Trojan, Lutz

[["dc.bibliographiccitation.firstpage","64"],["dc.bibliographiccitation.journal","Urology Case Reports"],["dc.bibliographiccitation.lastpage","66"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Uhlig, Annemarie"],["dc.contributor.author","Behnes, Carl Ludwig"],["dc.contributor.author","Strauss, Arne"],["dc.contributor.author","Trojan, Lutz"],["dc.contributor.author","Uhlig, Johannes"],["dc.contributor.author","Leitsmann, Conrad"],["dc.date.accessioned","2019-07-09T11:45:15Z"],["dc.date.available","2019-07-09T11:45:15Z"],["dc.date.issued","2018"],["dc.description.abstract","Primary Bladder Adenocarcinoma is a rare malignancy that has been observed in a heterogeneous pa- tient population. This case report presents a 51 year old female with muscle-invasive primary bladder adenocarcinoma diagnosed in 2008. After transurethral resection and cystectomy with ileum neobladder adjuvant radi- ochemotherapy was administered. Two years later, a symptomatic fistula between neobladder and ileoileal anastomosis was excised, resulting in urinary incontinency. In 2016, the patient shows no signs of disease relapse but suffers from reduction of bladder capacity. This case report presents classical symptoms of adenocarcinoma of the bladder and a possible treat- ment regimen with associated side effects."],["dc.identifier.doi","10.1016/j.eucr.2018.02.006"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15073"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59191"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2214-4420"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.subject.ddc","610"],["dc.title","Primary bladder adenocarcinoma: Case report with long-term follow-up"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","459"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","International Braz J Urol"],["dc.bibliographiccitation.lastpage","467"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Leitsmann, Conrad"],["dc.contributor.author","Thelen, Paul"],["dc.contributor.author","Schmid, Marianne"],["dc.contributor.author","Meller, Johannes"],["dc.contributor.author","Sahlmann, Carsten-Oliver"],["dc.contributor.author","Meller, Birgit"],["dc.contributor.author","Trojan, Lutz"],["dc.contributor.author","Strauss, Arne"],["dc.date.accessioned","2021-06-01T10:48:28Z"],["dc.date.available","2021-06-01T10:48:28Z"],["dc.date.issued","2019"],["dc.description.abstract","Purpose: 68Ga-PSMA PET/CT imaging is a promising modality for the staging of recurrent prostate cancer (PCa). Current evidence suggests limited diagnostic value of the 68Ga-PSMA PET/CT in PSA-levels ≤0.3ng/mL. Experimental data have demonstrated an increase in PSMA-expression in PCa metastases by androgen deprivation in vitro. The aim of the current study was to investigate a possible enhancing effect of PSMA with low-dose androgen deprivation in patients with BCR and low PSA-levels. Materials and Methods: Five patients with PCa and BCR, following radical prostatectomy, underwent 68Ga-PSMA PET/CT. A consecutive 68Ga-PSMA PET/CT was performed 6 to 11 days after injection of 80mg of Degarelix (Firmagon®). We recorded PSA and testosterone serum-levels and changes of PSMA-uptake in 68Ga-PSMA PET/CT images. Results: Median PSA prior 68Ga-PSMA PET/CT was 0.27ng/mL. All patients had a decrease in testosterone serum levels from median 2.95μg/l to 0.16μg/l following Degarelix injection. We observed an increase in the standardized uptake value (SUV) in PSMA-positive lymphogenous and osseous lesions in two patients following androgen deprivation. In another two patients, no PSMA positive signals were detected in either the first or the second scan. Conclusion: Our preliminary results of this feasibility assessment indicate a possible enhancing effect of PSMA-imaging induced by low-dose ADT. Despite several limitations and the small number of patients, this could be a new approach to improve staging by 68Ga-PSMA PET/CT in PCa patients with BCR after primary therapy. Further prospective studies with larger number of patients are needed to validate our findings."],["dc.identifier.doi","10.1590/s1677-5538.ibju.2018.0305"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85949"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","final"],["dc.relation.eissn","1677-6119"],["dc.relation.issn","1677-5538"],["dc.title","Enhancing PSMA-uptake with androgen deprivation therapy – a new way to detect prostate cancer metastases?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","JORS-D-20-00102R1"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Journal of Robotic Surgery"],["dc.bibliographiccitation.lastpage","9"],["dc.contributor.author","Leitsmann, Conrad"],["dc.contributor.author","Uhlig, Annemarie"],["dc.contributor.author","Popeneciu, I. Valentin"],["dc.contributor.author","Boos, Margarete"],["dc.contributor.author","Ahyai, Sascha A."],["dc.contributor.author","Schmid, Marianne"],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Trojan, Lutz"],["dc.contributor.author","Friedrich, Martin"],["dc.date.accessioned","2021-06-01T10:49:20Z"],["dc.date.available","2021-06-01T10:49:20Z"],["dc.date.issued","2020"],["dc.description.abstract","To reduce noise pollution and consequently stress during robot-assisted laparoscopic radical prostatectomy (RALP) the aim of our study was to evaluate the silent operation theatre optimisation system (SOTOS) in its effectiveness. In the operating room (OR) the noise level is between 80 and 85 decibel (dB). Noise corresponds to a major stress factor for surgical teams and especially surgeons. The use of the da Vinci surgical system entails an additional aspect of noise in the OR. The SOTOS surgical team used wired or wireless headphone/microphone combinations to communicate. We measured sound pressure levels in two different locations in the OR and the heart rate of every surgical team member as an indicator of the stress level. We further captured subjective acceptance of SOTOS as well as perioperative data such as surgical time. We prospectively randomised 32 RALP patients into two study arms. Sixteen surgeries were performed using SOTOS and 16 without (con- trol). Overall, the mean sound pressure level in the SOTOS group was 3.6 dB lower compared to the control (p < 0.001). The highest sound pressure level measured was 96 dB in the control group. Mean heart rates were 81.3 beats/min for surgeons and 90.8 beats/min for circulating nurses. SOTOS had no statistically significant effect on mean heart rates of the operating team. Subjective acceptance of SOTO was high. Our prospective evaluation of SOTOS in RALP could show a significant noise reduction in the OR and a high acceptance by the surgical stuff."],["dc.identifier.doi","10.1007/s11701-020-01135-x"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86250"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1863-2491"],["dc.relation.issn","1863-2483"],["dc.title","The Silent Operation Theatre Optimisation System (SOTOS©) to reduce noise pollution during da Vinci robot-assisted laparoscopic radical prostatectomy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Surgery"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Leitsmann, Conrad"],["dc.contributor.author","Schmid, Marianne"],["dc.contributor.author","Sahlmann, Carsten-Oliver"],["dc.contributor.author","Trojan, Lutz"],["dc.contributor.author","Strauss, Arne"],["dc.date.accessioned","2021-04-14T08:27:57Z"],["dc.date.available","2021-04-14T08:27:57Z"],["dc.date.issued","2021"],["dc.description.abstract","Purpose: Several studies have demonstrated an advantage of 68Ga-PSMA-PET/CT as staging modality for detection of prostate cancer (PCa) metastases. Data concerning metastatic manifestation and impact on PCa development of mesorectal lymph nodes (MLN) is limited. Our investigation describes MLN metastases as index lesion in 68Ga-PSMA PET/CT imaging for recurrent PCa. Methods: Twelve PCa patients with biochemical recurrence (BCR) after primary therapy who prospectively underwent a baseline 68Ga-PSMA-PET/CT initially showed MLN metastases. Eight of these patients received a follow-up 68Ga-PSMA-PET/CT to evaluate treatment response and further evolution. Prostate-specific antigen (PSA)-levels, changes in PSMA-uptake of MLN metastases and further 68Ga-PSMA PET/CT findings were recorded. Results: Median PSA at the first 68Ga-PSMA-PET/CT was 5.39 ng/ml. In all patients therapeutic management changed after the first 68Ga-PSMA-PET/CT. Androgen deprivation therapy (ADT) was initiated in seven of eight patients, one patient restarted initial ADT. Three patients additionally received salvage radiation therapy (sRT) including the prostatic lodge and docetaxel chemotherapy was started in one case. At follow-up, a decrease of PSA-level was detected in all patients (median 2.05 ng/ml) after median 10 months. In six of eight patients we observed a decrease or complete regress of PSMA-uptake in MLN in the follow-up 68Ga-PSMA-PET/CT. Conclusion: MLN metastases detected by 68Ga-PSMA-PET/CT seem to be a relevant localization of tumor manifestation and may serve as index lesion in the treatment of recurrent PCa. Besides the known oncological benefits of ADT and sRT, in case of sole MLN metastases individualized therapy like salvage lymphadenectomy or RT with a defined radiation field could be options for these patients."],["dc.identifier.doi","10.3389/fsurg.2021.637134"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82459"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","2296-875X"],["dc.rights","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Mesorectal Lymph Node Metastases as Index Lesion in 68Ga-PSMA-PET/CT Imaging for Recurrent Prostate Cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","64"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BJU International"],["dc.bibliographiccitation.lastpage","70"],["dc.bibliographiccitation.volume","127"],["dc.contributor.author","Kriegmair, Maximilian C."],["dc.contributor.author","Younsi, Nina"],["dc.contributor.author","Hiller, Kiriaki"],["dc.contributor.author","Leitsmann, Conrad"],["dc.contributor.author","Kowalewski, Karl F."],["dc.contributor.author","Siegel, Fabian"],["dc.contributor.author","Rothamel, Martin"],["dc.contributor.author","Ritter, Manuel"],["dc.contributor.author","Bolenz, Christian"],["dc.contributor.author","Kriegmair, Martin"],["dc.contributor.author","Trojan, Lutz"],["dc.contributor.author","Michel, Maurice S."],["dc.date.accessioned","2021-04-14T08:24:10Z"],["dc.date.available","2021-04-14T08:24:10Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1111/bju.15148"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81189"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1464-410X"],["dc.relation.issn","1464-4096"],["dc.title","Single‐ vs multiple‐layer wound closure for flank incisions: results of a prospective, randomised, double‐blinded multicentre study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","493"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The Prostate"],["dc.bibliographiccitation.lastpage","501"],["dc.bibliographiccitation.volume","82"],["dc.contributor.affiliation","Uhlig, Annemarie; 1\r\nDepartment of Urology\r\nUniversity Medical Center Goettingen\r\nGoettingen Germany"],["dc.contributor.affiliation","Bremmer, Felix; 2\r\nDepartment of Pathology\r\nUniversity Medical Center Goettingen\r\nGoettingen Germany"],["dc.contributor.affiliation","Mut, Tuna Till; 1\r\nDepartment of Urology\r\nUniversity Medical Center Goettingen\r\nGoettingen Germany"],["dc.contributor.affiliation","Ahyai, Sascha; 1\r\nDepartment of Urology\r\nUniversity Medical Center Goettingen\r\nGoettingen Germany"],["dc.contributor.affiliation","Reichert, Mathias; 1\r\nDepartment of Urology\r\nUniversity Medical Center Goettingen\r\nGoettingen Germany"],["dc.contributor.affiliation","Leitsmann, Marianne; 1\r\nDepartment of Urology\r\nUniversity Medical Center Goettingen\r\nGoettingen Germany"],["dc.contributor.affiliation","Trojan, Lutz; 1\r\nDepartment of Urology\r\nUniversity Medical Center Goettingen\r\nGoettingen Germany"],["dc.contributor.affiliation","Popeneciu, Ionel‐Valentin; 1\r\nDepartment of Urology\r\nUniversity Medical Center Goettingen\r\nGoettingen Germany"],["dc.contributor.author","Leitsmann, Conrad"],["dc.contributor.author","Uhlig, Annemarie"],["dc.contributor.author","Bremmer, Felix"],["dc.contributor.author","Mut, Tuna Till"],["dc.contributor.author","Ahyai, Sascha"],["dc.contributor.author","Reichert, Mathias"],["dc.contributor.author","Leitsmann, Marianne"],["dc.contributor.author","Trojan, Lutz"],["dc.contributor.author","Popeneciu, Ionel‐Valentin"],["dc.date.accessioned","2022-02-01T10:31:29Z"],["dc.date.available","2022-02-01T10:31:29Z"],["dc.date.issued","2021"],["dc.date.updated","2022-03-20T23:34:50Z"],["dc.description.abstract","Abstract Background The aim of our study was to evaluate the impact of prostate biopsy technique (transrectal ultrasound (US)—prostate biopsy (PBx) versus multiparametric magnetic resonance imaging (mpMRI) targeted prostate biopsy (MRI‐PBx) on intraoperative nerve‐sparing and the rate of secondary neurovascular‐bundle resection (SNR) in patients undergoing robot‐assisted laparoscopic radical prostatectomy (RARP). A real‐time investigation with a frozen‐section examination (NeuroSAFE) microscopically excluded or confirmed prostate cancer invasion of the nerve structures resulting in preservation of the neurovascular bundle or SNR. Additionally, we analyzed risk factors related to SNR, such as longer operation time and postoperative complications. Methods The total study cohort was stratified according to non‐nerve‐sparing versus nerve‐sparing RARP. Patients with nerve‐sparing approach were then stratified according to biopsy technique (PBx vs. MRI‐PBx). Further, we compared PBx versus MRI‐PBx according to SNR rate. Results We included a total of 470 consecutive patients, who underwent RARP for PCa at our institution between January 2016 and December 2019. Patients with a preoperative MRI‐PBx had a 2.12‐fold higher chance of successful nerve‐sparing (without SNR) compared to patients with PBx (p < 0.01). Patients with preoperative MRI‐PBx required 73% less intraoperative SNR compared to patients with PBx (p < 0.0001). Prior MRI‐PBx is thus a predictor for successful nerve‐sparing RARP approach. Conclusion Preoperative MRI‐PBx led to better oncological outcomes and less SNR. Young patients with good erectile function could benefit from a preoperative MRI‐PBx before nerve‐sparing RARP."],["dc.identifier.doi","10.1002/pros.24295"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/98873"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-517"],["dc.relation.eissn","1097-0045"],["dc.relation.issn","0270-4137"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made."],["dc.rights.uri","http://creativecommons.org/licenses/by-nc-nd/4.0/"],["dc.title","Impact of mpMRI targeted biopsy on intraoperative nerve‐sparing (NeuroSAFE) during robot‐assisted laparoscopic radical prostatectomy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1934"],["dc.bibliographiccitation.issue","16"],["dc.bibliographiccitation.journal","The Prostate"],["dc.bibliographiccitation.lastpage","1940"],["dc.bibliographiccitation.volume","75"],["dc.contributor.author","Hijazi, Sameh"],["dc.contributor.author","Meller, Birgit"],["dc.contributor.author","Leitsmann, Conrad"],["dc.contributor.author","Strauss, A."],["dc.contributor.author","Meller, J."],["dc.contributor.author","Ritter, Christian Oliver"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Schildhaus, H.-U."],["dc.contributor.author","Trojan, Lutz"],["dc.contributor.author","Sahlmann, Carsten-Oliver"],["dc.date.accessioned","2018-11-07T09:48:43Z"],["dc.date.available","2018-11-07T09:48:43Z"],["dc.date.issued","2015"],["dc.description.abstract","BACKGROUNDThe first evaluation of pelvic extended lymph node dissection (pLND) in oligometastatic prostate cancer (PCa) detected by Ga-68-PSMA PET/CT. METHODSRetrospective analysis of 35 PCa patients underwent Ga-68-PSMA PET/CT affected by biochemical recurrence (BCR) after curative treatment (n=23) or before primary therapy of high-risk PCa (n=12). We performed pLND associated with pathologic imaging in 17 men with nodal oligometastatic PCa. RESULTSIndicative lesions for PCa in PET/CT were detected in 91.4% (32 of 35) of patients. Nodal, bone, visceral (pulmonary), and within the prostate suspected disease were detected in 72% (23 of 32), 16% (5 of 32), 6% (2 of 32), and 47% (15 of 32) of patients, respectively. Median serum PSA in patients with pathological radiotracer uptake in recurrent and high-risk PCa patients was 2.9ng/ml (range 0.18-30) and 19.5ng/ml (range 6-90), respectively. The median number of removed lymph nodes with pLND in recurrent and high-risk PCa was 10 (range 4-17) and 12 (range 8-29) per patient and the median number of positive lymph nodes was 1 (range 1-2) and 3 (2-3) per patient, respectively. In total, two false positive and one false-negative lymph node were found. Diagnostic accuracies per nodal lesion in total of 213 removed nodes: sensitivity, 94%; specificity, 99%; positive predictive value (PPV), 89%, and negative predictive value (NPV), 99.5%. After pLND, 53% (9 of 17) of patients received androgen deprivation therapy and/or radiation therapy and hormonal therapy, while 47% (8 of 17) of patients remained free of any post-surgery therapy. Follow-up PSA remained less than 0.2ng/ml in 82% (14 of 17) of patients. After pLND, immediate BCR (PSA never measured less than 0.2ng/ml) in 18% (3 of 17) of patients was recorded. CONCLUSIONSThis represents the first study of pLND in the setting of nodal oligometastatic PCa detected by Ga-68-PSMA PET/CT. The use of Ga-68-PSMA PET/CT could be to improve the accuracy for the detection of nodal micrometastases. These promising findings need validation in larger studies. Prostate 75:1934-1940, 2015. (c) 2015 Wiley Periodicals, Inc."],["dc.identifier.doi","10.1002/pros.23091"],["dc.identifier.isi","000363219300013"],["dc.identifier.pmid","26356236"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35365"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1097-0045"],["dc.relation.issn","0270-4137"],["dc.title","Pelvic lymph node dissection for nodal oligometastatic prostate cancer detected by Ga-68-PSMA-positron emission tomography/computerized tomography"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","776"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","The Prostate"],["dc.bibliographiccitation.lastpage","780"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Hijazi, Sameh"],["dc.contributor.author","Meller, Birgit"],["dc.contributor.author","Leitsmann, Conrad"],["dc.contributor.author","Strauss, Arne"],["dc.contributor.author","Ritter, Christian"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Meller, Johannis"],["dc.contributor.author","Trojan, Lutz"],["dc.contributor.author","Sahlmann, Carsten-Oliver"],["dc.date.accessioned","2018-11-07T10:14:00Z"],["dc.date.available","2018-11-07T10:14:00Z"],["dc.date.issued","2016"],["dc.description.abstract","BACKGROUNDOur study is the first evaluation of nodal metastatic prostate cancer (PCa) to mesorectal lymph nodes (MLN) detected by Ga-68-PSMA-PET/CT. METHODSWe retrospectively analyzed 76 consecutive PCa patients who underwent Ga-68-PSMA-PET/CT: 61 PCa patients with biochemical recurrence (BCR) after curative treatment and 15 high-risk PCa before primary therapy. We assessed PET-positive MLN, which are indicative for PCa. RESULTSWe detected PET-positive lesions for PCa in Ga-68-PSMA-PET/CT in 66 of 76 (87%) patients. Nodal disease was imaged in 47 of 66 (71%) patients. Indicative mesorectal nodal lesions for PCa were detected in 12 of 76 (15.8%) patients. The median number of PET-positive MLN was one per patient. Seven of twelve patients had recurrent PCa after radical prostatectomy with a median PSA value of 1.84ng/ml (range 0.31-13). Five of twelve patients had untreated first diagnosed high-risk PCa with median PSA value of 90ng/ml (range 4.6-93) at PET/CT, respectively. For all PET positive MLN a morphological correlate was found in CT (shortest diameter median 4mm [range 4-21]; longest diameter median 7.5mm [range 5-25]). After PET/CT, four patients with recurrent PCa received hormonal therapy, one patient was treated with directed radiation therapy of MLN, one patient received chemotherapy, and one patient was treated with pelvic lymph node dissection. Three high-risk PCa patients received hormonal therapy, and two patients were treated with adjuvant hormonal therapy after radical prostatectomy. CONCLUSIONSDetection and exact location of nodal metastasis for PCa is crucial for the choice of treatment and the patient's prognosis. Ga-68-PSMA-PET/CT seems to improve the detection of nodal metastasis in PCa, especially concerning mesorectal lymph nodes. Prostate 76:776-780, 2016. (c) 2016 Wiley Periodicals, Inc."],["dc.identifier.doi","10.1002/pros.23168"],["dc.identifier.isi","000374860200008"],["dc.identifier.pmid","26880517"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40540"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1097-0045"],["dc.relation.issn","0270-4137"],["dc.title","See the unseen: Mesorectal lymph node metastases in prostate cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2104"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Neurourology and Urodynamics"],["dc.bibliographiccitation.lastpage","2111"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Seseke, Sandra"],["dc.contributor.author","Leitsmann, Conrad"],["dc.contributor.author","Hijazi, Sameh"],["dc.contributor.author","Trojan, Lutz"],["dc.contributor.author","Dechent, Peter"],["dc.date.accessioned","2020-12-10T14:07:00Z"],["dc.date.available","2020-12-10T14:07:00Z"],["dc.date.issued","2019"],["dc.description.abstract","AIMS: In recent years, the human brain-bladder control network has been visualized in different functional magnetic resonance imaging (fMRI) studies. The role of the brainstem and suprapontine regions has been elucidated. Especially the pontine region and the periaqueductal gray, as the central structures of the micturition circuit, were demonstrated. Detrusor sphincter dyssynergia (DSD) is a common problem in patients with neurological diseases. Residual urine and consecutive urinary tract infections with the risk of kidney damage remain a problem. In the present study, we used fMRI of the brain to compare the activation sites of patients with DSD with those of our previously published healthy controls with special emphasis on the brainstem region. METHODS: fMRI was performed in 11 patients with DSD who had an urge to void due to a filled bladder. In a nonvoiding model, they were instructed to contract or to relax the pelvic floor muscles repetitively. RESULTS: In patients with DSD, we could reproduce the activation sites found in healthy subjects, showing the regions in the brainstem as well as the other micturition-related areas. The activation of the pontine region was more rostral/dorsal compared with the healthy volunteers. CONCLUSION: Interestingly, we detected the well-known activation in the pontine region in the patients in the dorsal/rostral part compared with the more ventral activation in the healthy volunteers, suggesting that the L-region of the pontine micturition center is more prominent in cases of DSD."],["dc.identifier.doi","10.1002/nau.24112"],["dc.identifier.eissn","1520-6777"],["dc.identifier.issn","0733-2467"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16691"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70102"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.eissn","1520-6777"],["dc.relation.issn","1520-6777"],["dc.relation.issn","0733-2467"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.subject.ddc","610"],["dc.title","Functional MRI in patients with detrusor sphincter dyssynergia: Is the neural circuit affected?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]