Trost, Sarah Makbule

[["dc.bibliographiccitation.firstpage","127"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","136"],["dc.bibliographiccitation.volume","265"],["dc.contributor.author","Kittel-Schneider, Sarah"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Scherk, Harald"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Wolf, C."],["dc.contributor.author","Schmitt, A."],["dc.contributor.author","Malchow, Berend"],["dc.contributor.author","Hasan, Alkomiet"],["dc.contributor.author","Backens, Martin"],["dc.contributor.author","Reith, W."],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Reif, A."],["dc.date.accessioned","2018-11-07T10:00:31Z"],["dc.date.available","2018-11-07T10:00:31Z"],["dc.date.issued","2015"],["dc.description.abstract","The diacylglycerol kinase eta (DGKH) gene, first identified in a genome-wide association study, is one of the few replicated risk genes of bipolar affective disorder (BD). Following initial positive studies, it not only was found to be associated with BD but also implicated in the etiology of other psychiatric disorders featuring affective symptoms, rendering DGKH a cross-disorder risk gene. However, the (patho-)physiological role of the encoded enzyme is still elusive. In the present study, we investigated primarily the influence of a risk haplotype on amygdala volume in patients suffering from schizophrenia or BD as well as healthy controls and four single nucleotide polymorphisms conveying risk. There was a significant association of the DGKH risk haplotype with increased amygdala volume in BD, but not in schizophrenia or healthy controls. These findings add to the notion of a role of DGKH in the pathogenesis of BD."],["dc.description.sponsorship","DFG [RTG 1253/1, RE1632/5-1]; BMBF (DZHI) [01EO1004]; IZKF [Z3-24]"],["dc.identifier.doi","10.1007/s00406-014-0513-9"],["dc.identifier.isi","000350305500005"],["dc.identifier.pmid","24958494"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37825"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1433-8491"],["dc.relation.issn","0940-1334"],["dc.title","Influence of DGKH variants on amygdala volume in patients with bipolar affective disorder and schizophrenia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","53"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","63"],["dc.bibliographiccitation.volume","263"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Platz, B."],["dc.contributor.author","Usher, Juliana"],["dc.contributor.author","Scherk, Harald"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Ekawardhani, Savira"],["dc.contributor.author","Meyer, J."],["dc.contributor.author","Reith, W."],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T09:28:39Z"],["dc.date.available","2018-11-07T09:28:39Z"],["dc.date.issued","2013"],["dc.description.abstract","DTNBP1 is one of the most established susceptibility genes for schizophrenia, and hippocampal volume reduction is one of the major neuropathological findings in this severe disorder. Consistent with these findings, the encoded protein dysbindin-1 has been shown to be diminished in glutamatergic hippocampal neurons in schizophrenic patients. The aim of this study was to investigate the effects of two single nucleotide polymorphisms of DTNBP1 on grey matter volumes in human subjects using voxel-based morphometry. Seventy-two subjects were included and genotyped with respect to two single nucleotide polymorphisms of DTNBP1 (rs2619522 and rs1018381). All participants underwent structural magnetic resonance imaging (MRI). MRI data were preprocessed and statistically analysed using standard procedures as implemented in SPM5 (Statistical Parametric Mapping), in particular the voxel-based morphometry (VBM) toolbox. We found significant effects of the DTNBP1 SNP rs2619522 bilaterally in the hippocampus as well as in the anterior middle frontal gyrus and the intraparietal cortex. Carriers of the G allele showed significantly higher grey matter volumes in these brain regions than T/T homozygotes. Compatible with previous findings on a role of dysbindin in hippocampal functions as well as in major psychoses, the present study provides first direct in vivo evidence that the DTNBP1 SNP rs2619522 is associated with variation of grey matter volumes bilaterally in the hippocampus."],["dc.identifier.doi","10.1007/s00406-012-0320-0"],["dc.identifier.isi","000314296300006"],["dc.identifier.pmid","22580710"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30828"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","0940-1334"],["dc.title","The DTNBP1 (dysbindin-1) gene variant rs2619522 is associated with variation of hippocampal and prefrontal grey matter volumes in humans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Biological Psychiatry"],["dc.bibliographiccitation.volume","67"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Scherk, Harald"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Reith, Wolfgang"],["dc.contributor.author","Meyer, Jobst"],["dc.contributor.author","Falkai, Peter"],["dc.date.accessioned","2018-11-07T08:43:24Z"],["dc.date.available","2018-11-07T08:43:24Z"],["dc.date.issued","2010"],["dc.format.extent","163S"],["dc.identifier.isi","000277064200517"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19956"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.publisher.place","New york"],["dc.relation.conference","65th Annual Convention of the Society-of-Biological-Psychiatry"],["dc.relation.eventlocation","New Orleans, LA"],["dc.relation.issn","0006-3223"],["dc.title","Association of DISC1 Genetic Variation with Intermediate Phenotypes in Neuroimaging: Replication and Further Extension"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","101"],["dc.bibliographiccitation.journal","Bipolar Disorders"],["dc.bibliographiccitation.lastpage","102"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Scherk, Harald"],["dc.contributor.author","Focke, Niels K."],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Schmitt, A."],["dc.contributor.author","Reith, W."],["dc.contributor.author","Meyer, J."],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T08:55:10Z"],["dc.date.available","2018-11-07T08:55:10Z"],["dc.date.issued","2011"],["dc.identifier.isi","000300102400254"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22841"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Malden"],["dc.relation.conference","9th International Conference on Bipolar Disorder"],["dc.relation.eventlocation","Pittsburgh, PA"],["dc.relation.issn","1398-5647"],["dc.title","Effects of the bipolar disorder susceptibility gene CACNA1C on regional grey matter volumes: a voxel-based morphometry (VBM) study"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Psychiatry"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Platz, B."],["dc.contributor.author","Scherk, Harald"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Reith, W."],["dc.contributor.author","Meyer, J."],["dc.contributor.author","Falkai, Peter Gaston"],["dc.date.accessioned","2018-11-07T08:47:37Z"],["dc.date.available","2018-11-07T08:47:37Z"],["dc.date.issued","2010"],["dc.identifier.isi","000208225800180"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21000"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier France-editions Scientifiques Medicales Elsevier"],["dc.publisher.place","Paris"],["dc.relation.issn","0924-9338"],["dc.title","THE DTNBP1 (DYSBINDIN-1) GENE VARIANT RS2619522 IS ASSOCIATED WITH VARIATION OF HIPPOCAMPAL GREY MATTER VOLUME IN HUMANS"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","188"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Psychiatric Research"],["dc.bibliographiccitation.lastpage","196"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Platz, B."],["dc.contributor.author","Usher, Juliana"],["dc.contributor.author","Scherk, Harald"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Ekawardhani, Savira"],["dc.contributor.author","Meyer, J."],["dc.contributor.author","Reith, W."],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T09:28:40Z"],["dc.date.available","2018-11-07T09:28:40Z"],["dc.date.issued","2013"],["dc.description.abstract","DISC1 (Disrupted-In-Schizophrenia 1), one of the top candidate genes for schizophrenia, has been associated with a range of major mental illnesses over the last two decades. DISC) is crucially involved in neurodevelopmental processes of the human brain. Several haplotypes and single nucleotide polymorphisms of DISCI have been associated with changes of grey matter volumes in brain regions known to be altered in schizophrenia and other psychiatric disorders. The aim of the present study was to investigate the effects of two single nucleotide polymorphisms (SNPs) of DISCI on grey matter volumes in human subjects using voxel-based morphometry (VBM). 114/113 participating subjects (psychiatric patients and healthy controls) were genotyped with respect to two at-risk SNPs of DISC), rs6675281 and rs821616. All participants underwent structural magnetic resonance imaging (MRI). MRI data was statistically analyzed using voxel-based morphometry. We found significant alterations of grey matter volumes in prefrontal and temporal brain regions in association with rs6675281 and rs821616. These effects of DISC) polymorphisms on brain morphology provide further support for an involvement of DISC) in the neurobiology of major psychiatric disorders such as schizophrenia. (C) 2012 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.jpsychires.2012.10.006"],["dc.identifier.isi","000314330100008"],["dc.identifier.pmid","23140672"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30837"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0022-3956"],["dc.title","DISC1 (disrupted-in-schizophrenia 1) is associated with cortical grey matter volumes in the human brain: A voxel-based morphometry (VBM) study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","335"],["dc.bibliographiccitation.issue","2-3"],["dc.bibliographiccitation.journal","Schizophrenia Research"],["dc.bibliographiccitation.lastpage","336"],["dc.bibliographiccitation.volume","117"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Scherk, Harald"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Reith, Wolfgang"],["dc.contributor.author","Meyer, Jobst"],["dc.contributor.author","Falkai, Peter"],["dc.date.accessioned","2018-11-07T08:44:53Z"],["dc.date.available","2018-11-07T08:44:53Z"],["dc.date.issued","2010"],["dc.identifier.isi","000276936800580"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20300"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.publisher.place","Amsterdam"],["dc.relation.conference","2nd Conference of the Schizophrenia-International-Research-Society (SIRS)"],["dc.relation.eventlocation","Florence, ITALY"],["dc.relation.issn","0920-9964"],["dc.title","ASSOCIATION OF SCHIZOPHRENIA SUSCEPTIBILITY GENES WITH INTERMEDIATE PHENOTYPES: NEW FINDINGS FROM GENOMIC IMAGING"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]