Belov, Vladimir N.

[["dc.bibliographiccitation.firstpage","4246"],["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","Journal of Medicinal Chemistry"],["dc.bibliographiccitation.lastpage","4253"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Brands, M."],["dc.contributor.author","Endermann, R."],["dc.contributor.author","Gahlmann, R."],["dc.contributor.author","Kruger, J."],["dc.contributor.author","Raddatz, S."],["dc.contributor.author","Stoltefuss, J."],["dc.contributor.author","Belov, Vladimir N."],["dc.contributor.author","Nizamov, S."],["dc.contributor.author","Sokolov, Viktor V."],["dc.contributor.author","Meijere, Armin de"],["dc.date.accessioned","2018-11-07T10:03:05Z"],["dc.date.available","2018-11-07T10:03:05Z"],["dc.date.issued","2002"],["dc.description.abstract","The natural dipeptide antibiotic TAN 1057 A,B displays excellent antibacterial activity against staphylococci including methicillin resistant Staphylococcus aureus. However, the in vitro activity against additional Gram-positive strains, in particular pneumococci and Enterococcus faecalis, proved to be considerably lower. We report the synthesis and pharmacological evaluation of new derivatives of this natural product that displayed increased antibacterial potency against staphylococci and were also active against pneumococci. In particular, the analogues bearing modified beta-homoarginine side chains with methylated guanidine moieties were shown to be significantly more potent than the natural product TAN 1057 A,B."],["dc.identifier.doi","10.1021/jm0111191"],["dc.identifier.isi","000177913500015"],["dc.identifier.pmid","12213065"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38370"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0022-2623"],["dc.title","Novel antibiotics for the treatment of gram-positive bacterial infections"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY"],["dc.bibliographiccitation.volume","222"],["dc.contributor.author","Belov, Vladimir N."],["dc.contributor.author","Savchenko, Andrei I."],["dc.contributor.author","Sokolov, Viktor V."],["dc.contributor.author","Straub, Annika U."],["dc.contributor.author","de Meijere, Armin"],["dc.date.accessioned","2018-11-07T08:46:04Z"],["dc.date.available","2018-11-07T08:46:04Z"],["dc.date.issued","2001"],["dc.format.extent","U683"],["dc.identifier.isi","000170690003582"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20600"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Chemical Soc"],["dc.publisher.place","Washington"],["dc.relation.issn","0065-7727"],["dc.title","New route to 1-hetarylcyclopropan-1-ols: Synthesis of the pharmacologically active metabolite of bay 41-2272, a stimulator of soluble guanylate"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4093"],["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","European Journal of Organic Chemistry"],["dc.bibliographiccitation.lastpage","4097"],["dc.contributor.author","Belov, Vladimir N."],["dc.contributor.author","Sokolov, Viktor V."],["dc.contributor.author","Zlatopolskiy, Boris D."],["dc.contributor.author","de Meijere, Armin"],["dc.date.accessioned","2018-11-07T08:53:37Z"],["dc.date.available","2018-11-07T08:53:37Z"],["dc.date.issued","2011"],["dc.description.abstract","A new rearrangement of the cyclic L-glutamine derivative (S)-6-carbamoylamino-3-(methylamino)-2,3,4,5-tetrahydropyridin-2-one (2) and its descarbamoyl analogue 10-H was found to yield enantiomerically pure 5-carbamoylimino-1-methyl-L-proline amide (12-CONH(2)) and its descarbamoyl analogue 12-H, respectively. Cyclic amidines 2 and 10-H were generated from the amide N(2)-ZGlnOEt 3 in seven and six steps, respectively. Deprotection of (S)-6-amino-3-[(N-benzyloxycarbonyl-N-methyl)amino]-2,3,4,5-tetrahydropyridin-2-one (8) led directly to 5-iminoproline amide 12-H (via 10-H and the bicyclic orthoamidine 11-H) in 66% overall yield from 3. Carbamoylation of 8 with ZNCO (Z = PhCH(2)OCO) followed by hydrolytic removal of both Z groups gave 5-(carbamoylimino)proline amide 12-CONH(2) (via 2 and orthoamidine 11-CONH(2)) in 70% overall yield from 3."],["dc.description.sponsorship","Bayer AG"],["dc.identifier.doi","10.1002/ejoc.201100404"],["dc.identifier.isi","000293497900003"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22463"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1434-193X"],["dc.title","A Novel Rearrangement of Cyclic Glutamine Derivatives: Ring Contraction in 3,6-Diamino-2,3,4,5-tetrahydropyridin-2-ones to Yield 5-Iminoproline Amides"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2753"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","European Journal of Organic Chemistry"],["dc.bibliographiccitation.lastpage","2765"],["dc.contributor.author","Dalai, Suryakanta"],["dc.contributor.author","Belov, Vladimir N."],["dc.contributor.author","Nizamov, Shamil"],["dc.contributor.author","Rauch, Karsten"],["dc.contributor.author","Finsinger, Dirk"],["dc.contributor.author","de Meijere, Armin"],["dc.date.accessioned","2018-11-07T09:41:33Z"],["dc.date.available","2018-11-07T09:41:33Z"],["dc.date.issued","2006"],["dc.description.abstract","Under basic conditions (Et3N, dioxane), the aromatic amidines 4 and also S-methylisothiourea 4g cleanly undergo Michael addition to methyl 2-chloro-2-cyclopropylideneacelate (5), followed by intramolecular nucleophilic substitution, cyclopropyl to cyclobutyl ring enlargement, deprotonation and cyclization with elimination of methanol to afford the cyclobutene-annelated pyrimidinones 6 in 43-83 % yield (7 examples). Thermal cyclobutene-ring opening of the latter at 175 degrees C followed by regioselective Diels-Alder cycloaddition with phenyl vinyl sulfone gives the 2-aryl-6-(phenylsulfonyl)-5,6,7,8-tetrahydroquinazolinone derivatives 12 in 3983 % yield (7 examples). Base-induced elimination of benzenesulfinic acid and subsequent catalytic hydrogenation leads to the 2-aryltetrahydroquinazolinone derivatives 14 in excellent yields (6 examples). Deprotonation at the sulfonyl-substituted center, alkylation and subsequent elimination of benzenesulfinic acid followed by catalytic hydrogenation gives the 2,6-disubstituted tetrahydroquinazolinones 17a-R. Nucleophilic substitution of the methylthio group in 12g by secondary amines yields the 2-(dialkylamino)tetrahydroquinazolinones 14i-k. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)"],["dc.identifier.doi","10.1002/ejoc.200600060"],["dc.identifier.isi","000238601500011"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33757"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1434-193X"],["dc.title","Access to variously substituted 5,6,7,8-tetrahydro-3H-quinazolin-4-ones via Diels-Alder adducts of phenyl vinyl sulfone to cyclobutene-annelated pyrimidinones"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Naunyn-Schmiedeberg s Archives of Pharmacology"],["dc.bibliographiccitation.volume","372"],["dc.contributor.author","Mueller, M."],["dc.contributor.author","Belov, V."],["dc.contributor.author","de Meijere, Armin"],["dc.contributor.author","Handrich, Claudia"],["dc.contributor.author","Hallier, Ernst"],["dc.contributor.author","Bunger, J."],["dc.date.accessioned","2018-11-07T10:15:14Z"],["dc.date.available","2018-11-07T10:15:14Z"],["dc.date.issued","2006"],["dc.format.extent","132"],["dc.identifier.isi","000237126800518"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40769"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.conference","47th Spring Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie"],["dc.relation.eventlocation","Mainz, GERMANY"],["dc.relation.issn","0028-1298"],["dc.title","Biological monitoring after epichlorohydrin exposure: Development of a new method to determine the hemoglobin adduct N-(2,3-dihydroxypropyl)valine"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","no"],["dc.bibliographiccitation.issue","36"],["dc.bibliographiccitation.journal","ChemInform"],["dc.bibliographiccitation.lastpage","no"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Belov, Vladimir N."],["dc.contributor.author","Funke, Christian"],["dc.contributor.author","Labahn, Thomas"],["dc.contributor.author","Es-Sayed, Mazen"],["dc.contributor.author","de Meijere, Armin"],["dc.date.accessioned","2021-12-08T12:28:33Z"],["dc.date.available","2021-12-08T12:28:33Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1002/chin.199936225"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95737"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1522-2667"],["dc.relation.issn","0931-7597"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","ChemInform Abstract: Cyclopropyl Building Blocks in Organic Synthesis. Part 50. An Easy Access to Bicyclic Peptides with an Octahydro[2H]pyrazino[1,2-a]pyrazine Skeleton."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","no"],["dc.bibliographiccitation.issue","31"],["dc.bibliographiccitation.journal","ChemInform"],["dc.bibliographiccitation.lastpage","no"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","SOKOLOV, V. V."],["dc.contributor.author","KOZHUSHKOV, S. I."],["dc.contributor.author","NIKOLSKAYA, S."],["dc.contributor.author","BELOV, V. N."],["dc.contributor.author","ES-SAYED, M."],["dc.contributor.author","DE MEIJERE, A."],["dc.date.accessioned","2021-12-08T12:28:21Z"],["dc.date.available","2021-12-08T12:28:21Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1002/chin.199831259"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95658"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1522-2667"],["dc.relation.issn","0931-7597"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","ChemInform Abstract: Total Synthesis of TAN-1057 A/B, a New Dipeptide Antibiotic from Flexibacter sp. PK-74."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","50"],["dc.bibliographiccitation.journal","ChemInform"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Belov, Vladimir N."],["dc.contributor.author","Brands, Michael"],["dc.contributor.author","Raddatz, Siegfried"],["dc.contributor.author","Krueger, Jochen"],["dc.contributor.author","Nikolskaya, Sofia"],["dc.contributor.author","Sokolov, Viktor"],["dc.contributor.author","de Meijere, Armin"],["dc.date.accessioned","2021-12-08T12:29:18Z"],["dc.date.available","2021-12-08T12:29:18Z"],["dc.date.issued","2004"],["dc.identifier.doi","10.1002/chin.200450188"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/96025"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1522-2667"],["dc.relation.issn","0931-7597"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","First Enantioselective Synthesis of the Novel Antiinfective TAN-1057A (I) via Its Aminomethyl-Substituted Dihydropyrimidinone Heterocycle."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","no"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","ChemInform"],["dc.bibliographiccitation.lastpage","no"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","de Meijere, Armin"],["dc.contributor.author","von Seebah, Malte"],["dc.contributor.author","Zoellner, Stefan"],["dc.contributor.author","Kozhushkov, Sergei I."],["dc.contributor.author","Belov, Vladimir N."],["dc.contributor.author","Boese, Roland"],["dc.contributor.author","Haumann, Thomas"],["dc.contributor.author","Benet-Buchholz, Jordi"],["dc.contributor.author","Yufit, Dmitrii S."],["dc.contributor.author","Howard, Judith A. K."],["dc.date.accessioned","2021-12-08T12:28:53Z"],["dc.date.available","2021-12-08T12:28:53Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1002/chin.200205077"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95873"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1522-2667"],["dc.relation.issn","0931-7597"],["dc.rights.uri","http://doi.wiley.com/10.1002/tdm_license_1.1"],["dc.title","ChemInform Abstract: Spirocyclopropanated Bicyclopropylidenes: Straightforward Preparation, Physical Properties, and Chemical Transformations."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","551"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","European Journal of Organic Chemistry"],["dc.bibliographiccitation.lastpage","561"],["dc.contributor.author","Belov, Vladimir N."],["dc.contributor.author","Savchenko, Andrei I."],["dc.contributor.author","Sokolov, Viktor V."],["dc.contributor.author","Straub, Annika U."],["dc.contributor.author","de Meijere, Armin"],["dc.date.accessioned","2018-11-07T10:41:14Z"],["dc.date.available","2018-11-07T10:41:14Z"],["dc.date.issued","2003"],["dc.description.abstract","(E/Z)-2-(1-Allyloxycyclopropyl)-3-methoxyacrylonitrile (4-All) was designed and prepared in five steps (58% overall yield) from ethyl cyclopropylidenacetate as a valuable precursor to various 1-heteroarylcyclopropanols. Its condensation with amidines, guanidine, hydrazine, and methyl thioglycolate and subsequent removal of the allyl protecting group yields 1-heteroarylcyclopropanols such as 1-OH (36% over 2 steps), a very potent NO-independent stimulator of soluble guanylate cyclase. Direct cleavage of the allyl ether protecting group [by palladium-catalyzed substitution with lithium p-toluenesulfinate in AcOH or treatment with c-HexMgBr/Ti(OiPr)(4)] gives highly functionalized, sterically congested 1-heteroarylcyclopropanols 29, 30, and 34 with intact amino and ester groups. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)."],["dc.identifier.isi","000180805100020"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46487"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","1434-193X"],["dc.title","Cyclopropyl building blocks in organic synthesis, part 84. A new and productive route to 1-heteroarylcyclopropanols"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]