Carstens, Per-Ole

[["dc.bibliographiccitation.firstpage","2132"],["dc.bibliographiccitation.issue","20"],["dc.bibliographiccitation.journal","Neurology"],["dc.bibliographiccitation.lastpage","2138"],["dc.bibliographiccitation.volume","87"],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Carstens, Per-Ole"],["dc.contributor.author","Zhang, Shuo"],["dc.contributor.author","von Fintel, Eva"],["dc.contributor.author","Friede, Tim"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Schmidt, Jens"],["dc.date.accessioned","2020-12-10T18:41:43Z"],["dc.date.available","2020-12-10T18:41:43Z"],["dc.date.issued","2016"],["dc.description.abstract","Objective: To assess safety and feasibility of real-time (RT) MRI for evaluation of dysphagia and to compare this technique to standard assessment by flexible endoscopic evaluation of swallowing (FEES) and videofluoroscopy (VF) in a cohort of patients with inclusion body myositis (IBM). Methods: Using RT-MRI, FEES, and VF, an unselected cohort of 20 patients with IBM was studied as index disease with a uniform dysphagia. Symptoms of IBM and dysphagia were explored by standardized tools including Swallowing-Related Quality of Life Questionnaire (SWAL-QoL), IBM Functional Rating Scale, Patient-Reported Functional Assessment, and Medical Research Council Scale. Results: Dysphagia was noted in 80% of the patients and SWAL-QoL was impaired in patients with IBM compared to published reference values of healthy elderly. Swallowing in a supine position during RT-MRI was well-tolerated by all patients. RT-MRI equally revealed dysphagia compared to VF and FEES and correlated well with the SWAL-QoL. Only RT-MRI allowed precise time measurements and identification of the respective tissue morphology. The pharyngeal transit times were 2-fold longer compared to published reference values and significantly correlated with morphologic abnormalities. Conclusions: RT-MRI is safe and equally capable as VF to identify the cause of dysphagia in IBM. Advantages of RT-MRI include visualization of soft tissue, more reliable timing analysis, and lack of X-ray exposure. RT-MRI may become a routine diagnostic tool for detailed assessment of the esophagus and other moving parts of the body, facilitating longitudinal evaluations in daily practice and clinical trials."],["dc.identifier.doi","10.1212/WNL.0000000000003337"],["dc.identifier.eissn","1526-632X"],["dc.identifier.isi","000392236100014"],["dc.identifier.issn","0028-3878"],["dc.identifier.pmid","27770070"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77659"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1526-632X"],["dc.relation.issn","0028-3878"],["dc.title","Evaluation of dysphagia by novel real-time MRI"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Journal of Neurology"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Carstens, P.-O."],["dc.contributor.author","Zhang, S."],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Bremen, E."],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Schmidt, J."],["dc.date.accessioned","2018-11-07T09:56:03Z"],["dc.date.available","2018-11-07T09:56:03Z"],["dc.date.issued","2015"],["dc.format.extent","110"],["dc.identifier.isi","000357033500175"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36885"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","1st Congress of the European-Academy-of-Neurology"],["dc.relation.eventlocation","Berlin, GERMANY"],["dc.relation.issn","1468-1331"],["dc.relation.issn","1351-5101"],["dc.title","Evaluation of dysphagia in inclusion body myositis by novel real-time MRI"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9-10"],["dc.bibliographiccitation.journal","Neuromuscular Disorders"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Carstens, Per-Ole"],["dc.contributor.author","Zhang, S."],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Bremen, E."],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Schmidt, J."],["dc.date.accessioned","2018-11-07T09:34:35Z"],["dc.date.available","2018-11-07T09:34:35Z"],["dc.date.issued","2014"],["dc.format.extent","814"],["dc.identifier.doi","10.1016/j.nmd.2014.06.080"],["dc.identifier.isi","000342870200077"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32200"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.publisher.place","Oxford"],["dc.relation.conference","19th International Congress of the World-Muscle-Society"],["dc.relation.eventlocation","Berlin, GERMANY"],["dc.relation.issn","1873-2364"],["dc.relation.issn","0960-8966"],["dc.title","Real-time MRI for the evaluation of dysphagia in inclusion body myositis (IBM)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]