Gross, Uwe

[["dc.contributor.author","Kappas, Martin"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Kelleher, Dermot"],["dc.contributor.editor","Kappas, Martin W."],["dc.contributor.editor","Groß, Uwe"],["dc.contributor.editor","Kelleher, Dermot"],["dc.date.accessioned","2018-05-03T10:42:42Z"],["dc.date.available","2018-05-03T10:42:42Z"],["dc.date.issued","2012"],["dc.description.abstract","Human, animal and plant health is a field of work which offers opportunities for inter- and trans-disciplinary research. The whole topic bridges the natural and social sciences. Today, in a world of global environmental change it is widely recognized that human societies and their wellbeing depend on a sustainable equilibrium of ecosystem services and the possibility of cultural adaptation to global environmental change. The need to identify and quantify health risks related to global environmental change is now one of the most important challenges of humankind. Describing spatial (geographic, intra/inter-population) and temporal differences in health risks is an urgent task to understand societies’ vulnerabilities and priorities for interventions better. The Göttingen International Health Network (GIHN) is a research and teaching network in relation to this cross-cutting topic. The book provides a collection of articles which contribute to this issue of overriding importance and presents an overview of the GIHN launch event."],["dc.format.extent","400"],["dc.identifier.doi","10.17875/gup2012-387"],["dc.identifier.isbn","978-3-86395-047-7"],["dc.identifier.ppn","731806492"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8961"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/13949"],["dc.identifier.urn","urn:nbn:de:gbv:7-isbn-978-3-86395-047-7-3"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.notes.status","zu prüfen"],["dc.publisher","Universitätsverlag Göttingen"],["dc.publisher.place","Göttingen"],["dc.rights","CC BY-ND 3.0"],["dc.rights","Goescholar"],["dc.rights.access","openAccess"],["dc.rights.uri","https://creativecommons.org/licenses/by-nd/3.0"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject","Health; Global Environmental Change; Health Risks; GIHN Goettingen International Health Network"],["dc.subject.ddc","610"],["dc.title","Global health"],["dc.title.subtitle","a challenge for interdisciplinary research"],["dc.type","book_editor"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","1843"],["dc.bibliographiccitation.journal","Frontiers in Microbiology"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Seugendo, Mwanaisha"],["dc.contributor.author","Janssen, Iryna"],["dc.contributor.author","Lang, Vanessa"],["dc.contributor.author","Hasibuan, Irene"],["dc.contributor.author","Bohne, Wolfgang"],["dc.contributor.author","Cooper, Paul"],["dc.contributor.author","Daniel, Rolf"],["dc.contributor.author","Gunka, Katrin"],["dc.contributor.author","Kusumawati, R. L."],["dc.contributor.author","Mshana, Stephen E."],["dc.contributor.author","von Müller, Lutz"],["dc.contributor.author","Okamo, Benard"],["dc.contributor.author","Ortlepp, Jan R."],["dc.contributor.author","Overmann, Jörg"],["dc.contributor.author","Riedel, Thomas"],["dc.contributor.author","Rupnik, Maja"],["dc.contributor.author","Zimmermann, Ortrud"],["dc.contributor.author","Groß, Uwe"],["dc.date.accessioned","2019-07-09T11:45:47Z"],["dc.date.available","2019-07-09T11:45:47Z"],["dc.date.issued","2018"],["dc.description.abstract","Clostridioides (Clostridium) difficile infections (CDI) are considered worldwide as emerging health threat. Uptake of C. difficile spores may result in asymptomatic carrier status or lead to CDI that could range from mild diarrhea, eventually developing into pseudomembranous colitis up to a toxic megacolon that often results in high mortality. Most epidemiological studies to date have been performed in middle- and high income countries. Beside others, the use of antibiotics and the composition of the microbiome have been identified as major risk factors for the development of CDI. We therefore postulate that prevalence rates of CDI and the distribution of C. difficile strains differ between geographical regions depending on the regional use of antibiotics and food habits. A total of 593 healthy control individuals and 608 patients suffering from diarrhea in communities in Germany, Ghana, Tanzania and Indonesia were selected for a comparative multi-center cross-sectional study. The study populations were screened for the presence of C. difficile in stool samples. Cultured C. difficile strains (n = 84) were further subtyped and characterized using PCR-ribotyping, determination of toxin production, and antibiotic susceptibility testing. Prevalence rates of C. difficile varied widely between the countries. Whereas high prevalence rates were observed in symptomatic patients living in Germany and Indonesia (24.0 and 14.7%), patients from Ghana and Tanzania showed low detection rates (4.5 and 6.4%). Differences were also obvious for ribotype distribution and toxin repertoires. Toxin A+/B+ ribotypes 001/072 and 078 predominated in Germany, whereas most strains isolated from Indonesian patients belonged to toxin A+/B+ ribotype SLO160 and toxin A-/B+ ribotype 017. With 42.9-73.3%, non-toxigenic strains were most abundant in Africa, but were also found in Indonesia at a rate of 18.2%. All isolates were susceptible to vancomycin and metronidazole. Mirroring the antibiotic use, however, moxifloxacin resistance was absent in African C. difficile isolates but present in Indonesian (24.2%) and German ones (65.5%). This study showed that CDI is a global health threat with geographically different prevalence rates which might reflect distinct use of antibiotics. Significant differences for distributions of ribotypes, toxin production, and antibiotic susceptibilities were observed."],["dc.identifier.doi","10.3389/fmicb.2018.01843"],["dc.identifier.pmid","30131799"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15318"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59311"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1664-302X"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Prevalence and Strain Characterization of Clostridioides (Clostridium) difficile in Representative Regions of Germany, Ghana, Tanzania and Indonesia - A Comparative Multi-Center Cross-Sectional Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","170152"],["dc.bibliographiccitation.journal","Scientific data"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Schneider, Dominik"],["dc.contributor.author","Thürmer, Andrea"],["dc.contributor.author","Gollnow, Kathleen"],["dc.contributor.author","Lugert, Raimond"],["dc.contributor.author","Gunka, Katrin"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Daniel, Rolf"],["dc.date.accessioned","2019-07-09T11:44:31Z"],["dc.date.available","2019-07-09T11:44:31Z"],["dc.date.issued","2017-10-17"],["dc.description.abstract","We present bacterial 16S rRNA gene datasets derived from stool samples of 44 patients with diarrhea indicative of a Clostridioides difficile infection. For 20 of these patients, C. difficile infection was confirmed by clinical evidence. Stool samples from patients originating from Germany, Ghana, and Indonesia were taken and subjected to DNA isolation. DNA isolations of stool samples from 35 asymptomatic control individuals were performed. The bacterial community structure was assessed by 16S rRNA gene analysis (V3-V4 region). Metadata from patients and control individuals include gender, age, country, presence of diarrhea, concomitant diseases, and results of microbiological tests to diagnose C. difficile presence. We provide initial data analysis and a dataset overview. After processing of paired-end sequencing data, reads were merged, quality-filtered, primer sequences removed, reads truncated to 400 bp and dereplicated. Singletons were removed and sequences were sorted by cluster size, clustered at 97% sequence similarity and chimeric sequences were discarded. Taxonomy to each operational taxonomic unit was assigned by BLASTn searches against Silva database 123.1 and a table was constructed."],["dc.identifier.doi","10.1038/sdata.2017.152"],["dc.identifier.pmid","29039846"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14810"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59030"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2052-4463"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Gut bacterial communities of diarrheic patients with indications of Clostridioides difficile infection."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","European Journal of Microbiology and Immunology"],["dc.bibliographiccitation.lastpage","10"],["dc.contributor.author","Emele, Matthias F."],["dc.contributor.author","Karg, Matti"],["dc.contributor.author","Hotzel, Helmut"],["dc.contributor.author","Graaf-van Bloois, Linda"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Zautner, Andreas E."],["dc.date.accessioned","2019-07-09T11:51:43Z"],["dc.date.available","2019-07-09T11:51:43Z"],["dc.date.issued","2019"],["dc.description.abstract","ampylobacter fetus is a causative agent of intestinal illness and, occasionally, severe systemic infections and meningitis. C. fetus currently comprises three subspecies: C. fetus subspecies fetus (Cff), C. fetus subspecies venerealis (Cfv), and C. fetus subspecies testudinum (Cft). Cff and Cfv are primarily associated with mammals whereas Cft is associated with reptiles. To offer an alternative to laborious sequence-based techniques such as multilocus sequence typing (MLST) and polymerase chain reaction (PCR)-ribotyping for this species, the purpose of the study was to develop a typing scheme based on proteotyping. In total, 41 representative C. fetus strains were analyzed by intact cell mass spectrometry and compared to MLST results. Biomarkers detected in the mass spectrum of C. fetus subsp. fetus reference strain LMG 6442 (NCTC 10842) as well as corresponding isoforms were associated with the respective amino acid sequences and added to the C. fetus proteotyping scheme. In combination, the 9 identified biomarkers allow the differentiation of Cft subspecies strains from Cff and Cfv subspecies strains. Biomarkers to distinguish between Cff and Cfv were not found. The results of the study show the potential of proteotyping to differentiate different subspecies, but also the limitations of the method."],["dc.identifier.doi","10.1556/1886.2019.00006"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16175"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59994"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2062-8633"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.subject.ddc","610"],["dc.title","Differentiation of Campylobacter fetus subspecies by proteotyping"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","4244"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Emele, Matthias Frederik"],["dc.contributor.author","Možina, Sonja Smole"],["dc.contributor.author","Lugert, Raimond"],["dc.contributor.author","Bohne, Wolfgang"],["dc.contributor.author","Masanta, Wycliffe Omurwa"],["dc.contributor.author","Riedel, Thomas"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Zautner, Andreas Erich"],["dc.date.accessioned","2019-07-09T11:50:14Z"],["dc.date.available","2019-07-09T11:50:14Z"],["dc.date.issued","2019"],["dc.description.abstract","Besides Campylobacter jejuni, Campylobacter coli is the most common bacterial cause of gastroenteritis worldwide. C. coli is subdivided into three clades, which are associated with sample source. Clade 1 isolates are associated with acute diarrhea in humans whereas clade 2 and 3 isolates are more commonly obtained from environmental waters. The phylogenetic classification of an isolate is commonly done using laborious multilocus sequence typing (MLST). The aim of this study was to establish a proteotyping scheme using MALDI-TOF MS to offer an alternative to sequence-based methods. A total of 97 clade-representative C. coli isolates were analyzed by MALDI-TOF-based intact cell mass spectrometry (ICMS) and evaluated to establish a C. coli proteotyping scheme. MLST was used as reference method. Different isoforms of the detectable biomarkers, resulting in biomarker mass shifts, were associated with their amino acid sequences and included into the C. coli proteotyping scheme. In total, we identified 16 biomarkers to differentiate C. coli into the three clades and three additional sub-clades of clade 1. In this study, proteotyping has been successfully adapted to C. coli. The established C. coli clades and sub-clades can be discriminated using this method. Especially the clinically relevant clade 1 isolates can be differentiated clearly."],["dc.identifier.doi","10.1038/s41598-019-40842-w"],["dc.identifier.pmid","30862911"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15886"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59727"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2045-2322"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Proteotyping as alternate typing method to differentiate Campylobacter coli clades"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","1800083"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","PROTEOMICS – Clinical Applications"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Masanta, Wycliffe O."],["dc.contributor.author","Zautner, Andreas E."],["dc.contributor.author","Lugert, Raimond"],["dc.contributor.author","Bohne, Wolfgang"],["dc.contributor.author","Gross, Uwe"],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Dakna, Mohammed"],["dc.contributor.author","Lenz, Christof"],["dc.date.accessioned","2019-07-09T11:51:53Z"],["dc.date.available","2019-07-09T11:51:53Z"],["dc.date.issued","2018"],["dc.description.abstract","PURPOSE: Bile acids are crucial components of the intestinal antimicrobial defense and represent a significant stress factor for enteric pathogens. Adaptation processes of Campylobacter jejuni to this hostile environment are analyzed in this study by a proteomic approach. EXPERIMENTAL DESIGN: Proteome profiling by label-free mass spectrometry (SWATH-MS) has been used to characterize the adaptation of C. jejuni to sublethal concentrations of seven bile acids. RESULTS: The bile acids with the lowest inhibitory concentration (IC50 ), deoxycholic and chenodeoxycholic acid, induce the most significant proteome changes. Overall a downregulation of all basic biosynthetic pathways and a general decrease in the transcription machinery are found. Concurrently, an induction of factors involved in detoxification of reactive oxygen species, protein folding, and bile acid exporting efflux pumps is detected. Exposure to deoxycholic and chenodeoxycholic acid results in an increased expression of components of the more energy-efficient aerobic respiration pathway, while the anaerobic branches of the electron transport chain are down-expressed. CONCLUSIONS AND CLINICAL RELEVANCE: The results show that C. jejuni has a differentiated system of adaptation to bile acid stresses. The findings enhance the understanding of the pathogenesis of campylobacteriosis, especially for survival of C. jejuni in the human intestine, and may provide clues to future medical treatment."],["dc.identifier.doi","10.1002/prca.201800083"],["dc.identifier.pmid","30246935"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16217"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60032"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Proteome Profiling by Label‐Free Mass Spectrometry Reveals Differentiated Response of Campylobacter jejuni 81–176 to Sublethal Concentrations of Bile Acids"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","3260289"],["dc.bibliographiccitation.journal","Mediators of inflammation"],["dc.bibliographiccitation.volume","2017"],["dc.contributor.author","Nau, Julia"],["dc.contributor.author","Eller, Silvia Kathrin"],["dc.contributor.author","Wenning, Johannes"],["dc.contributor.author","Spekker-Bosker, Katrin Henrike"],["dc.contributor.author","Schroten, Horst"],["dc.contributor.author","Schwerk, Christian"],["dc.contributor.author","Hotop, Andrea"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Däubener, Walter"],["dc.date.accessioned","2019-07-09T11:44:54Z"],["dc.date.available","2019-07-09T11:44:54Z"],["dc.date.issued","2017"],["dc.description.abstract","Porcine infections are currently not the state-of-the-art model to study human diseases. Nevertheless, the course of human and porcine toxoplasmosis is much more comparable than that of human and murine toxoplasmosis. For example, severity of infection, transplacental transmission, and interferon-gamma-induced antiparasitic effector mechanisms are similar in pigs and humans. In addition, the severe immunosuppression during acute infection described in mice does not occur in the experimentally infected ones. Thus, we hypothesise that porcine Toxoplasma gondii infection data are more representative for human toxoplasmosis. We therefore suggest that the animal model chosen must be critically evaluated for its assignability to human diseases."],["dc.identifier.doi","10.1155/2017/3260289"],["dc.identifier.pmid","28883687"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14965"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59124"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1466-1861"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Experimental Porcine Toxoplasma gondii Infection as a Representative Model for Human Toxoplasmosis."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","196"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Memorias do Instituto Oswaldo Cruz"],["dc.bibliographiccitation.lastpage","200"],["dc.bibliographiccitation.volume","104"],["dc.contributor.author","Lüder, Carsten"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Fonseca Ferreira-da-Silva, Marialice da"],["dc.contributor.author","Mendonça Rodrigues, Renata"],["dc.contributor.author","Ferreira de Andrade, Elisabete"],["dc.contributor.author","Carvalho, Laís de"],["dc.contributor.author","Santos Barbosa, Helene"],["dc.date.accessioned","2011-03-10T15:14:02Z"],["dc.date.accessioned","2021-10-27T13:22:34Z"],["dc.date.available","2011-03-10T15:14:02Z"],["dc.date.available","2021-10-27T13:22:34Z"],["dc.date.issued","2009"],["dc.description.abstract","Although the predilection for Toxoplasma gondii to form cysts in the nervous system and skeletal and heart muscles has been described for more than fifty years, skeletal muscle cells (SkMCs) have not been explored as a host cell type to study the Toxoplasma-host cell interaction and investigate the intracellular development of the parasite. Morphological aspects of the initial events in the Toxoplasma-SkMC interaction were analysed and suggest that there are different processes of protozoan adhesion and invasion and of the subsequent fate of the parasite inside the parasitophorous vacuole (PV). Using scanning electron microscopy,Toxoplasma tachyzoites from the mouse-virulent RH strain were found to be attached to SkMCs by the anterior or posterior region of the body, with or without expansion of the SkMC membrane. This suggests that different types of parasite internalization occurred. Asynchronous multiplication and differentiation of T. gondii were observed. Importantly, intracellular parasites were seen to display high amounts of amylopectin granules in their cytoplasm, indicating that tachyzoites of the RH strain were able to differentiate spontaneously into bradyzoites in SkMCs. This stage conversion occurred in approximately 3% of the PVs. This is particularly intriguing as tachyzoites of virulent Toxoplasma strains are not thought to be prone to cyst formation. We discuss whether biological differences in host cells are crucial to Toxoplasma stage conversion and suggest that important questions concerning the host cell type and its relevance in Toxoplasma differentiation are still unanswered."],["dc.identifier.doi","10.1590/S0074-02762009000200012"],["dc.identifier.fs","396270"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5960"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/92106"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","1678-8060"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Spontaneous stage differentiation of mouse-virulent Toxoplasma gondii RH parasites in skeletal muscle cells: an ultrastructural evaluation."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","72"],["dc.bibliographiccitation.journal","International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases"],["dc.bibliographiccitation.lastpage","77"],["dc.bibliographiccitation.volume","78"],["dc.contributor.author","Mirambo, Mariam M."],["dc.contributor.author","Aboud, Said"],["dc.contributor.author","Majigo, Mtebe"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Mshana, Stephen E."],["dc.date.accessioned","2019-07-09T11:49:47Z"],["dc.date.available","2019-07-09T11:49:47Z"],["dc.date.issued","2019"],["dc.description.abstract","OBJECTIVE: This study investigated the adverse pregnancy outcomes among pregnant women with acute Rubella infections in the city of Mwanza, Tanzania. METHODS: A longitudinal study was conducted between 2014 and 2016 among pregnant women attending antenatal clinics. Women were screened for Rubella IgG and IgM antibodies using enzyme immunoassay (EIA). IgM seropositive pregnant women were followed up until the end of the pregnancy to determine Congenital Rubella Syndrome, congenital infections and other pregnancy outcomes. RESULTS: The median age of 685 enrolled pregnant women was 23 (IQR: 19-27) years. A total of 629(91.8%) were Rubella IgG seropositive while 61 (8.9%) were IgM seropositive. The IgM seropositivity was found to decrease significantly from first trimester to third trimester, p<0.001. Forty six (83.6%) of 55 Rubella IgM seropositive women had adverse pregnancy outcomes and 6 (10.9%) delivered neonates with CRS, making the overall incidence of CRS to be 6/685 (0.87%). First trimester IgM seropositive women had significantly higher adverse pregnancy outcomes than those in second/third trimesters (70.4% vs. 35.7, p=0.01). CONCLUSION: There is one case of CRS in every 100 pregnancies necessitating additional strategies to reach a goal of elimination of CRS in developing countries."],["dc.identifier.doi","10.1016/j.ijid.2018.10.020"],["dc.identifier.pmid","30391418"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15767"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59629"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1878-3511"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.subject.ddc","610"],["dc.title","Adverse pregnancy outcomes among pregnant women with acute Rubella infections in Mwanza city, Tanzania"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","2630"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Frontiers in microbiology"],["dc.bibliographiccitation.lastpage","15"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Acar, İlhan E."],["dc.contributor.author","Saçar Demirci, Müşerref D."],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Allmer, Jens"],["dc.date.accessioned","2019-07-09T11:45:04Z"],["dc.date.available","2019-07-09T11:45:04Z"],["dc.date.issued","2017"],["dc.description.abstract","MicroRNAs (miRNAs) are involved in post-transcriptional modulation of gene expression and thereby have a large influence on the resulting phenotype. We have previously shown that miRNAs may be involved in the communication betweenToxoplasma gondiiand its hosts and further confirmed a number of proposed specific miRNAs. Yet, little is known about the internal regulation via miRNAs inT. gondii. Therefore, we predicted pre-miRNAs directly from the type II ME49 genome and filtered them. For the confident hairpins, we predicted the location of the mature miRNAs and established their target genes. To add further confidence, we evaluated whether the hairpins and their targets were co-expressed. Such co-expressed miRNA and target pairs define a functional interaction. We extracted all such functional interactions and analyzed their differential expression among strains of all three clonal lineages (RH, PLK, and CTG) and between the two stages present in the intermediate host (tachyzoites and bradyzoites). Overall, we found ~65,000 expressed interactions of which ~5,500 are differentially expressed among strains but none are significantly differentially expressed between developmental stages. Since miRNAs and target decoys can be used as therapeutics we believe that the list of interactions we provide will lead to novel approaches in the treatment of toxoplasmosis."],["dc.identifier.doi","10.3389/fmicb.2017.02630"],["dc.identifier.pmid","29354114"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15023"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59152"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1664-302X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","The Expressed MicroRNA-mRNA Interactions ofToxoplasma gondii."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]