Chaieb, Leila

[["dc.bibliographiccitation.firstpage","97"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Brain Stimulation"],["dc.bibliographiccitation.lastpage","105"],["dc.bibliographiccitation.volume","1"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Boros, Klara"],["dc.contributor.author","Poreisz, Csaba"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Terney, Daniella"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T11:16:21Z"],["dc.date.available","2018-11-07T11:16:21Z"],["dc.date.issued","2008"],["dc.description.abstract","Objective Inteference with brain rhythms by noninvasive transcranial stimulation that uses weak transcranial alternating current may reveal itself to be a new tool for investigating cortical mechanisms currently unresolved. Here. we aim to extend transcranial direct current stimulation (tDCS) techniques to transcranial alternating Current stimulation (tACS). Background Parameters such as electrode size and position were taken from those used ill Previous tDCS Studies. Methods Motor evoked potentials (MEPs) revealed by transcranial magnetic stimulation (TMS), electroencephalogram (EEG)-power, and reaction times measured in a motor implicit learning task, were analyzed to detect changes in cortical excitability after 2-10 minutes of AC stimulation and sinusoidal DC stimulation (tSDCS) by using 1, W, 15, 30, and 45 Hz and sham stimulation over the primary motor cortex in 50 healthy subjects (eight-16 subjects in each study). Results A significantly improved implicit motor learning was observed after 10 Hz AC stimulation only. No significant changes were observed in any of the analyzed frequency bands of EEG and with regard to the MEP amplitudes after AC or tSDCS stimulation. Similarly, if the anodal or cathodal DC stimulation was superimposed on 5, 10, and 15 Hz AC stimulation, the MEP amplitudes did not change significantly. Conclusions Transcranial application of weak AC current may appear to be a tool for basic and clinical research in diseases with altered EEG activity. However, its effect seems to be weaker than tDCS stimulation, at in the present context of stimulus intensity and duration. Further studies are required to extend cautiously the safety range and uncover its influence on neuronal circuitries. (C) 2008 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.brs.2007.10.001"],["dc.identifier.isi","000262716600008"],["dc.identifier.pmid","20633376"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54566"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1935-861X"],["dc.title","Comparatively weak after-effects of transcranial alternating current stimulation (tACS) on cortical excitability in humans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","79"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Pain and Symptom Management"],["dc.bibliographiccitation.lastpage","91"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Terney, Daniella"],["dc.contributor.author","Bergmann, Inga"],["dc.contributor.author","Poreisz, Csaba"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Boros, Klara"],["dc.contributor.author","Nitsche, Michael Andreas"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Antal, Andrea"],["dc.date.accessioned","2018-11-07T11:13:38Z"],["dc.date.available","2018-11-07T11:13:38Z"],["dc.date.issued","2008"],["dc.description.abstract","Transcranial direct current stimulation (tDCS) was recently reintroduced as a tool for inducing relatively long-lasting changes in cortical excitability in focal brain regions. Anodal stimulation over the primary motor cortex enhances cortical excitability, whereas cathodal stimulation decreases it. Prior studies have shown that enhancement of D2 receptor activity by pergolide consolidates tDCS-generated excitability diminution for up to 24 hours and that cathodal stimulation of the primary motor cortex diminishes experimentally induced pain sensation and reduces the N2-P2 amplitude of laser-evoked potentials immediately poststimulation. In the present study, we investigated the effect of pergolide and cathodal tDCS over the primary motor cortex on laser-evoked potentials and acute pain perception induced with a Tm:YAG laser in a double-blind, randomized, placebo-con trolled, crossover study. The amplitude changes of laser-evoked potentials and subjective pain rating scores of 12 healthy subjects were analyzed prior to and following 15 minutes cathodal tDCS combined with pergolide or placebo intake at five different time points. Our results indicate that the amplitude of the N2 component was significantly reduced following cathodal tDCS for up to two hours. Additionally, pergolide prolonged the effect of the cathodal tDCS for up to 24 hours, and a significantly lowered Pain sensation was observed for up to 40 minutes. Our study is a further step toward clinical application of cathodal tDCS over the primary motor cortex using pharmacological intervention to prolong the excitability-diminishing effect on pain perception for up to 24 hours poststimulation. Furthermore, it demonstrates the potential for repetitive daily stimulation therapy for pain patients."],["dc.identifier.doi","10.1016/j.jpainsymman.2007.08.014"],["dc.identifier.isi","000257688400009"],["dc.identifier.pmid","18358692"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53942"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","0885-3924"],["dc.title","Pergolide increases the efficacy of cathodal direct current stimulation to reduce the amplitude of laser-evoked potentials in humans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","230"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Brain Stimulation"],["dc.bibliographiccitation.lastpage","237"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Antal, Andrea"],["dc.contributor.author","Chaieb, Leila"],["dc.contributor.author","Moliadze, Vera"],["dc.contributor.author","Monte-Silva, Katia K."],["dc.contributor.author","Poreisz, Csaba"],["dc.contributor.author","Thirugnanasambandam, Nivethida"],["dc.contributor.author","Nitsche, Michael A."],["dc.contributor.author","Shoukier, Moneef"],["dc.contributor.author","Ludwig, Harald"],["dc.contributor.author","Paulus, Walter J."],["dc.date.accessioned","2018-11-07T08:38:19Z"],["dc.date.available","2018-11-07T08:38:19Z"],["dc.date.issued","2010"],["dc.description.abstract","Background The brain-derived neurotrophic factor (BDNF) gene is involved in mechanisms of synaptic plasticity in the adult brain. It has been demonstrated that BDNF also plays a significant role in shaping externally induced human brain plasticity. Plasticity induced in the human motor cortex by intermittent theta-burst stimulation (iTBS) was impaired in individuals expressing the Va166Met polymorphism. Methods To explore whether this polymorphism is also important for other neuroplasticity-inducing tools in humans with modes of action differing from that of iTBS, namely, transcranial direct current (tDCS) and random noise stimulation (tRNS), we retrospectively analyzed the data of 64 subjects studied in our laboratory with regard to BDNF genotype. Results Fifteen subjects with the Va166Met allele, 46 subjects with the Val66Val allele, and 3 Met66Met carriers were identified. The response of the Va166Met allele carriers to stimulation differed in two protocols compared with the response of Val66Val individuals. For iTBS (15 subjects, 5 heterozygotes), plasticity could be only induced in the Val66Val allele carriers. However, for facilitatory tDCS (24 subjects, 10 heterozygotes), as well as for inhibitory tDCS, (19 subjects, 8 heterozygotes), carriers of the Val66-Met allele displayed enhanced plasticity, whereas for transcranial random noise stimulation (29 subjects, 8 heterozygotes), the difference between groups was not so pronounced. Conclusions BDNF polymorphism has a definite impact on plasticity in humans, which might differ according to the mechanism of plasticity induction. This impact of BDNF on plasticity should be taken into account for future studies, as well as having wider ranging implications for the treatment of neuropsychiatric disorders with transcranial stimulation tools, as it may predetermine their efficacy for the treatment of disease and rehabilitation. (C) 2010 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.brs.2009.12.003"],["dc.identifier.isi","000283814200008"],["dc.identifier.pmid","20965453"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18739"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1935-861X"],["dc.title","Brain-derived neurotrophic factor (BDNF) gene polymorphisms shape cortical plasticity in humans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]