Hosseini, Shahrbanou

[["dc.bibliographiccitation.firstpage","873"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Genes"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Hosseini, Shahrbanou"],["dc.contributor.author","Schmitt, Armin Otto"],["dc.contributor.author","Tetens, Jens"],["dc.contributor.author","Brenig, Bertram"],["dc.contributor.author","Simianer, Henner"],["dc.contributor.author","Sharifi, Ahmad Reza"],["dc.contributor.author","Gültas, Mehmet"],["dc.date.accessioned","2021-08-12T07:45:56Z"],["dc.date.available","2021-08-12T07:45:56Z"],["dc.date.issued","2021"],["dc.description.abstract","The transcriptional regulation of gene expression in higher organisms is essential for different cellular and biological processes. These processes are controlled by transcription factors and their combinatorial interplay, which are crucial for complex genetic programs and transcriptional machinery. The regulation of sex-biased gene expression plays a major role in phenotypic sexual dimorphism in many species, causing dimorphic gene expression patterns between two different sexes. The role of transcription factor (TF) in gene regulatory mechanisms so far has not been studied for sex determination and sex-associated colour patterning in zebrafish with respect to phenotypic sexual dimorphism. To address this open biological issue, we applied bioinformatics approaches for identifying the predicted TF pairs based on their binding sites for sex and colour genes in zebrafish. In this study, we identified 25 (e.g., STAT6-GATA4; JUN-GATA4; SOX9-JUN) and 14 (e.g., IRF-STAT6; SOX9-JUN; STAT6-GATA4) potentially cooperating TFs based on their binding patterns in promoter regions for sex determination and colour pattern genes in zebrafish, respectively. The comparison between identified TFs for sex and colour genes revealed several predicted TF pairs (e.g., STAT6-GATA4; JUN-SOX9) are common for both phenotypes, which may play a pivotal role in phenotypic sexual dimorphism in zebrafish."],["dc.description.abstract","The transcriptional regulation of gene expression in higher organisms is essential for different cellular and biological processes. These processes are controlled by transcription factors and their combinatorial interplay, which are crucial for complex genetic programs and transcriptional machinery. The regulation of sex-biased gene expression plays a major role in phenotypic sexual dimorphism in many species, causing dimorphic gene expression patterns between two different sexes. The role of transcription factor (TF) in gene regulatory mechanisms so far has not been studied for sex determination and sex-associated colour patterning in zebrafish with respect to phenotypic sexual dimorphism. To address this open biological issue, we applied bioinformatics approaches for identifying the predicted TF pairs based on their binding sites for sex and colour genes in zebrafish. In this study, we identified 25 (e.g., STAT6-GATA4; JUN-GATA4; SOX9-JUN) and 14 (e.g., IRF-STAT6; SOX9-JUN; STAT6-GATA4) potentially cooperating TFs based on their binding patterns in promoter regions for sex determination and colour pattern genes in zebrafish, respectively. The comparison between identified TFs for sex and colour genes revealed several predicted TF pairs (e.g., STAT6-GATA4; JUN-SOX9) are common for both phenotypes, which may play a pivotal role in phenotypic sexual dimorphism in zebrafish."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.3390/genes12060873"],["dc.identifier.pii","genes12060873"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88580"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-448"],["dc.relation.eissn","2073-4425"],["dc.relation.orgunit","Abteilung Tierzucht und Haustiergenetik"],["dc.rights","CC BY 4.0"],["dc.title","In Silico Prediction of Transcription Factor Collaborations Underlying Phenotypic Sexual Dimorphism in Zebrafish (Danio rerio)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","13332"],["dc.bibliographiccitation.issue","23"],["dc.bibliographiccitation.journal","Ecology and Evolution"],["dc.bibliographiccitation.lastpage","13343"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Hosseini, Shahrbanou"],["dc.contributor.author","Simianer, Henner"],["dc.contributor.author","Tetens, Jens"],["dc.contributor.author","Brenig, Bertram"],["dc.contributor.author","Herzog, Sebastian"],["dc.contributor.author","Sharifi, Ahmad Reza"],["dc.date.accessioned","2021-06-01T10:50:10Z"],["dc.date.available","2021-06-01T10:50:10Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1002/ece3.5788"],["dc.identifier.eissn","2045-7758"],["dc.identifier.issn","2045-7758"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16873"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86556"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","2045-7758"],["dc.relation.issn","2045-7758"],["dc.relation.orgunit","Fakultät für Physik"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Efficient phenotypic sex classification of zebrafish using machine learning methods"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","341"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Genomics"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Hosseini, Shahrbanou"],["dc.contributor.author","Ngoc-Thuy Ha, Ngoc-Thuy Ha"],["dc.contributor.author","Simianer, Henner"],["dc.contributor.author","Falker-Gieske, Clemens"],["dc.contributor.author","Brenig, Bertram B."],["dc.contributor.author","Franke, Andre"],["dc.contributor.author","Hörstgen-Schwark, Gabriele"],["dc.contributor.author","Tetens, Jens"],["dc.contributor.author","Herzog, Sebastian"],["dc.contributor.author","Sharifi, Ahmad R."],["dc.date.accessioned","2019-07-09T11:51:19Z"],["dc.date.available","2019-07-09T11:51:19Z"],["dc.date.issued","2019"],["dc.description.abstract","Abstract Background Elevated water temperature, as is expected through climate change, leads to masculinization in fish species with sexual plasticity, resulting in changes in population dynamics. These changes are one important ecological consequence, contributing to the risk of extinction in small and inbred fish populations under natural conditions, due to male-biased sex ratio. Here we investigated the effect of elevated water temperature during embryogenesis on sex ratio and sex-biased gene expression profiles between two different tissues, namely gonad and caudal fin of adult zebrafish males and females, to gain new insights into the molecular mechanisms underlying sex determination (SD) and colour patterning related to sexual attractiveness. Results Our study demonstrated sex ratio imbalances with 25.5% more males under high-temperature condition, resulting from gonadal masculinization. The result of transcriptome analysis showed a significantly upregulated expression of male SD genes (e.g. dmrt1, amh, cyp11c1 and sept8b) and downregulation of female SD genes (e.g. zp2.1, vtg1, cyp19a1a and bmp15) in male gonads compared to female gonads. Contrary to expectations, we found highly differential expression of colour pattern (CP) genes in the gonads, suggesting the ‘neofunctionalisation’ of those genes in the zebrafish reproduction system. However, in the caudal fin, no differential expression of CP genes was identified, suggesting the observed differences in colouration between males and females in adult fish may be due to post-transcriptional regulation of key enzymes involved in pigment synthesis and distribution. Conclusions Our study demonstrates male-biased sex ratio under high temperature condition and support a polygenic SD (PSD) system in laboratory zebrafish. We identify a subset of pathways (tight junction, gap junction and apoptosis), enriched for SD and CP genes, which appear to be co-regulated in the same pathway, providing evidence for involvement of those genes in the regulation of phenotypic sexual dimorphism in zebrafish."],["dc.identifier.doi","10.1186/s12864-019-5722-1"],["dc.identifier.pmid","31060508"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16103"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59925"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Genetic mechanism underlying sexual plasticity and its association with colour patterning in zebrafish (Danio rerio)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Cell and Developmental Biology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.affiliation","Hosseini, Shahrbanou; \r\n1\r\nMolecular Biology of Livestock and Molecular Diagnostics Group, Department of Animal Sciences, University of Goettingen, Göttingen, Germany"],["dc.contributor.affiliation","Trakooljul, Nares; \r\n5\r\nResearch Institute for Farm Animal Biology (FBN), Institute of Genome Biology, Genomics Unit, Dummerstorf, Germany"],["dc.contributor.affiliation","Hirschfeld, Marc; \r\n1\r\nMolecular Biology of Livestock and Molecular Diagnostics Group, Department of Animal Sciences, University of Goettingen, Göttingen, Germany"],["dc.contributor.affiliation","Wimmers, Klaus; \r\n5\r\nResearch Institute for Farm Animal Biology (FBN), Institute of Genome Biology, Genomics Unit, Dummerstorf, Germany"],["dc.contributor.affiliation","Simianer, Henner; \r\n4\r\nCenter for Integrated Breeding Research (CiBreed), University of Goettingen, Göttingen, Germany"],["dc.contributor.affiliation","Tetens, Jens; \r\n2\r\nFunctional Breeding Group, Department of Animal Sciences, University of Goettingen, Göttingen, Germany"],["dc.contributor.affiliation","Sharifi, Ahmad Reza; \r\n4\r\nCenter for Integrated Breeding Research (CiBreed), University of Goettingen, Göttingen, Germany"],["dc.contributor.affiliation","Brenig, Bertram; \r\n1\r\nMolecular Biology of Livestock and Molecular Diagnostics Group, Department of Animal Sciences, University of Goettingen, Göttingen, Germany"],["dc.contributor.author","Hosseini, Shahrbanou"],["dc.contributor.author","Trakooljul, Nares"],["dc.contributor.author","Hirschfeld, Marc"],["dc.contributor.author","Wimmers, Klaus"],["dc.contributor.author","Simianer, Henner"],["dc.contributor.author","Tetens, Jens"],["dc.contributor.author","Sharifi, Ahmad Reza"],["dc.contributor.author","Brenig, Bertram"],["dc.date.accessioned","2022-08-04T07:53:42Z"],["dc.date.available","2022-08-04T07:53:42Z"],["dc.date.issued","2022-07-15"],["dc.date.updated","2022-07-29T05:41:30Z"],["dc.description.abstract","The plasticity of sexual phenotype in response to environmental conditions results in biased sex ratios, and their variation has an effect on population dynamics. Epigenetic modifications can modulate sex ratio variation in species, where sex is determined by genetic and environmental factors. However, the role of epigenetic mechanisms underlying skewed sex ratios is far from being clear and is still an object of debate in evolutionary developmental biology. In this study, we used zebrafish as a model animal to investigate the effect of DNA methylation on sex ratio variation in sex-biased families in response to environmental temperature. Two sex-biased families with a significant difference in sex ratio were selected for genome-wide DNA methylation analysis using reduced representation bisulfite sequencing (RRBS). The results showed significant genome-wide methylation differences between male-biased and female-biased families, with a greater number of methylated CpG sites in testes than ovaries. Likewise, pronounced differences between testes and ovaries were identified within both families, where the male-biased family exhibited a higher number of methylated sites than the female-biased family. The effect of temperature showed more methylated positions in the high incubation temperature than the control temperature. We found differential methylation of many reproduction-related genes (e.g., sox9a, nr5a2, lhx8a, gata4) and genes involved in epigenetic mechanisms (e.g., dnmt3bb.1, dimt1l, hdac11, h1m) in both families. We conclude that epigenetic modifications can influence the sex ratio variation in zebrafish families and may generate skewed sex ratios, which could have a negative consequence for population fitness in species with genotype-environment interaction sex-determining system under rapid environmental changes."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.3389/fcell.2022.880779"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112615"],["dc.language.iso","en"],["dc.relation.eissn","2296-634X"],["dc.relation.orgunit","Abteilung Functional Breeding"],["dc.relation.orgunit","Zentrum für Integrierte Züchtungsforschung"],["dc.rights","CC BY 4.0"],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0/"],["dc.title","Epigenetic Regulation of Phenotypic Sexual Plasticity Inducing Skewed Sex Ratio in Zebrafish"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]