Moser, Norman

[["dc.bibliographiccitation.firstpage","1223"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Clinical Oral Investigations"],["dc.bibliographiccitation.lastpage","1234"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Moser, Norman"],["dc.contributor.author","Goldstein, Jan"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Epple, Matthias"],["dc.contributor.author","Schliephake, Henning"],["dc.date.accessioned","2018-06-25T07:45:51Z"],["dc.date.available","2018-06-25T07:45:51Z"],["dc.date.issued","2018-04"],["dc.description.abstract","(1) Objectives: The aim of the present study was to test the hypothesis that the ratio of angiogenic and osteogenic signaling affects ectopic bone formation when delivered in different amounts. (2) Materials and methods: Porous composite PDLLA/CaCO3 scaffolds were loaded with rhBMP2 and rhVEGF in different dosage combinations and implanted into the gluteal muscles of 120 adult male Wistar rats. Bone formation and expression of alkaline phosphatase and Runx2 were quantified by histomorphometry. Spatial distribution across the scaffolds was assessed by using a grid that discriminated between the periphery and center of the scaffolds. (3) Results: The evaluation showed that the combined delivery of bone morphogenetic protein BMP2 and VEGF in different dosage combinations did not enhance the overall quantity of ectopic bone formation compared to the delivery of BMP2 alone. The addition of VEGF generally upregulated Runx2 after 4 weeks, which may have retarded terminal osteogenic differentiation. However, slow combined delivery of 1.5–2.0 μg BMP2 combined with 50 ng VEGF165 over a period of 5 weeks supported a more even distribution of bone formation across the implanted scaffolds whereas higher amounts of VEGF did not elicit this effect. (4) Conclusions: The findings suggest that structural organization rather than the quantity of ectopic bone formation is affected by the dosage and the ratio of BMP2 and VEGF levels at the observed intervals. Clinical relevance The development of carriers for dual growth factor delivery has to take into account the necessity to carefully balance the ratio of growth release."],["dc.identifier.doi","10.1007/s00784-017-2202-3"],["dc.identifier.pmid","28936783"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15134"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1436-3771"],["dc.title","Experimental variation of the level and the ratio of angiogenic and osteogenic signaling affects the spatiotemporal expression of bone-specific markers and organization of bone formation in ectopic sites"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","347"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","International Journal of Oral and Maxillofacial Surgery"],["dc.bibliographiccitation.lastpage","354"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Quast, A."],["dc.contributor.author","Santander, P."],["dc.contributor.author","Witt, D."],["dc.contributor.author","Damm, A."],["dc.contributor.author","Moser, N."],["dc.contributor.author","Schliephake, H."],["dc.contributor.author","Meyer-Marcotty, P."],["dc.date.accessioned","2020-12-10T14:24:37Z"],["dc.date.available","2020-12-10T14:24:37Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.ijom.2018.09.001"],["dc.identifier.issn","0901-5027"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72307"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Traditional face-bow transfer versus three-dimensional virtual reconstruction in orthognathic surgery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","201"],["dc.bibliographiccitation.issue","Pt A"],["dc.bibliographiccitation.journal","Journal of controlled release : official journal of the Controlled Release Society"],["dc.bibliographiccitation.lastpage","209"],["dc.bibliographiccitation.volume","220"],["dc.contributor.author","Lohse, N."],["dc.contributor.author","Moser, N."],["dc.contributor.author","Backhaus, S."],["dc.contributor.author","Annen, T."],["dc.contributor.author","Epple, M."],["dc.contributor.author","Schliephake, H."],["dc.date.accessioned","2018-06-25T07:52:25Z"],["dc.date.available","2018-06-25T07:52:25Z"],["dc.date.issued","2015"],["dc.description.abstract","The aim of the present study was to test the hypothesis that different amounts of vascular endothelial growth factor and bone morphogenic protein differentially affect bone formation when applied for repair of non-healing defects in the rat mandible. Porous composite PDLLA/CaCO3 carriers were fabricated as slow release carriers and loaded with rhBMP2 and rhVEGF165 in 10 different dosage combinations using gas foaming with supercritical carbon dioxide. They were implanted in non-healing defects of the mandibles of 132 adult Wistar rats with additional lateral augmentation. Bone formation was assessed both radiographically (bone volume) and by histomorphometry (bone density). The use of carriers with a ratio of delivery of VEGF/BMP between 0.7 and 1.2 was significantly related to the occurrence of significant increases in radiographic bone volume and/or histologic bone density compared to the use of carriers with a ratio of delivery of ≤ 0.5 when all intervals and all outcome parameters were considered. Moreover, simultaneous delivery at this ratio helped to \"save\" rhBMP2 as both bone volume and bone density after 13 weeks were reached/surpassed using half the dosage required for rhBMP2 alone. It is concluded, that the combined delivery of rhVEGF165 and rhBMP2 for repair of critical size mandibular defects can significantly enhance volume and density of bone formation over delivery of rhBMP2 alone. It appears from the present results that continuous simultaneous delivery of rhVEGF165 and rhBMP2 at a ratio of approximately 1 is favourable for the enhancement of bone formation."],["dc.identifier.doi","10.1016/j.jconrel.2015.10.032"],["dc.identifier.pmid","26485046"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15136"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1873-4995"],["dc.title","Continuous delivery of rhBMP2 and rhVEGF165 at a certain ratio enhances bone formation in mandibular defects over the delivery of rhBMP2 alone--An experimental study in rats"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1618"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery"],["dc.bibliographiccitation.lastpage","1629"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Troeltzsch, Markus"],["dc.contributor.author","Troeltzsch, Matthias"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Gruber, Rudolph"],["dc.contributor.author","Brockmeyer, Phillipp"],["dc.contributor.author","Moser, Norman"],["dc.contributor.author","Rau, Anna"],["dc.contributor.author","Schliephake, Henning"],["dc.date.accessioned","2018-06-25T07:48:54Z"],["dc.date.available","2018-06-25T07:48:54Z"],["dc.date.issued","2016-10"],["dc.description.abstract","To evaluate the efficacy of grafting materials in lateral and vertical ridge augmentations."],["dc.identifier.doi","10.1016/j.jcms.2016.07.028"],["dc.identifier.pmid","27622971"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15135"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1878-4119"],["dc.title","Clinical efficacy of grafting materials in alveolar ridge augmentation: A systematic review"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Clinical Oral Investigations"],["dc.contributor.author","Quast, Anja"],["dc.contributor.author","Santander, Petra"],["dc.contributor.author","Leding, Johanna"],["dc.contributor.author","Klenke, Daniela"],["dc.contributor.author","Moser, Norman"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Meyer-Marcotty, Philipp"],["dc.date.accessioned","2021-04-14T08:30:47Z"],["dc.date.available","2021-04-14T08:30:47Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00784-020-03730-6"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83373"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1436-3771"],["dc.relation.issn","1432-6981"],["dc.title","Orthodontic incisor decompensation in orthognathic therapy—success and efficiency in three dimensions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","617"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","QUINTESSENCE INTERNATIONAL"],["dc.bibliographiccitation.lastpage","621"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Santander, Petra"],["dc.contributor.author","Sievers, Denise"],["dc.contributor.author","Moser, Norman"],["dc.date.accessioned","2018-11-07T10:11:49Z"],["dc.date.available","2018-11-07T10:11:49Z"],["dc.date.issued","2016"],["dc.description.abstract","Non-restorative sleep has considerable consequences for daily life. A sleep disorder is recognized by symptoms such as daytime fatigue and performance or concentration disorders. Furthermore, it increases the risk of developing cardiovascular, metabolic, and neurologic diseases. The diagnosis and therapy of sleep disorders is not only in the sleep medicine doctor's hands. A multidisciplinary approach reflects the affected patients' choice. Dentists can make an important contribution, especially to the therapy of sleep-related breathing disorder."],["dc.identifier.doi","10.3290/j.qi.a36172"],["dc.identifier.isi","000383362000010"],["dc.identifier.pmid","27319815"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40120"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Quintessence Publishing Co Inc"],["dc.relation.issn","1936-7163"],["dc.relation.issn","0033-6572"],["dc.title","Sleep-related breathing disorders and dentistry: What is the relationship?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","668"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Oral Oncology"],["dc.bibliographiccitation.lastpage","673"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Kramer, Franz-Josef"],["dc.contributor.author","Böhrnsen, Florian"],["dc.contributor.author","Moser, Norman"],["dc.contributor.author","Schliephake, Henning"],["dc.date.accessioned","2018-06-26T06:55:52Z"],["dc.date.available","2018-06-26T06:55:52Z"],["dc.date.issued","2015"],["dc.description.abstract","The submental island flap has become increasingly popular in the treatment of intraoral defects following tumor ablation. However, there was concern that the elevation of the pedicled flap might interfere with the efficiency of level I-lymph node dissection and decrease the oncologic prognosis of the patients."],["dc.identifier.doi","10.1016/j.oraloncology.2015.03.011"],["dc.identifier.pmid","25962940"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15147"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1879-0593"],["dc.title","The submental island flap for the treatment of intraoral tumor-related defects: No effect on recurrence rates"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","301"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Oral and Maxillofacial Surgery"],["dc.bibliographiccitation.lastpage","307"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Brockmeyer, Phillipp"],["dc.contributor.author","Hahn, Wolfram"],["dc.contributor.author","Fenge, Stefan"],["dc.contributor.author","Moser, Norman"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Gruber, Rudolf Matthias"],["dc.date.accessioned","2021-06-01T10:49:17Z"],["dc.date.available","2021-06-01T10:49:17Z"],["dc.date.issued","2015"],["dc.identifier.doi","10.1007/s10006-015-0499-0"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86229"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1865-1569"],["dc.relation.issn","1865-1550"],["dc.title","Reduced somatosensory impairment by piezosurgery during orthognathic surgery of the mandible"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1303"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","International Journal of Oral and Maxillofacial Surgery"],["dc.bibliographiccitation.lastpage","1310"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Quast, A."],["dc.contributor.author","Santander, P."],["dc.contributor.author","Trautmann, Johanna"],["dc.contributor.author","Moser, N."],["dc.contributor.author","Schliephake, H."],["dc.contributor.author","Meyer-Marcotty, P."],["dc.date.accessioned","2021-04-14T08:32:02Z"],["dc.date.available","2021-04-14T08:32:02Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.ijom.2020.02.011"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83783"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.issn","0901-5027"],["dc.title","A new approach in three dimensions to define pre- and intraoperative condyle–fossa relationships in orthognathic surgery – is there an effect of general anaesthesia on condylar position?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie"],["dc.contributor.author","Olbrisch, Carolin"],["dc.contributor.author","Santander, Petra"],["dc.contributor.author","Moser, Norman"],["dc.contributor.author","Klenke, Daniela"],["dc.contributor.author","Meyer-Marcotty, Philipp"],["dc.contributor.author","Quast, Anja"],["dc.date.accessioned","2022-09-01T09:51:15Z"],["dc.date.available","2022-09-01T09:51:15Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract\n \n Purpose\n We aimed to comprehensively analyse a possible correlation between skeletal malocclusions, gender and mandibular characteristics in all three dimensions in adults and to identify mandibular characteristics that are typical for extreme skeletal patterns.\n \n \n Methods\n A 3D model of the skull was calculated in 111 adult patients (mean age = 27.0 ± 10.2 years; 49 women, 62 men) from available computed tomography or cone beam computed tomography scans of their heads. Based on the 3D models, the skeletal patterns were examined in (a) the transversal dimension regarding asymmetry according to menton deviation, (b) the sagittal dimension according to the Wits appraisal and (c) the vertical dimension according to the maxillomandibular plane angle. The mandibular characteristics assessed were linear (ramus height and width, body length), angular (ramus, gonial and body angle) and volumetric (ramus/mandibular volume, body/mandibular volume) parameters.\n \n \n Results\n \n No correlation between transversal skeletal asymmetry and mandibular characteristics were found, while sagittal (\n F\n (16, 174) = 3.32,\n p\n  < 0.001, η\n 2\n  = 0.23) and vertical (\n F\n (16, 174) = 3.18,\n p\n  < 0.001, η\n 2\n  = 0.23) skeletal patterns were shown to have a significant effect on the mandible. Gender correlated with mandibular characteristics independently from the skeletal pattern. Discriminant analysis revealed that class II and III patients differed in ramus and body angle with class II patients showing higher angles (ramus angle: class II = 89.8 ± 3.9° vs. class III = 84.4 ± 4.8°; body angle: class II = 87.7 ± 4.8° vs. class III = 82.1 ± 5.2°). Hypo- and hyperdivergent patients were discriminated by gonial angle, body angle and body/mandibular volume with hyperdivergent patients having a greater gonial and body angle and body/mandibular volume (gonial angle: hypodivergent = 114 ± 9.3° vs. hyperdivergent = 126.4 ± 8.6°; body angle: hypodivergent = 82.9 ± 4.4° vs. hyperdivergent = 87.7 ± 6.5°; body/mandibular volume: hypodivergent = 72.4 ± 2.7% vs. hyperdivergent = 76.2 ± 2.6%).\n \n \n \n Conclusion\n When analysing 3D data for treatment planning of adult patients, the orthodontist should pay attention to angular and volumetric characteristics of the mandible to identify extreme skeletal sagittal or vertical malocclusions."],["dc.description.abstract","Zusammenfassung\n \n Zielsetzung\n Das Ziel der vorliegenden Studie lag in einer umfassenden dreidimensionalen Analyse einer möglichen Korrelation zwischen skelettalen Malokklusionen, dem Geschlecht und mandibulären Charakteristika bei Erwachsenen und der Identifizierung von Mandibulacharakteristika, welche typischerweise bei extremen Gesichtsschädelaufbauten auftreten.\n \n \n Methoden\n Von 111 erwachsenen Patienten (mittleres Alter = 27,0 ± 10,2 Jahre; 49 Frauen, 62 Männer), bei denen ein Computertomographie- oder ein digitaler Volumentomographie-Scan des Kopfes vorlag, wurde ein 3‑D-Modell des Schädels erstellt. Anhand dessen wurden der Gesichtsschädelaufbau in a) der transversalen Dimension bezüglich möglicher Asymmetrien anhand der Menton-Deviation, b) der sagittalen Dimension anhand des Wits-Wertes und c) der vertikalen Dimension anhand des Interbasiswinkels klassifiziert. Die Mandibulacharakteristika wurden linear (Ramushöhe und -breite, Corpuslänge), angulär (Ramus, Kiefer- und Corpuswinkel) und volumetrisch (Ramus/Mandibula-Volumen, Corpus/Mandibula-Volumen) beurteilt.\n \n \n Ergebnisse\n \n Es wurde kein Zusammenhang zwischen einer transversalen Gesichtsasymmetrie und den Mandibulacharakteristika gefunden. Jedoch zeigte sich, dass der sagittale (\n F\n (16, 174) = 3,32,\n p\n  < 0,001, η\n 2\n  = 0,23) und vertikale (\n F\n (16, 174) = 3,18,\n p\n  < 0,001, η\n 2\n  = 0,23) Gesichtsschädelaufbau einen signifikanten Einfluss auf die Mandibula hatte. Das Geschlecht beeinflusste unabhängig vom Gesichtsschädelaufbau die Charakteristika der Mandibula.\n \n Klasse-II- und –III-Patienten unterschieden sich signifikant bezüglich Ramus- und Corpuswinkel (Ramuswinkel: Klasse II = 89,8 ± 3,9° vs. Klasse III = 84,4 ± 4,8°; Corpuswinkel: Klasse II = 87,7 ± 4,8° vs. Klasse III = 82,1 ± 5,2°). Patienten mit skelettal offenem und tiefem Biss unterschieden sich signifikant hinsichtlich Kieferwinkel, Corpuswinkel und Corpus/Mandibula-Volumen (Kieferwinkel: Tiefbiss = 114 ± 9,3° vs. offener Biss = 126,4 ± 8,6°; Corpuswinkel: Tiefbiss = 82,9 ± 4,4° vs. offener Biss = 87,7 ± 6,5°; Corpus/Mandibula-Volumen: Tiefbiss = 72,4 ± 2,7 % vs. offener Biss = 76,2 ± 2,6 %),\n \n \n Schlussfolgerung\n Um extreme sagittale oder vertikale Dysgnathien zu erkennen, sollte der Kieferorthopäde bei der Analyse von 3‑D-Daten für die Behandlungsplanung erwachsener Patienten auf anguläre und volumetrische Charakteristika der Mandibula achten."],["dc.identifier.doi","10.1007/s00056-022-00419-1"],["dc.identifier.pii","419"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113918"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-597"],["dc.relation.eissn","1615-6714"],["dc.relation.issn","1434-5293"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Three-dimensional mandibular characteristics in skeletal malocclusion"],["dc.title.alternative","A cross-sectional study"],["dc.title.translated","Dreidimensionale Charakteristika der Mandibula bei skelettalen Malokklusionen"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]