Chaieb, Leila

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Neuroscience and Rehabilitation"],["dc.bibliographiccitation.volume","1"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Moliadze, Vera"],["dc.contributor.author","Zarrouki, Driss"],["dc.contributor.author","Shoukier, Moneef"],["dc.contributor.author","Paulus, Walter"],["dc.date.accessioned","2016-08-04T08:38:52Z"],["dc.date.accessioned","2021-10-27T13:20:37Z"],["dc.date.available","2016-08-04T08:38:52Z"],["dc.date.available","2021-10-27T13:20:37Z"],["dc.date.issued","2014"],["dc.description.abstract","Background: The brain-derived neurotrophic factor (BDNF) gene is involved in mechanisms of synaptic plasticity in the brain and has been demonstrated to also play a role in influencing brain plasticity induced by transcranial magnetic and electrical stimulation. Objective and methods: This is an update of a previous study from our laboratory. We retrospectively analysed the data of 115 healthy subjects participating in 130 experimental sessions, measuring the amplitude of motor evoked potentials (MEPs) before and after transcranial stimulation of the primary motor cortex (M1). We explored whether BDNF polymorphism shapes the effects of excitatory theta burst stimulation (iTBS, n=23), anodal (n=32) and cathodal (n=19) transcranial direct current (tDCS), random noise (tRNS, n=33) and alternating current (tACS, n=13) stimulation. Results: Although a trend toward altered plasticity was observed in Val- 66Met allele carriers to stimulation with regard to all protocols compared with the response of Val66Val individuals, no significant GENOTYPE x TIME interaction was found. Conclusions: The BDNF polymorphism is suggested to have an impact on transcranial stimulation-induced plasticity in humans, which differs according to the mechanism of plasticity induction. However, according to our data, we suggest that genotyping in general, in transcranial stimulation studies including small number of subjects and at least when the M1 is stimulated, is not necessary. Nevertheless, the impact of BDNF on plasticity inducing protocols might be taken into account for e.g. in cognitive studies, when the prefrontal cortex is stimulated."],["dc.identifier.doi","10.17653/2374-9091.SS0004"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13522"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91970"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","2374-9091"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","BDNF Gene Polymorphisms and Motor Cortical Plasticity in Healthy Humans: When Should We Consider It"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","14147"],["dc.bibliographiccitation.issue","52"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","14155"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Terney, Daniella"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Moliadze, Vera"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T11:07:51Z"],["dc.date.available","2018-11-07T11:07:51Z"],["dc.date.issued","2008"],["dc.description.abstract","For > 20 years, noninvasive transcranial stimulation techniques like repetitive transcranial magnetic stimulation (rTMS) and direct current stimulation (tDCS) have been used to induce neuroplastic-like effects in the human cortex, leading to the activity-dependent modification of synaptic transmission. Here, we introduce a novel method of electrical stimulation: transcranial random noise stimulation (tRNS), whereby a random electrical oscillation spectrum is applied over the motor cortex. tRNS induces consistent excitability increases lasting 60 min after stimulation. These effects have been observed in 80 subjects through both physiological measures and behavioral tasks. Higher frequencies (100-640 Hz) appear to be responsible for generating this excitability increase, an effect that may be attributed to the repeated opening of Na(+) channels. In terms of efficacy tRNS appears to possess at least the same therapeutic potential as rTMS/tDCS in diseases such as depression, while furthermore avoiding the constraint of current flow direction sensitivity characteristic of tDCS."],["dc.identifier.doi","10.1523/JNEUROSCI.4248-08.2008"],["dc.identifier.isi","000261985900014"],["dc.identifier.pmid","19109497"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6239"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52675"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Neuroscience"],["dc.relation.issn","0270-6474"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Increasing Human Brain Excitability by Transcranial High-Frequency Random Noise Stimulation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]