Beutner, Dirk

[["dc.bibliographiccitation.firstpage","e0194989"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Thierauf, Julia"],["dc.contributor.author","Weissinger, Stephanie E."],["dc.contributor.author","Veit, Johannes A."],["dc.contributor.author","Affolter, Annette"],["dc.contributor.author","Laureano, Natalia K."],["dc.contributor.author","Beutner, Dirk"],["dc.contributor.author","Heiduschka, Gregor"],["dc.contributor.author","Kadletz, Lorenz"],["dc.contributor.author","Meyer, Moritz"],["dc.contributor.author","Quaas, Alexander"],["dc.contributor.author","Plinkert, Peter"],["dc.contributor.author","Hoffmann, Thomas K."],["dc.contributor.author","Hess, Jochen"],["dc.contributor.editor","Ahmad, Aamir"],["dc.date.accessioned","2020-12-10T18:42:06Z"],["dc.date.available","2020-12-10T18:42:06Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1371/journal.pone.0194989"],["dc.identifier.eissn","1932-6203"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15681"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77807"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Low SOX2 expression marks a distinct subset of adenoid cystic carcinoma of the head and neck and is associated with an advanced tumor stage"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2466"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Cancers"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Arolt, Christoph"],["dc.contributor.author","Meyer, Moritz"],["dc.contributor.author","Hoffmann, Franziska"],["dc.contributor.author","Wagener-Ryczek, Svenja"],["dc.contributor.author","Schwarz, David"],["dc.contributor.author","Nachtsheim, Lisa"],["dc.contributor.author","Beutner, Dirk"],["dc.contributor.author","Odenthal, Margarete"],["dc.contributor.author","Guntinas-Lichius, Orlando"],["dc.contributor.author","Buettner, Reinhard"],["dc.contributor.author","von Eggeling, Ferdinand"],["dc.contributor.author","Klußmann, Jens Peter"],["dc.contributor.author","Quaas, Alexander"],["dc.date.accessioned","2021-04-14T08:32:36Z"],["dc.date.available","2021-04-14T08:32:36Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.3390/cancers12092466"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83961"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.publisher","MDPI"],["dc.relation.eissn","2072-6694"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Expression Profiling of Extracellular Matrix Genes Reveals Global and Entity-Specific Characteristics in Adenoid Cystic, Mucoepidermoid and Salivary Duct Carcinomas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","153"],["dc.bibliographiccitation.issue","2-3"],["dc.bibliographiccitation.journal","Journal of Membrane Biology"],["dc.bibliographiccitation.lastpage","165"],["dc.bibliographiccitation.volume","209"],["dc.contributor.author","Nouvian, Regis"],["dc.contributor.author","Beutner, D."],["dc.contributor.author","Parsons, T. D."],["dc.contributor.author","Moser, Tobias"],["dc.date.accessioned","2017-09-07T11:53:28Z"],["dc.date.available","2017-09-07T11:53:28Z"],["dc.date.issued","2006"],["dc.description.abstract","Faithful information transfer at the hair cell afferent synapse requires synaptic transmission to be both reliable and temporally precise. The release of neurotransmitter must exhibit both rapid on and off kinetics to accurately follow acoustic stimuli with a periodicity of 1 ms or less. To ensure such remarkable temporal fidelity, the cochlear hair cell afferent synapse undoubtedly relies on unique cellular and molecular specializations. While the electron microscopy hallmark of the hair cell afferent synapse - the electron-dense synaptic ribbon or synaptic body - has been recognized for decades, dissection of the synapse's molecular make-up has only just begun. Recent cell physiology studies have added important insights into the synaptic mechanisms underlying fidelity and reliability of sound coding. The presence of the synaptic ribbon links afferent synapses of cochlear and vestibular hair cells to photoreceptors and bipolar neurons of the retina. This review focuses on major advances in understanding the hair cell afferent synapse molecular anatomy and function that have been achieved during the past years."],["dc.identifier.doi","10.1007/s00232-005-0854-4"],["dc.identifier.gro","3143759"],["dc.identifier.isi","000238293000006"],["dc.identifier.pmid","16773499"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11219"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1308"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: NIDCD NIH HHS [R01 DC3783, R01 DC003783]"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.relation.issn","0022-2631"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Structure and function of the hair cell ribbon synapse"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","219"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Laryngoscope Investigative Otolaryngology"],["dc.bibliographiccitation.lastpage","225"],["dc.bibliographiccitation.volume","7"],["dc.contributor.affiliation","Bevis, Nicholas F.; 1\r\nDepartment of Otorhinolaryngology, Head and Neck Surgery\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Klinge‐Strahl, Astrid; 1\r\nDepartment of Otorhinolaryngology, Head and Neck Surgery\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Strenzke, Nicola; 1\r\nDepartment of Otorhinolaryngology, Head and Neck Surgery\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Beutner, Dirk; 1\r\nDepartment of Otorhinolaryngology, Head and Neck Surgery\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.author","Wrobel, Christian"],["dc.contributor.author","Bevis, Nicholas F."],["dc.contributor.author","Klinge‐Strahl, Astrid"],["dc.contributor.author","Strenzke, Nicola"],["dc.contributor.author","Beutner, Dirk"],["dc.date.accessioned","2022-01-11T14:08:14Z"],["dc.date.available","2022-01-11T14:08:14Z"],["dc.date.issued","2021"],["dc.date.updated","2022-03-21T13:34:48Z"],["dc.description.abstract","Abstract Objective Evaluation of the self‐perceived hearing impairment and performance after cochlear implantation in patients with definite Menière's disease (MD). Patients and Methods Seventeen unilaterally or bilaterally profoundly hearing‐impaired patients suffering from MD who received a cochlear implantat (CI) were eligible for inclusion in this study. Their self‐perceived hearing impairment using the short Speech Spatial and Qualities of Hearing Scale (SSQ12) as well as their performance in speech perception (German language Freiburger mono‐ and multisyllable test, Oldenburger sentence test) were compared with a best‐matched control group of non‐MD patients up to 24 months of follow‐up. Results MD patients improved significantly in perception of monosyllables presented at 65 dBSPL, from preoperatively best aided 18.2% [2.4, 34.0] to 51.7% [39.4, 63.9] 1 year after cochlear implantation (mean [95% confidence interval]). Their performance approached the matched controls with 63.2% [55.7, 70.8]. Monosyllables presented at a lower intensity of 55 dBSPL revealed a significant underperformance of the MD patients (21.1% [12.6, 29.6]) in contrast to the non‐MD controls (39.1% [30.9, 47.4]) 12 months post‐CI. Self‐assessed hearing disability was significantly more pronounced in MD patients with a mean total SSQ12 score of 3.6 [2.4, 4.9] in comparison to 6.1 [5.4, 6.8] of the matched non‐MD controls after 12 months of cochlear implantation. Conclusion Cochlear implantation substantially improves hearing capabilities in profoundly hearing‐impaired patients with MD, but they tend to underperform in comparison to non‐MD patients at least at lower sound pressure levels. This is likely one reason for the poorer self‐assessed hearing function of cochlear implanted MD patients. Level of Evidence 3, retrospective, nonrandomized follow‐up study."],["dc.description.abstract","The current study evaluates self‐perceived hearing function using the SSQ12 as well as speech perception in cochlear implanted patients with Menière's disease. It reveals greater self‐assessed hearing impairment with an accompanying worse speech perception at lower sound pressure levels of Menière patients in comparison to a best‐matched control group of non‐Menière CI patients. image"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.1002/lio2.714"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/97975"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-507"],["dc.relation.eissn","2378-8038"],["dc.relation.issn","2378-8038"],["dc.rights","CC BY-NC-ND 4.0"],["dc.title","Performance and self‐perceived hearing impairment after cochlear implantation in Menière's disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","496"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Laryngoscope Investigative Otolaryngology"],["dc.bibliographiccitation.lastpage","502"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Beutner, Dirk"],["dc.contributor.author","Vent, Julia"],["dc.contributor.author","Seehawer, Julia"],["dc.contributor.author","Luers, Jan Christoffer"],["dc.contributor.author","Lang‐Roth, Ruth"],["dc.contributor.author","Wrobel, Christian"],["dc.date.accessioned","2021-06-01T09:42:08Z"],["dc.date.available","2021-06-01T09:42:08Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract Objective Investigation of the gustatory function in a large cohort of cochlear implanted patients using lateralized taste‐strip tests. Patients and Methods One hundred and seven unilaterally or bilaterally profoundly hearing impaired or deaf patients who received cochlear implants (n = 113) were included in this study. Data on gustometry, subjective gustatory dysfunction, and the detailed surgical procedure were acquired retrospectively. Gustatory function, assessed using lateralized taste‐strip tests, was performed the day before, 3 days after cochlear implantation, and on the day of the initial CI adjustment (39 days ±7.3 SD). Results Averaged taste‐strip scores of the cohort declined significantly from preoperatively 12.3 [11.8; 12.7] (mean [95% confidence intervals]) to 10.5 [9.7; 11.2] on the implanted side about 6 weeks after surgery. Patients with intraoperatively exposed and rerouted, or a severed, chorda tympani nerve (CTN) showed significantly reduced unilateral postoperative scores (10.1 [8.8; 11.4] and 9.3 [8.1; 10.5], respectively), when compared to not exposing or to leaving a bony layer over the CTN. Total taste‐strip test scores showed a significant decline 6 weeks postoperatively in CI‐patients expressing a subjective gustatory dysfunction (from 23.6 [21.4; 25.8] to 17.5 [14.2; 20.8]), as opposed to patients with a documented subjectively normal taste. Conclusion We consider postoperative gustatory dysfunction as a relevant side effect post cochlear implantation, at least within the first month. Taste‐strip based gustometry is a suitable diagnostic tool to assess taste function in CI patients and is recommended to be performed routinely. Level of Evidence 3, retrospective, nonrandomized follow‐up study."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1002/lio2.567"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85153"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","2378-8038"],["dc.relation.issn","2378-8038"],["dc.rights","CC BY-NC-ND 4.0"],["dc.title","Taste‐strip gustometry in cochlear implanted patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","1882"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","International Journal of Molecular Sciences"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Hinkelbein, Jochen"],["dc.contributor.author","Jansen, Stefanie"],["dc.contributor.author","Iovino, Ivan"],["dc.contributor.author","Kruse, Silvia"],["dc.contributor.author","Meyer, Moritz"],["dc.contributor.author","Cirillo, Fabrizio"],["dc.contributor.author","Drinhaus, Hendrik"],["dc.contributor.author","Hohn, Andreas"],["dc.contributor.author","Klein, Corinna"],["dc.contributor.author","De Robertis, Edoardo"],["dc.contributor.author","Beutner, Dirk"],["dc.date.accessioned","2019-07-09T11:44:32Z"],["dc.date.available","2019-07-09T11:44:32Z"],["dc.date.issued","2017"],["dc.description.abstract","Hypobaric hypoxia (HH) during airline travel induces several (patho-) physiological reactions in the human body. Whereas severe hypoxia is investigated thoroughly, very little is known about effects of moderate or short-term hypoxia, e.g. during airline flights. The aim of the present study was to analyse changes in serum protein expression and activation of signalling cascades in human volunteers staying for 30 min in a simulated altitude equivalent to airline travel. After approval of the local ethics committee, 10 participants were exposed to moderate hypoxia (simulation of 2400 m or 8000 ft for 30 min) in a hypobaric pressure chamber. Before and after hypobaric hypoxia, serum was drawn, centrifuged, and analysed by two-dimensional gel electrophoresis (2-DIGE) and matrix-assisted laser desorption/ionization followed by time-of-flight mass spectrometry (MALDI-TOF). Biological functions of regulated proteins were identified using functional network analysis (GeneMania(®), STRING(®), and Perseus(®) software). In participants, oxygen saturation decreased from 98.1 ± 1.3% to 89.2 ± 1.8% during HH. Expression of 14 spots (i.e., 10 proteins: ALB, PGK1, APOE, GAPDH, C1QA, C1QB, CAT, CA1, F2, and CLU) was significantly altered. Bioinformatic analysis revealed an association of the altered proteins with the signalling cascades \"regulation of haemostasis\" (four proteins), \"metabolism\" (five proteins), and \"leukocyte mediated immune response\" (five proteins). Even though hypobaric hypoxia was short and moderate (comparable to an airliner flight), analysis of protein expression in human subjects revealed an association to immune response, protein metabolism, and haemostasis."],["dc.identifier.doi","10.3390/ijms18091882"],["dc.identifier.pmid","28858246"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14814"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59033"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.issn","1422-0067"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Thirty Minutes of Hypobaric Hypoxia Provokes Alterations of Immune Response, Haemostasis, and Metabolism Proteins in Human Serum."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]