Schott, Peter

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Grebe, Cornelia"],["dc.contributor.author","Keller, M."],["dc.contributor.author","Kogler, Harald"],["dc.contributor.author","Nguyen, P."],["dc.contributor.author","Schmidt, A."],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Schott, Peter"],["dc.date.accessioned","2018-11-07T09:28:02Z"],["dc.date.available","2018-11-07T09:28:02Z"],["dc.date.issued","2006"],["dc.format.extent","474"],["dc.identifier.isi","000240668403226"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30680"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.eventlocation","Barcelona, SPAIN"],["dc.relation.issn","1522-9645"],["dc.relation.issn","0195-668X"],["dc.title","Identification of BRCA1 associated Protein 2 (BRAP) as a modulator of myocardial hypertrophy and heart failure"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Schott, Peter"],["dc.contributor.author","Grebe, Cornelia"],["dc.contributor.author","Unsoeld, Bernhard W."],["dc.contributor.author","Schmidt, A."],["dc.contributor.author","Koegler, Harald"],["dc.contributor.author","Guan-Schmidt, Kaomei"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.date.accessioned","2018-11-07T10:58:53Z"],["dc.date.available","2018-11-07T10:58:53Z"],["dc.date.issued","2007"],["dc.format.extent","8"],["dc.identifier.isi","000208702200022"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50568"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.issn","0195-668X"],["dc.title","Disturbed MAPK signaling and heart failure in Impedes Mitogenic Signaling (IMP) transgenic mice"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Circulation Research"],["dc.bibliographiccitation.volume","105"],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Grebe, Cornelia"],["dc.contributor.author","Schott, Peter"],["dc.contributor.author","Unsoeld, Bernhard W."],["dc.contributor.author","Maenner, Joerg"],["dc.contributor.author","Schmidt, Albrecht"],["dc.contributor.author","Kurz, Kathrin"],["dc.contributor.author","Knoell, Ralph"],["dc.contributor.author","Kramann, Nadine"],["dc.contributor.author","Guan, Kaomei"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.date.accessioned","2018-11-07T11:24:12Z"],["dc.date.available","2018-11-07T11:24:12Z"],["dc.date.issued","2009"],["dc.format.extent","E15"],["dc.identifier.isi","000270150800039"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56352"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","Basic Cardiovascular Sciences Conference 2009"],["dc.relation.eventlocation","Lake Las Vegas, Henderson, NV"],["dc.relation.issn","0009-7330"],["dc.title","Impedes Mitogenic Signal Propagation (IMP) Is Essential for Embryonic Heart and Brain Development and Controls Cardiac Performance via MAPK Signaling in Vivo"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2724"],["dc.bibliographiccitation.issue","23"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.lastpage","2732"],["dc.bibliographiccitation.volume","113"],["dc.contributor.author","Koegler, Harald"],["dc.contributor.author","Schott, Peter"],["dc.contributor.author","Toischer, Karl"],["dc.contributor.author","Milting, Hendrik"],["dc.contributor.author","Van, Phuc Nguyen"],["dc.contributor.author","Kohlhaas, Michael"],["dc.contributor.author","Grebe, Cornelia"],["dc.contributor.author","Kassner, Astrid"],["dc.contributor.author","Domeier, Erik"],["dc.contributor.author","Teucher, Nils"],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Knoell, Ralph"],["dc.contributor.author","Maier, Lars S."],["dc.contributor.author","El-Banayosy, Aly"],["dc.contributor.author","Koerfer, Reiner"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.date.accessioned","2017-09-07T11:52:41Z"],["dc.date.available","2017-09-07T11:52:41Z"],["dc.date.issued","2006"],["dc.description.abstract","Background - In heart failure ( HF), ventricular myocardium expresses brain natriuretic peptide ( BNP). Despite the association of elevated serum levels with poor prognosis, BNP release is considered beneficial because of its antihypertrophic, vasodilating, and diuretic properties. However, there is evidence that BNP-mediated signaling may adversely influence cardiac remodeling, with further impairment of calcium homeostasis. Methods and Results - We studied the effects of BNP on preload-dependent myocardial sarcoplasmic reticulum Ca2+ ATPase ( SERCA2a) expression. In rabbit isolated muscle strips stretched to high preload and shortening isotonically over 6 hours, the SERCA/glyceraldehyde phosphate dehydrogenase mRNA ratio was enhanced by 168% ( n = 8) compared with unloaded preparations ( n = 8; P < 0.001). Recombinant human BNP at a concentration typically found in end-stage HF patients ( 350 pg/mL) abolished SERCA upregulation by stretch ( n = 9; P < 0.0001 versus BNP free). Inhibition of cyclic guanosine 3', 5' monophosphate ( cGMP)-phosphodiesterase-5 mimicked this effect, whereas inhibition of cGMP-dependent protein kinase restored preload-dependent SERCA upregulation in the presence of recombinant human BNP. Furthermore, in myocardium from human end-stage HF patients undergoing cardiac transplantation ( n = 15), BNP expression was inversely correlated with SERCA levels. Moreover, among 23 patients treated with left ventricular assist devices, significant SERCA2a recovery occurred in those downregulating BNP. Conclusions - Our data indicate that preload stimulates SERCA expression. BNP antagonizes this mechanism via guanylyl cyclase-A, cGMP, and cGMP-dependent protein kinase. This novel action of BNP to uncouple preload-dependent SERCA expression may adversely affect contractility in patients with HF."],["dc.identifier.doi","10.1161/CIRCULATIONAHA.105.608828"],["dc.identifier.gro","3143676"],["dc.identifier.isi","000238223400010"],["dc.identifier.pmid","16754798"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1216"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1524-4539"],["dc.relation.issn","0009-7322"],["dc.title","Relevance of brain natriuretic peptide in preload-dependent regulation of cardiac sarcoplasmic reticulum Ca2+ ATPase expression"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Grebe, Cornelia"],["dc.contributor.author","Schott, Peter"],["dc.contributor.author","Unsoeld, Bernhard W."],["dc.contributor.author","Boecker, C."],["dc.contributor.author","Schmidt, A."],["dc.contributor.author","Kurz, K."],["dc.contributor.author","Knoell, Ralph"],["dc.contributor.author","Guan, Kaomei"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.date.accessioned","2018-11-07T11:24:44Z"],["dc.date.available","2018-11-07T11:24:44Z"],["dc.date.issued","2009"],["dc.format.extent","219"],["dc.identifier.isi","000208702602277"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56474"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.issn","0195-668X"],["dc.title","Impedes Mitogenic Signal Propagation (IMP) is responsive towards neurohumoral stimulation controlling MAPK mediated development and cardiac growth"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Circulation Research"],["dc.bibliographiccitation.volume","99"],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Schott, Peter"],["dc.contributor.author","Grebe, Cornelia"],["dc.contributor.author","Keller, Manuel"],["dc.contributor.author","Schmidt, Albrecht"],["dc.contributor.author","Kogler, Harald"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.date.accessioned","2018-11-07T09:17:46Z"],["dc.date.available","2018-11-07T09:17:46Z"],["dc.date.issued","2006"],["dc.format.extent","E46"],["dc.identifier.isi","000240209800161"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28246"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.eventlocation","Keystone, CO"],["dc.relation.issn","0009-7330"],["dc.title","BRCA1-associated protein 2: A novel modulator of ERK-MAPK signaling in heart failure"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","18"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.volume","118"],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Grebe, Cornelia"],["dc.contributor.author","Schott, Peter"],["dc.contributor.author","Unsoeld, Bernhard W."],["dc.contributor.author","Schmidt, Albrecht"],["dc.contributor.author","Kurz, Kathrin"],["dc.contributor.author","Knoell, Ralph"],["dc.contributor.author","Kramann, Nadine"],["dc.contributor.author","Guan-Schmidt, Kaomei"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.date.accessioned","2018-11-07T11:09:54Z"],["dc.date.available","2018-11-07T11:09:54Z"],["dc.date.issued","2008"],["dc.format.extent","S423"],["dc.identifier.isi","000262104500692"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53102"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","81st Annual Scientific Session of the American-Heart-Association"],["dc.relation.eventlocation","New Orleans, LA"],["dc.relation.issn","0009-7322"],["dc.title","Impedes Mitogenic Signal Propagation (IMP) Is Essential for Embryonic Development and Controls Cardiac Size and Function via MAPK"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.volume","126"],["dc.contributor.author","Grebe, Cornelia"],["dc.contributor.author","Schott, Peter"],["dc.contributor.author","Unsoeld, Bernhard W."],["dc.contributor.author","Maenner, Joerg"],["dc.contributor.author","Didie, Michael"],["dc.contributor.author","Kurz, Katrin"],["dc.contributor.author","Koenll, Ralph"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Seidler, Tim"],["dc.date.accessioned","2018-11-07T09:03:19Z"],["dc.date.available","2018-11-07T09:03:19Z"],["dc.date.issued","2012"],["dc.identifier.isi","000208885002013"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24881"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.issn","1524-4539"],["dc.relation.issn","0009-7322"],["dc.title","Brca1-associated Protein 2 (BRAP) is Essential for Embryonic Heart Development and for Neonatal Cardiomyocyte Proliferation"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Circulation Research"],["dc.bibliographiccitation.volume","103"],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Grebe, Cornelia"],["dc.contributor.author","Schott, Peter"],["dc.contributor.author","Unsoeld, Bernhard W."],["dc.contributor.author","Schmidt, Albrecht"],["dc.contributor.author","Kurz, Katrin"],["dc.contributor.author","Knoell, Ralph"],["dc.contributor.author","Guan, Kaomei"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.date.accessioned","2018-11-07T11:12:01Z"],["dc.date.available","2018-11-07T11:12:01Z"],["dc.date.issued","2008"],["dc.format.extent","E46"],["dc.identifier.isi","000258845200070"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53564"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","Basic Cardiovascular Sciences Conference"],["dc.relation.eventlocation","Keystone, CO"],["dc.relation.issn","0009-7330"],["dc.title","Impedes Mitogenic Signal Propagation (IMP) Is Essential for Embryonic Development but Mediates Detrimental Cardiac MAPK Signaling In Vivo"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","46"],["dc.bibliographiccitation.issue","18"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.lastpage","47"],["dc.bibliographiccitation.volume","114"],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Schott, Peter"],["dc.contributor.author","Grebe, Cornelia"],["dc.contributor.author","Unsoeld, Bernhard W."],["dc.contributor.author","Kogler, Harald"],["dc.contributor.author","Schmidt, Albrecht"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.date.accessioned","2018-11-07T09:05:09Z"],["dc.date.available","2018-11-07T09:05:09Z"],["dc.date.issued","2006"],["dc.identifier.isi","000241792800228"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25257"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.eventlocation","Chicago, IL"],["dc.relation.issn","0009-7322"],["dc.title","Inhibition of ERK-MAPK signalling via BRCA1 associated protein 2 (BRAP) leads to heart failure in transgenic mice"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]