Otto, Markus

[["dc.bibliographiccitation.firstpage","124"],["dc.bibliographiccitation.journal","Cortex"],["dc.bibliographiccitation.lastpage","135"],["dc.bibliographiccitation.volume","83"],["dc.contributor.author","Teipel, Stefan J."],["dc.contributor.author","Raiser, Theresa"],["dc.contributor.author","Riedl, Lina"],["dc.contributor.author","Riederer, Isabelle"],["dc.contributor.author","Schroeter, Matthias L."],["dc.contributor.author","Bisenius, Sandrine"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Grothe, Michel J."],["dc.contributor.author","Prudlo, Johannes"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Landwehrmeyer, Bernhard G."],["dc.contributor.author","Anderl-Straub, Sarah"],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Danek, Adrian"],["dc.date.accessioned","2018-11-07T10:07:28Z"],["dc.date.available","2018-11-07T10:07:28Z"],["dc.date.issued","2016"],["dc.description.abstract","Primary progressive aphasia (PPA) is characterized by profound destruction of cortical language areas. Anatomical studies suggest an involvement of cholinergic basal forebrain (BF) in PPA syndromes, particularly in the area of the nucleus subputaminalis (NSP). Here we aimed to determine the pattern of atrophy and structural covariance as a proxy of structural connectivity of BF nuclei in PPA variants. We studied 62 prospectively recruited cases with the clinical diagnosis of PPA and 31 healthy older control participants from the cohort study of the German consortium for frontotemporal lobar. degeneration (FTLD). We determined cortical and BF atrophy based on high-resolution magnetic resonance imaging (MRI) scans. Patterns of structural covariance of BF with cortical regions were determined using voxel-based partial least square analysis. We found significant atrophy of total BF and BF subregions in PPA patients compared with controls [F(1, 82) = 20.2, p < .001]. Atrophy was most pronounced in the NSP and the posterior BF, and most severe in the semantic variant and the nonfluent variant of PPA. Structural covariance analysis in healthy controls revealed associations of the BF nuclei, particularly the NSP, with left hemispheric predominant prefrontal, lateral temporal, and parietal cortical areas, including Broca's speech area (p < .001, permutation test). In contrast, the PPA patients showed preserved structural covariance of the BF nuclei mostly with right but not with left hemispheric cortical areas (p < .001, permutation test). Our findings agree with the neuroanatomically proposed involvement of the cholinergic BF, particularly the NSP, in PPA syndromes. We found a shift from a structural covariance of the BF with left hemispheric cortical areas in healthy aging towards right hemispheric cortical areas in PPA, possibly reflecting a consequence of the profound and early destruction of cortical language areas in PPA. (C) 2016 The Author(s). Published by Elsevier Ltd."],["dc.identifier.doi","10.1016/j.cortex.2016.07.004"],["dc.identifier.isi","000385599300011"],["dc.identifier.pmid","27509365"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14211"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39287"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.eissn","0010-9452"],["dc.relation.issn","1973-8102"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Atrophy and structural covariance of the cholinergic basal forebrain in primary progressive aphasia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","175628641984605"],["dc.bibliographiccitation.journal","Therapeutic Advances in Neurological Disorders"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Wurster, Claudia D."],["dc.contributor.author","Günther, René"],["dc.contributor.author","Steinacker, Petra"],["dc.contributor.author","Dreyhaupt, Jens"],["dc.contributor.author","Wollinsky, Kurt"],["dc.contributor.author","Uzelac, Zeljko"],["dc.contributor.author","Witzel, Simon"],["dc.contributor.author","Kocak, Tugrul"],["dc.contributor.author","Winter, Benedikt"],["dc.contributor.author","Koch, Jan C."],["dc.contributor.author","Lingor, Paul"],["dc.contributor.author","Petri, Susanne"],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Hermann, Andreas"],["dc.contributor.author","Otto, Markus"],["dc.date.accessioned","2020-12-10T18:38:37Z"],["dc.date.available","2020-12-10T18:38:37Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1177/1756286419846058"],["dc.identifier.eissn","1756-2864"],["dc.identifier.issn","1756-2864"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16746"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77390"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.title","Neurochemical markers in CSF of adolescent and adult SMA patients undergoing nusinersen treatment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","791"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Cells"],["dc.bibliographiccitation.volume","10"],["dc.contributor.affiliation","Ruf, Wolfgang P.; \t\t \r\n\t\t Department of Neurology, Ulm University, 89081 Ulm, Germany, wolfgang.ruf@uni-ulm.de"],["dc.contributor.affiliation","Freischmidt, Axel; \t\t \r\n\t\t Department of Neurology, Ulm University, 89081 Ulm, Germany, axel.freischmidt@uni-ulm.de\t\t \r\n\t\t German Center for Neurodegenerative Diseases (DNZE), 89081 Ulm, Germany, axel.freischmidt@uni-ulm.de"],["dc.contributor.affiliation","Grozdanov, Veselin; \t\t \r\n\t\t Department of Neurology, Ulm University, 89081 Ulm, Germany, veselin.grozdanov@uni-ulm.de"],["dc.contributor.affiliation","Roth, Valerie; \t\t \r\n\t\t Department of Neurology, Ulm University, 89081 Ulm, Germany, valerie.roth@christophorus-kliniken.de"],["dc.contributor.affiliation","Brockmann, Sarah J.; \t\t \r\n\t\t Department of Neurology, Ulm University, 89081 Ulm, Germany, sarah.brockmann@uni-ulm.de"],["dc.contributor.affiliation","Mollenhauer, Brit; \t\t \r\n\t\t Department of Neurology, Universitätsmedizin Göttingen and Paracelsus-Elena-Klinik, 34128 Kassel, Germany, brit.mollenhauer@paracelsus-kliniken.de"],["dc.contributor.affiliation","Martin, Dorothea; \t\t \r\n\t\t Department of Neurology, Technische Universität München, 80333 Munich, Germany, Dorothea.a.martin@gmail.com"],["dc.contributor.affiliation","Haslinger, Bernhard; \t\t \r\n\t\t Department of Neurology, Technische Universität München, 80333 Munich, Germany, bernhard.haslinger@tum.de"],["dc.contributor.affiliation","Fundel-Clemens, Katrin; \t\t \r\n\t\t Boehringer Ingelheim Pharma GmbH & Co. KG, Div. Research Department, 88400 Biberach, Germany, katrin.fundel-clemens@boehringer-ingelheim.com"],["dc.contributor.affiliation","Otto, Markus; \t\t \r\n\t\t Department of Neurology, Ulm University, 89081 Ulm, Germany, markus.otto@uni-ulm.de"],["dc.contributor.affiliation","Arnim, Christine von; \t\t \r\n\t\t Department of Geriatrics, Göttingen University, 37075 Göttingen, Germany, christine.arnim@med.uni-goettingen.de"],["dc.contributor.affiliation","Holzmann, Karlheinz; \t\t \r\n\t\t Genomics-Core Facility, Center for Biomedical Research, University Hospital Ulm, 89081 Ulm, Germany, karlheinz.holzmann@uni-ulm.de"],["dc.contributor.affiliation","Ludolph, Albert C.; \t\t \r\n\t\t Department of Neurology, Ulm University, 89081 Ulm, Germany, Albert.Ludolph@rku.de\t\t \r\n\t\t German Center for Neurodegenerative Diseases (DNZE), 89081 Ulm, Germany, Albert.Ludolph@rku.de"],["dc.contributor.affiliation","Weishaupt, Jochen H.; \t\t \r\n\t\t Institute for Neurodegeneration, Universitätsmedizin Mannheim, 68167 Mannheim, Germany, Jochen.Weishaupt@medma.uni-heidelberg.de"],["dc.contributor.affiliation","Danzer, Karin M.; \t\t \r\n\t\t Department of Neurology, Ulm University, 89081 Ulm, Germany, Karin.Danzer@uni-ulm.de"],["dc.contributor.author","Ruf, Wolfgang P."],["dc.contributor.author","Freischmidt, Axel"],["dc.contributor.author","Grozdanov, Veselin"],["dc.contributor.author","Roth, Valerie"],["dc.contributor.author","Brockmann, Sarah J."],["dc.contributor.author","Mollenhauer, Brit"],["dc.contributor.author","Martin, Dorothea"],["dc.contributor.author","Haslinger, Bernhard"],["dc.contributor.author","Fundel-Clemens, Katrin"],["dc.contributor.author","Danzer, Karin M."],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Arnim, Christine von"],["dc.contributor.author","Holzmann, Karlheinz"],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Weishaupt, Jochen H."],["dc.date.accessioned","2021-06-01T09:42:32Z"],["dc.date.available","2021-06-01T09:42:32Z"],["dc.date.issued","2021"],["dc.date.updated","2022-02-09T13:21:12Z"],["dc.description.abstract","Accumulating evidence suggests that microRNAs (miRNAs) are a contributing factor to neurodegenerative diseases. Although altered miRNA profiles in serum or plasma have been reported for several neurodegenerative diseases, little is known about the interaction between dysregulated miRNAs and their protein binding partners. We found significant alterations of the miRNA abundance pattern in serum and in isolated serum-derived extracellular vesicles of Parkinson’s disease (PD) patients. The differential expression of miRNA in PD patients was more robust in serum than in isolated extracellular vesicles and could separate PD patients from healthy controls in an unsupervised approach to a high degree. We identified a novel protein interaction partner for the strongly dysregulated hsa-mir-4745-5p. Our study provides further evidence for the involvement of miRNAs and HNF4a in PD. The demonstration that miRNA-protein binding might mediate the pathologic effects of HNF4a both by direct binding to it and by binding to proteins regulated by it suggests a complex role for miRNAs in pathology beyond the dysregulation of transcription."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft"],["dc.identifier.doi","10.3390/cells10040791"],["dc.identifier.eissn","2073-4409"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85280"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.publisher","MDPI"],["dc.relation.eissn","2073-4409"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Protein Binding Partners of Dysregulated miRNAs in Parkinson’s Disease Serum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","33"],["dc.bibliographiccitation.journal","Cortex"],["dc.bibliographiccitation.lastpage","40"],["dc.bibliographiccitation.volume","117"],["dc.contributor.author","Albrecht, Franziska"],["dc.contributor.author","Mueller, Karsten"],["dc.contributor.author","Ballarini, Tommaso"],["dc.contributor.author","Lampe, Leonie"],["dc.contributor.author","Diehl-Schmid, Janine"],["dc.contributor.author","Fassbender, Klaus"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Jahn, Holger"],["dc.contributor.author","Jech, Robert"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Landwehrmeyer, Bernhard"],["dc.contributor.author","Lauer, Martin"],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Lyros, Epameinondas"],["dc.contributor.author","Prudlo, Johannes"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Synofzik, Matthis"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Danek, Adrian"],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Schroeter, Matthias L."],["dc.contributor.author","Anderl-Straub, Sarah"],["dc.contributor.author","Brüggen, Katharina"],["dc.contributor.author","Fischer, Marie"],["dc.contributor.author","Förstl, Hans"],["dc.contributor.author","Hammer, Anke"],["dc.contributor.author","Homola, György"],["dc.contributor.author","Just, Walter"],["dc.contributor.author","Levin, Johannes"],["dc.contributor.author","Marroquin, Nicolai"],["dc.contributor.author","Marschhauser, Anke"],["dc.contributor.author","Nagl, Magdalena"],["dc.contributor.author","Oberstein, Timo"],["dc.contributor.author","Polyakova, Maryna"],["dc.contributor.author","Pellkofer, Hannah"],["dc.contributor.author","Richter-Schmidinger, Tanja"],["dc.contributor.author","Rossmeier, Carola"],["dc.contributor.author","Schuemberg, Katharina"],["dc.contributor.author","Semler, Elisa"],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Steinacker, Petra"],["dc.contributor.author","Thöne-Otto, Angelika"],["dc.contributor.author","Uttner, Ingo"],["dc.contributor.author","Zech, Heike"],["dc.date.accessioned","2020-12-10T14:23:17Z"],["dc.date.available","2020-12-10T14:23:17Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.cortex.2019.02.015"],["dc.identifier.issn","0010-9452"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16567"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71890"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Unraveling corticobasal syndrome and alien limb syndrome with structural brain imaging"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Alzheimer's Research & Therapy"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Semler, Elisa"],["dc.contributor.author","Anderl-Straub, Sarah"],["dc.contributor.author","Uttner, Ingo"],["dc.contributor.author","Diehl-Schmid, Janine"],["dc.contributor.author","Danek, Adrian"],["dc.contributor.author","Einsiedler, Beate"],["dc.contributor.author","Fassbender, Klaus"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Huppertz, Hans-Jürgen"],["dc.contributor.author","Jahn, Holger"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Landwehrmeyer, Bernhard"],["dc.contributor.author","Lauer, Martin"],["dc.contributor.author","Muche, Rainer"],["dc.contributor.author","Prudlo, Johannes"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Schroeter, Matthias L."],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Otto, Markus"],["dc.date.accessioned","2020-12-10T18:39:07Z"],["dc.date.available","2020-12-10T18:39:07Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1186/s13195-018-0345-3"],["dc.identifier.eissn","1758-9193"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15204"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77549"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","In goescholar not merged with http://resolver.sub.uni-goettingen.de/purl?gs-1/15508 but duplicate"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)."],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","A language-based sum score for the course and therapeutic intervention in primary progressive aphasia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","656"],["dc.bibliographiccitation.journal","NeuroImage. Clinical"],["dc.bibliographiccitation.lastpage","662"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Meyer, Sebastian"],["dc.contributor.author","Mueller, Karsten"],["dc.contributor.author","Stuke, Katharina"],["dc.contributor.author","Bisenius, Sandrine"],["dc.contributor.author","Diehl-Schmid, Janine"],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Kornhuber, Johannes"],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Prudlo, Johannes"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Schuemberg, Katharina"],["dc.contributor.author","Yakushev, Igor"],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Schroeter, Matthias L."],["dc.date.accessioned","2019-07-09T11:44:53Z"],["dc.date.available","2019-07-09T11:44:53Z"],["dc.date.issued","2017"],["dc.description.abstract","PURPOSE: Frontotemporal lobar degeneration (FTLD) is a common cause of early onset dementia. Behavioral variant frontotemporal dementia (bvFTD), its most common subtype, is characterized by deep alterations in behavior and personality. In 2011, new diagnostic criteria were suggested that incorporate imaging criteria into diagnostic algorithms. The study aimed at validating the potential of imaging criteria to individually predict diagnosis with machine learning algorithms. MATERIALS & METHODS: Brain atrophy was measured with structural magnetic resonance imaging (MRI) at 3 Tesla in a multi-centric cohort of 52 bvFTD patients and 52 healthy control subjects from the German FTLD Consortium's Study. Beside group comparisons, diagnosis bvFTD vs. controls was individually predicted in each subject with support vector machine classification in MRI data across the whole brain or in frontotemporal, insular regions, and basal ganglia known to be mainly affected based on recent meta-analyses. Multi-center effects were controlled for with a new method, \"leave one center out\" conjunction analyses, i.e. repeatedly excluding subjects from each center from the analysis. RESULTS: Group comparisons revealed atrophy in, most consistently, the frontal lobe in bvFTD beside alterations in the insula, basal ganglia and temporal lobe. Most remarkably, support vector machine classification enabled predicting diagnosis in single patients with a high accuracy of up to 84.6%, where accuracy was highest in a region-of-interest approach focusing on frontotemporal, insular regions, and basal ganglia in comparison with the whole brain approach. CONCLUSION: Our study demonstrates that MRI, a widespread imaging technology, can individually identify bvFTD with high accuracy in multi-center imaging data, paving the road to personalized diagnostic approaches in the future."],["dc.identifier.doi","10.1016/j.nicl.2017.02.001"],["dc.identifier.pmid","28348957"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14946"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59118"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2213-1582"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.subject.ddc","610"],["dc.subject.mesh","Aged"],["dc.subject.mesh","Atrophy"],["dc.subject.mesh","Brain"],["dc.subject.mesh","Brain Mapping"],["dc.subject.mesh","Cohort Studies"],["dc.subject.mesh","Female"],["dc.subject.mesh","Frontotemporal Dementia"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Image Processing, Computer-Assisted"],["dc.subject.mesh","Magnetic Resonance Imaging"],["dc.subject.mesh","Male"],["dc.subject.mesh","Middle Aged"],["dc.subject.mesh","Predictive Value of Tests"],["dc.subject.mesh","Support Vector Machine"],["dc.title","Predicting behavioral variant frontotemporal dementia with pattern classification in multi-center structural MRI data."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","17565"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","International Journal of Molecular Sciences"],["dc.bibliographiccitation.lastpage","17588"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Abdelhak, Ahmed"],["dc.contributor.author","Junker, Andreas"],["dc.contributor.author","Brettschneider, Johannes"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Tumani, Hayrettin"],["dc.date.accessioned","2018-11-07T09:53:26Z"],["dc.date.available","2018-11-07T09:53:26Z"],["dc.date.issued","2015"],["dc.description.abstract","Many neurodegenerative disorders share a common pathophysiological pathway involving axonal degeneration despite different etiological triggers. Analysis of cytoskeletal markers such as neurofilaments, protein tau and tubulin in cerebrospinal fluid (CSF) may be a useful approach to detect the process of axonal damage and its severity during disease course. In this article, we review the published literature regarding brain-specific CSF markers for cytoskeletal damage in primary progressive multiple sclerosis and amyotrophic lateral sclerosis in order to evaluate their utility as a biomarker for disease progression in conjunction with imaging and histological markers which might also be useful in other neurodegenerative diseases associated with affection of the upper motor neurons. A long-term benefit of such an approach could be facilitating early diagnostic and prognostic tools and assessment of treatment efficacy of disease modifying drugs."],["dc.description.sponsorship","BMBF-funded competence network multiple sclerosis (KKNMS)"],["dc.identifier.doi","10.3390/ijms160817565"],["dc.identifier.isi","000366826100046"],["dc.identifier.pmid","26263977"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12759"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36329"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mdpi Ag"],["dc.relation.issn","1422-0067"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Brain-Specific Cytoskeletal Damage Markers in Cerebrospinal Fluid: Is There a Common Pattern between Amyotrophic Lateral Sclerosis and Primary Progressive Multiple Sclerosis?"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Halbgebauer, Steffen"],["dc.contributor.author","Nagl, Magdalena"],["dc.contributor.author","Klafki, Hans"],["dc.contributor.author","Haußmann, Ute"],["dc.contributor.author","Steinacker, Petra"],["dc.contributor.author","Oeckl, Patrick"],["dc.contributor.author","Kassubek, Jan"],["dc.contributor.author","Pinkhardt, Elmar"],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Soininen, Hilkka"],["dc.contributor.author","Herukka, Sanna-Kaisa"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Otto, Markus"],["dc.date.accessioned","2017-09-07T11:44:30Z"],["dc.date.available","2017-09-07T11:44:30Z"],["dc.date.issued","2016"],["dc.description.abstract","Early detection of dementia in Parkinson disease is a prerequisite for preventive therapeutic approaches. Modified serpinA1 in cerebrospinal fluid (CSF) was suggested as an early biomarker for differentiation between Parkinson patients with (PDD) or without dementia (PD). Within this study we aimed to further explore the diagnostic value of serpinA1. We applied a newly developed nanoscale method for the detection of serpinA1 based on automated capillary isoelectric focusing (CIEF). A clinical sample of 102 subjects including neurologically healthy controls (CON), PD and PDD patients was investigated. Seven serpinA1 isoforms of different charge were detected in CSF from all three diagnostic groups. The mean CSF signals of the most acidic serpinA1 isoform differed significantly (p < 0.01) between PDD (n = 29) and PD (n = 37) or CON (n = 36). Patients above the cut-off of 6.4 have a more than six times higher risk for an association with dementia compared to patients below the cut off. We propose this serpinA1 CIEF-immunoassay as a novel tool in predicting cognitive impairment in PD patients and therefore for patient stratification in therapeutic trials."],["dc.identifier.doi","10.1038/srep26145"],["dc.identifier.gro","3151674"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13360"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8492"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","public"],["dc.notes.submitter","chake"],["dc.relation.issn","2045-2322"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Modified serpinA1 as risk marker for Parkinson’s disease dementia: Analysis of baseline data"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Neurology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Wurster, Claudia D."],["dc.contributor.author","Koch, Jan C."],["dc.contributor.author","Cordts, Isabell"],["dc.contributor.author","Dreyhaupt, Jens"],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Uzelac, Zeljko"],["dc.contributor.author","Witzel, Simon"],["dc.contributor.author","Winter, Benedikt"],["dc.contributor.author","Kocak, Tugrul"],["dc.contributor.author","Schocke, Michael"],["dc.contributor.author","Weydt, Patrick"],["dc.contributor.author","Wollinsky, Kurt"],["dc.contributor.author","Ludolph, Albert C."],["dc.contributor.author","Deschauer, Marcus"],["dc.contributor.author","Lingor, Paul"],["dc.contributor.author","Tumani, Hayrettin"],["dc.contributor.author","Hermann, Andreas"],["dc.contributor.author","Günther, René"],["dc.date.accessioned","2020-12-10T18:44:33Z"],["dc.date.available","2020-12-10T18:44:33Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.3389/fneur.2019.01179"],["dc.identifier.eissn","1664-2295"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16957"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78499"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Routine Cerebrospinal Fluid (CSF) Parameters in Patients With Spinal Muscular Atrophy (SMA) Treated With Nusinersen"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]