Walter, Lutz

[["dc.bibliographiccitation.firstpage","970"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","The Journal of Immunology"],["dc.bibliographiccitation.lastpage","975"],["dc.bibliographiccitation.volume","174"],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Dressel, Ralf"],["dc.contributor.author","Schmidt, Bernhard"],["dc.contributor.author","Günther, Eberhard"],["dc.contributor.author","Walter, Lutz"],["dc.date.accessioned","2022-10-06T13:26:53Z"],["dc.date.available","2022-10-06T13:26:53Z"],["dc.date.issued","2005"],["dc.identifier.doi","10.4049/jimmunol.174.2.970"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115191"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1550-6606"],["dc.relation.issn","0022-1767"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","The Rat Expresses Two Complement Factor C4 Proteins, but Only One Isotype Is Expressed in the Liver"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","85"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Immunogenetics"],["dc.bibliographiccitation.lastpage","93"],["dc.bibliographiccitation.volume","63"],["dc.contributor.author","Averdam, Anne"],["dc.contributor.author","Kuschal, Christiane"],["dc.contributor.author","Otto, Nicole"],["dc.contributor.author","Westphal, Nico"],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Reinhardt, Richard"],["dc.contributor.author","Walter, Lutz"],["dc.date.accessioned","2022-10-06T13:31:02Z"],["dc.date.available","2022-10-06T13:31:02Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1007/s00251-010-0487-3"],["dc.identifier.pii","487"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115286"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1432-1211"],["dc.relation.issn","0093-7711"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Sequence analysis of the grey mouse lemur (Microcebus murinus) MHC class II DQ and DR region"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","773"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Immunogenetics"],["dc.bibliographiccitation.lastpage","777"],["dc.bibliographiccitation.volume","56"],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Walter, Lutz"],["dc.date.accessioned","2022-10-06T13:30:43Z"],["dc.date.available","2022-10-06T13:30:43Z"],["dc.date.issued","2004"],["dc.identifier.doi","10.1007/s00251-004-0744-4"],["dc.identifier.pii","744"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115283"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1432-1211"],["dc.relation.issn","0093-7711"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Considerable haplotypic diversity in the RT1-CE class I gene region of the rat major histocompatibility complex"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1047"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","American Journal of Primatology"],["dc.bibliographiccitation.lastpage","1054"],["dc.bibliographiccitation.volume","72"],["dc.contributor.author","Thinh, Van Ngoc"],["dc.contributor.author","Rawson, Benjamin"],["dc.contributor.author","Hallam, Chris"],["dc.contributor.author","Kenyon, Marina"],["dc.contributor.author","Nadler, Tilo"],["dc.contributor.author","Walter, Lutz"],["dc.contributor.author","Roos, Christian"],["dc.date.accessioned","2021-06-01T10:49:20Z"],["dc.date.available","2021-06-01T10:49:20Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1002/ajp.20861"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86248"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0275-2565"],["dc.title","Phylogeny and distribution of crested gibbons (genus Nomascus) based on mitochondrial cytochrome b gene sequence data"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","629"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Molecular Phylogenetics and Evolution"],["dc.bibliographiccitation.lastpage","636"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Nadler, Tilo"],["dc.contributor.author","Walter, Lutz"],["dc.date.accessioned","2021-06-01T10:50:00Z"],["dc.date.available","2021-06-01T10:50:00Z"],["dc.date.issued","2008"],["dc.identifier.doi","10.1016/j.ympev.2008.03.006"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86490"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","1055-7903"],["dc.title","Mitochondrial phylogeny, taxonomy and biogeography of the silvered langur species group (Trachypithecus cristatus)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","174"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Gene"],["dc.bibliographiccitation.lastpage","181"],["dc.bibliographiccitation.volume","371"],["dc.contributor.author","Rump, Andreas"],["dc.contributor.author","Rösen-Wolff, Angela"],["dc.contributor.author","Gahr, Manfred"],["dc.contributor.author","Seidenberg, Jürgen"],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Walter, Lutz"],["dc.contributor.author","Günther, Viola"],["dc.contributor.author","Roesler, Joachim"],["dc.date.accessioned","2022-10-06T13:33:08Z"],["dc.date.available","2022-10-06T13:33:08Z"],["dc.date.issued","2006"],["dc.identifier.doi","10.1016/j.gene.2005.11.036"],["dc.identifier.pii","S0378111905007201"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115553"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0378-1119"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","A splice-supporting intronic mutation in the last bp position of a cryptic exon within intron 6 of the CYBB gene induces its incorporation into the mRNA causing chronic granulomatous disease (CGD)"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","79"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Frontiers in zoology"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Liu, Guangjian"],["dc.contributor.author","Walter, Lutz"],["dc.contributor.author","Tang, Suni"],["dc.contributor.author","Tan, Xinxin"],["dc.contributor.author","Shi, Fanglei"],["dc.contributor.author","Pan, Huijuan"],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Liu, Zhijin"],["dc.contributor.author","Li, Ming"],["dc.date.accessioned","2019-07-09T11:41:12Z"],["dc.date.available","2019-07-09T11:41:12Z"],["dc.date.issued","2014"],["dc.description.abstract","BACKGROUND: Umami and sweet tastes are two important basic taste perceptions that allow animals to recognize diets with nutritious carbohydrates and proteins, respectively. Until recently, analyses of umami and sweet taste were performed on various domestic and wild animals. While most of these studies focused on the pseudogenization of taste genes, which occur mostly in carnivores and species with absolute feeding specialization, omnivores and herbivores were more or less neglected. Catarrhine primates are a group of herbivorous animals (feeding mostly on plants) with significant divergence in dietary preference, especially the specialized folivorous Colobinae. Here, we conducted the most comprehensive investigation to date of selection pressure on sweet and umami taste genes (TAS1Rs) in catarrhine primates to test whether specific adaptive evolution occurred during their diversification, in association with particular plant diets. RESULTS: We documented significant relaxation of selective constraints on sweet taste gene TAS1R2 in the ancestral branch of Colobinae, which might correlate with their unique ingestion and digestion of leaves. Additionally, we identified positive selection acting on Cercopithecidae lineages for the umami taste gene TAS1R1, on the Cercopithecinae and extant Colobinae and Hylobatidae lineages for TAS1R2, and on Macaca lineages for TAS1R3. Our research further identified several site mutations in Cercopithecidae, Colobinae and Pygathrix, which were detected by previous studies altering the sensitivity of receptors. The positively selected sites were located mostly on the extra-cellular region of TAS1Rs. Among these positively selected sites, two vital sites for TAS1R1 and four vital sites for TAS1R2 in extra-cellular region were identified as being responsible for the binding of certain sweet and umami taste molecules through molecular modelling and docking. CONCLUSIONS: Our results suggest that episodic and differentiated adaptive evolution of TAS1Rs pervasively occurred in catarrhine primates, most concentrated upon the extra-cellular region of TAS1Rs."],["dc.format.extent","16"],["dc.identifier.doi","10.1186/s12983-014-0079-4"],["dc.identifier.pmid","25389445"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11833"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58372"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1742-9994"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Differentiated adaptive evolution, episodic relaxation of selective constraints, and pseudogenization of umami and sweet taste genes TAS1Rs in catarrhine primates."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","19"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Genome Medicine"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Wilson, Gareth A"],["dc.contributor.author","Butcher, Lee M"],["dc.contributor.author","Foster, Holly R"],["dc.contributor.author","Feber, Andrew"],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Walter, Lutz"],["dc.contributor.author","Woszczek, Grzegorz"],["dc.contributor.author","Beck, Stephan"],["dc.contributor.author","Bell, Christopher G"],["dc.date.accessioned","2019-07-09T11:39:42Z"],["dc.date.available","2019-07-09T11:39:42Z"],["dc.date.issued","2014"],["dc.description.abstract","Background Common human diseases are caused by the complex interplay of genetic susceptibility as well as environmental factors. Due to the environment’s influence on the epigenome, and therefore genome function, as well as conversely the genome’s facilitative effect on the epigenome, analysis of this level of regulation may increase our knowledge of disease pathogenesis. Methods In order to identify human-specific epigenetic influences, we have performed a novel genome-wide DNA methylation analysis comparing human, chimpanzee and rhesus macaque. Results We have identified that the immunological Leukotriene B4 receptor (LTB4R, BLT1 receptor) is the most epigenetically divergent human gene in peripheral blood in comparison with other primates. This difference is due to the co-ordinated active state of human-specific hypomethylation in the promoter and human-specific increased gene body methylation. This gene is significant in innate immunity and the LTB4/LTB4R pathway is involved in the pathogenesis of the spectrum of human inflammatory diseases. This finding was confirmed by additional neutrophil-only DNA methylome and lymphoblastoid H3K4me3 chromatin comparative data. Additionally we show through functional analysis that this receptor has increased expression and a higher response to the LTB4 ligand in human versus rhesus macaque peripheral blood mononuclear cells. Genome-wide we also find human species-specific differentially methylated regions (human s-DMRs) are more prevalent in CpG island shores than within the islands themselves, and within the latter are associated with the CTCF motif. Conclusions This result further emphasises the exclusive nature of the human immunological system, its divergent adaptation even from very closely related primates, and the power of comparative epigenomics to identify and understand human uniqueness."],["dc.identifier.doi","10.1186/gm536"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12726"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58027"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Human-specific epigenetic variation in the immunological Leukotriene B4 Receptor (LTB4R/BLT1) implicated in common inflammatory diseases"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","17"],["dc.bibliographiccitation.journal","BMC evolutionary biology"],["dc.bibliographiccitation.lastpage","13"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Andriaholinirina, Nicole"],["dc.contributor.author","Fausser, Jean-Luc"],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Zinner, Dietmar"],["dc.contributor.author","Thalmann, Urs"],["dc.contributor.author","Rabarivola, Clément"],["dc.contributor.author","Ravoarimanana, Iary"],["dc.contributor.author","Ganzhorn, Jörg U."],["dc.contributor.author","Meier, Bernhard"],["dc.contributor.author","Hilgartner, Roland"],["dc.contributor.author","Walter, Lutz"],["dc.contributor.author","Zaramody, Alphonse"],["dc.contributor.author","Langer, Christoph"],["dc.contributor.author","Hahn, Thomas"],["dc.contributor.author","Zimmermann, Elke"],["dc.contributor.author","Radespiel, Ute"],["dc.contributor.author","Craul, Mathias"],["dc.contributor.author","Tomiuk, Jürgen"],["dc.contributor.author","Tattersall, Ian"],["dc.contributor.author","Rumpler, Yves"],["dc.date.accessioned","2019-07-09T11:52:29Z"],["dc.date.available","2019-07-09T11:52:29Z"],["dc.date.issued","2006"],["dc.description.abstract","Background: The number of species within the Malagasy genus Lepilemur and their phylogenetic relationships is disputed and controversial. In order to establish their evolutionary relationships, a comparative cytogenetic and molecular study was performed. We sequenced the complete mitochondrial cytochrome b gene (1140 bp) from 68 individuals representing all eight sportive lemur species and most major populations, and compared the results with those obtained from cytogenetic studies derived from 99 specimens. Results: Interspecific genetic variation, diagnostic characters and significantly supported phylogenetic relationships were obtained from the mitochondrial sequence data and are in agreement with cytogenetic information. The results confirm the distinctiveness of Lepilemur ankaranensis, L. dorsalis, L. edwardsi, L. leucopus, L. microdon, L. mustelinus, L. ruficaudatus and L. septentrionalis on species level. Additionally, within L. ruficaudatus large genetic differences were observed among different geographic populations. L. dorsalis from Sahamalaza Peninsula and from the Ambanja/Nosy Be region are paraphyletic, with the latter forming a sister group to L. ankaranensis."],["dc.identifier.doi","10.1186/1471-2148-6-17"],["dc.identifier.fs","42806"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4397"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60200"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","590"],["dc.subject.ddc","599"],["dc.subject.ddc","610"],["dc.subject.ddc","599.8"],["dc.title","Molecular phylogeny and taxonomic revision of the sportive lemurs (Lepilemur, Primates)"],["dc.title.alternative","Research article"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","970"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","The Journal of Immunology"],["dc.bibliographiccitation.lastpage","975"],["dc.bibliographiccitation.volume","174"],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Dressel, Ralf"],["dc.contributor.author","Schmidt, B."],["dc.contributor.author","Gunther, E."],["dc.contributor.author","Walter, L."],["dc.date.accessioned","2018-11-07T08:32:31Z"],["dc.date.available","2018-11-07T08:32:31Z"],["dc.date.issued","2005"],["dc.description.abstract","The complement component C4 is well known for its complex genetics inhuman and mouse where it is part of a tandemly duplicated module. For the rat, no such information had been available until recently. A C4 gene duplication could be identified also in the rat, but the duplicated module maps similar to200 kb centromerically from the canonical C4-1 gene. In this study, we present the genomic organization of the two C4 gene-containing modules and the expression of the two C4 genes in the rat (Rattus norvegicus). The duplicated module contains an intact C4 gene as well as Cyp21 and Stk19 pseudogenes. Quantitative mRNA expression analyses revealed that both C4 genes are transcribed in various organs and tissues, but displaying ample differences of C4-1 and C4-2 expression. Most notably, C4-2 is not expressed in the liver. At variance to the mouse, the expression of the rat C4 genes does not exhibit any sex dependency. By using two-dimensional gel electrophoresis and mass spectrometry, products of both C4 genes could be identified in rat serum samples. These two rat C4 isotypes are nearly identical, but differ in a functionally important amino acid residue that is known to influence the functional properties of the C4 isotypes in human."],["dc.identifier.isi","000226360500048"],["dc.identifier.pmid","15634920"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17358"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Immunologists"],["dc.relation.issn","0022-1767"],["dc.title","The rat expresses two complement factor C4 proteins, but only one isotype is expressed in the liver"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]