Waldmann-Beushausen, Regina

[["dc.bibliographiccitation.journal","Journal of Molecular and Cellular Cardiology"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Post, Heiner"],["dc.contributor.author","Schmidt, Albrecht"],["dc.contributor.author","Schmitto, Jan"],["dc.contributor.author","Schultz, Georg"],["dc.contributor.author","Waldmann-Beushausen, Regina"],["dc.contributor.author","Doerge, Hilmar"],["dc.contributor.author","Pieske, Burkert M."],["dc.date.accessioned","2018-11-07T11:01:58Z"],["dc.date.available","2018-11-07T11:01:58Z"],["dc.date.issued","2007"],["dc.format.extent","S202"],["dc.identifier.doi","10.1016/j.yjmcc.2007.03.612"],["dc.identifier.isi","000247669000553"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51269"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Ltd- Elsevier Science Ltd"],["dc.publisher.place","London"],["dc.relation.conference","19th World Congress of the International-Society-for-Heart-Research"],["dc.relation.eventlocation","Bologna, ITALY"],["dc.relation.issn","1095-8584"],["dc.relation.issn","0022-2828"],["dc.title","Simvastatin suppresses inflammation and preserves myocardial function after coronary microembolisation in rabbits"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","7"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","The Thoracic and Cardiovascular Surgeon"],["dc.bibliographiccitation.lastpage","9"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Tempes, Tasso"],["dc.contributor.author","Waldmann-Beushausen, Regina"],["dc.contributor.author","Ballat, Carola"],["dc.contributor.author","Bensch, M."],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T08:33:21Z"],["dc.date.available","2018-11-07T08:33:21Z"],["dc.date.issued","2009"],["dc.description.abstract","Background: Renal failure after open-heart surgery is a serious complication resulting in increased mortality and morbidity. The aim of the study was to find out whether different strategies for open-heart surgery would result in renal histological differences in a neonatal animal model. Methods: The renal tissue of newborn piglets was examined after mild hypothermic cardiopulmonary bypass (CPB group; n = 10), deep hypothermic circulatory arrest (DHCA group; n = 8), instrumentation without extracorporeal circulation (sham; n = 3), and the data were compared with those of normal porcine neonatal kidneys (control: n=6). The severity of tissue damage was graded using a 4-point scoring system (0: normal morphology, 3: severe damage). Apoptotic cells and granulocytes were counted. Results: The histological score was higher in all groups compared with controls (p<0.05) and higher in the CPB group compared with the DHCA group (p<0.05). More apoptotic cells and granulocytes were found in the CPB group compared with controls and the DHCA group (p<0.05). Conclusions: Although changes in the kidney tissue of newborn piglets are detectable after any cardiac procedure, changes are more profound after cardiopulmonary bypass with mild hypothermia."],["dc.identifier.doi","10.1055/s-2008-1039061"],["dc.identifier.isi","000263567500002"],["dc.identifier.pmid","19169989"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17557"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0171-6425"],["dc.title","Histological Changes in Neonatal Kidneys after Cardiopulmonary Bypass and Deep Hypothermic Circulatory Arrest"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Post, Heiner"],["dc.contributor.author","Schmidt, A."],["dc.contributor.author","Schmitto, J."],["dc.contributor.author","Waldmann-Beushausen, Regina"],["dc.contributor.author","Schultz, Georg"],["dc.contributor.author","Ballhausen, M."],["dc.contributor.author","Schoendube, F."],["dc.contributor.author","Pieske, Burkert M."],["dc.date.accessioned","2018-11-07T10:58:55Z"],["dc.date.available","2018-11-07T10:58:55Z"],["dc.date.issued","2007"],["dc.format.extent","519"],["dc.identifier.isi","000208702202610"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50578"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.issn","0195-668X"],["dc.title","Suppression of inflammation and preservation of myocardial function by simvastatin after coronary microembolisation in rabbits"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","348"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The International Journal of Artificial Organs"],["dc.bibliographiccitation.lastpage","353"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Schmitto, J.D."],["dc.contributor.author","Ortmann, P."],["dc.contributor.author","Wachter, R."],["dc.contributor.author","Hintze, E."],["dc.contributor.author","Popov, A. F."],["dc.contributor.author","Kolat, P."],["dc.contributor.author","Liakopoulos, O.J."],["dc.contributor.author","Waldmann-Beushausen, R."],["dc.contributor.author","DÖrge, H."],["dc.contributor.author","Schöndube, F. A."],["dc.date.accessioned","2021-06-01T10:47:54Z"],["dc.date.available","2021-06-01T10:47:54Z"],["dc.date.issued","2008"],["dc.description.abstract","Objective: Although a large variety of animal models for acute ischemia and acute heart failure exist, valuable models for studies on the effect of ventricular assist devices in chronic heart failure are scarce. We aimed to establish a stable and reproducible animal model of chronic heart failure in sheep. Methods: Sheep (n=8, 77 +/- 4 kg) were anesthesized and a 5F sheath was implanted into the left carotid artery. The left main coronary artery was catheterized under flouroscopic guidance and bolus injection of polysterol microspheres (90 mu m, n=25.000) was performed. Microembolization (ME) was repeated up to three times in two to three week intervals until animals started to develop stable clinical signs of heart failure. Clinical and echocardiographic data were analyzed at baseline (base) and at three months (3 mo) after first ME. All animals were followed for 3 months after first microembolization and then sacrificed for histological examination. Another four healthy sheep (79 +/- 6 kg) served as control animals. Results: All animals developed clinical signs of heart failure as indicated by increased heart rate at rest (68 +/- 4 bpm (base) to 93 +/- 5 bpm (3 mo) (p<0.05)), increased respiratory rate at rest (28 +/- 5 (base) to 38 +/- 7 (3 mo) (p<0.05)) and increased body weight 77 +/- 2 kg to 81 +/- 2 kg (p<0.05) due to pleural effusion, peripheral edema and ascites. Echocardiographic evaluation revealed significantly an increase of left ventricular enddiastolic diameter from 46 +/- 3 mm (base) to 61 +/- 4 mm (3 mo) (p<0.05). Clinically and echocardiographically no significant changes were revealed in healthy control animals. Conclusions: We conclude that multiple sequential intracoronary microembolization can effectively induce myocardial dysfunction with clinical and echocardiographical signs of chronic ischemic cardiomyopathy. The present model may be suitable in experimental work on heart failure and left ventricular assist devices, e. g. for studying the impact of mechanical unloading, mechanisms of recovery and reverse remodeling."],["dc.identifier.doi","10.1177/039139880803100412"],["dc.identifier.isi","000256470700011"],["dc.identifier.pmid","18432592"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85758"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wichtig Editore"],["dc.relation.eissn","1724-6040"],["dc.relation.issn","0391-3988"],["dc.title","Chronic Heart Failure Induced by Multiple Sequential Coronary Microembolization in Sheep"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","74"],["dc.bibliographiccitation.journal","International Journal of Cardiology"],["dc.bibliographiccitation.lastpage","79"],["dc.bibliographiccitation.volume","251"],["dc.contributor.author","Ziebolz, D."],["dc.contributor.author","Jahn, C."],["dc.contributor.author","Pegel, J."],["dc.contributor.author","Semper-Pinnecke, E."],["dc.contributor.author","Mausberg, R.F."],["dc.contributor.author","Waldmann-Beushausen, R."],["dc.contributor.author","Schöndube, F.A."],["dc.contributor.author","Danner, B.C."],["dc.date.accessioned","2020-12-10T14:24:31Z"],["dc.date.available","2020-12-10T14:24:31Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.ijcard.2017.09.001"],["dc.identifier.issn","0167-5273"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72278"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Periodontal bacteria DNA findings in human cardiac tissue - Is there a link of periodontitis to heart valve disease?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","274"],["dc.bibliographiccitation.issue","18"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.lastpage","275"],["dc.bibliographiccitation.volume","114"],["dc.contributor.author","Post, Heiner"],["dc.contributor.author","Schmidt, Albrecht"],["dc.contributor.author","Schmitto, Jan"],["dc.contributor.author","Schultz, Georg"],["dc.contributor.author","Waldmann-Beushausen, Regina"],["dc.contributor.author","Dorge, Hilmar"],["dc.contributor.author","Pieske, Burkert M."],["dc.date.accessioned","2018-11-07T09:05:32Z"],["dc.date.available","2018-11-07T09:05:32Z"],["dc.date.issued","2006"],["dc.identifier.isi","000241792801608"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25346"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","79th Annual Scientific Session of the American-Heart-Association"],["dc.relation.eventlocation","Chicago, IL"],["dc.relation.issn","0009-7322"],["dc.title","Simvastatin preserves myocardial function after coronary microembolisation in rabbits"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","273"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Interactive Cardiovascular and Thoracic Surgery"],["dc.bibliographiccitation.lastpage","279"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Bougioukas, Ioannis"],["dc.contributor.author","Didilis, Vassilios N."],["dc.contributor.author","Emigholz, Jenny"],["dc.contributor.author","Waldmann-Beushausen, Regina"],["dc.contributor.author","Stojanovic, Tom"],["dc.contributor.author","Muehlfeld, Christian"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Danner, Bernhard Christoph"],["dc.date.accessioned","2018-11-07T10:10:44Z"],["dc.date.available","2018-11-07T10:10:44Z"],["dc.date.issued","2016"],["dc.description.abstract","OBJECTIVES: Lung ischaemia-reperfusion injury (LIRI) frequently occurs after lung transplantation or cardiac surgery with cardiopulmonary bypass, thus increasing postoperative morbidity and mortality. As LIRI is associated with the release of reactive oxygen species and a subsequent inflammatory reaction, we tested whether amifostine, a thiol and free radical scavenger, has a beneficial effect on LIRI. METHODS: A total number of 72 Wistar rats were subjected to LIRI with or without a single or double dose of amifostine (100 mg/kg, intraperitoneally). Experimental induction of LIRI was performed by clamping either the left lung hilum or the pulmonary artery alone for 60 min, followed by 90 min of reperfusion. Control groups consisted of LIRI and NaCl, a sham group and a no intervention group (baseline). At the end of the experiments, the left lung was analysed by quantitative RT-PCR of inflammatory marker gene expression, western blot of activated nuclear factor-kappa B (NF-kappa B) and light and electron microscopy. RESULTS: In placebo and amifostine groups, the expression levels of pro-inflammatory markers were increased significantly and to a similar extent independent of the type of ischaemia induction. In contrast, amifostine reduced the activation of NF-kappa B in comparison with placebo. This effect was present independent of the type of ischaemia or the application of a single or double dose of amifostine. However, oedema formation, blood-gas barrier damage and inflammatory reaction were similar in all amifostine or placebo LIRI groups. CONCLUSIONS: Despite a significant reduction in NF-kappa B activation, amifostine failed to decrease the inflammatory response and structural changes induced by LIRI in this experimental setting."],["dc.identifier.doi","10.1093/icvts/ivw105"],["dc.identifier.isi","000383248800017"],["dc.identifier.pmid","27121071"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39918"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1569-9285"],["dc.relation.issn","1569-9293"],["dc.title","The effect of amifostine on lung ischaemia-reperfusion injury in rats"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","233"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","ASAIO Journal"],["dc.bibliographiccitation.lastpage","236"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Ortmann, Philipp"],["dc.contributor.author","Akdis, Mustafa"],["dc.contributor.author","Alekuzei, Haidar"],["dc.contributor.author","Steinke, Katja"],["dc.contributor.author","Kolat, Philipp"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Liakopoulos, Oliver Joannis"],["dc.contributor.author","Waldmann-Beushausen, Regina"],["dc.contributor.author","Mirzaie, Masoud"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Seipelt, Ralf G."],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T11:15:19Z"],["dc.date.available","2018-11-07T11:15:19Z"],["dc.date.issued","2008"],["dc.description.abstract","We evaluated the newly developed miniaturized HIA microdiagonal blood pump (MDP) as a continuous flow left ventricular assist device. In a sheep model (n = 6), the MDP was implanted through left lateral thoracotomy and placed paracorporeally with inflow conduit to left atrium and outflow conduit to descending aorta. The sheep were pumped at a mean flow rate of 2.5 L/min for 7 days. Anticoagulation was applied by intravenous heparin administration. Postoperatively, activated clotting time was held stable with values of 200 seconds. During follow-up, blood samples (creatinine kinase, creatinine, glutamic-oxaloacetic transaminase (aspartate aminotransferase) (GOT), glutamate dehydrogenase (GLDH), gamma-GT, plasma-free hemoglobin, and hemoglobine) were taken daily. After 7 days, the sheep were killed for macroscopic examination. Systemic artery pressures remained stable during the whole test period. Because of operative reasons, the hemoglobin value (7.5 +/- 0.61 g/dl) decreased perioperatively, but recovered within the test period, whereas creatinine kinase increased initially after thoracotomy, but decreased to normal within days. Renal and liver functions were slightly impaired perioperatively, indicated by temporarily enhanced values of GOT, gamma-GT, GLDH, and creatinine. The MDP did not produce significant hemolysis as measured by plasma-free hemoglobin levels. Wound infections did not occur. We conclude that the MDP ran successfully as an left ventricular assist device for 7 days in sheep has potential for long-term support, and may serve as an alternative to current technologies. Presented data were not obtained in a clinical trial; however, the results are promising enough to proceed with longer duration animal studies."],["dc.identifier.doi","10.1097/MAT.0b013e318175258e"],["dc.identifier.isi","000256186600003"],["dc.identifier.pmid","18496271"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54340"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1058-2916"],["dc.title","Miniaturized HIA microdiagonal pump as left ventricular assist device in a sheep model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","E35"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Artificial Organs"],["dc.bibliographiccitation.lastpage","E39"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Zwiehoff, Julia M."],["dc.contributor.author","Waldmann-Beushausen, Regina"],["dc.contributor.author","Schneider, Simon"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T09:30:27Z"],["dc.date.available","2018-11-07T09:30:27Z"],["dc.date.issued","2013"],["dc.description.abstract","Still little is known about the effect of cardiac surgery on neonatal hepatic tissue. We examined the effect of cardiopulmonary bypass (CPB) and the effect of deep hypothermic circulatory arrest (DHCA) on neonatal hepatic tissue. Liver biopsies of neonatal piglets were taken after CPB (n=4), after DHCA (n=5), and after surgery without CPB (non-CPB; n=3). Additionally, findings were compared to those of control piglets (n=9). The liver specimens were fixed, stained with hematoxylin and eosin, and scored regarding inflammatory reaction, hepatocellular edema, and apoptosis. Inflammation score of treated groups was higher than in control; CPB 2.5+/-0.5, DHCA 1.6+/-0.4, non-CPB 1.2+/-0.6, control 0.4+/-0.3 (P<0.001 CPB and DHCA vs. control; P<0.05 non-CPB vs. control). Hepatic cell edema was more evident after DHCA (score 2.0+/-0.4 vs. 0.2+/-0.3 in control and 0.6+/-0.5 after CPB; P<0.001 and P<0.05, respectively). The highest apoptotic cell count was in the non-CPB group (22.3+/-6.3 vs. 11.4+/-3.6 in control and 8.9+/-5.4 after CPB; P<0.05). The present study showed that (i) surgical trauma induces hepatic cell apoptosis; (ii) CPB increases hepatic inflammatory reaction; and (iii) DHCA amplifies hepatic cell edema."],["dc.identifier.doi","10.1111/j.1525-1594.2012.01577.x"],["dc.identifier.isi","000313706400011"],["dc.identifier.pmid","23305585"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31310"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","8th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion"],["dc.relation.eventlocation","Istanbul, TURKEY"],["dc.relation.issn","1525-1594"],["dc.relation.issn","0160-564X"],["dc.title","The Effect of Cardiopulmonary Bypass and Hypothermic Circulatory Arrest on Hepatic Histology in Newborn Animals: An Experimental Study"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]