Viezens, Lennart Maximilian

[["dc.bibliographiccitation.firstpage","277"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Medicina (Kaunas)"],["dc.bibliographiccitation.volume","58"],["dc.contributor.affiliation","Koepke, Leon-Gordian; 1Division of Spine Surgery, Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; m.stangenberg@uke.de (M.S.); m.dreimann@uke.de (M.D.); ann.heuer@uke.de (A.H.); l.viezens@uke.de (L.V.)"],["dc.contributor.affiliation","Weiser, Lukas; 2Clinic for Trauma, Orthopedics and Plastic Surgery, University Medical Center Göttingen, Georg-August-Universität, 37075 Göttingen, Germany; lukas.weiser@med.uni-goettingen.de"],["dc.contributor.affiliation","Stangenberg, Martin; 1Division of Spine Surgery, Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; m.stangenberg@uke.de (M.S.); m.dreimann@uke.de (M.D.); ann.heuer@uke.de (A.H.); l.viezens@uke.de (L.V.)"],["dc.contributor.affiliation","Dreimann, Marc; 1Division of Spine Surgery, Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; m.stangenberg@uke.de (M.S.); m.dreimann@uke.de (M.D.); ann.heuer@uke.de (A.H.); l.viezens@uke.de (L.V.)"],["dc.contributor.affiliation","Heuer, Annika; 1Division of Spine Surgery, Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; m.stangenberg@uke.de (M.S.); m.dreimann@uke.de (M.D.); ann.heuer@uke.de (A.H.); l.viezens@uke.de (L.V.)"],["dc.contributor.affiliation","Strahl, André; 4Division of Orthopedics, Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; a.strahl@uke.de"],["dc.contributor.affiliation","Viezens, Lennart; 1Division of Spine Surgery, Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; m.stangenberg@uke.de (M.S.); m.dreimann@uke.de (M.D.); ann.heuer@uke.de (A.H.); l.viezens@uke.de (L.V.)"],["dc.contributor.author","Koepke, Leon-Gordian"],["dc.contributor.author","Weiser, Lukas"],["dc.contributor.author","Stangenberg, Martin"],["dc.contributor.author","Dreimann, Marc"],["dc.contributor.author","Heuer, Annika"],["dc.contributor.author","Strahl, André"],["dc.contributor.author","Viezens, Lennart"],["dc.date.accessioned","2022-04-01T10:03:22Z"],["dc.date.available","2022-04-01T10:03:22Z"],["dc.date.issued","2022"],["dc.date.updated","2022-09-03T20:07:05Z"],["dc.description.abstract","Background and Objectives: In osteoporotic fractures of the spine with resulting kyphosis and threatening compression of neural structures, therapeutic decisions are difficult. The posterior vertebral column resection (pVCR) has been described by different authors as a surgical treatment in a single-stage posterior procedure. The aim of this study is to evaluate midterm outcomes of patients treated by pVCR due to severe osteoporotic fractures. Materials and Methods: Retrospective data analysis of all the patients treated for osteoporotic fractures by pVCR from 2012–2020 at two centers was performed. Demographic data, visual analog scale (VAS), Frankel scale (FS), Karnofsky performance status (KPS), radiological result and spinal fusion rates were evaluated. Results: A total of 17 patients were included. The mean age was 70 ± 10.2 y. The mean VAS decreased significantly from 7.7 ± 2.8 preoperatively to 3.0 ± 1.6 at last follow-up (p < 0.001) and the segmental kyphosis decreased from 29.4 ± 14.1° to 7.9 ± 8.0° (p < 0.001). The neurologic function on the FS did not worsen in any and improved in four of the patients. The median KPS remained stable over the whole observation period (70% vs. 70%). Spinal fusion was observed in nine out of nine patients who received CT follow-up >120 days after index surgery. Conclusions: This study showed that pVCR is a safe surgical technique with few surgical complications and no neurological deterioration considering the cohort. The patients’ segmental kyphosis and VAS improved significantly, while the KPS remained stable."],["dc.identifier.doi","10.3390/medicina58020277"],["dc.identifier.pii","medicina58020277"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/106152"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","1648-9144"],["dc.rights","CC BY 4.0"],["dc.title","Outcome after Posterior Vertebral Column Resection in Patients with Severe Osteoporotic Fractures—A Retrospective Analysis from Two Centers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","301"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Operative Orthopädie und Traumatologie"],["dc.bibliographiccitation.lastpage","310"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Viezens, L."],["dc.contributor.author","Sehmisch, S."],["dc.contributor.author","Lehmann, W."],["dc.contributor.author","Weiser, L."],["dc.date.accessioned","2020-12-10T14:08:03Z"],["dc.date.available","2020-12-10T14:08:03Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00064-019-0609-5"],["dc.identifier.eissn","1439-0981"],["dc.identifier.issn","0934-6694"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16565"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70360"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Pedikelsubtraktionsosteotomie zur Korrektur rigider Deformitäten"],["dc.title.alternative","Pedicle subtraction osteotomy to correct rigid deformities"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","275"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Operative Orthopädie und Traumatologie"],["dc.bibliographiccitation.lastpage","283"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Viezens, Lennart"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Weiser, Lukas"],["dc.contributor.author","Dreimann, Marc"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.date.accessioned","2020-12-10T14:08:03Z"],["dc.date.available","2020-12-10T14:08:03Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00064-019-0615-7"],["dc.identifier.eissn","1439-0981"],["dc.identifier.issn","0934-6694"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16357"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70363"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Dorsale Stabilisation der Halswirbelkörper HWK1/HWK2 modifiziert nach Goel-Harms mit HWK-1-Pedikelschrauben"],["dc.title.alternative","Dorsal stabilization of C1/C2 modified according to Goel-Harms with C1 pedicle screws"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","979"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Cancer"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Mussawy, Haider"],["dc.contributor.author","Viezens, Lennart"],["dc.contributor.author","Schroeder, Malte"],["dc.contributor.author","Hettenhausen, Svenja"],["dc.contributor.author","Sündermann, Jördis"],["dc.contributor.author","Wellbrock, Jasmin"],["dc.contributor.author","Kossow, Kai"],["dc.contributor.author","Schaefer, Christian"],["dc.date.accessioned","2019-07-09T11:46:01Z"],["dc.date.available","2019-07-09T11:46:01Z"],["dc.date.issued","2018"],["dc.description.abstract","Abstract Background Prostate cancer-related morbidity is associated with its preferential spread to the bone. Although the molecular interactions between the bone microenvironment and cancer cells have been researched extensively, the relevance of the microvascular properties of prostate cancer bone metastases remains largely unknown. Most preclinical studies focusing on microvascular analyses are based on heterotopic tumor implantation, whereas the impact of the microenvironment on site-specific growth behavior and angiogenesis is rarely addressed. Methods The microvascular changes associated with tumor growth in bone and soft tissue were characterized by implanting single cell suspensions of LnCap, Du145, and Pc3 cells into the femur (femur window) or striated muscle (dorsal skinfold chamber) of NSG mice. Tumor growth and the local microvasculature were analyzed for 21 days using intravital fluorescence microscopy. Results The results showed a higher engraftment of tumor cells in bone than in striated muscle associated with accelerated growth of LnCap cells and Pc3 cells. Permeability, blood flow, and tissue perfusion rates were greater in bone than in striated muscle. Du145 cells showed similar growth behavior in both tissues with similar vascular properties. The bone microenvironment facilitated tumor engraftment and growth. Increased microvascular density in striated muscle led to a higher tumor burden during early growth, whereas the increased perfusion promoted later prostate cancer growth in bone. Conclusions Monitoring prostate cancer microcirculation in bone and soft tissue may be useful to evaluate the organ-specific efficacy of new treatments."],["dc.identifier.doi","10.1186/s12885-018-4905-5"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15380"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59365"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","BioMed Central"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","The bone microenvironment promotes tumor growth and tissue perfusion compared with striated muscle in a preclinical model of prostate cancer in vivo"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","284"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Operative Orthopädie und Traumatologie"],["dc.bibliographiccitation.lastpage","292"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Weiser, Lukas"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Viezens, Lennart"],["dc.date.accessioned","2020-12-10T14:08:03Z"],["dc.date.available","2020-12-10T14:08:03Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00064-019-0608-6"],["dc.identifier.eissn","1439-0981"],["dc.identifier.issn","0934-6694"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16356"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70359"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Techniken zur Steigerung der Pedikelschraubenstabilität im osteoporotischen Knochen"],["dc.title.alternative","Techniques to increase pedicle screw stability in osteoporotic vertebrae"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","311"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Operative Orthopädie und Traumatologie"],["dc.bibliographiccitation.lastpage","320"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Sehmisch, S."],["dc.contributor.author","Lehmann, W."],["dc.contributor.author","Dreimann, M."],["dc.contributor.author","Oberthür, S."],["dc.contributor.author","Viezens, L."],["dc.contributor.author","Weiser, L."],["dc.date.accessioned","2020-12-10T14:08:04Z"],["dc.date.available","2020-12-10T14:08:04Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00064-019-0616-6"],["dc.identifier.eissn","1439-0981"],["dc.identifier.issn","0934-6694"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16566"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70364"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Posterior vertebral column resection (PVCR) zur Korrektur von Hyperkyphosen bei osteoporotischen Frakturen der Brustwirbelsäule"],["dc.title.alternative","Posterior vertebral column resection for correction of kyphotic deformity due to osteoporotic fractures of the thoracic spine"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","293"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Operative Orthopädie und Traumatologie"],["dc.bibliographiccitation.lastpage","300"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Weiser, Lukas"],["dc.contributor.author","Sehmisch, Stephan"],["dc.contributor.author","Viezens, Lennart"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.date.accessioned","2020-12-10T14:08:03Z"],["dc.date.available","2020-12-10T14:08:03Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00064-019-0611-y"],["dc.identifier.eissn","1439-0981"],["dc.identifier.issn","0934-6694"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16355"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70362"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Intraoperative Revision von primär ausgerissenen Pedikelschrauben"],["dc.title.alternative","Intraoperative revision of initially loosened pedicle screws"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]