Trojan, Lutz

[["dc.bibliographiccitation.firstpage","459"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","International Braz J Urol"],["dc.bibliographiccitation.lastpage","467"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Leitsmann, Conrad"],["dc.contributor.author","Thelen, Paul"],["dc.contributor.author","Schmid, Marianne"],["dc.contributor.author","Meller, Johannes"],["dc.contributor.author","Sahlmann, Carsten-Oliver"],["dc.contributor.author","Meller, Birgit"],["dc.contributor.author","Trojan, Lutz"],["dc.contributor.author","Strauss, Arne"],["dc.date.accessioned","2021-06-01T10:48:28Z"],["dc.date.available","2021-06-01T10:48:28Z"],["dc.date.issued","2019"],["dc.description.abstract","Purpose: 68Ga-PSMA PET/CT imaging is a promising modality for the staging of recurrent prostate cancer (PCa). Current evidence suggests limited diagnostic value of the 68Ga-PSMA PET/CT in PSA-levels ≤0.3ng/mL. Experimental data have demonstrated an increase in PSMA-expression in PCa metastases by androgen deprivation in vitro. The aim of the current study was to investigate a possible enhancing effect of PSMA with low-dose androgen deprivation in patients with BCR and low PSA-levels. Materials and Methods: Five patients with PCa and BCR, following radical prostatectomy, underwent 68Ga-PSMA PET/CT. A consecutive 68Ga-PSMA PET/CT was performed 6 to 11 days after injection of 80mg of Degarelix (Firmagon®). We recorded PSA and testosterone serum-levels and changes of PSMA-uptake in 68Ga-PSMA PET/CT images. Results: Median PSA prior 68Ga-PSMA PET/CT was 0.27ng/mL. All patients had a decrease in testosterone serum levels from median 2.95μg/l to 0.16μg/l following Degarelix injection. We observed an increase in the standardized uptake value (SUV) in PSMA-positive lymphogenous and osseous lesions in two patients following androgen deprivation. In another two patients, no PSMA positive signals were detected in either the first or the second scan. Conclusion: Our preliminary results of this feasibility assessment indicate a possible enhancing effect of PSMA-imaging induced by low-dose ADT. Despite several limitations and the small number of patients, this could be a new approach to improve staging by 68Ga-PSMA PET/CT in PCa patients with BCR after primary therapy. Further prospective studies with larger number of patients are needed to validate our findings."],["dc.identifier.doi","10.1590/s1677-5538.ibju.2018.0305"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85949"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","final"],["dc.relation.eissn","1677-6119"],["dc.relation.issn","1677-5538"],["dc.title","Enhancing PSMA-uptake with androgen deprivation therapy – a new way to detect prostate cancer metastases?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","JORS-D-20-00102R1"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Journal of Robotic Surgery"],["dc.bibliographiccitation.lastpage","9"],["dc.contributor.author","Leitsmann, Conrad"],["dc.contributor.author","Uhlig, Annemarie"],["dc.contributor.author","Popeneciu, I. Valentin"],["dc.contributor.author","Boos, Margarete"],["dc.contributor.author","Ahyai, Sascha A."],["dc.contributor.author","Schmid, Marianne"],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Trojan, Lutz"],["dc.contributor.author","Friedrich, Martin"],["dc.date.accessioned","2021-06-01T10:49:20Z"],["dc.date.available","2021-06-01T10:49:20Z"],["dc.date.issued","2020"],["dc.description.abstract","To reduce noise pollution and consequently stress during robot-assisted laparoscopic radical prostatectomy (RALP) the aim of our study was to evaluate the silent operation theatre optimisation system (SOTOS) in its effectiveness. In the operating room (OR) the noise level is between 80 and 85 decibel (dB). Noise corresponds to a major stress factor for surgical teams and especially surgeons. The use of the da Vinci surgical system entails an additional aspect of noise in the OR. The SOTOS surgical team used wired or wireless headphone/microphone combinations to communicate. We measured sound pressure levels in two different locations in the OR and the heart rate of every surgical team member as an indicator of the stress level. We further captured subjective acceptance of SOTOS as well as perioperative data such as surgical time. We prospectively randomised 32 RALP patients into two study arms. Sixteen surgeries were performed using SOTOS and 16 without (con- trol). Overall, the mean sound pressure level in the SOTOS group was 3.6 dB lower compared to the control (p < 0.001). The highest sound pressure level measured was 96 dB in the control group. Mean heart rates were 81.3 beats/min for surgeons and 90.8 beats/min for circulating nurses. SOTOS had no statistically significant effect on mean heart rates of the operating team. Subjective acceptance of SOTO was high. Our prospective evaluation of SOTOS in RALP could show a significant noise reduction in the OR and a high acceptance by the surgical stuff."],["dc.identifier.doi","10.1007/s11701-020-01135-x"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86250"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1863-2491"],["dc.relation.issn","1863-2483"],["dc.title","The Silent Operation Theatre Optimisation System (SOTOS©) to reduce noise pollution during da Vinci robot-assisted laparoscopic radical prostatectomy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","64"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BJU International"],["dc.bibliographiccitation.lastpage","70"],["dc.bibliographiccitation.volume","127"],["dc.contributor.author","Kriegmair, Maximilian C."],["dc.contributor.author","Younsi, Nina"],["dc.contributor.author","Hiller, Kiriaki"],["dc.contributor.author","Leitsmann, Conrad"],["dc.contributor.author","Kowalewski, Karl F."],["dc.contributor.author","Siegel, Fabian"],["dc.contributor.author","Rothamel, Martin"],["dc.contributor.author","Ritter, Manuel"],["dc.contributor.author","Bolenz, Christian"],["dc.contributor.author","Kriegmair, Martin"],["dc.contributor.author","Trojan, Lutz"],["dc.contributor.author","Michel, Maurice S."],["dc.date.accessioned","2021-04-14T08:24:10Z"],["dc.date.available","2021-04-14T08:24:10Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1111/bju.15148"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81189"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1464-410X"],["dc.relation.issn","1464-4096"],["dc.title","Single‐ vs multiple‐layer wound closure for flank incisions: results of a prospective, randomised, double‐blinded multicentre study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1934"],["dc.bibliographiccitation.issue","16"],["dc.bibliographiccitation.journal","The Prostate"],["dc.bibliographiccitation.lastpage","1940"],["dc.bibliographiccitation.volume","75"],["dc.contributor.author","Hijazi, Sameh"],["dc.contributor.author","Meller, Birgit"],["dc.contributor.author","Leitsmann, Conrad"],["dc.contributor.author","Strauss, A."],["dc.contributor.author","Meller, J."],["dc.contributor.author","Ritter, Christian Oliver"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Schildhaus, H.-U."],["dc.contributor.author","Trojan, Lutz"],["dc.contributor.author","Sahlmann, Carsten-Oliver"],["dc.date.accessioned","2018-11-07T09:48:43Z"],["dc.date.available","2018-11-07T09:48:43Z"],["dc.date.issued","2015"],["dc.description.abstract","BACKGROUNDThe first evaluation of pelvic extended lymph node dissection (pLND) in oligometastatic prostate cancer (PCa) detected by Ga-68-PSMA PET/CT. METHODSRetrospective analysis of 35 PCa patients underwent Ga-68-PSMA PET/CT affected by biochemical recurrence (BCR) after curative treatment (n=23) or before primary therapy of high-risk PCa (n=12). We performed pLND associated with pathologic imaging in 17 men with nodal oligometastatic PCa. RESULTSIndicative lesions for PCa in PET/CT were detected in 91.4% (32 of 35) of patients. Nodal, bone, visceral (pulmonary), and within the prostate suspected disease were detected in 72% (23 of 32), 16% (5 of 32), 6% (2 of 32), and 47% (15 of 32) of patients, respectively. Median serum PSA in patients with pathological radiotracer uptake in recurrent and high-risk PCa patients was 2.9ng/ml (range 0.18-30) and 19.5ng/ml (range 6-90), respectively. The median number of removed lymph nodes with pLND in recurrent and high-risk PCa was 10 (range 4-17) and 12 (range 8-29) per patient and the median number of positive lymph nodes was 1 (range 1-2) and 3 (2-3) per patient, respectively. In total, two false positive and one false-negative lymph node were found. Diagnostic accuracies per nodal lesion in total of 213 removed nodes: sensitivity, 94%; specificity, 99%; positive predictive value (PPV), 89%, and negative predictive value (NPV), 99.5%. After pLND, 53% (9 of 17) of patients received androgen deprivation therapy and/or radiation therapy and hormonal therapy, while 47% (8 of 17) of patients remained free of any post-surgery therapy. Follow-up PSA remained less than 0.2ng/ml in 82% (14 of 17) of patients. After pLND, immediate BCR (PSA never measured less than 0.2ng/ml) in 18% (3 of 17) of patients was recorded. CONCLUSIONSThis represents the first study of pLND in the setting of nodal oligometastatic PCa detected by Ga-68-PSMA PET/CT. The use of Ga-68-PSMA PET/CT could be to improve the accuracy for the detection of nodal micrometastases. These promising findings need validation in larger studies. Prostate 75:1934-1940, 2015. (c) 2015 Wiley Periodicals, Inc."],["dc.identifier.doi","10.1002/pros.23091"],["dc.identifier.isi","000363219300013"],["dc.identifier.pmid","26356236"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35365"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1097-0045"],["dc.relation.issn","0270-4137"],["dc.title","Pelvic lymph node dissection for nodal oligometastatic prostate cancer detected by Ga-68-PSMA-positron emission tomography/computerized tomography"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","776"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","The Prostate"],["dc.bibliographiccitation.lastpage","780"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Hijazi, Sameh"],["dc.contributor.author","Meller, Birgit"],["dc.contributor.author","Leitsmann, Conrad"],["dc.contributor.author","Strauss, Arne"],["dc.contributor.author","Ritter, Christian"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Meller, Johannis"],["dc.contributor.author","Trojan, Lutz"],["dc.contributor.author","Sahlmann, Carsten-Oliver"],["dc.date.accessioned","2018-11-07T10:14:00Z"],["dc.date.available","2018-11-07T10:14:00Z"],["dc.date.issued","2016"],["dc.description.abstract","BACKGROUNDOur study is the first evaluation of nodal metastatic prostate cancer (PCa) to mesorectal lymph nodes (MLN) detected by Ga-68-PSMA-PET/CT. METHODSWe retrospectively analyzed 76 consecutive PCa patients who underwent Ga-68-PSMA-PET/CT: 61 PCa patients with biochemical recurrence (BCR) after curative treatment and 15 high-risk PCa before primary therapy. We assessed PET-positive MLN, which are indicative for PCa. RESULTSWe detected PET-positive lesions for PCa in Ga-68-PSMA-PET/CT in 66 of 76 (87%) patients. Nodal disease was imaged in 47 of 66 (71%) patients. Indicative mesorectal nodal lesions for PCa were detected in 12 of 76 (15.8%) patients. The median number of PET-positive MLN was one per patient. Seven of twelve patients had recurrent PCa after radical prostatectomy with a median PSA value of 1.84ng/ml (range 0.31-13). Five of twelve patients had untreated first diagnosed high-risk PCa with median PSA value of 90ng/ml (range 4.6-93) at PET/CT, respectively. For all PET positive MLN a morphological correlate was found in CT (shortest diameter median 4mm [range 4-21]; longest diameter median 7.5mm [range 5-25]). After PET/CT, four patients with recurrent PCa received hormonal therapy, one patient was treated with directed radiation therapy of MLN, one patient received chemotherapy, and one patient was treated with pelvic lymph node dissection. Three high-risk PCa patients received hormonal therapy, and two patients were treated with adjuvant hormonal therapy after radical prostatectomy. CONCLUSIONSDetection and exact location of nodal metastasis for PCa is crucial for the choice of treatment and the patient's prognosis. Ga-68-PSMA-PET/CT seems to improve the detection of nodal metastasis in PCa, especially concerning mesorectal lymph nodes. Prostate 76:776-780, 2016. (c) 2016 Wiley Periodicals, Inc."],["dc.identifier.doi","10.1002/pros.23168"],["dc.identifier.isi","000374860200008"],["dc.identifier.pmid","26880517"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40540"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1097-0045"],["dc.relation.issn","0270-4137"],["dc.title","See the unseen: Mesorectal lymph node metastases in prostate cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]