Chaieb, Leila

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Neuroscience and Rehabilitation"],["dc.bibliographiccitation.volume","1"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Moliadze, Vera"],["dc.contributor.author","Zarrouki, Driss"],["dc.contributor.author","Shoukier, Moneef"],["dc.contributor.author","Paulus, Walter"],["dc.date.accessioned","2016-08-04T08:38:52Z"],["dc.date.accessioned","2021-10-27T13:20:37Z"],["dc.date.available","2016-08-04T08:38:52Z"],["dc.date.available","2021-10-27T13:20:37Z"],["dc.date.issued","2014"],["dc.description.abstract","Background: The brain-derived neurotrophic factor (BDNF) gene is involved in mechanisms of synaptic plasticity in the brain and has been demonstrated to also play a role in influencing brain plasticity induced by transcranial magnetic and electrical stimulation. Objective and methods: This is an update of a previous study from our laboratory. We retrospectively analysed the data of 115 healthy subjects participating in 130 experimental sessions, measuring the amplitude of motor evoked potentials (MEPs) before and after transcranial stimulation of the primary motor cortex (M1). We explored whether BDNF polymorphism shapes the effects of excitatory theta burst stimulation (iTBS, n=23), anodal (n=32) and cathodal (n=19) transcranial direct current (tDCS), random noise (tRNS, n=33) and alternating current (tACS, n=13) stimulation. Results: Although a trend toward altered plasticity was observed in Val- 66Met allele carriers to stimulation with regard to all protocols compared with the response of Val66Val individuals, no significant GENOTYPE x TIME interaction was found. Conclusions: The BDNF polymorphism is suggested to have an impact on transcranial stimulation-induced plasticity in humans, which differs according to the mechanism of plasticity induction. However, according to our data, we suggest that genotyping in general, in transcranial stimulation studies including small number of subjects and at least when the M1 is stimulated, is not necessary. Nevertheless, the impact of BDNF on plasticity inducing protocols might be taken into account for e.g. in cognitive studies, when the prefrontal cortex is stimulated."],["dc.identifier.doi","10.17653/2374-9091.SS0004"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13522"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91970"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","2374-9091"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","BDNF Gene Polymorphisms and Motor Cortical Plasticity in Healthy Humans: When Should We Consider It"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","14147"],["dc.bibliographiccitation.issue","52"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","14155"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Terney, Daniella"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Moliadze, Vera"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T11:07:51Z"],["dc.date.available","2018-11-07T11:07:51Z"],["dc.date.issued","2008"],["dc.description.abstract","For > 20 years, noninvasive transcranial stimulation techniques like repetitive transcranial magnetic stimulation (rTMS) and direct current stimulation (tDCS) have been used to induce neuroplastic-like effects in the human cortex, leading to the activity-dependent modification of synaptic transmission. Here, we introduce a novel method of electrical stimulation: transcranial random noise stimulation (tRNS), whereby a random electrical oscillation spectrum is applied over the motor cortex. tRNS induces consistent excitability increases lasting 60 min after stimulation. These effects have been observed in 80 subjects through both physiological measures and behavioral tasks. Higher frequencies (100-640 Hz) appear to be responsible for generating this excitability increase, an effect that may be attributed to the repeated opening of Na(+) channels. In terms of efficacy tRNS appears to possess at least the same therapeutic potential as rTMS/tDCS in diseases such as depression, while furthermore avoiding the constraint of current flow direction sensitivity characteristic of tDCS."],["dc.identifier.doi","10.1523/JNEUROSCI.4248-08.2008"],["dc.identifier.isi","000261985900014"],["dc.identifier.pmid","19109497"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6239"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52675"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Neuroscience"],["dc.relation.issn","0270-6474"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Increasing Human Brain Excitability by Transcranial High-Frequency Random Noise Stimulation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","230"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Brain Stimulation"],["dc.bibliographiccitation.lastpage","237"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Moliadze, Vera"],["dc.contributor.author","Monte-Silva, Katia K."],["dc.contributor.author","Poreisz, Csaba"],["dc.contributor.author","Thirugnanasambandam, Nivethida"],["dc.contributor.author","Nitsche, Michael A."],["dc.contributor.author","Shoukier, Moneef"],["dc.contributor.author","Ludwig, Harald"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T08:38:19Z"],["dc.date.available","2018-11-07T08:38:19Z"],["dc.date.issued","2010"],["dc.description.abstract","Background The brain-derived neurotrophic factor (BDNF) gene is involved in mechanisms of synaptic plasticity in the adult brain. It has been demonstrated that BDNF also plays a significant role in shaping externally induced human brain plasticity. Plasticity induced in the human motor cortex by intermittent theta-burst stimulation (iTBS) was impaired in individuals expressing the Va166Met polymorphism. Methods To explore whether this polymorphism is also important for other neuroplasticity-inducing tools in humans with modes of action differing from that of iTBS, namely, transcranial direct current (tDCS) and random noise stimulation (tRNS), we retrospectively analyzed the data of 64 subjects studied in our laboratory with regard to BDNF genotype. Results Fifteen subjects with the Va166Met allele, 46 subjects with the Val66Val allele, and 3 Met66Met carriers were identified. The response of the Va166Met allele carriers to stimulation differed in two protocols compared with the response of Val66Val individuals. For iTBS (15 subjects, 5 heterozygotes), plasticity could be only induced in the Val66Val allele carriers. However, for facilitatory tDCS (24 subjects, 10 heterozygotes), as well as for inhibitory tDCS, (19 subjects, 8 heterozygotes), carriers of the Val66-Met allele displayed enhanced plasticity, whereas for transcranial random noise stimulation (29 subjects, 8 heterozygotes), the difference between groups was not so pronounced. Conclusions BDNF polymorphism has a definite impact on plasticity in humans, which might differ according to the mechanism of plasticity induction. This impact of BDNF on plasticity should be taken into account for future studies, as well as having wider ranging implications for the treatment of neuropsychiatric disorders with transcranial stimulation tools, as it may predetermine their efficacy for the treatment of disease and rehabilitation. (C) 2010 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.brs.2009.12.003"],["dc.identifier.isi","000283814200008"],["dc.identifier.pmid","20965453"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18739"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1935-861X"],["dc.title","Brain-derived neurotrophic factor (BDNF) gene polymorphisms shape cortical plasticity in humans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]