Chebbok, Mohammed

[["dc.bibliographiccitation.artnumber","299"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Cardiovascular Disorders"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Sadlonova, Monika"],["dc.contributor.author","Vogelgsang, Jonathan"],["dc.contributor.author","Lange, Claudia"],["dc.contributor.author","Günther, Irina"],["dc.contributor.author","Wiesent, Adriana"],["dc.contributor.author","Eberhard, Charlotte"],["dc.contributor.author","Ehrentraut, Julia"],["dc.contributor.author","Kirsch, Mareike"],["dc.contributor.author","Hansen, Niels"],["dc.contributor.author","Esselmann, Hermann"],["dc.contributor.author","Timäus, Charles"],["dc.contributor.author","Asendorf, Thomas"],["dc.contributor.author","Breitling, Benedict"],["dc.contributor.author","Chebbok, Mohammed"],["dc.contributor.author","Heinemann, Stephanie"],["dc.contributor.author","Celano, Christopher"],["dc.contributor.author","Kutschka, Ingo"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Baraki, Hassina"],["dc.contributor.author","von Arnim, Christine A. F."],["dc.date.accessioned","2022-08-04T12:01:17Z"],["dc.date.available","2022-08-04T12:01:17Z"],["dc.date.issued","2022-06-30"],["dc.date.updated","2022-07-25T11:18:49Z"],["dc.description.abstract","Background Postoperative delirium is a common complication of cardiac surgery associated with higher morbidity, longer hospital stay, risk of cognitive decline, dementia, and mortality. Geriatric patients, patients undergoing cardiac surgery, and intensive care patients are at a high risk of developing postoperative delirium. Gold standard assessments or biomarkers to predict risk factors for delirium, cognitive decline, and dementia in patients undergoing cardiac surgery are not yet available. Methods The FINDERI trial (FINd DElirium RIsk factors) is a prospective, single-center, observational study. In total, 500 patients aged ≥ 50 years undergoing cardiac surgery at the Department of Cardiovascular and Thoracic Surgery of the University of Göttingen Medical Center will be recruited. Our primary aim is to validate a delirium risk assessment in context of cardiac surgery. Our secondary aims are to identify specific preoperative and perioperative factors associated with delirium, cognitive decline, and accelerated dementia after cardiac surgery, and to identify blood-based biomarkers that predict the incidence of postoperative delirium, cognitive decline, or dementia in patients undergoing cardiac surgery. Discussion This prospective, observational study might help to identify patients at high risk for delirium prior to cardiac surgery, and to identify important biological mechanisms by which cardiac surgery is associated with delirium. The predictive value of a delirium screening questionnaire in cardiac surgery might be revealed. Finally, the identification of specific blood biomarkers might help to predict delirium, cognitive decline, and dementia in patients undergoing cardiac surgery. Trial registration: Ethics approval for this study was obtained from the IRB of the University of Göttingen Medical Center. The investigators registered this study in the German Clinical Trials Register (DRKS; https://www.drks.de ) (DRKS00025095) on April 19th, 2021."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.citation","BMC Cardiovascular Disorders. 2022 Jun 30;22(1):299"],["dc.identifier.doi","10.1186/s12872-022-02732-4"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112643"],["dc.language.iso","en"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.subject","Delirium"],["dc.subject","Cognitive decline"],["dc.subject","Dementia"],["dc.subject","Delirium risk assessment"],["dc.subject","Cardiac surgery"],["dc.subject","Biomarkers"],["dc.title","Identification of risk factors for delirium, cognitive decline, and dementia after cardiac surgery (FINDERI—find delirium risk factors): a study protocol of a prospective observational study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","118"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Neurology"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Schnieder, Marlena"],["dc.contributor.author","Chebbok, Mohammed"],["dc.contributor.author","Didié, Michael"],["dc.contributor.author","Wolf, Frieder"],["dc.contributor.author","Badr, Mostafa"],["dc.contributor.author","Allam, Ibrahim"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Schroeter, Marco R."],["dc.date.accessioned","2021-04-14T08:28:09Z"],["dc.date.accessioned","2022-08-18T12:34:55Z"],["dc.date.available","2021-04-14T08:28:09Z"],["dc.date.available","2022-08-18T12:34:55Z"],["dc.date.issued","2021-03-17"],["dc.date.updated","2022-07-29T12:07:15Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n Echocardiography is one of the main diagnostic tools for the diagnostic workup of stroke and is already well integrated into the clinical workup. However, the value of transthoracic vs. transesophageal echocardiography (TTE/TEE) in stroke patients is still a matter of debate. Aim of this study was to characterize relevant findings of TTE and TEE in the management of stroke patients and to correlate them with subsequent clinical decisions and therapies.\r\n \r\n \r\n Methods\r\n We evaluated n = 107 patients admitted with an ischemic stroke or transient ischemic attack to our stroke unit of our university medical center. They underwent TTE and TEE examination by different blinded investigators.\r\n \r\n \r\n Results\r\n Major cardiac risk factors were found in 8 of 98 (8.2%) patients and minor cardiac risk factors for stroke were found in 108 cases. We found a change in therapeutic regime after TTE or TEE in 22 (22.5%) cases, in 5 (5%) cases TEE leads to the change of therapeutic regime, in 4 (4%) TTE and in 13 cases (13.3%) TTE and TEE lead to the same change in therapeutic regime. The major therapy change was the indication to close a patent foramen ovale (PFO) in 9 (9.2%) patients with TTE and in 10 (10.2%) patients with TEE (p = 1.000).\r\n \r\n \r\n Conclusion\r\n Major finding with clinical impact on therapy change is the detection of PFO. But for the detection of PFO, TTE is non inferior to TEE, implicating that TTE serves as a good screening tool for detection of PFO, especially in young age patients.\r\n \r\n \r\n Trial registration\r\n The trial was registered and approved prior to inclusion by our local ethics committee (1/3/17)."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.citation","BMC Neurology. 2021 Mar 17;21(1):118"],["dc.identifier.doi","10.1186/s12883-021-02136-5"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17746"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82515"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112935"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","BioMed Central"],["dc.relation.eissn","1471-2377"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject","Stroke"],["dc.subject","Echocardiography"],["dc.subject","Patent foramen ovale"],["dc.subject","Cardio-embolic stroke"],["dc.title","Comparing the diagnostic value of Echocardiography In Stroke (CEIS) – results of a prospective observatory cohort study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]