Commichau, Fabian M.

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[["dc.bibliographiccitation.firstpage","2771"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Environmental Microbiology"],["dc.bibliographiccitation.lastpage","2791"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Gibhardt, Johannes"],["dc.contributor.author","Heidemann, Jana L."],["dc.contributor.author","Bremenkamp, Rica"],["dc.contributor.author","Rosenberg, Jonathan"],["dc.contributor.author","Seifert, Roland"],["dc.contributor.author","Kaever, Volkhard"],["dc.contributor.author","Ficner, Ralf"],["dc.contributor.author","Commichau, Fabian M."],["dc.date.accessioned","2021-04-14T08:26:38Z"],["dc.date.available","2021-04-14T08:26:38Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1111/1462-2920.15008"],["dc.identifier.eissn","1462-2920"],["dc.identifier.issn","1462-2912"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82025"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1462-2920"],["dc.relation.issn","1462-2912"],["dc.title","An extracytoplasmic protein and a moonlighting enzyme modulate synthesis of c‐di‐AMP in Listeria monocytogenes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","416"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Bacteriology"],["dc.bibliographiccitation.lastpage","426"],["dc.bibliographiccitation.volume","198"],["dc.contributor.author","Rismondo, Jeanine"],["dc.contributor.author","Gibhardt, Johannes"],["dc.contributor.author","Rosenberg, Jonathan"],["dc.contributor.author","Kaever, Volkhard"],["dc.contributor.author","Halbedel, Sven"],["dc.contributor.author","Commichau, Fabian M."],["dc.date.accessioned","2018-11-07T10:18:49Z"],["dc.date.available","2018-11-07T10:18:49Z"],["dc.date.issued","2016"],["dc.description.abstract","Cyclic diadenylate monophosphate (c-di-AMP) is a second messenger utilized by diverse bacteria. In many species, including the Gram-positive human pathogen Listeria monocytogenes, c-di-AMP is essential for growth. Here we show that the single diadenylate cyclase of L. monocytogenes, CdaA, is an integral membrane protein that interacts with its potential regulatory protein, CdaR, via the transmembrane protein domain. The presence of the CdaR protein is not required for the membrane localization and abundance of CdaA. We have also found that CdaR negatively influences CdaA activity in L. monocytogenes and that the role of CdaR is most evident at a high growth temperature. Interestingly, a cdaR mutant strain is less susceptible to lysozyme. Moreover, CdaA contributes to cell division, and cells depleted of CdaA are prone to lysis. The observation that the growth defect of a CdaA depletion strain can be partially restored by increasing the osmolarity of the growth medium suggests that c-di-AMP is important for maintaining the integrity of the protective cell envelope. Overall, this work provides new insights into the relationship between CdaA and CdaR. IMPORTANCE Cyclic diadenylate monophosphate (c-di-AMP) is a recently identified second messenger that is utilized by the Gram-positive human pathogen Listeria monocytogenes. Here we show that the single diadenylate cyclase of L. monocytogenes, CdaA, is an integral membrane protein that interacts with CdaR, its potential regulatory protein. We show that CdaR is not required for membrane localization or abundance of the diadenylate cyclase, but modulates its activity. Moreover, CdaA seems to contribute to cell division. Overall, this work provides new insights into the relationship between CdaA and CdaR and their involvement in cell growth."],["dc.identifier.doi","10.1128/JB.00845-15"],["dc.identifier.isi","000369163300008"],["dc.identifier.pmid","26527648"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41528"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Microbiology"],["dc.relation.issn","1098-5530"],["dc.relation.issn","0021-9193"],["dc.title","Phenotypes Associated with the Essential Diadenylate Cyclase CdaA and Its Potential Regulator CdaR in the Human Pathogen Listeria monocytogenes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Journal of Bacteriology"],["dc.bibliographiccitation.volume","201"],["dc.contributor.author","Quintana, Ingrid M."],["dc.contributor.author","Gibhardt, Johannes"],["dc.contributor.author","Turdiev, Asan"],["dc.contributor.author","Hammer, Elke"],["dc.contributor.author","Commichau, Fabian M."],["dc.contributor.author","Lee, Vincent T."],["dc.contributor.author","Magni, Christian"],["dc.contributor.author","Stülke, Jörg"],["dc.contributor.editor","Stock, Ann M."],["dc.date.accessioned","2020-12-10T18:37:01Z"],["dc.date.available","2020-12-10T18:37:01Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1128/JB.00028-19"],["dc.identifier.eissn","1098-5530"],["dc.identifier.issn","0021-9193"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76816"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","The KupA and KupB Proteins of Lactococcus lactis IL1403 Are Novel c-di-AMP Receptor Proteins Responsible for Potassium Uptake"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","175"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Trends in Microbiology"],["dc.bibliographiccitation.lastpage","185"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Commichau, Fabian M."],["dc.contributor.author","Gibhardt, Johannes"],["dc.contributor.author","Halbedel, Sven"],["dc.contributor.author","Gundlach, Jan"],["dc.contributor.author","Stülke, Jörg"],["dc.date.accessioned","2020-12-10T15:21:36Z"],["dc.date.available","2020-12-10T15:21:36Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.tim.2017.09.003"],["dc.identifier.issn","0966-842X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73083"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","A Delicate Connection: c-di-AMP Affects Cell Integrity by Controlling Osmolyte Transport"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1009"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Molecular Microbiology"],["dc.bibliographiccitation.lastpage","1024"],["dc.bibliographiccitation.volume","111"],["dc.contributor.author","Hauf, Samuel"],["dc.contributor.author","Herrmann, Jennifer"],["dc.contributor.author","Miethke, Marcus"],["dc.contributor.author","Gibhardt, Johannes"],["dc.contributor.author","Commichau, Fabian M."],["dc.contributor.author","Müller, Rolf"],["dc.contributor.author","Fuchs, Stephan"],["dc.contributor.author","Halbedel, Sven"],["dc.date.accessioned","2020-12-10T18:29:11Z"],["dc.date.available","2020-12-10T18:29:11Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1111/mmi.14205"],["dc.identifier.eissn","1365-2958"],["dc.identifier.issn","0950-382X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76554"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Aurantimycin resistance genes contribute to survival of Listeria monocytogenes during life in the environment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","16020"],["dc.bibliographiccitation.issue","44"],["dc.bibliographiccitation.journal","Journal of Biological Chemistry"],["dc.bibliographiccitation.lastpage","16033"],["dc.bibliographiccitation.volume","294"],["dc.contributor.author","Gibhardt, Johannes"],["dc.contributor.author","Hoffmann, Gregor"],["dc.contributor.author","Turdiev, Asan"],["dc.contributor.author","Wang, Mengyi"],["dc.contributor.author","Lee, Vincent T."],["dc.contributor.author","Commichau, Fabian M."],["dc.date.accessioned","2020-12-10T18:12:59Z"],["dc.date.available","2020-12-10T18:12:59Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1074/jbc.RA119.010046"],["dc.identifier.eissn","1083-351X"],["dc.identifier.issn","0021-9258"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74550"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","c-di-AMP assists osmoadaptation by regulating the Listeria monocytogenes potassium transporters KimA and KtrCD"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","1462-2920.16084"],["dc.bibliographiccitation.journal","Environmental Microbiology"],["dc.contributor.author","Wang, Mengyi"],["dc.contributor.author","Wamp, Sabrina"],["dc.contributor.author","Gibhardt, Johannes"],["dc.contributor.author","Holland, Gudrun"],["dc.contributor.author","Schwedt, Inge"],["dc.contributor.author","Schmidtke, Kai‐Uwe"],["dc.contributor.author","Scheibner, Katrin"],["dc.contributor.author","Halbedel, Sven"],["dc.contributor.author","Commichau, Fabian M."],["dc.date.accessioned","2022-07-01T07:35:09Z"],["dc.date.available","2022-07-01T07:35:09Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1111/1462-2920.16084"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112098"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-581"],["dc.relation.eissn","1462-2920"],["dc.relation.issn","1462-2912"],["dc.title","Adaptation of Listeria monocytogenes to perturbation of c‐di‐AMP metabolism underpins its role in osmoadaptation and identifies a fosfomycin uptake system"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","eaal3011"],["dc.bibliographiccitation.issue","475"],["dc.bibliographiccitation.journal","Science Signaling"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Gundlach, Jan"],["dc.contributor.author","Herzberg, Christina"],["dc.contributor.author","Kaever, Volkhard"],["dc.contributor.author","Gunka, Katrin"],["dc.contributor.author","Hoffmann, Tamara"],["dc.contributor.author","Weiss, Martin"],["dc.contributor.author","Gibhardt, Johannes"],["dc.contributor.author","Thuermer, Andrea"],["dc.contributor.author","Hertel, Dietrich"],["dc.contributor.author","Daniel, Rolf"],["dc.contributor.author","Bremer, Erhard"],["dc.contributor.author","Commichau, Fabian M."],["dc.contributor.author","Stulke, Joerg"],["dc.date.accessioned","2018-11-07T10:24:56Z"],["dc.date.available","2018-11-07T10:24:56Z"],["dc.date.issued","2017"],["dc.description.abstract","The second messenger cyclic di-adenosine monophosphate (c-di-AMP) is essential in the Gram-positive model organism Bacillus subtilis and in related pathogenic bacteria. It controls the activity of the conserved ydaO riboswitch and of several proteins involved in potassium (K+) uptake. We found that the YdaO protein was conserved among several different bacteria and provide evidence that YdaO functions as a K+ transporter. Thus, we renamed the gene and protein KimA (K+ importer A). Reporter activity assays indicated that expression beyond the c-di-AMP-responsive riboswitch of the kimA upstream regulatory region occurred only in bacteria grown in medium containing low K+ concentrations. Furthermore, mass spectrometry analysis indicated that c-di-AMP accumulated in bacteria grown in the presence of high K+ concentrations but not in low concentrations. A bacterial strain lacking all genes encoding c-di-AMP-synthesizing enzymes was viable when grown in medium containing low K+ concentrations, but not at higher K+ concentrations unless it acquired suppressor mutations in the gene encoding the cation exporter NhaK. Thus, our results indicated that the control of potassium homeostasis is an essential function of c-di-AMP."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [SPP1879]"],["dc.identifier.doi","10.1126/scisignal.aal3011"],["dc.identifier.isi","000400128400003"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42751"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Amer Assoc Advancement Science"],["dc.relation.issn","1937-9145"],["dc.relation.issn","1945-0877"],["dc.title","Control of potassium homeostasis is an essential function of the second messenger cyclic di-AMP in Bacillus subtilis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]