946"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59118"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2213-1582"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.subject.ddc","610"],["dc.subject.mesh","Aged"],["dc.subject.mesh","Atrophy"],["dc.subject.mesh","Brain"],["dc.subject.mesh","Brain Mapping"],["dc.subject.mesh","Cohort Studies"],["dc.subject.mesh","Female"],["dc.subject.mesh","Frontotemporal Dementia"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Image Processing, Computer-Assisted"],["dc.subject.mesh","Magnetic Resonance Imaging"],["dc.subject.mesh","Male"],["dc.subject.mesh","Middle Aged"],["dc.subject.mesh","Predictive Value of Tests"],["dc.subject.mesh","Support Vector Machine"],["dc.title","Predicting behavioral variant frontotemporal dementia with pattern classification in multi-center structural MRI data."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","961"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Neurology"],["dc.bibliographiccitation.lastpage","969"],["dc.bibliographiccitation.volume","88"],["dc.contributor.author","Steinacker, Petra"],["dc.contributor.author","Semler, Elisa"],["dc.contributor.author","Anderl-Straub, Sarah"],["dc.contributor.author","Diehl-Schmid, Janine"],["dc.contributor.author","Schroeter, Matthias L."],["dc.contributor.author","Uttner, Ingo"],["dc.contributor.author","Foerstl, Hans"],["dc.contributor.author","Landwehrmeyer, Bernhard"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Oeckl, Patrick"],["dc.contributor.author","Huppertz, Hans-Jürgen"],["dc.contributor.author","Fassbender, Klaus"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Prudlo, Johannes"],["dc.contributor.author","Roßmeier, Carola"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Volk, Alexander E."],["dc.contributor.author","Lauer, Martin"],["dc.contributor.author","Danek, Adrian"],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","von Arnim, Christine A. F."],["dc.date.accessioned","2020-12-10T18:41:44Z"],["dc.date.available","2020-12-10T18:41:44Z"],["dc.date.issued","2017"],["dc.description.abstract","Objective: To assess the utility of serum neurofilament for diagnosis and monitoring of primary progressive aphasia (PPA) variants. Methods: We investigated neurofilament light chain (NF-L) levels in blood of 99 patients with PPA (40 with nonfluent variant PPA [nfvPPA], 38 with semantic variant PPA [svPPA], 21 with logopenic variant PPA [lvPPA]) and compared diagnostic performance with that reached by CSF NF-L, phosphorylated neurofilament heavy chain (pNF-H), b-amyloid (Ab(1)-42), tau, and phosphorylated tau. The longitudinal change of blood NF-L levels was measured and analyzed for correlation with functional decline and brain atrophy. Results: Serum NF-L is increased in PPA compared to controls and discriminates between nfvPPA/svPPA and lvPPA with 81% sensitivity and 67% specificity (cutoff 31 pg/mL). CSF NF-L, pNF-H, tau, phosphorylated tau, and Ab1-42 achieved similar performance, and pNF-H was the only marker for discrimination of nfvPPA from svPPA/lvPPA. In most patients with nfvPPA and svPPA, but not lvPPA, serum NF-L increased within follow-up. The increase correlated with functional decline and progression of atrophy of the left frontal lobe of all patients with PPAs and the right middle frontal gyrus of patients with nfvPPA and svPPA. Conclusions: Blood level of NF-L can aid the differential diagnosis of PPA variants, especially in combination with CSF pNF-H. Because serum NF-L correlates with functional decline and atrophy in the disease course, it qualifies as an objective disease status marker. Extended follow-up studies with cases of known neuropathology are imperative."],["dc.identifier.doi","10.1212/WNL.0000000000003688"],["dc.identifier.eissn","1526-632X"],["dc.identifier.isi","000397343300012"],["dc.identifier.issn","0028-3878"],["dc.identifier.pmid","28179468"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77660"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1526-632X"],["dc.relation.issn","0028-3878"],["dc.title","Neurofilament as a blood marker for diagnosis and monitoring of primary progressive aphasias"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","102112"],["dc.bibliographiccitation.journal","NeuroImage: Clinical"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Ballarini, Tommaso"],["dc.contributor.author","Albrecht, Franziska"],["dc.contributor.author","Mueller, Karsten"],["dc.contributor.author","Jech, Robert"],["dc.contributor.author","Diehl-Schmid, Janine"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Lauer, Martin"],["dc.contributor.author","Fassbender, Klaus"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Synofzik, Matthis"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Schroeter, Matthias L"],["dc.date.accessioned","2020-12-10T15:20:31Z"],["dc.date.available","2020-12-10T15:20:31Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.nicl.2019.102112"],["dc.identifier.issn","2213-1582"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72697"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Disentangling brain functional network remodeling in corticobasal syndrome – A multimodal MRI study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]