Commichau, Fabian M.

[["dc.bibliographiccitation.artnumber","32"],["dc.bibliographiccitation.journal","Frontiers in Molecular Biosciences"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Richts, Björn"],["dc.contributor.author","Rosenberg, Jonathan"],["dc.contributor.author","Commichau, Fabian M."],["dc.date.accessioned","2019-07-09T11:51:21Z"],["dc.date.available","2019-07-09T11:51:21Z"],["dc.date.issued","2019"],["dc.description.abstract","The B6 vitamer pyridoxal 5′-phosphate (PLP) is a co-factor for proteins and enzymes that are involved in diverse cellular processes. Therefore, PLP is essential for organisms from all kingdoms of life. Here we provide an overview about the PLP-dependent proteins from the Gram-positive soil bacterium Bacillus subtilis. Since B. subtilis serves as a model system in basic research and as a production host in industry, knowledge about the PLP-dependent proteins could facilitate engineering the bacteria for biotechnological applications. The survey revealed that the majority of the PLP-dependent proteins are involved in metabolic pathways like amino acid biosynthesis and degradation, biosynthesis of antibacterial compounds, utilization of nucleotides as well as in iron and carbon metabolism. Many PLP-dependent proteins participate in de novo synthesis of the co-factors biotin, folate, heme, and NAD+ as well as in cell wall metabolism, tRNA modification, regulation of gene expression, sporulation, and biofilm formation. A surprisingly large group of PLP-dependent proteins (29%) belong to the group of poorly characterized proteins. This review underpins the need to characterize the PLP-dependent proteins of unknown function to fully understand the “PLP-ome” of B. subtilis."],["dc.identifier.doi","10.3389/fmolb.2019.00032"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16110"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59932"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation","info:eu-repo/grantAgreement/EC/H2020/720776/EU//Rafts4Biotech"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","570"],["dc.title","A Survey of Pyridoxal 5′-Phosphate-Dependent Proteins in the Gram-Positive Model Bacterium Bacillus subtilis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","18"],["dc.bibliographiccitation.journal","Current Opinion in Biotechnology"],["dc.bibliographiccitation.lastpage","29"],["dc.bibliographiccitation.volume","56"],["dc.contributor.author","Acevedo-Rocha, Carlos G."],["dc.contributor.author","Gronenberg, Luisa S."],["dc.contributor.author","Mack, Matthias"],["dc.contributor.author","Commichau, Fabian M."],["dc.contributor.author","Genee, Hans J."],["dc.date.accessioned","2019-07-09T11:51:53Z"],["dc.date.available","2019-07-09T11:51:53Z"],["dc.date.issued","2019"],["dc.description.abstract","Vitamins are essential compounds in human and animal diets. Their demand is increasing globally in food, feed, cosmetics, chemical and pharmaceutical industries. Most current production methods are unsustainable because they use non-renewable sources and often generate hazardous waste. Many microorganisms produce vitamins naturally, but their corresponding metabolic pathways are tightly regulated since vitamins are needed only in catalytic amounts. Metabolic engineering is accelerating the development of microbial cell factories for vitamins that could compete with chemical methods that have been optimized over decades, but scientific hurdles remain. Additional technological and regulatory issues need to be overcome for innovative bioprocesses to reach the market. Here, we review the current state of development and challenges for fermentative processes for the B vitamin group."],["dc.identifier.doi","10.1016/j.copbio.2018.07.006"],["dc.identifier.pmid","30138794"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16220"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60034"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation","info:eu-repo/grantAgreement/EC/H2020/686070/EU//DD-DeCaF"],["dc.relation","info:eu-repo/grantAgreement/EC/H2020/720776/EU//Rafts4Biotech"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","570"],["dc.title","Microbial cell factories for the sustainable manufacturing of B vitamins"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]